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Influence of electromagnetic parameters on solidification structure of pure AI in the case of identical power

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Journal of Iron and Steel Research International 2018年第8期25卷 854-861页

作者： Yong-yong Gong Shu-min Cheng Yu-yi Zhong Xiang Wang Yun-hu Zhang Qi-jie Zhai Hong-gang Zhong Zhi-shuai Xu Rong Yue Ning Pei College of Science Shanghai University Shanghai 200444China Shanghai Key Laboratory of Modern Metallurgy and Materials Processing Shanghai University Shanghai 200444China School of Materials Science and Engineering Shanghai University Shanghai 200444 China Materials Genome Institute Shanghai UniversityShanghai 200444 China

Pulsed magneto-oscillation （PMO） as a new electromagnetic technology to generate the grain refinement in metals and alloys was significantly developed in recent years. The influence of electromagnetic parameters on the grain size reduction in pure AI was investigated under the application of PMO with a constant inputting power. The experimental results show that the grain refinement degree could be improved with the increase in the current intensity in the case of the identical power. Moreover, through analysing the electromagnetic force and resistance force applied on the nucleus, a criterion of the nucleus detached from the mould wall was constructed. Based on the criterion, the detachment of nuclei with finer radius could cause better effect of the grain refinement, when applying a higher current peak. The movement of the detached grains was considered by analysing the influence of electromagnetic force and forced flow.

关键词： Grain refinement Pure Al Solidification Pulsed magneto-oscillation Identical power

新型简化胰岛素抵抗评价指标对T2DM患者左心室亚临床收缩功能受损的预测价值

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解放军医学杂志 2024年第2期49卷 137-143页

作者：陈艳艳李梦颖周洁付建芳张颖王奕王铖刘向阳拓胜军刘丽文李泽平李晓苗空军军医大学第一附属医院内分泌科陕西西安710032 空军军医大学第一附属医院超声科陕西西安710032 南昌大学玛丽女王学院医学部江西南昌330038

目的分析新型简化胰岛素抵抗评价指标对2型糖尿病(T2DM)患者左心室亚临床收缩功能受损的预测价值。方法收集2021年6-12月就诊于空军军医大学第一附属医院内分泌科的150例左心室射血分数(LVEF)≥50%的T2DM患者进行回顾性分析。所有患者... 详细信息

目的分析新型简化胰岛素抵抗评价指标对2型糖尿病(T2DM)患者左心室亚临床收缩功能受损的预测价值。方法收集2021年6-12月就诊于空军军医大学第一附属医院内分泌科的150例左心室射血分数(LVEF)≥50%的T2DM患者进行回顾性分析。所有患者均接受二维斑点追踪超声心动图检查,并测量左心室整体纵向应变(GLS)。将受试者根据GLS值分为左心室亚临床收缩功能正常组(GLS≥18%组,n=80)与左心室亚临床收缩功能受损组(GLS<18%组,n=70)。此外,计算体重指数(BMI)、三酰甘油/高密度脂蛋白胆固醇比值(TG/HDL-C比值)、TG-葡萄糖(TyG)指数、TyG-BMI指数(TyG-BMI)、TyG-WHR指数(TyG-WHR)、胰岛素抵抗代谢指数(METS-IR),作为新型简化胰岛素抵抗评价指标,并进行两组间比较。采用Pearson相关分析法分析简化胰岛素抵抗评价指标与GLS的相关性。采用受试者工作特征(ROC)曲线下面积(AUC)评估新型简化胰岛素抵抗评价指标对GLS<18%人群的诊断效能。基于高血压分层的二元logistics回归分析简化胰岛素抵抗评估指标与GLS<18%的独立相关性。结果150例患者年龄(54.5±13.7)岁,其中男96例(64.0%),女54例(36.0%)。与GLS≥18%组比较,GLS<18%组患者的TG/HDL-C比值、Ty G指数、Ty G-BMI、METS-IR均明显增高,差异有统计学意义(P<0.05)。Pearson相关分析显示,TG/HDL-C比值、Ty G指数、Ty G-BMI、Ty G-WHR、METS-IR均与GLS呈负相关(P<0.05)。ROC曲线分析显示,Ty G指数对评价GLS<18%具有一定的预测价值(AUC=0.678,95%CI 0.591~0.765,P<0.001)。基于高血压分层且校正混杂因素后,二元logistics回归分析显示,Ty G指数与GLS<18%独立相关(OR=3.249,95%CI 1.045~10.103,P=0.042)。结论新型简化胰岛素抵抗评价指标与T2DM患者左心室亚临床收缩功能受损密切相关。TyG指数是识别该人群左心室亚临床收缩功能受损的有效指标。

