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Robust fuzzy control of Takagi-Sugeno fuzzy neural networks with discontinuous activation functions and time delays

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Journal of Systems Engineering and Electronics 2011年第3期22卷 473-481页

作者： Yaonan Wang Xiru wu yi Zuo College of Electrical and Information Engineering Hunan UniversityChangsha 410082P.R.China School of Energy and Power Engineering Changsha University of Science and TechnologyChangsha 410004P.R.China

The problem of global robust asymptotical stability for a class of Takagi-Sugeno fuzzy neural networks（TSFNN） with discontinuous activation functions and time delays is investigated by using Lyapunov stability *** on linear matrix inequalities（LMIs）,we originally propose robust fuzzy control to guarantee the global robust asymptotical stability of *** with the existing literature,this paper removes the assumptions on the neuron activations such as Lipschitz conditions,bounded,monotonic increasing property or the right-limit value is bigger than the left one at the discontinuous ***,the results are more general and ***,two numerical examples are given to show the effectiveness of the proposed stability results.

关键词： delayed neural network global robust asymptotical stability discontinuous neuron activation linear matrix inequality(LMI) Takagi-sugeno(T-S) fuzzy model.

Decidability of linearizabilities for relaxed data structures

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Science China(Information Sciences) 2018年第1期61卷 113-122页

作者： Chao WANG yi LV Peng wu State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences University of Chinese Academy of Sciences

Many recent implementations of concurrent data structures relaxed their linearizability requirements for better performance and scalability. Quasi-linearizability, k-linearizability and regular-relaxed linearizability are three quantitative relaxation variants of linearizability that have been proposed as correctness conditions of relaxed data structures, yet preserving the intuition of linearizability. Quasi-linearizability has been proved undecidable. In this paper, we first show that k-linearizability is undecidable for a bounded number of processes, by reducing quasi-linearizability into it. We then show that regular-relaxed linearizability is decidable for a bounded number of processes. We also find that the number of the states of a relaxed specification is exponential to the number of the states of the underlying specification automaton(representing its relaxation strategy), and polynomial to the number of the states of the underlying quantitative sequential specification and the number of operations.

关键词： concurrent data structures quantitative relaxation linearizability decidability finite automata

The Width-Flux Relation of the Broad Iron KαLine during the State Transitions of the Black Hole X-Ray Binaries

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Research in Astronomy and Astrophysics 2023年第6期23卷 220-227页

作者： hang-ying Shui Fu-Guo Xie Zhen Yan Ren-yi Ma Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen UniversityXiamen 361005China SHAO-XMU Joint Center for Astrophysics Xiamen 361005China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China

The observations of varying broad iron lines during the state transition of the black hole X-ray binaries have been *** this work,the relation between the normalized intensity and the width of iron lines is investigated,in order to understand better the variation of iron lines and possibly its connection to state *** the uncertainties due to ionization and illuminating X-rays,only the effects of geometry and gravity are taken into *** scenarios were studied,i.e.,the continuous disk model,the innermost annulus model,and the cloud *** shown by our calculations,at given iron width,the line flux of the cloud model is smaller than that of the continuous disk model;while for the innermost annulus model,the width is almost unrelated with the *** range of the line strength depends on both the BH spin and the inclination of the *** then apply to the observation of MAXI J1631-479 by Nuclear Spectroscopic Telescope Array during its decay from the soft state to the intermediate *** estimated the relative line strength and width according to the spectral fitting results in Xu et al.,and then compared with our theoretical width-flux *** was found that the cloud model was more *** further modeled the iron line profiles,and found that the cloud model can explain both the line profile and its variation with reasonable parameters.

关键词： accretion accretion disks black hole physics X-rays:binaries

Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage

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Chinese Journal of Integrative Medicine 2022年第7期28卷 594-602页

作者： CHEN Song DING yi-hang SHI Song-sheng TU Xian-kun Department of Neurosurgery Fujian Medical University Union HospitalNeurosurgery Research Institute of Fujian ProvinceFuzhou 350001China

Objective: To determine whether Schisandrin B(Sch B) attenuates early brain injury(EBI) in rats with subarachnoid hemorrhage(SAH). Methods: Sprague-Dawley rats were divided into sham(sham operation), SAH, SAH+vehicle, and SAH+Sch B groups using a random number table. Rats underwent SAH by endovascular perforation and received Sch B(100 mg/kg) or normal saline after 2 and 12 h of SAH. SAH grading, neurological scores, brain water content, Evan’s blue extravasation, and terminal transferase-mediated dUTP nick end-labeling(TUNEL) staining were carried out 24 h after SAH. Immunofluorescent staining was performed to detect the expressions of ionized calcium binding adapter molecule 1(Iba-1) and myeloperoxidase(MPO) in the rat brain, while the expressions of B-cell lymphoma 2(Bcl-2), Bax, Caspase-3, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3), apoptosis-associated specklike protein containing the caspase-1 activator domain(ASC), Caspase-1, interleukin(IL)-1β, and IL-18 in the rat brains were detected by Western blot. Results: Compared with the SAH group, Sch B significantly improved the neurological function, reduced brain water content, Evan’s blue content, and apoptotic cells number in the brain of rats(P<0.05 or P<0.01). Moreover, Sch B decreased SAH-induced expressions of Iba-1 and MPO(P<0.01). SAH caused the elevated expressions of Bax, Caspase-3, NLRP3, ASC, Caspase-1, IL-1β, and IL-18 in the rat brain(P<0.01), all of which were inhibited by Sch B(P<0.01). In addition, Sch B increased the Bcl-2 expression(P<0.01). Conclusion: Sch B attenuated SAH-induced EBI, which might be associated with the inhibition of neuroinflammation, neuronal apoptosis, and the NLRP3 inflammatory signaling pathway.

关键词： schisandrin B subarachnoid hemorrhage early brain injury inflammation neuronal apoptosis nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 Chinese medicine

Activating PPARy Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia

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Current Medical Science 2020年第1期40卷 55-62页

作者： hang hang Li-kun WANG Si-ying REN An-jun SONG Guo-feng wu Department of Emergency The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China

The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1(NQO1)and y-glutamylcysteine synthetase(γ-GCS)in brain tissues after intracerebral hemorrhage(ICH).The microglial cells obtained from newborn rats were cultured and then randomly divided into the normal control group(NC group),model control group(MC group),rosiglitazone(RSG)intervention group(RSG group),retinoic-acid intervention group(RSG+RA group),and sulfbraphane group(RSG+SF group).The expression levels of NQO1,γ-GCS,and nuclear factor E2-related factor 2(Nrf2)were measured by real-time polymerase chain reaction(RT-PCR)and Western blotting,*** results showed that the levels of NQO1,γ-GCS and Nrf2 were significantly increased in the MC group and the RSG group as compared with those in the NC group(Pying the increase of NQO1 and γ-GCS in thrombin-activated microglia may be associated with the activation of Nrf2.

关键词： rosiglitazone peroxisome proliferator-activated receptor y nuclear factor E2-related factor 2 nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase γ-glutamylcysteine synthetase

Lifetime prediction and failure analysis of organic coatings by EIS

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中国有色金属学会会刊：英文版 2004年第z1期14卷 455-458页

作者： YAN Rui wu hang MA Shi-ning XU Bin-shi Surface Engineering Research Institute of CMES Chinese Mechanical Engineering Society Beijing 100072 China Surface Engineering Research Institute of CMES Chinese Mechanical Engineering Society Beijing 100072 China Surface Engineering Research Institute of CMES Chinese Mechanical Engineering Society Beijing 100072 China Surface Engineering Research Institute of CMES Chinese Mechanical Engineering Society Beijing 100072 China

Organic coatings are widely used to control the corrosion of steel structure. The anticorrosive property of these coatings depends on their barrier properties, making a separation between the corrosive medium and the substrate. But unavoidable completely small pores, cracks and other defects in organic coatings may cause ions, water, gases, and other corrosive species penetrate and distribute in the coatings, causing accumulation and swelling of coatings, so leading to the degradation of coatings. In addition, water affects the permeation of oxygen and other corrosive medium, consequently the presence of such substances at coating-metal interface promotes corrosion of metal substrate. So the absorbability of the coatings to water may be one of the most important factors in undercoating corrosion. In recent years, electrochemical impedance spectroscopy (EIS) has been established and frequently used as a non-destructive testing method for assessing the performance of organic coatings, especially for the determination of the water content in organic coatings, since the capacitance of the coatings is sensitive to the penetration of water. So from EIS it can extract a wealth of information on the electrochemical corrosion of coated steels, especially, it can be utilized to assess organic coatings used under particular surroundings. The principle, methods and application of EIS on evaluating life-span and analyzing failure mechanism of organic coatings are also introduced briefly. Combining other analysis techniques such as XRD, SEM and FTIR with electrochemical technique, it will blaze a way in studying degradation mechanism of organic coatings and estimating their lifetime.

