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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng Zhang Li-Ping wang Wen-Wei Hu De-Sheng Weng Xiang Xu yi-Zhuo Li Yan Tang Wei-Hong Zhang jie-Yao Li Xiao Zheng qi-Jing wang Yong-qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu qiong Shen yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen xin-qiao Li Ce Cai Shuo Xiao qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-qiu Zhang Yue Huang Lu Li xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-Li Shi Peng Zhang qi-Bin yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou wang xing Zhou yi Zhao wang-Chen Xue Chao Zheng Jia-Cong Liu xing-Bo Han Jin-Ling qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-jie Hou Yu-Sa wang Rui qiao Xiang Ma Xiao-Bo Li Ping wang xin-ying Song Li-Ming Song Shi-jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Leukocyte cell-derived chemotaxin 2(LECT2)regulates liver ischemia-reperfusion injury

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Liver Research 2024年第3期8卷 165-171页

作者： Meng-qi Dong Yuan xie Zhi-Liang Tang Xue-Wen Zhao Fu-Zhen Lin Guang-Yu Zhang Zhi-Hao Huang Zhi-Min Liu Yuan Lin Feng-Yong Liu Wei-jie Zhou State Key Laboratory of Organ Failure Research Department of General SurgeryGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People's Hospital of ZhaoqingZhaoqingGuangdongChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijingChina

Background and aim Hepatic ischemia–reperfusion injury(IRI)is a significant challenge in liver transplantation,trauma,hypovolemic shock,and hepatectomy,with limited effective interventions *** study aimed to investigate the role of leukocyte cell-derived chemotaxin 2(LECT2)in hepatic IRI and assess the therapeutic potential of Lect2-short hairpin RNA(shRNA)delivered through adeno-associated virus(AAV)*** and methods This study analyzed human liver and serum samples from five patients undergoing the Pringle ***2-knockout and C57BL/6J mice were *** IRI was induced by clamping the hepatic *** included recombinant human LECT2(rLECT2)and ***2 expression levels and serum biomarkers including alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine,and blood urea nitrogen(BUN)were *** analysis of liver necrosis and quantitative reverse-transcription polymerase chain reaction were *** Serum and liver LECT2 levels were elevated during hepatic *** LECT2 protein and mRNA levels increased post ***2-knockout mice had reduced weight loss;hepatic necrosis;and serum ALT,AST,creatinine,and BUN ***2 treatment exacerbated weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN).AAV-Lect2-shRNA treatment significantly reduced weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN),indicating therapeutic *** Elevated LECT2 levels during hepatic IRI increased liver *** knockout or shRNA-mediated knockdown of Lect2 reduced liver damage,indicating its therapeutic ***-mediated Lect2-shRNA delivery mitigated hepatic IRI,offering a potential new treatment strategy to enhance clinical outcomes for patients undergoing liver-related surgeries or trauma.

关键词： Hepatic ischemia-reperfusion injury(IRI) Leukocyte cell-derived chemotaxin 2 (LECT2) Adeno-associated virus(AAV)

Association between tobacco exposure and bladder cancer recurrence:A systematic review and meta-analysis

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World Journal of Methodology 2024年第2期14卷 145-157页

作者： Lei Xiang qi-qi xie Si-Si Xu Wen-jie Ruan Dong-Hui Xu Yao-Yao Gan Jia Zuo Wen-Jun Xu Zhi-Peng Li Department of Rehabilitation Medicine First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

BACKGROUND However,the connection between smoking and the prognosis of patients with bladder cancer remains *** To determine whether smoking is linked to the recurrence and progression of bladder *** As of July 20,2022,relevant English-language research was identified by searching PubMed,the Web of Science,and the Cochrane *** pooled the available data from the included studies using a random effects *** analysis and sensitivity analysis were also *** A total of 12 studies were included in this *** combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status[odd ratios(OR)=1.76,95%CI:1.84-2.93],and the progression of bladder cancer was significantly greater in smokers than in nonsmokers(OR=1.21,95%CI:1.02-1.44).Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were(OR=1.85,95%CI:1.11-3.07).Former smokers also had a greater risk of relapse than did never-smokers(OR=1.73,95%CI:1.09-2.73).Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are(OR=2.13,95%CI:1.74-2.61).CONCLUSION This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.

关键词： Smoking Bladder Cancer Recurrence Progress

后疫情时代我国青少年的网络行为问题风险及其应对策略

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应用心理学 2024年第5期30卷 442-456页

作者：谢东杰苏彦捷谢爱武王一伊中共广东省委党校(广东行政学院) 广州510053 北京大学心理与认知科学学院行为与心理健康北京市重点实验室北京100871

尽管新冠疫情呈结束态势,但是疫情相关经历对青少年长期的心理发展仍有不利影响。元分析结果显示,疫情期间我国青少年网络行为问题(网络成瘾、智能手机成瘾)检出率为30.90%(95%CI[24.40%,37.40%])。后疫情时代我国青少年面临的网络行为... 详细信息

