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Chinese Chemical Letters 2011年第12期22卷 1509-1512页

作者： tian qiang Wang Xiu Li Zhao Jian Yuan hao State Key Lab of Electronic Films and Integrated Devices School of Microelectronics and Solid State Electronics University of Electronic Science and Technology of China Chengdu 610054 China Institute of Chemical Materials China Academy of Engineering Physics Mianyang 621900 China

Ring-opening suspension polymerization of p-dioxanone（PDO） in supercritical carbon dioxide（scCO_2） was investigated in the presence of poly（caprolactone）-perfluropolyether-poly（caprolactone）（PCL-PFPE-PCL）.The molecular weight,yield and particle morphology of poly（p-dioxanone）（PPDO） were *** stabilizer was effective to stabilize the ring-opening polymerization（ROP） of PDO in scCO_2,leading to the formation of resorbable microparticles in a＂one pot＂*** mean size of PPDO microparticles obtained from suspension polymerizations was sensitive to the rate of agitation and the stabilizer *** method to generate PPDO microparticles has overcome its unprocessable drawback with common organic solvents and provided new product form for biomedical applications.

关键词： Biodegradable Poly(p-dioxanone) Polymerization Stabilizer Microparticle

“三高四新”视域下高等数学应用型人才培养教学改革研究

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湖北开放职业学院学报 2024年第15期37卷 44-46页

作者：黎可毕文毅黄昊天湖南信息学院通识教育学院湖南长沙少410151

本文主要围绕高等数学应用型人才培养的教学改革展开,探究“三高四新”视域下如何更好地培养应用型数学人才,从教学内容、教学方法、师资队伍、实践教学和产教融合五个方面分析和探索解决教学现状问题的改革方法,提出在“三高四新”战... 详细信息

本文主要围绕高等数学应用型人才培养的教学改革展开,探究“三高四新”视域下如何更好地培养应用型数学人才,从教学内容、教学方法、师资队伍、实践教学和产教融合五个方面分析和探索解决教学现状问题的改革方法,提出在“三高四新”战略背景下,将“理学+技术+思维”模式应用到教学中,“横向融合,纵向递进”,多途径、全方位地施行人才培养模式,在“三新”(即新思维、新工具、新能力)维度下进行改进,从而提升学生解决问题、分析问题的实践能力,培养学生创新、创业、创造的应用能力,将学生教育与国家战略、省份崛起相融合,为行业的经济增长注入活力,将学生培养成符合社会要求的人才,也让高等数学应用型人才培养走高质量教学之路。

关键词： “三高四新” 高等数学应用型人才创新实践产教融合

大柴胡汤历史沿革、临床应用和药理作用研究进展及其质量标志物预测分析

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中国中药杂志 2024年第8期49卷 2064-2075页

作者：汲晓玲周游李泽浩强发晶邴一凡赵俊毅邹翔曲中原哈尔滨商业大学药学院黑龙江哈尔滨150076 哈尔滨商业大学药物工程技术研究中心黑龙江哈尔滨150076

大柴胡汤是和解少阳、内泻热结之经典方剂,张仲景专为少阳、阳明合病所设。国内外大量研究表明大柴胡汤具有保肝、利胆、抗炎等药理作用,现代临床多用于治疗急性胰腺炎、急性胆囊炎、胆石症等消化系统疾病。该研究采用文献计量学与统计... 详细信息

大柴胡汤是和解少阳、内泻热结之经典方剂,张仲景专为少阳、阳明合病所设。国内外大量研究表明大柴胡汤具有保肝、利胆、抗炎等药理作用,现代临床多用于治疗急性胰腺炎、急性胆囊炎、胆石症等消化系统疾病。该研究采用文献计量学与统计学相结合的方法,选择古籍数据库及中国知网(CNKI)数据库,检索大柴胡汤的相关文献,考证该方组成与剂量、炮制方法、主治病症及现代临床应用,并以质量标志物(Q-marker)的“五原则”为纲领预测大柴胡汤的质量标志物。结果提示柴胡皂苷a、黄芩苷和6-姜辣素等可作为大柴胡汤潜在的质量标志物,为中医临床研究及复方制剂开发和应用提供依据。

关键词：大柴胡汤历史沿革临床应用药理作用质量标志物

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多分舱箱式气浮结构系泊状态下运动响应分析

船海工程 2024年第3期53卷 50-54页

作者：余葵李梦源刘宪庆邓皓天周强重庆交通大学河海学院重庆400074 国家内河航道整治工程技术研究中心重庆400074

基于MOSES软件建立多分舱箱式气浮结构数值模型并模拟多种系泊布置方式,对气浮箱的纵荡、纵摇及垂荡进行时域分析,研究系缆点位置、锚链数量、抛锚方式,以及分舱数对气浮箱运动响应的影响。结果表明,系缆点位置、锚链数量、抛锚方式,以... 详细信息