关键词： organic coatings lifetime prediction failure analysis electrochemical impedance spectro scopy

Genetic analysis and molecular detection of resistance to chlorpyrifos mediated by the A216S substitution in acetylcholinesterase-1 in the plant bug Apolygus lucorum

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Insect Science 2020年第6期27卷 1224-1232页

作者： Kai-Ran Zuo yi-Hua Yang yi-Dong wu Shu-Wen wu College of Plant Protection Nanjing Agricultural UniversityNanjingChina

The green plant bug Apolygus lucorum is a major pest of Bacillus thuringiensis cotton in ***,we reported that chlorpyrifos resistance in a laboratory-selected strain of ***(BZ-R)is associated with the homozygosis of an allele in the ace-1 gene encoding an alanine to serine substitution at position 216 of *** we describe the results of crosses between the resistant BZ-R strain(41-fold to chlorpyrifos)and the unselected susceptible BZ-S strain homozygous for the wild type alanine allele at position *** to chlorpyrifos was inherited as a semi-dominant trait mainly controlled by a single autosomal gene and co-segregates strongly but not completely with the serine substitution in *** bioassays and enzyme assays showed that minor contributions to resistance are also made by enhanced cytochrome P450 and carboxylesterase activities.A survey of 25 field populations from five Chinese provinces showed strong positive correlations between 50%lethal concentration against chlorpyrifos and S216 allele and genotype frequencies,although the most tolerant populations still only show 40%-50%S216 allele *** results above provide important information for designing effective resistance monitoring and management strategies for *** in China.

关键词： acetylcholinesterase-1 Apolygus lucorum chlorpyrifos resistance inheritance

Research in non-equalization machining method for spatial cam

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第9期9卷 1258-1263页

作者： Jun-hua CHEN yi-jie wu Institute of Mechanical and Electrical Engineering Ningbo Institute of Technology Zhefiang University Ningbo 315010 China Institute of Modern Manufacture Engineering Zhejiang University Hangzhou 310027 China

Many kinds of devices with cam have been widely used in various mechanical equipments. However, non-equalization machining for spatial cam trough remains to be a difficult problem. This paper focuses on the analysis of running conditions and machining processes of spatial cam with oscillating follower. We point out the common errors in the biased distance cutting. By analyzing the motion of oscillating follower of spatial cam, we present a new 3D curve expansion model of spatial cam trough-outline. Based on this model, we have proposed a machining method for trochoidal milling with non-equalization diameter cutter. This new method has led to a creative and effective way for non-equalization diameter machining for spatial cam with oscillating follower.

关键词： Oscillating follower Spatial cam 3D curve exoansion Trochoidal milling Non-eaualization diameter

Discovery of an enantiopure N-[2-hydroxy-3-phenyl piperazine propyl]-aromatic carboxamide derivative as highly selectiveα_(1D/1A)-adrenoceptor antagonist and homology modelling

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Chinese Chemical Letters 2024年第11期35卷 435-441页

作者： Junjun Huang Ran Chen Yajian Huang hang Zhang Anran Zheng Qing Xiao Dan wu Ruxia Duan Zhi Zhou Fei He Wei yi The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacologythe NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China Department of Pharmacy The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China

α_(1)-Adrenergic receptor(AR)blockers can be effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms(BPH/LUTS),their usage is limited by cardiovascular-related side effects that are caused by the subtype nonselective nature or low selectivity of many current *** previously reported that phenylpiperazine analogues with amide and propane linker were moderateα_(1D/1A)adrenoceptor antagonists and exhibited better anti-BPH effect than lead compound naftopidil(NAF)in vivo,however,with modestα_(1D/1A)-subtype ***,we replaced propane moiety with2-hydroxypropanol linker and synthesized twenty-seven racemic derivatives with modified aromatic and hetero aromatic *** these new compounds,quinoline surrogate 17 exhibited extremely weak antagonistic affinity onα_(1B)in both cell-based calcium assay and tissue-based functional assay,so that elicited significantα_(1A/1B)andα_(1D/1B)***,the R enantiomer of 17 preferentially displayed superior anti-BPH effect in rat model compared with S-17,supporting ligand regulates the receptor in a highly stereospecific ***,the computer-aided modelling research was also performed in order to deeply understand the unique binding mode of R-17 in complex withα_(1A)and the subtype receptor selectivity for R-17 was also rationalized in this *** together,our work enriched the diversity of phenylpiperazines for the treatment of BPH/LUTS,and provided a basis for discovery ofα_(1D/1A)-selective ligands.

关键词： Benign prostatic hyperplasia α_(1)-AR antagonist Phenylpiperazine Homology modelling Subtype selectivity