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World Journal of Hepatology 2024年第4期16卷 494-505页

作者： Yang zheng yi-hui zheng Jia-hui Wang Tie-Jian Zhao Lei Wang Tian-Jian Liang Department of Medicine Faculty of Chinese Medicine ScienceGuangxi University of Chinese MedicineNanning 530222Guangxi Zhuang Autonomous RegionChina

The endoplasmic reticulum(ER)is connected to mitochondria through mitochondria-associated ER membranes(MAMs).MAMs provide a framework for crosstalk between the ER and mitochondria,playing a crucial role in regulating cellular calcium balance,lipid metabolism,and cell *** of MAMs is involved in the development of chronic liver disease(CLD).In CLD,changes in MAMs structure and function occur due to factors such as cellular stress,inflammation,and oxidative stress,leading to abnormal interactions between mitochondria and the ER,resulting in liver cell injury,fibrosis,and impaired liver *** Chinese medicine has shown some research progress in regulating MAMs signaling and treating *** paper reviews the literature on the association between mitochondria and the ER,as well as the intervention of traditional Chinese medicine in regulating CLD.

关键词： Mitochondria Endoplasmic reticulum Mitochondria-associated ER membranes Traditional Chinese medicine Chronic liver disease

Advances of machine learning in materials science: Ideas and techniques

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Frontiers of physics 2024年第1期19卷 155-194页

作者： Sue Sin Chong yi Sheng Ng hui-Qiong Wang Jin-Cheng zheng Department of New Energy Science and Engineering Xiamen University MalaysiaSepang 43900Malaysia Engineering Research Center of Micro-nano Optoelectronic Materials and Devices Ministry of EducationFujian Key Laboratory of Semiconductor Materials and ApplicationsCI Center for OSEDand Department of PhysicsXiamen UniversityXiamen 361005China

In this big data era, the use of large dataset in conjunction with machine learning (ML) has been increasingly popular in both industry and academia. In recent times, the field of materials science is also undergoing a big data revolution, with large database and repositories appearing everywhere. Traditionally, materials science is a trial-and-error field, in both the computational and experimental departments. With the advent of machine learning-based techniques, there has been a paradigm shift: materials can now be screened quickly using ML models and even generated based on materials with similar properties;ML has also quietly infiltrated many sub-disciplinary under materials science. However, ML remains relatively new to the field and is expanding its wing quickly. There are a plethora of readily-available big data architectures and abundance of ML models and software;The call to integrate all these elements in a comprehensive research procedure is becoming an important direction of material science research. In this review, we attempt to provide an introduction and reference of ML to materials scientists, covering as much as possible the commonly used methods and applications, and discussing the future possibilities.

关键词： machine learning materials science

Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process

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Petroleum Science 2024年第2期21卷 1369-1384页

作者： Chong-zheng Sun Yu-Xing Li hui Han Xiao-yi Geng Xiao Lu College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation Safety China University of PetroleumQingdao 266580ShandongChina

Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat *** results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow.

关键词： Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow

The Logarithmic Sobolev Inequality for a Submanifold in Manifolds with Nonnegative Sectional Curvature

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 487-496页

作者： Chengyang yi Yu zheng School of Mathematical Sciences East China Normal UniversityShanghai 200241China

The authors prove a sharp logarithmic Sobolev inequality which holds for compact submanifolds without boundary in Riemannian manifolds with nonnegative sectional curvature of arbitrary dimension and *** the Michael-Simon Sobolev inequality,this inequality includes a term involving the mean *** extends a recent result of Brendle with Euclidean setting.

关键词： Logarithmic Sobolev inequality Nonnegative sectional curvature Submanifold

Spontaneous anchoring Cl into α-Co（OH）2 as efficient and stable oxygen reduction electrocatalysts for seawater battery

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Rare Metals 2024年第7期43卷 3074-3083页

作者： Wang zheng Xue-Rong zheng Qi Lu Yan-hui Cao Yang Wang Hai-Peng Fu Jin-Feng Zhang yi-Da Deng Wen-Bin Hu School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin University State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan University Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern University

Seawater battery is an advanced energy storage system that enables conversion of chemical energy to electricity by consuming metals,dissolved oxygen and seawater in anode,cathode and electrolyte,***,the oxygen reduction reaction（ORR） activity and stability of electrocatalysts can be easily deactivated due to the severe Cl-permeation and corrosion in seawater ***,we developed a structural buffer engineering strategy by spontaneously anchoring Cl-into α-Co（OH）2as efficient and stable ORR electrocatalysts,in which the ultrathin α-Co（OH）2nanosheets were synthesized using an ultrafast solution high-temperature shock（SHTS） *** large lattice space（～ 0.8 nm） of layered α-Co（OH）2ensured the spontaneously penetration of Cl-into the lattice structure and replaced part of OH-to form α-Co（OH）*** continuous leaching and compensating of saturated Cl in α-Co（OH）2-xClxcould enhance the Cl-corrosion resistance and modulate electronic structure of Co metallic sites,thus improving the ORR electrocatalytic activity and stability in seawater *** α-Co（OH）2-xClxseawater batteries display superior onset and half-wave potentials of 0.71 and 0.66 V,respectively,which are much better than the counterparts of α-Co（OH）2and of β-Co（OH）2with no Cl-penetrating and no buffer *** α-Co（OH）2-xClx-based seawater batteries display stable open-circuit potential of 1.69 V and outstanding specific capacity of 1345 mAh·g-1.