关键词：糖尿病 2型胰岛素抵抗三酰甘油-葡萄糖指数左心室整体纵向应变

Strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome

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Eye and Vision 2021年第1期8卷 47-58页

作者： Yutong Kang Shudan Lin Xueli Ma Yanlin Che yiju Chen Tian Wan Die Zhang Jiao Shao jie Xu yi Xu Yongliang Lou Meiqin Zheng Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina National Clinical Research Center for Ocular Diseases WenzhouZhejiangChina Wenzhou Key Laboratory of Sanitary Microbiology Key Laboratory of Laboratory MedicineMinistry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouZhejiang 325035China

Background:There is growing evidence indicating that the microbial communities that dwell on the human ocular surface are crucially important for ocular surface health and *** is known about interspecies interactions,functional profiles,and strain heterogeneity across individuals in healthy ocular surface ***:To comprehensively characterize the strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome,we performed shotgun metagenomics sequencing on ocular surface mucosal membrane swabs of 17 healthy ***:The healthy ocular surface microbiome was classified into 12 phyla,70 genera,and 140 *** number of species in each healthy ocular surface microbiome ranged from 6 to 47,indicating differences in microbial diversity among *** species with high relative abundances and high positivity rates were Streptococcus pyogenes,Staphylococcus epidermidis,Propionibacterium acnes,Corynebacterium accolens,and Enhydrobacter aerosaccus.A correlation network analysis revealed a competitive interaction of Staphylococcus epidermidis with Streptococcus pyogenes in ocular surface microbial *** epidermidis and Streptococcus pyogenes revealed phylogenetic diversity among different *** the functional level,the pathways related to transcription were the most *** also found that there were abundant lipid and amino acid metabolism pathways in the healthy ocular surface ***:This study explored the strain heterogeneity,cooccurrence network,taxonomic composition,and functional profile of the healthy ocular surface *** findings have important significance for the future development of probiotic-based eye therapeutic drugs.

关键词： Healthy ocular surface microbiome Cooccurrence network Functional composition Strain level

Effect of Ti and Al on microstructure and partitioning behavior of alloying elements in Ni-based powder metallurgy superalloys

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International Journal of Minerals,Metallurgy and Materials 2019年第4期26卷 500-506页

作者： yin-long Shao Jing Xu Hao Wang yi-wen Zhang Jian Jia Jian-tao Liu Hai-liang Huang Ming Zhang Zhi-cheng Wang Hong-fei Zhang Ben-fu Hu Guangdong Provincial Key Laboratory for Technology and Application of Metal Toughening Guangdong Institute of Materials and Processing School of Materials Science and Engineering University of Science and Technology Beijing High Temperature Material Research Institute Central Iron and Steel Research Institute

The microstructure and partitioning behaviors of alloying elements in the γ and γ′ phases in Ni-based powder metallurgy superalloys with different Ti and Al contents were investigated. The results showed that Ti and Al were mainly enriched in the γ′ phase, partially partitioned in the γ matrix, and slightly distributed in the carbides. Different Ti and Al contents in various alloys influenced the composition and amount of MC carbides but did not influence the MC carbides' morphology. With increasing Ti and Al contents, γ + γ′ fan-type structures formed at the grain boundary, eventually resulting in a coarsened γ′ phase. In addition, the morphology of the secondary γ′ phase transformed from nearly spherical to cuboidal. The saturation degrees of Cr, Co, and Mo in the γ matrix were substantially improved with increasing Ti and Al contents.

关键词： superalloy Al Ti microstructure partitioning

Energy Requirements for Maintenance and Growth of German Mutton Merino Crossbred Lambs

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Journal of Integrative Agriculture 2013年第4期12卷 670-677页

作者： DENG Kai-dong DIAO Qi-yu JIANG Cheng-gang TU Yan ZHANG Nai-feng LIU jie MA Tao ZHAO yi-guang XU Gui-shan Feed Research Institute Chinese Academy of Agricultural Sciences College of Animal Science Jinling Institute of Technology

