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Influence of electroacupuncture on ghrelin and the phosphoinositide 3-kinase/protein kinase B/endothelial nitric oxide synthase signaling pathway in spontaneously hypertensive rats

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Journal of Integrative Medicine 2022年第5期20卷 432-441页

作者： Yue Zhang Dong-ling Zhong Ya-ling Zheng Yu-xi Li yi-jie Huang yi-jing jiang Rong-jiang Jin Juan Li School of Health Preservation and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Rehabilitation Medicine The Second People’s Hospital of ChengduChengdu 610017Sichuan ProvinceChina Department of Rehabilitation Medicine The Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Rehabilitation Medicine Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350003Fujian ProvinceChina

Objective To investigate the influence of electroacupuncture(EA)on ghrelin and the phosphoinositide 3-kinase/protein kinase B/endothelial nitric oxide synthase(PI3K/Akt/eNOS)signaling pathway in spontaneously hypertensive rats(SHRs).Methods Eight Wistar-Kyoto rats were used as the healthy blood pressure(BP)control(normal group),and 32 SHRs were randomized into model group,EA group,EA plus ghrelin group(EA+G group),and EA plus PF04628935 group(a potent ghrelin receptor blocker;EA+P group)using a random number *** in the normal group and model group did not receive treatment,but were immobilized for 20 min per day,5 times a week,for 4 continuous *** in the EA group,EA+G group and EA+P group were immobilized and given EA treatment in 20 min sessions,5 times per week,for 4 ***,1 h before EA,SHRs in the EA+G group and EA+P group were intraperitoneally injected with ghrelin or PF04628935,respectively,for 4 *** tail-cuff method was used to measure *** the 4-week intervention,the rats were sacrificed by cervical dislocation,and pathological morphology of the abdominal aorta was observed using hematoxylin-eosin(HE)***-linked immunosorbent assay(ELISA)was used to detect the levels of ghrelin,nitric oxide(NO),endothelin-1(ET-1)and thromboxane A2(TXA2)in the *** thoracic aortic ring experiment was performed to evaluate *** blot was used to measure the expression of PI3K,Akt,phosphorylated Akt(p-Akt)and eNOS proteins in the abdominal ***,quantitative real-time polymerase chain reaction(qRT-PCR)was conducted to measure the relative levels of mRNA expression for PI3K,Akt and eNOS in the abdominal *** EA significantly reduced the systolic BP(SBP)and diastolic BP(DBP)(P<0.05).HE staining showed that EA improved the morphology of the vascular endothelium to some *** of ELISA indicated that higher concentrations of ghrelin and NO,and lower concentrations of ET-1 and TXA2 we

关键词： Electroacupuncture Hypertension Vascular endothelial dysfunction Ghrelin PI3K/Akt/eNOS signaling pathway

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Modulatory effect of International standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI

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Neural Regeneration Research 2019年第12期14卷 2126-2131页

作者： Wai-Yeung Chung Song-Yan Liu jing-Chun Gao yi-jing jiang jing Zhang Shan-Shan Qu Ji-Ping Zhang Xiao-Long Tan Jun-Qi Chen Sheng-Xu Wang School of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong Province China School of Chinese Medicine The Chinese University of Hong Kong Shatin Hong Kong Special Administrative Region China Department of Neurology China-Japan Union Hospital of Jilin University Changchun Jilin Province China Department of Rehabilitation Medicine Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong Province China Department of Rehabilitation Medicine Rehabilitation Hospital Fujian University of Traditional Chinese Medicine Fuzhou Fujian Province China Department of Medical Image Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong Province China

The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women;50–70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043).

关键词： nerve regeneration resting-state functional magnetic resonance imaging International Standard Scalp Acupuncture acupoint specificity brain functional connectivity healthy elderly volunteers low frequency fluctuation regional homogeneity functional connectivity neural regeneration

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PHOTOCHEMISTRY OF HYPOCRELLIN A (V)——PHOTOREACTION OF HYPOCRELLIN A AND MERCAPTOETHANOL

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Chinese Science Bulletin 1989年第20期34卷 1694-1698页

作者：安静仪蒋丽金 Institute of Photographic Chemistry Academia Sinica Beijing

*** Hypocrellin A(abbreviated HA) from Hypocrellia bambusae (B. ct Br.)sacc. growing in Yunnan Province, China, is an efficient phototherapeutic agent. Recently HA irradiation with visible light has been successfully used for the treatment of white lesions of vulva and vitiligo. In molecular level, studies on phototherapeutic mechanism have been focused on the structure, photophysical and photochemical properties of HA and its derivatives. The photoreactions, which are closely related to phototherapeutic activities, have not been re-

