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PREDECESSOR-SET TECHNIQUE FOR RELIABILITY EVALUATION OF A STOCHASTIC MANUFACTURING SYSTEM

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Journal of Systems Science and Systems Engineering 2015年第2期24卷 190-210页

作者： yi-kuei lin ping-chen chang Department of Industrial Management National Taiwan University of Science & Technology

This paper studies the reliability evaluation of a stochastic manufacturing system with multiple production lines in parallel. Multiple repairs and different failure rates, never simultaneously addressed in earlier works, are taken into account. First, a revised graphical methodology integrating transformation and decomposition is utilized to construct the stochastic manufacturing system as a multi-state manufacturing network （MSMN）. In particular, a ＂predecessor-set＂ technique is proposed to deal with multiple repairs. An algorithm is proposed to generate the lowest capacity vectors （LCVs） that stations should provide to satisfy the workloads. Subsequently, the system reliability of the MSMN, which is defined as the probability of demand satisfaction, is calculated in terms of the LCVs. A real case of a printed circuit board manufacturing system is utilized to demonstrate how the system reliability can be evaluated. A further decision making issue is addressed based on the derived system reliability.

关键词： Multi-state manufacturing network (MSMN) predecessor-set lowest capacity vector(LCV) different failure rates multiple repairs system reliability

GRAPHICAL-BASED RELIABILITY EVALUATION OF MULTIPLE DISTINCT PRODUCTION linES

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Journal of Systems Science and Systems Engineering 2013年第1期22卷 73-92页

作者： yi-kuei lin ping-chen chang Department of Industrial Management National Taiwan University of Science & Technology

This paper proposes a graphical-based methodology to evaluate the performance of a manufacturing system in terms of network *** focus on a manufacturing system which consists of multiple distinct production lines.A transformation technique is developed to build the manufacturing system as a manufacturing *** such a manufacturing network,the capacity of each machine is multistate due to failure,partial failure,or ***,this manufacturing network is also regarded as a multistate *** evaluate the probability that the manufacturing network can meet a given demand,where the probability is referred to as the system reliability.A simple algorithm integrating decomposition technique is proposed to generate the minimal capacity vectors that machines should provide to eventually satisfy *** system reliability is derived in terms of such capacity vectors afterwards.A practical application in the context of IC card manufacturing system is utilized to demonstrate the performance evaluation procedure.

关键词： Graphical-based methodology transformation decomposition multiple distinct production lines system reliability

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

A Modified Differential Transform Method (DTM) for Analyzing Irreversibility of Heat Transfer in Flow Through a Moving Plate with Variable Temperature

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Communications in Theoretical Physics 2017年第11期67卷 647-653页

作者： yin-Wei lin kuei-Hao chang Cha'o-Kuang chen Department of Mathematics and Finance Putian University Research and Services Headquarters and Technology Transfer and Business Incubation Center National Cheng Kung University Department of Mechanical Engineering National Cheng Kung University

In this paper, the entropy generation of a flow through a movable plate with variable temperature is *** similarity variables are applied to transform the local entropy generation rate to entropy generation number.A modified differential transform method(DTM) with shooting method is used to obtain the similarity solution of the entropy generation. The effects of different parameters(Prandtl number, variable wall temperature) on the irreversibility(such as N_(sh), N_(sf), N_(sx)) are analyzed and discussed. Moreover, it is worth mentioning that DTM is of advantage because its numerical solution is differentiation and integration. Therefore, its analysis result is reliable and high accuracy.

关键词： sakiadis entropy generation irreversibility moving plate differential transform DTM

Rapid synthesis of Ti-MCM-41 by microwave-assisted hydrothermal method towards photocatalytic degradation of oxytetracycline

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Journal of Environmental Sciences 2016年第6期28卷 76-87页

作者： Hanlin chen Yen-ping Peng Ku-Fan chen Chia-Hsiang Lai Yung-chang lin College of Environment and Energy South China University of Technology Department of Environmental Science and Engineering Tunghai University Department of Civil Engineering "National"Chi Nan University Department of Safety Health and Environmental EngineeringCentral Taiwan University of Science and Technology Department of Electrical Engineering Cheng Shiu University

This study employed microwave-assisted hydrothermal method to synthesize Ti-MCM-41,which are mesoporous materials with a high surface area and excellent photocatalytic ability. Fourier transform infrared spectroscopy（FTIR）, X-ray diffraction（XRD）, X-ray photoelectron spectroscopy（XPS）, transmission electron microscopy（TEM）, and ultraviolet–visible spectroscopy（UV–Vis） were employed. The XRD findings showed that Ti-MCM-41 exhibited a peak at 2θ of 2.2°, which was attributed to the hexagonal MCM-41 structure. The BET（Brunauer–Emmett–Teller） results agreed with the TEM findings that Ti-MCM-41 has a pore size of about 3–5 nm and a high surface area of 883 m-2/g. FTIR results illustrated the existence of Si–O–Si and Si–O–Ti bonds in Ti-MCM-41. The appearance of Ti2 p peaks in the XPS results confirmed the FTIR findings that the Ti was successfully doped into the MCM-41 structure. Zeta（ζ）-potential results indicated that the iso-electric point（IEP） of Ti-MCM-41 was at about pH 3.02. In this study, the photocatalytic degradation of oxytetracycline（OTC） at different pH was investigated under Hg lamp irradiation（wavelength 365 nm）. The rate constant（K′obs） for OTC degradation was 0.012 min-1at pH 3. Furthermore, TOC（total organic carbon） and high resolution LC–MS（liquid chromatography–mass spectrometry） analyses were conducted to elucidate the possible intermediate products and degradation pathway for OTC. The TOC removal efficiency of OTC degradation was 87.0%, 74.4% and 50.9% at pH 3, 7 and 10, respectively. LC–MS analysis results showed that the degradation products from OTC resulted from the removal of functional groups from the OTC ring.

关键词： Oxytetracycline Ti-MCM-41 Microwave hydrothermal synthesis Photocatalytic degradation

Effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow, gastric motiiity and brain-gut peptide

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World Journal of Gastroenterology 2007年第15期13卷 2229-2233页

作者： Ya-ping lin Shou-Xiang yi Jie Yan Xiao-Rong chang The Institute of Acupuncture Moxibustion and Massage Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China

AIM： To observe the effect of acupuncture at Foot- Yangming Meridian on gastric mucosal blood flow （GMBF）, gastric motility and brain-gut peptide. METHODS： Sixty SD rats were randomly divided into 6 groups： normal control group, model group （group with gastric mucosal damage, GMD）, Sibai group （with acupuncture at Sibai point ＋ GMD）, Tianshu group （with acupuncture at Tianshu point ＋ GMD）, Zusanli group （with acupuncture at Zusanli point ＋ GMD） and non-acupoint group （with acupuncture at non-acupoint ＋ GMD）. The GMD model group was induced by infusing pure alcohol into gastric cavity. H2 Gas Clearance Test （HGCT） was used to measure GMBF, the frequency and amplitude of gastric motility were measured by the method of aerocyst, the content of brain-gut peptide in sinus ventriculi and bulbus medullae were detected by radioimmunoassay. RESULTS： Inhibitory effect of the frequency and amplitude of gastric motility were shown in model group, and the rates of frequency and amplitude changes were remarkably different from the normal control group （-19.41 ± 17.21 vs-4.71 ± 10.32, P 〈 0.05; -51.61 ± 29.02 vs 1.81 ± 14.12, P 〈 0.01）. In comparison with control group, the GMBF was 0.52 ± 0.161 mL vs 1.03 ± 0.255 mL per 100g tissue/min, P 〈 0.01, the content of motilin in sinus ventriculi and bulbus medullae was 63.04 ± 7.77 pg/mL vs 72.91 ± 8.42 pg/mL, P 〈 0.05 and 50.96 ± 8.77 pg/mL vs 60.76 ± 8.05 pg/mL, P 〈 0.05, but the content of somatostatin in sinus ventriculi and bulbus medullae was 179.85 ± 43.13 ng/g vs 90.54 ± 40.42 ng/g, P 〈 0.01 and 532.86 ± 122.58 ng/g vs 370.91 ± 76.29 ng/g, P 〈 0.05,respectively. In comparison with model group, the amplitude of gastric motility was 1.52 ± 20.13, -6.52 ± 23.31, 6.92 ± 25.21 vs -51.61 ± 29.02, P 〈 0.01 and GMBF was 0.694 ± 0.160 mL vs 0.893 ± 0.210 mL, 1.038 ± 0.301 mL vs 0.52 ± 0.161 mL per 100g tissue/rain, P 〈 0.01, respectively in Tianshu, Sibai and Zusanli groups, the content of motilin in sinus ventriculi and bulbus medul