A comparative slaughter trial and a metabolism trial were conducted to determine the requirement of net energy （NE） and metabolizable energy （ME） by the crossbreed of German Mutton Merino×Inner Mongolia Merino for fattening from 35 to 50 kg of body weight （BW）. 49 crossbred female lambs （（33.9＋2.3）（SD） kg BW） of German Mutton Merino×lnner Mongolia Merino were used. 34 lambs were randomly chosen for comparative slaughter, which were offered an identical mixture diet （concentrate：roughage=55：45） at 100, 75 or 55% of ad libitum intake, whereas the remainders were used in the metabolism trial to evaluate the ME of the diet after methane production was measured by open-circuit respirometry. As feed intake decreased from 100 to 75 and 55% of ad libitum intake, the apparent digestibility of dry matter （DM） linearly increased （P=-0.010） from 60.8 to 63.6 and 66.9%, respectively, and methane production decreased from 52.1 to 44.3 and 39.9 L d-l, respectively, but the ratio of methane energy to gross energy intake increased linearly （P=0.010） from 8.20 to 8.96 and 10.97%, respectively. Consequently, the ME values of the diet increased from 9.35 to 9.64 and 9.85 MJ kg-~ DM, respectively. The NE requirement for maintenance （NEro） was 255 kJ kg-1 BW0.75, and the ME requirement for maintenance （MEre） was 352 kJ kg-I BW~.75, with a partial energy efficiency for maintenance （km） of 0.72. The NE requirement for growth （NEg） ranged from 1.26 to 4.66 MJ d-1as average daily gains increased from 100 to 300 g d-1, with a partial energy efficiency for growth （ks） of 0.45. These results indicated that the NEg required by crossbred female lambs of German Mutton Merinoxlnner Mongolia Merino was lower than the recommendation of the American or British nutritional system.

关键词： efficiency growth maintenance metabolizable energy net energy sheep

Analysis of Phytochemical Constituents of Zuogui Wan in Rat Serum and its Effects on Early Embryonic Development of Mice

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World Journal of Traditional Chinese Medicine 2020年第3期6卷 324-330页

作者： Ya-Fei Guo Kai-Xia Xu jie-Wei Hong Shuang yin Xin Niu Qian-Jin Feng ying-Li Wang Institute of Chinese and Food Engineering Shanxi University of Chinese Medicine College of Basic Medical Sciences Shanxi University of Chinese MedicineJinzhong School of Basic Medical Sciences Beijing University of Chinese MedicineBeijingChina School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideAustralia

Objective:Zuogui Wan(ZGW)has been used as a typical prescription for tonifying kidney essence in traditional Chinese *** objective of this study is to elucidate the phytochemical constituents of ZGW-treated rat serum(ZGWRS)using ultra-performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight high-definition mass spectrometry(UPLC-ESI-Q-TOF-MS).Methods:ZGW was administered to rats,and the phytochemical constituents in rat serum were determined using *** analysis in negative ion mode was adopted to characterize the chemical constituents of *** partial least squares discriminant analysis was applied for the discovery of constituents of ZGW that entered the serum of *** fertilized eggs collected from the same experiment were randomly divided into four groups,including the normal,40 mmol/L glucose,40 mmol/L glucose 5%control rat serum,and 40 mmol/L glucose 5%ZGWRS *** were cultivated at 37°C and 5%CO2 in a saturated humidity CO2 *** blastocyst rate and two-cell rate were used to evaluate the effects of ZGWRS on embryonic ***:Thirteen constituents were identified in the ZGWRS,among which sweroside,loganin,morroniside,loganic acid,and 8-epiloganic acid were from Fructus Corni(Shan Zhu Yu).5-Hydroxymethyl-2-furfural-glucuronide,2-H-5-hydroxymethyl-2-furfural-glucuronide,3-hydroxy-2,6,6-trimethyl-1-cyclohexene-1-carboxylic acid,andβ-D-ribofuranuronic acid methyl ester triacetate were from Radix Rehmanniae Preparata(Shu Di Huang).Coumaric acid was from Fructus Lycii(Gou Qi Zi).Kaempferol-3-beta-O-glucuronide and cuscutamine were from Semen Cuscutae(Tu Si Zi).The embryonic development was significantly inhibited using 40 mmol/L *** with the normal group,the blastocyst rate of the glucose group was *** blastocyst rate of the 40 mmol/L glucose 5%ZGWRS group was significantly higher than that of the glucose group,indicating that ZGWRS negates the

关键词： Orthogonal partial least squared discriminant analysis ultra-performance liquid chromatograph-electrospray ionization/quadrupole-time-of-flight high-definition mass spectrometry Zuogui Wan

火炮身管烧蚀磨损状态下弹带挤进过程仿真分析

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机械工程与自动化 2024年第2期 23-25页

作者：张誉瀚张嘉易郝永平赵洪力孙宝印沈阳理工大学机械工程学院辽宁沈阳110159 辽宁省先进制造技术装备重点实验室辽宁沈阳110159 辽沈工业集团有限公司辽宁沈阳110045