尽管新冠疫情呈结束态势,但是疫情相关经历对青少年长期的心理发展仍有不利影响。元分析结果显示,疫情期间我国青少年网络行为问题(网络成瘾、智能手机成瘾)检出率为30.90%(95%CI[24.40%,37.40%])。后疫情时代我国青少年面临的网络行为问题风险不容忽视。可借鉴生态系统理论,从个体、微观系统、中间系统、外部系统、宏观系统和时序系统层面加以应对,为相关的科学研究者、政策制定者和实践工作者带来一定启发和参考依据。

关键词：后疫情时代青少年网络使用问题生态系统理论

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土工格栅加筋橡胶碎石动力特性试验研究

岩土力学 2024年第1期45卷 87-96,107页

作者：蔡永明王志杰齐逸飞杨广庆王贺石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室河北石家庄050043 石家庄铁道大学土木工程学院河北石家庄050043 石家庄铁道大学道路与铁道工程安全保障省部共建教育部重点实验室河北石家庄050043

土工格栅加筋是提升橡胶碎石混合料承载能力的重要方式。为探究土工格栅加筋橡胶碎石复合体动力特性及其作用机制,基于分级循环荷载作用下大型三轴试验,对3种代表性橡胶掺量碎石混合料进行不同层数土工格栅加筋,分析其累积塑性应变、滞... 详细信息

土工格栅加筋是提升橡胶碎石混合料承载能力的重要方式。为探究土工格栅加筋橡胶碎石复合体动力特性及其作用机制,基于分级循环荷载作用下大型三轴试验,对3种代表性橡胶掺量碎石混合料进行不同层数土工格栅加筋,分析其累积塑性应变、滞回曲线发展演化规律,对比动弹性模量、阻尼比等动力特性关键参数,探讨耦合作用影响机制。研究结果表明:同级动应力作用下土工格栅加筋可减缓累积塑性应变的增大,随着加筋层数的增多,加筋效果更为明显;橡胶掺量增加可提升试样延性,但导致承载能大幅降低,不利于筋材加筋效果的发挥;滞回曲线形态主要取决于橡胶掺量,随着橡胶掺量增加,其形态更加饱满、倾斜,其排列更加稀疏;土工格栅加筋可提升复合体动弹性模量,并随筋材层数增多呈现出明显增长阶段;橡胶掺量对阻尼比初始值以及变化趋势产生主要影响。

关键词：土工格栅橡胶碎石加筋层数动力特性大型三轴试验

考虑纵径向热应变的竖向受荷能量桩简化分析方法

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工程力学 2024年第7期41卷 121-133页

作者：江杰陈朝棋欧孝夺陈秋怡广西大学土木建筑工程学院广西南宁530004 工程防灾与结构安全教育部重点实验室广西南宁530004 广西防灾减灾与工程安全重点实验室广西南宁530004

为探究温度对能量桩荷载传递机理及相关力学响应的影响,引入平面瞬态温度场方程,将温度场与应力场解耦。基于平面应力模型,将能量桩与桩周土考虑为具有协调变形的整体,计算了径向热应力。在此基础上,将其与双曲线荷载传递模型结合,对桩... 详细信息

为探究温度对能量桩荷载传递机理及相关力学响应的影响,引入平面瞬态温度场方程,将温度场与应力场解耦。基于平面应力模型,将能量桩与桩周土考虑为具有协调变形的整体,计算了径向热应力。在此基础上,将其与双曲线荷载传递模型结合,对桩土界面处的极限摩阻力进行修正。将纵向热应变考虑在竖向荷载传递方程中,得到可同时衡量纵向和径向热效应的竖向受荷能量桩承载特性分析方法。利用增量法对能量桩荷载传递控制方程进行求解,得到桩身轴力、桩侧阻力、桩身位移等相关力学响应。通过与既有文献进行对比,验证了该模型的合理性。通过参数分析,研究了温度和竖向力作用下能量桩的荷载传递特性。结果表明:温度会改变能量桩的荷载传递特性,提高能量桩的运行温度可小幅增加其承载力。该文方法的计算流程清晰,可为能量桩的设计提供参考。

关键词：桩基工程能量桩荷载传递法力学响应径向热应力

A comprehensive index to evaluate cognitive health at the population scale

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中华医学杂志(英文版) 2024年第18期137卷 2024 Aug 9页

作者： Lu Yuanyuan Mao Fan yin Peng Chang jie Zhao Zhenping Yang Kun qin qi Zhou Maigeng Tang yi Department of Neurology and Innovation Center for Neurological Disorders Xuanwu Hospital Capital Medical University National Center for Neurological Disorders Beijing China Department on Obesity and Metabolic Diseases Control and Prevention National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Department on Vital Registry and Mortality Surveillance National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China National Center for Neurological Disorders Xuanwu Hospital Capital Medical University Beijing China Department on Risk Factors Surveillance National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui qiU Xiao-tang wang Mei LI qing-bo LI Shan-shan wang Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li xie Wen-wen LIANG qing-shun HUANG Yuan ZHU Sheng-ling LONG jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction