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Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling

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World Journal of Stem Cells 2024年第2期16卷 151-162页

作者： jing-yi li Ting-Ting Wang li Ma Yu Zhang Di Zhu Department of Medical Cosmetology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Plastic Surgery China-Japan Friendship HospitalBeijing 100029China Senior Department of Hematology The Fifth Medical CentreGeneral Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Orthopaedic Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Osteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic *** osteoporosis,bone mesenchymal stem cells(BMSCs)exhibit an increased ability to differentiate into adipocytes and a decreased ability to differentiate into osteoblasts,resulting in bone *** domain-containing 1C(JMJD1C)has been demonstrated to suppress *** To examine the effect of JMJD1C on the osteogenesis of BMSCs and the potential underlying *** BMSCs were isolated from mouse bone marrow *** Red O staining,Alizarin red staining,alkaline phosphatase staining and the expression of adipo-genic and osteogenic-associated genes were assessed to determine the differen-tiation of *** marrow-derived macrophages(BMMs)were incubated with receptor activator of nuclear factor-kappaΒligand to induce osteoclast differentiation,and osteoclast differen-tiation was confirmed by tartrate-resistant acid phosphatase *** related genes were measured via reverse transcription coupled to the quantitative polymerase chain reaction and western ***-linked immunosorbent assays were used to measure the levels of inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6 and interleukin-1 *** The osteogenic and adipogenic differentiation potential of BMSCs isolated from mouse bone marrow samples was ***1C mRNA and protein expression was upregulated in BMSCs after osteoblast induction,while p-nuclear factor-κB(NF-κB)and inflammatory cytokines were not significantly *** of JMJD1C repressed osteogenic differentiation and enhanced NF-κB activation and inflammatory cytokine release in ***,JMJD1C expression decreased during BMM osteoclast *** The JMJD1C/NF-κB signaling pathway is potentially involved in BMSC osteogenic differentiation and may play vital roles in the pathogenesis of osteoporosis.

关键词： Osteoporosis Mesenchymal stem cells Osteogenesis Jumonji domain-containing 1C Nuclear factor-κB

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Comprehensive evaluation of rare case:From diagnosis to treatment of a sigmoid Schwannoma:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 244-250页

作者： jing-yi li Xi-Zhuang Gao Jian Zhang Xiang-Zheng Meng yi-Xian Cao Kun Zhao Clinical Medical College of Jining Medical University Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Gastroenterology The First People's Hospital of JiningJining 272000Shandong ProvinceChina

BACKGROUND Schwannomas are uncommon tumors originating from Schwann cells,forming the neural *** account for approximately 2%-6%of all mesenchymal tumors and are most commonly identified in peripheral nerve trunks,with rarity in the gastrointestinal *** gastrointestinal locations,the stomach harbors the majority of nerve sheath tumors,while such occurrences in the sigmoid colon are exceptionally *** SUMMARY This study presented a clinical case involving a 60-year-old female patient who,during colonoscopy,was diagnosed with a submucosal lesion that was later identified as a nerve sheath *** patient underwent surgical resection,and the diagnosis was confirmed through *** study highlighted an exceptionally uncommon occurrence of a nerve sheath tumor in the sigmoid colon,which was effectively managed within our ***,a comprehensive review of relevant studies was *** The preoperative diagnosis of nerve sheath tumors poses challenges,as the definitive diagnosis still relies on pathology and *** categorized as benign,these tumors have the potential to demonstrate malignant ***,the optimal treatment approach entails the complete surgical excision of the tumor,ensuring the absence of residual lesions at the margins.

关键词： Schwannoma Gastrointestinal stromal tumors Treatment Sigmoid colon Case report

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Milestone progress of the HEPS booster commissioning

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Nuclear Science and Techniques 2024年第1期35卷 170-177页

作者： Yue-Mei Peng Jian-She Cao Jin-Hui Chen Hai-yi Dong Ping He yi Jiao ling Kang Wen Kang Jian li jing-yi li Guo-Ping lin Fang liu Feng-li Long Cai Meng Xin Qi Hua-Min Qu Yan-Feng Sui Sheng Wang Gang Xu Qiang Ye jing Zhang Pei Zhang Wei-Min Pan Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China University of the Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China

The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in *** HEPS injector consists of a linear accelerator(linac)and a full energy *** booster captures the electron beam from the linac and increases its energy to the value required for the storage *** full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target *** milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam *** measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,*** paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.