为探究火炮身管膛线不同磨损状态下弹带挤进过程中的受力及动态响应情况,基于Johnson-Cook本构关系模型建立了不同磨损状态下的身管模型,并利用有限元显式分析求解了弹炮耦合模型,得到了不同身管磨损状态下弹带受力及弹丸运动响应结果,... 详细信息

为探究火炮身管膛线不同磨损状态下弹带挤进过程中的受力及动态响应情况,基于Johnson-Cook本构关系模型建立了不同磨损状态下的身管模型,并利用有限元显式分析求解了弹炮耦合模型,得到了不同身管磨损状态下弹带受力及弹丸运动响应结果,包括挤进过程弹体速度、加速度、法向位移等运动曲线。由仿真结果可以看出:膛线不均匀磨损会导致弹丸在挤进过程中产生较大的径向位移和振动,烧蚀产生的烧蚀坑及裂缝会加剧这一现象;但轴向速度、位移变化平滑,加速度受弹底压力影响较大。

关键词：身管弹带挤进膛线磨损烧蚀仿真

Wave-particle duality relation with a quantum N-path beamsplitter

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Chinese Physics B 2021年第5期30卷 220-228页

作者： Dong-Yang Wang Jun-jie Wu yi-Zhi Wang Yong Liu An-Qi Huang Chun-Lin Yu Xue-Jun Yang Institute for Quantum Information&State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China College of Information and Communication National University of Defense TechnologyXi'an 710006China China Greatwall Quantum Laboratory China Greatwall Technology Group CO.LTD.Changsha 410073China

The wave-particle duality relation derived by Englert sets an upper bound of the extractable information from wave and particle properties in a two-path ***,previous studies demonstrated that the introduction of a quantum beamsplitter in the interferometer could break the limitation of this upper bound,due to interference between wave and particle *** the other line,a lot of efforts have been made to generalize this relation from the two-path setup to the N-path ***,it is an interesting question that whether a quantum N-path beamsplitter can break the limitation as *** paper systemically studies the model of a quantum N-path beamsplitter,and finds that the generalized wave-particle duality relation between interference visibility and path distinguishability is also broken in certain *** further study the maximal extractable information's reliance on the interference between wave and particle properties,and derive a quantitative *** then propose an experimental methodology to verify the break of the *** work reflects the effect of quantum superposition on wave-particle duality,and exhibits a new aspect of the relation between visibility and path distinguishability in N-path ***,it implies the observer's influence on wave-particle duality.

关键词： wave-particle duality interference visibility path distinguishability quantum N-path beamsplitter

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

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Cellular & Molecular Immunology 2015年第6期12卷 729-742页

作者： Yang Xiao Fang Liu Jingyi Yang Maohua Zhong Ejuan Zhang Yaoming Li Dihan Zhou Yuan Cao Wei Li jie Yu yi Yang Huimin Yan Mucosal immunity Research Group State Key Laboratory of Virology Wuhan institute of Virology Chinese Academy of Sciences Wuhan China

Flagellin is a potent activator of a broad range of cell types that are involved in innate and adaptive immunity. Therefore, it is a good adjuvant candidate for vaccines, and it might function as a biological protectant against both major acute radiation syndrome during cancer radiotherapy and a mitigator of radiation emergencies. However, accumulating evidence has implicated flagellin in the occurrence of some inflammatory diseases, such as acute lung inflammation, cardiovascular collapse and inflammatory bowel disease. The aim of this study was to elucidate whether only flagellin-TLR5 signaling activation plays a role in the pathophysiology of liver or whether some other flagellin activity also contributes to liver injury either via bacterial infections or during clinical applications. Recombinant flagellin proteins with or without TLR5-stimulating activity were used to evaluate the role of flagellin-TLR5 signaling in liver injury in wild-type and TLR5 KO mice. Gross lesions and large areas of hepatocellular necrosis were observed in liver tissue 12 h after the intraperitoneal administration of 100 or 200 pg flagellin （FliC） in a dose-and time-dependent manner in wild-type mice, but not in TLR5 KO mice. Deletion of the N-terminal or TLR5 binding domain of flagellin inhibited flagellin-induced inflammatory responses and the subsequent acute liver function abnormality and damage. These data confirmed that flagellin is an essential determinant of liver injury and demonstrated that the over-activation of TLR5 signaling by high-dose flagellin caused acute inflammatory responses, neutrophil accumulation and oxidative stress in the liver, which contributes to the progression and severity of flagellin-induced liver injury.

关键词： flagellin liver injury pathological effect TLR5