关键词： Electro-acupuncture Foot-Yangming Meridian Gastric motility Motilin Somatostatin

Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： chen Yu lin Hung Ju chen yi Kit Chan Wei ping Hsia Yu Len Huang Chia Jen chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

Effect of yttrium treatment on alumina inclusions in high carbon steel

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Journal of Iron and Steel Research International 2022年第4期29卷 655-664页

作者： yi Wang chang-rong Li lin-zhu Wang Xing-qiang Xiong Lu chen School of Materials and Metallurgy Guizhou UniversityGuiyang 550025GuizhouChina Guizhou Key Laboratory of Metallurgical Engineering and Process Energy Conservation Guiyang 550025GuizhouChina

Aluminum oxide inclusions in SWRS82B steel seriously affect the drawing performance of steel *** effects of different addition amounts of yttrium(within the range of 0%–0.026%)on the composition,morphology,size and spacing of aluminum oxide inclusions were studied by scanning electron microscopy and energy spectrum *** on classical thermodynamics and FactSage software,the predominance diagram of inclusions in Fe–O–S–Y system and the effect of the addition of rare earth yttrium on the stability of alumina inclusions were *** results showed that molten steel was modified by adding the rare earth element *** can be inferred that the approximate route of target inclusion modification was:Al_(2)O_(3)→Y_(2)S_(3)+YAlO_(3)+Al_(2)O_(3)→Y_(2)S_(3)+YAlO_(3)+Y_(2)O_(2)S+YAlO_(3)+Al_(2)O_(3)→Y_(2)S_(3)+Y_(2)O_(2)*** experimental samples with 0.026%added yttrium had the best inclusion characteristics,in which the inclusion surface density distribution was uniform,and the interfacial distance between inclusions was mainly in the range of 100–500μ*** modification,the average inclusion size in molten steel was reduced by 6.9–8.6μ*** mechanism of yttrium modification was discussed based on actual calculation results and experimental results.

关键词： Yttrium treatment Modification of aluminum inclusions Inclusion evolution Thermodynamics

Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis

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Science China Chemistry 2018年第6期61卷 702-707页

作者： chen-chen chen Shuai Gao Hua-Song Ai Qian Qu chang-lin Tian yi-Ming Li High Magnetic Field Laboratory Chinese Academy of Sciences Hefei 230031 China School of Life Sciences University of Science and Technology of China Hefei 230026 China School of Biological and Medical Engineering Hefei University of Technology Hefei 230009 China Department of Chemistry Tsinghua University Beijing 100084 China

Snake toxin Calciseptine as a natural antagonist of L-type calcium channel has potential drug values, but its structural information remains unknown. Here, we report the total chemical synthesis of Calciseptine by using hydrazide based native chemical ligation. The crystal structure of Calciseptine was determined by racemic protein crystallography technique. Compared to the structure of its homologous family protein, we found that Calciseptine is adopting a typical three-finger structure.

关键词： protein chemical synthesis calciseptine hydrazide based native chemical ligation racemic protein crystallography