检索结果-南通市图书馆

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrothermal Syntheses, Crystal Structures and Luminescence Properties of Zn(Ⅱ) and Cu(Ⅱ) Complexes Based on 2,2'-((Sulfonylbis(4,1-phenylene))bis(oxy))diacetic Acid

引用

Chinese Journal of Structural Chemistry 2020年第2期39卷 294-300,186页

作者： wu Qi-Qi WEN yi-hang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical ChemistryZhejiang Normal UniversityJinhuaZhejiang 321004China

The 2,2'-((sulfonylbis(4,1-phenylene))bis(oxy))diacetic acid(H2L) and 4,4'-bipyridine(4,4'-bipy) are employed as organic ligands to react with metal salts to obtain two new metal-organic frameworks(MOFs), namely [M2L2(4,4'-bipy)](M = Zn(1), Cu(2)). They have been successfully synthesized under hydrothermal conditions. Single-crystal X-ray diffraction reveals that two complexes are isostructural and crystallize in orthorhombic system with space group Pbcn. All L^(2-) ligands bridge metal ions to form an infinite 1D Z-shaped chain along the a axis. Then through 4,4'-bipy, contiguous Z-shaped chains are linked to form a 2D layer structure. The luminescent studies of the H2L ligand and complex 1 in the solid state and thermogravimetric analyses(TGA) of two complexes are investigated.

关键词： hydrothermal syntheses 2,2'-((sulfonylbis(4,1-phenylene))bis(oxy))diacetic acid crystal structure luminescence property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reversal of circularly polarized luminescence direction and an“onoff”switch driven by exchange between UV light irradiation and the applied direct current electric field

引用

Science China Chemistry 2022年第10期65卷 1945-1952页

作者： Kun Yao Zheng Liu hang Li Dan Xu Wen-Hua Zheng yi-wu Quan yi-Xiang Cheng Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Key Laboratory of High Performance Polymer Material and Technology of Ministry of Education Department of Polymer Science and EngineeringSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

We report the rational design of a dual stimulus-activated quaternary chiral emission nematic liquid crystals(Q-N*-LCs)containing light-driven chiral dopant R-S-R-1,a static chiral dopant S-2 and an achiral Nile Red(NR)in a nematic liquid crystal(SLC1717).The dopant R-S-R-1 acts as a dynamic chiral donor and an energy donor,and the achiral NR serves as a circularly polarized luminescence(CPL)emitter and energy ***,this kind of Q-N*-LCs appears reversal CPL emission direction(L-CPL)using 365 nm UV light irradiation compared with the initial state(R-CPL).Most importantly,the“On-Off”CPL switch behavior of Q-N*-LCs can be repeatedly driven by revoking or rearranging the applied direct current(DC)electric *** OR chiral information logic gate demonstrates that this dual driven Q-N*-LCs can be potentially used for chiral information storage and coding.

关键词： chiral supramolecular liquid crystals circularly polarized luminescence light and electricity dual stimuli-activated Förster resonance energy transfer

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stable Label-Specific Features Generation for Multi-Label Learning via Mixture-Based Clustering Ensemble

引用

IEEE/CAA Journal of Automatica Sinica 2022年第7期9卷 1248-1261页

作者： yi-Bo Wang Jun-yi hang Min-Ling Zhang School of Computer Science and Engineering Southeast UniversityNanjing 210096China IEEE

Multi-label learning deals with objects associated with multiple class labels,and aims to induce a predictive model which can assign a set of relevant class labels for an unseen *** each class might possess its own characteristics,the strategy of extracting label-specific features has been widely employed to improve the discrimination process in multi-label learning,where the predictive model is induced based on tailored features specific to each class label instead of the identical instance *** a representative approach,LIFT generates label-specific features by conducting clustering ***,its performance may be degraded due to the inherent instability of the single clustering *** improve this,a novel multi-label learning approach named SENCE(stable label-Specific features gENeration for multi-label learning via mixture-based Clustering Ensemble)is proposed,which stabilizes the generation process of label-specific features via clustering ensemble ***,more stable clustering results are obtained by firstly augmenting the original instance repre-sentation with cluster assignments from base clusters and then fitting a mixture model via the expectation-maximization(EM)*** experiments on eighteen benchmark data sets show that SENCE performs better than LIFT and other well-established multi-label learning algorithms.

关键词： Clustering ensemble expectation-maximization al-gorithm label-specific features multi-label learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of strand and final electromagnetic stirrers of round bloom casters with multiple sections

引用

International Journal of Minerals,Metallurgy and Materials 2016年第10期23卷 1150-1156页

作者： Rui Wang Yan-ping Bao yi-hong Li hang-hang An State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Material Science and Technology Taiyuan University of Science and Technology

Strand electromagnetic stirring（S-EMS） and final electromagnetic stirring（F-EMS） are the main methods used to improve the center porosity and segregation for round blooms. To optimize the stirring conditions, nail shooting tests were conducted for three sections of large round blooms with diameters of ф380 mm, ф450 mm, and ф600 mm. Acid leaching and sulfur print tests were used to investigate the shell thickness. Based on the results of nail shooting tests, a mathematical model of solidification was established, and the variation of shell thickness and the central solid fraction were exactly calculated by the model. By taking all sections into account, the locations of S-EMS and F-EMS were optimized for each section. In the results, the macro-segregation of various sections is improved after the locations of S-EMS and F-EMS systems are changed.