关键词： High energy photon source Booster Beam commissioning

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Screened peptides from one-bead one-compound technique extend half-life of peptide drugs in circulation through binding to albumin

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Chinese Chemical Letters 2024年第3期35卷 384-388页

作者： yi-jing li lingze Zhang Ming-Hao Pang Pei-Pei Yang Lu-Ming Guo Kuo Zhang Da-Yong Hou Lei Wang Hao Wang Hui Cao State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Peptide drugs are known for their high biological ***,compared with small molecule drugs,peptide drugs are easily oxidized and hydrolyzed as well as short in ***,inspired by the long circulation of albumin in blood,we screened albumin binding peptides(ABPs)from a one-bead one-compound(OBOC)peptide library to increase the half-life of peptide *** displaying random peptides were screened using fluorescent labeled human serum *** beads with specific binding to albumin were isolated for *** selected ABPs can effectively bind to albumin,thus possessing the long circulation of *** dissociation constant(K_(D))of ABPs to albumin is up to 1×10^(-8)mol/*** one of ABPs(ABP2)was coupled to triptorelin,the circulation half-life of triptorelin in mice was significantly prolonged to 263.50 h much longer than that of triptorelin alone(179.07 h).In addition,the combination therapy using ABP-conjugated triptorelin and doxorubicin(DOX)can effectively inhibit the proliferation of tumor cells in *** OBOC screening strategy and resulting ABPs showed great potential for enhancing the delivery efficiency of peptide drugs.

关键词： One-bead one-compound Combinatorial library Albumin binding Drug delivery Triptorelin

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Simultaneous rectal neuroendocrine tumors and pituitary adenoma:A case report and review of literature

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世界胃肠病学杂志:英文版 2023年第34期29卷 5082-5090页

作者： jing-yi li Jie Chen Jun liu Su-Zhen Zhang Department of Gastroenterology Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neuroendocrine Tumor Fudan University Shanghai Cancer CenterShanghai 200032China Department of Gastroenterology Shanxi Bethune HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Neuroendocrine tumors(NET)are rare heterogeneous tumors that arise from neuroendocrine cells throughout the ***,a rare and slowly progressive disorder,usually results from a growth hormone(GH)-secreting pituitary *** SUMMARY We herein describe a 38-year-old patient who was initially diagnosed with *** colonoscopy,two bulges were identified and subsequently removed through endoscopic submucosal *** the surgical intervention,the excised tissue samples were examined and confirmed to be grade 2 NET.^(18)F-ALF-NOTATATE positron emission tomography-computed tomography(PET/CT)and 68Ga-DOTANOC PET/CT revealed metastases in the peri-intestinal lymph nodes,prompting laparoscopic low anterior resection with total mesorectal *** patient later returned to the hospital because of hyperglycemia and was found to have facial changes,namely a larger nose,thicker lips,and mandibular *** tests and magnetic resonance imaging(MRI)suggested a GH-secreting pituitary *** pituitary adenoma shrunk after treatment with octreotide and was neuroendoscopically resected via a trans-sphenoidal ***-exome sequencing analysis revealed no genetic *** patient recovered well with no evidence of recurrence during *** ^(18)F-ALF-NOTATE PET/CT and MRI with pathological analysis can effectively diagnose rare cases of pituitary adenomas complicated with rectal NET.

关键词： Neuroendocrine neoplasm Pituitary adenoma Rectum Diagnosis Case report

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Development and simulation of a gridded thermionic cathode electron gun for a high-energy photon source

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Nuclear Science and Techniques 2023年第3期34卷 73-81页

作者： Sheng-Chang Wang Da-Yong He Cai Meng jing-yi li Zu-Sheng Zhou Jin-Dong liu Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

A gridded thermionic cathode electron gun was developed for the linear accelerator of the High Energy Photon Source(HEPS).An electron gun should provide a large maximum bunch charge with a wide adjustable *** satisfy these requirements,the shape of the electrode was optimized using a multi-objective genetic algorithm.A large bunch charge with an adjustable range was achieved using the grid-limited gun,the flow of which was analyzed using 3-D *** electron gun has been manufactured and tested,and the measured data of the grid-limited current and simulation results are compared and discussed in this study.

关键词： Electron gun Multi-objective genetic algorithm Grid CST

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Development of RF windows for 650 MHz multibeam klystron

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Nuclear Science and Techniques 2023年第9期34卷 58-68页

作者： Sheng-Chang Wang Zu-Sheng Zhou Zhi-Jun Lu Zhi-Qing liu Shigeki Fukuda Yu liu jing-yi li Wei-Ming li National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Kunshan Guo li Electronic Technology Co. Ltd.Kunshan 215300China High Energy Accelerator Research Organization KEK 1-1 OhoTsukubaIbaraki 305-0801Japan

Radio frequency windows are developed and evaluated for a 650 MHz continuous-wave multibeam ***-pillbox windows with alumina and beryllia disks are designed with an average RF power of CW 400 *** of a cold test and tuning procedures are *** final measured S11 curves under the required bandwidth are less than-32.0 and-26.9 dB for alumina and beryllia windows,*** windows are tested up to CW 143 kW for traveling waves and CW 110 kW for standing waves using a solid-state amplifier as an RF power *** simulations for windows and benchmark studies for the thermal analysis of ceramic disks are introduced.