关键词： Hypocrellin A phototherapy aromatic nucleophilic substitution mercaptoethanol hydroxyethyl thiosubstituted Hypocrellin A

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吡喃酮型花色苷衍生物的制备、光谱特性及抗氧化活性研究

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光谱学与光谱分析 2017年第7期37卷 2120-2127页

作者：吴闹王静祎江甜李书艺祝振洲何静仁武汉轻工大学食品科学与工程学院湖北省农产品加工与转化重点实验室湖北武汉430023

吡喃酮型花色苷衍生物是一类具有非氧鎓离子结构和内酯型吡喃环结构的新型多酚类化合物。本研究以植物花色苷为原料,通过羧基吡喃花色苷形成及微氧化等两步反应法,结合柱色谱分离纯化技术,制备高纯度的吡喃酮花色苷衍生物A(Oxovitisin A... 详细信息

吡喃酮型花色苷衍生物是一类具有非氧鎓离子结构和内酯型吡喃环结构的新型多酚类化合物。本研究以植物花色苷为原料,通过羧基吡喃花色苷形成及微氧化等两步反应法,结合柱色谱分离纯化技术,制备高纯度的吡喃酮花色苷衍生物A(Oxovitisin A)标准品;高效液相色谱-光电二极管阵列检测器-串联质谱法(HPLC-DAD-ESI-MS/MS)分析鉴定出纯化后反应产物Oxovitisin A的纯度达99%以上。利用荧光光谱仪、紫外可见光谱仪及超微弱化学发光光谱仪研究了Oxovitisin A及其前体物质花色苷(锦葵素-3-葡萄糖苷,Mv-3-gluc)与羧基吡喃花色苷A(Vitisin A))的光谱特性、色泽稳定性及抗氧化活性。结果表明:Oxovitisin A在440nm激发波长下有最大荧光峰,最大发射波长490nm,而具有氧鎓离子结构的两种前体物质无荧光特性。紫外光谱结合LAB色泽空间表征参数显示Oxovitisin A在不同pH值条件下具有不同的结构稳定性和色泽稳定性。Mv-3-gluc,VitisinA和Oxovitisin A在不同体系中均表现出良好的抗氧化活性,清除超氧阴离子自由基的IC50值分别为71.4,30.7和19μg·mL-1(抗坏血酸28μg·mL-1),清除羟自由基的IC50值分别为1.68,3.524,2.854μg·mL-1(抗坏血酸8.441μg·mL-1),对双氧水清除率的IC50值分别为1.311,0.4098和0.288μg·mL-1(抗坏血酸3.265μg·mL-1),表明Oxovitisin A清除自由基和抗氧化的能力均高于反应前体物Mv-3-gluc和VitisinA及抗坏血酸。

关键词：吡喃酮型花色苷衍生物 Oxovitisin A HPLC-MS/MS分析光谱特性抗氧化

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu Fan Shuyong jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen jiang Fei Long Liyuan Han Qifeng Han yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu Dong Zhouhua jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

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Zinc-based fiber-shaped rechargeable batteries:Insights into structures,electrodes,and electrolytes

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Nano Research 2025年第1期18卷 278-293页

作者： Xuan Zhang Hongcheng Zhang Mengxiang Chen jingqi Lu Evgeny Zhuravlev jing jiang Pin Liu Shengyang Dong Du Yuan Guoyin Zhu Lianbo Ma yizhou Zhang Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004China

The rapid evolution of flexible wearable electronics has spurred a growing demand for energy storage devices,characterized by low-cost manufacturing processes,high safety standards,exceptional electrochemical performance and robust mechanical *** novel flexible devices,fiber-shaped batteries(FSBs)have emerged as prominent solutions exceptionally suited to future applications,owing to their unique one-dimensional(1D)architecture,remarkable flexibility,potential for miniaturization,adaptability to deformation and compatibility with the conventional textile *** the forefront research on fiber-shaped batteries,zincbased FSBs(ZFSBs)have garnered significant attentions,featured by the promising electrochemical properties of metallic *** enthusiasm is driven by the impressive capacity of Zn(820 mAh·g^(-1))and its low redox potential(Zn/Zn^(2+):-0.76 V *** hydrogen electrode).This review aims to consolidate recent achievements in the structural design,fabrication processes and electrode materials of flexible ***,we highlight three representative structural configurations:parallel type,twisted type and coaxial *** also place special emphasis on electrode modifications and electrolyte ***,we delve into the promising development opportunities and anticipate future challenges associated with ZFSBs,emphasizing their potential roles in powering the next generation of wearable electronics.

关键词： zinc-based batteries fiber-shape parallel type twisted type coaxial type

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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