基于MOSES软件建立多分舱箱式气浮结构数值模型并模拟多种系泊布置方式,对气浮箱的纵荡、纵摇及垂荡进行时域分析,研究系缆点位置、锚链数量、抛锚方式,以及分舱数对气浮箱运动响应的影响。结果表明,系缆点位置、锚链数量、抛锚方式,以及分舱数量会影响结构运动响应,系缆点位于箱顶、8根锚链交叉抛锚是最有利的系泊布置方式,增加分舱可以在一定程度上减小箱式气浮结构的运动响应。

关键词：气浮结构锚缆系泊 MOSES

Pretreatment elevated fibrinogen level predicts worse oncologic outcomes in upper tract urothelial carcinoma

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Asian Journal of Andrology 2020年第2期22卷 177-183页

作者： Hang Xu Jian-Zhong Ai Ping Tan tian-Hai Lin Xi Jin Li-Na gong hao-Ran Lei Lu Yang qiang Wei Department of Urology and Institute of Urology West China HospitalSichuan UniversityChengdu 610041China

This study aimed to further validate the prognostic role of fibrinogen in upper tract urothelial carcinoma(UTUC)in a large Chinese cohort.A total of 703 patients who underwent radical nephroureterectomy were retrospectively *** levels of≥4.025 g l?1 were defined as *** regression analysis was performed to determine the association between fibrinogen and adverse pathological ***–Meier analysis and Cox regression models were used to assess the associations of fibrinogen with cancer-specific survival(CSS),disease recurrence-free survival(RFS),and overall survival(OS).Harrell c-index and decision curve analysis were used to assess the clinical utility of multivariate *** median follow-up duration was 42(range:1–168)*** regression analysis revealed that elevated fibrinogen was associated with higher tumor stage and grade,lymph node involvement,lymphovascular invasion,sessile carcinoma,concomitant variant histology,and positive surgical margins(all P<0.05).Multivariate Cox regression analysis demonstrated that elevated fibrinogen was independently associated with decreased CSS(hazard ratio[HR]:2.33;P<0.001),RFS(HR:2.09;P<0.001),and OS(HR:2.09;P<0.001).The predictive accuracies of the multivariate models were improved by 3.2%,2.0%,and 2.8%for CSS,RFS,and OS,respectively,when fibrinogen was *** curve analysis showed an added benefit for CSS prediction when fibrinogen was added to the *** fibrinogen may be a strong independent predictor of worse oncologic outcomes in UTUC;therefore,it may be valuable to apply this marker to the current risk stratification in UTUC.

关键词： fibrinogen prognosis radical nephroureterectomy upper tract urothelial carcinoma

Multiplex network infomax:Multiplex network embedding via information fusion

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Digital Communications and Networks 2023年第5期9卷 1157-1168页

作者： qiang Wang hao Jiang ying Jiang Shuwen yi Qi Nie Geng Zhang Electronic Information School Wuhan UniversityWuhan430072China School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou510006China China Electric Power Research Institute Beijing100192China

For networking of big data applications,an essential issue is how to represent networks in vector space for further mining and analysis tasks,e.g.,node classification,clustering,link prediction,and *** existing studies on this subject mainly concentrate on monoplex networks considering a single type of relation among ***,numerous real-world networks are naturally composed of multiple layers with different relation types;such a network is called a multiplex *** majority of existing multiplex network embedding methods either overlook node attributes,resort to node labels for training,or underutilize underlying information shared across multiple *** this paper,we propose Multiplex Network Infomax(MNI),an unsupervised embedding framework to represent information of multiple layers into a unified embedding *** be more specific,we aim to maximize the mutual information between the unified embedding and node embeddings of each *** the basis of this framework,we present an unsupervised network embedding method for attributed multiplex *** results show that our method achieves competitive performance on not only node-related tasks,such as node classification,clustering,and similarity search,but also a typical edge-related task,i.e.,link prediction,at times even outperforming relevant supervised methods,despite that MNI is fully unsupervised.

关键词： Network embedding Multiplex network Mutual information maximization

个体化预测急性脑梗死患者阿替普酶溶栓出血风险的Nomgram模型的初步建立及验证

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中南药学 2024年第8期22卷 2225-2229页

作者：庞天义满德强常群临泉县人民医院安徽阜阳236400

目的分析急性脑梗死患者阿替普酶溶栓出血的危险因素并建立相应的Nomgram风险预测模型。方法回顾性分析2020年1月至2022年1月于我院就诊采用阿替普酶静脉溶栓治疗的108例急性脑梗死患者作为研究对象,收集患者的临床资料,将患者的年龄、... 详细信息