关键词： RF window High-power test MBK

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lipoprotein(a)variability is associated with mean follow-up Creactive protein in patients with coronary artery disease following percutaneous coronary intervention

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World Journal of Clinical Cases 2022年第35期10卷 12909-12919页

作者： Si-Si Zhang Wen-yi Hu yi-jing li Juan Yu Shang Sang Zakareya M Alsalman Da-Qi Xie Department of Cardiology Ningbo Ninth HospitalNingbo 315300Zhejiang ProvinceChina

BACKGROUND Increased lipoprotein(a)[lp(a)]has proinflammatory effects,which increase the risk of coronary artery ***,the association between lp(a)variability and follow-up C-reactive protein(CRP)level in patients undergoing percutaneous coronary intervention(PCI)has not been *** To explore the association between lp(a)variability and mean CRP levels within the 1st year *** Results of lp(a)and CRP measurements from at least three follow-up visits of patients who had received PCI were retrospectively *** deviation(SD),coefficient of variation(CV),and variability independent of the mean(VIM)are presented for the variability for lp(a)and linear regression analysis was conducted to correlate lp(a)variability and mean follow-up CRP *** relationship of lp(a)variability and inflammation status was analyzed by restricted cubic spline ***,exploratory analysis was performed to test the consistency of results in different *** A total of 2712 patients were *** with higher variability of lp(a)had a higher level of mean follow-up CRP(Plity was positively correlated with the mean follow-up CRP(SD:β=0.023,Plinear regression *** analysis showed that the positive association remained consistent in most *** Lp(a)variability correlated with mean follow-up CRP level and high variability could be considered an independent risk factor for increased post-PCI CRP level.

关键词： lipoprotein(a) Variability C-reactive protein Coronary artery disease Percutaneous coronary intervention

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Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance li-ion battery

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Rare Metals 2024年第7期43卷 2994-3006页

作者： ying li yi-Han Zhao Lu-Lu Zhao Peng-Fei Wang ying Xie Ting-Feng yi School of Materials Science and Engineering Northeastern University Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at Qinhuangdao Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang University

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries（liBs） due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of li+limits its practical *** this work,C-Sb composite was constructed as anode material of liBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2（the mass ratio of polyacrylonitrile to Sb source is 1:2） electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g-1at 0.1,0.2,0.3,0.5,1 and 2 A·g-1,*** when the current density returned to 0.1 A·g-1,the charge capacity was 939.3 mAh·g-1,revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory（DFT） calculations revealed the gradual enhancement of the interface interaction between Sbxliyand amorphous carbon（AMC） with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sbxliyto *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

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Atomistic study on the microscopic mechanism of grain boundary embrittlement induced by small dense helium bubbles in iron

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Nuclear Science and Techniques 2024年第3期35卷 84-95页

作者： Lei Peng Yong-Jie Sun jing-yi Shi yi-Fei liu Shang-Ming Chen liu-liu li State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

The helium bubbles induced by 14 MeV neutron irradiation can cause intergranular fractures in reduced activation ferritic martensitic steel,which is a candidate structural material for fusion *** order to elucidate the susceptibility of different grain boundaries(GBs)to helium-induced embrittlement,the tensile fracture processes of 10 types of GBs with and without helium bubbles in body-centered cubic(bcc)iron at the relevant service temperature of 600 K were investigated via molecular dynamics *** results indicate that in the absence of helium bubbles,the GBs studied here can be classified into two distinct categories:brittle GBs and ductile *** atomic scale analysis shows that the plastic deformation of ductile GB at high temperatures originates from complex plastic deformation mechanisms,including the Bain/Burgers path phase transition and deformation twinning,in which the Bain path phase transition is the most dominant plastic deformation ***,the presence of helium bubbles severely inhibits the plastic deformation channels of the GBs,resulting in a significant decrease in elongation at *** bubble-decorated GBs,the ultimate tensile strength increases with the increase in the misorientation ***,the coherent twin boundary∑3{112}was found to maintain relatively high fracture strength and maximum failure strain under the influence of helium bubbles.

关键词： Helium bubble Grain boundary Embrittlement Reduced activation ferritic martensitic steel Molecular dynamics Bain path

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