关键词： Seawater battery Oxygen reduction electrocatalyst Solution high-temperature shock Structural buffer engineering

Single-atom-mediated electron islands boost photocatalytic CO_(2)chemical fixation

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Science China Chemistry 2024年第7期67卷 2292-2299页

作者： Shu Shang Lei Li Xin He hui Wang Lirong zheng Wei Shao Xiaodong Zhang yi Xie Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science CenterHefei 230031China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Chemistry and Chemical Engineering Hefei Normal UniversityHefei 230031China

Photocatalytic cycloadditions of CO_(2)with epoxides are emerging as a significant platform for the green synthesis of valuable carbonates,where efficient catalytic systems with spatially separated charge carriers are ***,a single p-block metal atom is proposed to be a candidate for photogenerated electron localization on a metal oxide *** taking the Bi single-atom supported on ZnO nanosheet(Bi1/ZnO)as an example,we show that the Bi atom plays the role of an electron island in the sea of delocalized holes within ***,the as-formed electron island could readily promote the rate-determining ring-opening process of cycloaddition *** from the unique spatially separated electrons and holes,the Bi1/ZnO achieves a high yield of cyclic carbonates with almost 100%*** study provides a pioneering strategy for enhancing the performances of photocatalytic CO_(2)chemical fixation.

关键词： electron islands CO_(2)photofixation photogenerated charge carriers

Early colorectal cancer screening–no time to lose

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World Journal of Gastroenterology 2024年第23期30卷 2959-2963页

作者： ying Wang zheng-Long Wu yi-Gang Wang hui Wang Xiao-Yuan Jia College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Oncology Zhejiang Xiaoshan HospitalHangzhou 310018Zhejiang ProvinceChina

In this editorial,we comment on the article entitled“Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?”by Agatsuma et *** cancer(CRC)is emerging as an important health issue as its incidence continues to rise globally,adversely affecting the quality of *** the public has become more aware of CRC prevention,most patients lack screening *** poor lifestyle practices can lead to CRC and symptoms can appear in the early stages of ***,due to the lack of awareness of the disease,most of the CRC patients are diagnosed already at an advanced stage and have a poor prognosis.

关键词： Colorectal cancer The immunochemical fecal occult blood test Diagnostic route Cancer screening Stage at diagnosis

Differentially private SGD with random features

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 1-23页

作者： WANG yi-guang GUO zheng-chu Polytechnic Institute of Zhejiang University Zhejiang UniversityHangzhou 310015China School of Mathematical Sciences Zhejiang UniversityHangzhou 310058China

In the realm of large-scale machine learning,it is crucial to explore methods for reducing computational complexity and memory demands while maintaining generalization ***,since the collected data may contain some sensitive information,it is also of great significance to study privacy-preserving machine learning *** paper focuses on the performance of the differentially private stochastic gradient descent(SGD)algorithm based on random *** begin,the algorithm maps the original data into a lowdimensional space,thereby avoiding the traditional kernel method for large-scale data storage ***,the algorithm iteratively optimizes parameters using the stochastic gradient descent ***,the output perturbation mechanism is employed to introduce random noise,ensuring algorithmic *** prove that the proposed algorithm satisfies the differential privacy while achieving fast convergence rates under some mild conditions.

关键词： learning theory differential privacy stochastic gradient descent random features reproducing kernel Hilbert spaces

Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

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Zoological Research 2024年第4期45卷 747-766页

作者： Hong-yi zheng Tian-Zhang Song Yong-Tang zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19

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World Journal of Stem Cells 2024年第4期16卷 353-374页

作者： Xiang-yi Hou La-Mu Danzeng yi-Lin Wu Qian-hui Ma zheng Yu Mei-ying Li Li-Sha Li The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchun 130021Jilin ProvinceChina Department of Pharmacy Jilin UniversityChangchun 130021Jilin ProvinceChina The First Hospital of Jilin University Jilin UniversityChangchun 130021Jilin ProvinceChina

Coronavirus disease 2019(COVID-19)is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection typically presents with fever and respiratory symptoms,which can progress to severe respiratory distress syndrome and multiple organ *** severe cases,these complications may even lead to *** of the causes of COVID-19 deaths is the cytokine storm caused by an overactive immune ***,suppressing the overactive immune response may be an effective strategy for treating *** stem cells(MSCs)and their derived exosomes(MSCs-Exo)have potent homing abilities,immunomodulatory functions,regenerative repair,and antifibrotic effects,promising an effective tool in treating *** this paper,we review the main mechanisms and potential roles of MSCs and MSCs-Exo in treating *** also summarize relevant recent clinical trials,including the source of cells,the dosage and the efficacy,and the clinical value and problems in this field,providing more theoretical references for the clinical use of MSCs and MSCs-Exo in the treatment of COVID-19.

关键词： COVID-19 Cytokine storm Immunomodulation Mesenchymal stem cell Mesenchymal stem cell-derived exosomes