关键词： continuous casting electromagnetic stirring blooms mathematical models optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

引用

Journal of Thermal Science 2025年第1期 24-33页

作者： LIN Yongjie Zhang Cancan wu Yuting Zhang yi LU Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/（Δp）1/3was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29% to 17.18% over the unopened-hole solution.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The jet over a stretching wall with suction or injection

引用

Science China(Physics,Mechanics & Astronomy) 2011年第3期54卷 502-510页

作者： XU hang wu GuoXiong State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Mechanical Engineering University College London London WC1E7JE UK

The steady laminar wall jet over a stretching surface in the presence of lateral suction or injection is considered. Similarity solutions absent in previous publications are found in some new ranges of parameters in the governing equation. The accuracy and reliability of the solutions have been checked through detailed convergence study and compared with the solutions from the numerical method and analytic method, and excellent agreement has been found. This gives the strongest evidence that those solutions are indeed new ones.

关键词： wall jet stretching wall injection/suction similarity solution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantification of photosynthetic inorganic carbon utilisation via a bidirectional stable carbon isotope tracer

引用

Acta Geochimica 2016年第2期35卷 130-147页

作者： Hongtao hang Yanyou wu State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081 China University of Chinese Academy of Sciences Beijing 100049China

The amount of bicarbonate utilised by plants is usually ignored because of limited measurement methods. Accordingly, this study quantified the photosynthetic assimilation of inorganic carbon （COe and HCO3-） by plants. The net photosynthetic COa assimilation （PN）, the photosynthetic assimilation of CO2 and bicarbonate （PN＇）, the proportion of increased leaf area （lEA） and the stable carbon isotope composition （δ13C） of Orychophragmus violaceus （Ov） and Brassica juncea （B j） under three bicarbonate levels （5, 10 and 15 mm NaHCO3） were examined to determine the relationship among PN, PN＇ and fLA. PN＇, not PN, changed synchronously with fLA. Moreover, the proportions of exogenous bicarbonate and total bicarbonate （including exogenous bicarbonate and dissolved CO2-generated bicarbonate） utilised by Ov were 2.27 % and 5.28 % at 5 mm bicarbonate, 7.06 % and 13.28 % at 10 mm bicarbonate, and 8.55 % and 17.31% at 15 mm bicarbonate, respectively. Meanwhile, the propor- tions of exogenous bicarbonate and total bicarbonate uti- lised by Bj were 1.77 % and 3.28 % at 5 mm bicarbonate, 2.11% and 3.10 % at 10 mm bicarbonate, and 2.36 % and 3.09 % at 15 mm bicarbonate, respectively. Therefore, the dissolved CO2-generated bicarbonate and exogenous bicarbonate are important sources of inorganic carbon for plants.

关键词： Karst Bicarbonate - Photosynthesis -Inorganic carbonic utilization Stable carbon isotopecomposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-Born-Oppenheimer study of the muonic molecule ion 4Heμ^+

引用

Chinese Physics B 2020年第4期29卷 226-231页

作者： hang Yang Meng-Shan wu yi Zhang Ting-Yun Shi Kalman Varga Jun-yi Zhang State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Physics and Astronomy Vanderbilt UniversityNashvilleTennessee 37235USA

Accurate non-Born-Oppenheimer variational calculations of all bound states of the positive muon molecular ion 4Heμ^+ have been performed using explicitly correlated Gaussian functions in conjunction with the global *** the energies obtained are accurate in the order of 10-6 Hartree(1 Hartree=27.2114 eV).Compared with the binding energies obtained from calculations based on the Born-Oppenheimer potential with the mass-weighted adiabatic corrections(***.110487(1984)),the largest relative deviation is up to 15%.By analyzing the average interparticle distances and possibility distributions of interparticle distances of this system,it is confirmed that the Born-Oppenheimer approximation is reasonable for this system and that 4Heμ^+ can be regarded as a system of positive muon bound to a slightly distorted helium atom.

关键词： positive muon variational calculation explicitly correlated Gaussian

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

引用

Neural Regeneration Research 2021年第6期16卷 1052-1061页

作者： Qiu-Shi Gao Ya-Han Zhang hang Xue Zi-yi wu Chang Li Ping Zhao Department of Anesthesiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent *** classical Rice-Vannucci model was used to induce hypoxic-ischemic injury,and newborn(postnatal day 7)rats were treated with 2.4%sevoflurane for 30 minutes after hypoxic-ischemic *** results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats,decreased astrogliosis and glial scar formation,increased numbers of dendritic spines,and protected the histomorphology of the ***,sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of *** of 1.52μg of the hypoxia-inducible factor-1αinhibitor YC-1(Lificiguat)into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by *** finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic *** underlying mechanism may be related to upregulated DJ-1 expression,reduced ubiquitination of hypoxia-inducible factor-1α,and stabilized hypoxiainducible factor-1α*** study was approved by the Laboratory Animal Care Committee of China Medical University,China(approval No.2016PS337K)on November 9,2016.

关键词： brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：