目的分析急性脑梗死患者阿替普酶溶栓出血的危险因素并建立相应的Nomgram风险预测模型。方法回顾性分析2020年1月至2022年1月于我院就诊采用阿替普酶静脉溶栓治疗的108例急性脑梗死患者作为研究对象,收集患者的临床资料,将患者的年龄、性别、高血压、高血脂、基线血糖水平、基线NIHSS评分以及吸烟、饮酒史等因素与溶栓后是否发生出血不良反应进行单因素分析,随后建立Logistic回归模型筛选患者溶栓后发生出血的独立危险因素,根据筛选出的独立危险因素建立Nomgram风险预测模型,并对该模型进行内部验证。结果溶栓后共40例患者发生出血,其中高龄(OR=2.083,95%CI:1.216~2.950)、高血压(OR=4.402,95%CI:2.001~9.652)、高基线NIHSS评分(OR=1.615,95%CI:1.150~2.080)、高基线血糖水平(OR=2.561,95%CI:1.440~4.517)为溶栓后发生出血的独立危险因素,根据筛选出的独立危险因素,构建个体化预测急性脑梗死患者阿替普酶溶栓出血风险的Nomgram模型,该模型的C-index指数为0.738,表明模型具有较好的区分度,对该模型进行验证后发现预测值和观察值基本一致,表明该预测模型具有良好的一致性。结论本研究通过筛选出急性脑梗死患者采用阿替普酶静脉溶栓治疗后发生出血的独立危险因素建立了能够预测出血不良反应发生风险的Nomgram模型,此风险预测模型区分度及一致性良好,对快速甄别急性脑梗死患者阿替普酶溶栓出血的高风险人群,针对相关危险因素及早采取有效的应对措施有着较为重要的指导意义。

关键词：急性脑梗死阿替普酶静脉溶栓危险因素 Nomgram模型

Giant and controllable Goos—Hänchen shift of a reflective beam off a hyperbolic metasurface of polar crystals

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Chinese Physics B 2024年第1期33卷 428-435页

作者：薛天李宇博宋浩元王相光张强付淑芳周胜王选章 Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Educationand School of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China Department of Basic Courses Guangzhou Maritime UniversityGuangzhou 510725China

We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH *** on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ_(0) is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 10^(8) λ_(0)/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.

关键词： Goos–H?nchen shift black phosphorus surface plasmon phonon polaritons sensitivity metasurfaces

转录组测序分析外源水杨酸诱导茶树热激蛋白基因的响应

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江苏农业学报 2024年第4期40卷 607-614页

作者：刘悦曲浩田易萍陈春林冉隆珣陈林波云南省农业科学院茶叶研究所/云南省茶树种质资源创新与配套栽培技术工程研究中心/云南省茶学重点实验室云南昆明666201

水杨酸是诱导植物抗性机制中重要的信号分子,外源喷施水杨酸能够调控多种防御相关蛋白质,提升农作物的抗病能力。开展外源水杨酸诱导茶树抗性机制的研究能够挖掘抗病基因,为茶树抗病育种提供分子基础。本研究采集外源喷施水杨酸0 h、6 h... 详细信息

水杨酸是诱导植物抗性机制中重要的信号分子,外源喷施水杨酸能够调控多种防御相关蛋白质,提升农作物的抗病能力。开展外源水杨酸诱导茶树抗性机制的研究能够挖掘抗病基因,为茶树抗病育种提供分子基础。本研究采集外源喷施水杨酸0 h、6 h、12 h、24 h、48 h的茶树叶片进行转录组测序与分析,结果表明,外源喷施水杨酸6 h、12 h、24 h、48 h时茶树叶片内差异表达基因数量分别为9 360个、3 399个、596个、115个,外源水杨酸处理后各时间点均发生差异表达的基因共604个。KEGG功能富集结果显示,处理后6 h时富集于植物激素信号转导、植物-病原菌互作、核糖体、剪接体和碳代谢通路上的差异表达基因数量分别为95个、73个、121个、94个、154个。差异表达基因中有12个热激因子基因、40个热激蛋白基因和12个WRKY家族转录因子基因上调表达。处理48 h后,无上调表达的热激因子基因,但仍有28个热激蛋白基因上调表达。病程相关蛋白基因在检测阶段均上调表达。外源水杨酸的诱导作用在处理6 h时最为明显,并且引起了大量热激蛋白的响应。本研究结果为开展外源水杨酸诱导茶树抗病机制和茶树抗病分子育种研究提供了参考。

关键词：外源水杨酸茶树转录组差异表达基因热激蛋白

Channel estimation based on distributed compressed sensing in amplify-and-forward relay networks

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The Journal of China Universities of Posts and Telecommunications 2010年第5期17卷 44-49页

作者： WANG Dong-hao NIU Kai HE Zhi-qiang tian Bao-yu School of Information and Telecommunication Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

In orthogonal frequency-division multiplexing （OFDM） amplify-and-forward （AF） relay networks,in order to exploit diversity gains over frequency-selective fading channels,the receiver needs to acquire the knowledge of channel state information （CSI）.In this article,based on the recent methodology of distributed compressed sensing （DCS）,a novel channel estimation scheme is *** joint sparsity model 2 （JSM-2） in DCS theory and simultaneous orthogonal matching pursuit （SOMP） are both introduced to improve the estimation performance and increase the spectral *** results show that compared with current compressed sensing （CS） methods,the estimation error of our scheme is reduced dramatically in high SNR region while the pilot number is still kept small.

关键词： channel estimation DCS relay networks SOMP