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Sex-specific differences in ossification patterns of the atlas and axis:a computed tomography study

World Journal of Pediatrics 2022年第4期18卷 263-270页

作者： Wei-Liang Wu Xiao-Bo Shao yi-guo shen Jian-Song Chen Qiang Shu Department of Orthopedic Surgery Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineAdministrative BuildingNo.3333 Binsheng RoadHangzhou 310052China

Background We investigated the sex-specific differences in ossification patterns of the first two cervical vertebrae in Chinese children.Methods A retrospective computed tomography(CT)study was performed between June 2016 and December 2020.Patients younger than 16 years with cervical CT images acquired<1.5 mm slice thickness were included.All eligible patients were stratified into 2 sex groups and 16 age groups based on 1-year intervals.The ossification status of each synchondrosis and ossification variants were evaluated.Results A total of 910 subjects(518 males and 392 females)were included in the study.For the Cl vertebra,the neurocentral synchondroses closed at a median age of 8 years in males and 6.3 years in females,and the posterior synchondrosis fused at 5.4 years in males and at 4.4 years in females.Multifocal anterior arch ossification centers were present in 74 of 411(18%)subjects,whereas posterior arch variants were observed in 18 of 258(7%)subjects.For the C2 vertebra,the sequence of complete fusion was as follows:posterior synchondrosis,neurocentral synchondroses,and dentoneural synchondrosis.Uniquely,a fusion line was observed in the dentocentral synchondrosis through adolescence.Anterior arch variants of the C2 vertebra occurred in 17 of 248(6.9%)subjects.There was no significant difference between the sexes in ossification variants.Conclusions All synchondroses of the first two cervical vertebrae fuse slightly earlier in females.The sequence of fusion follows a posterior-to-anterior and caudal-to-cephalad pattern in both sexes.Congenital variants are not rare and should not be confused with trauma.

关键词： Cervical vertebra Fusion Ossification center Ossification variant Synchondrosis

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Stability of trivalent human papillomavirus(types 16,18,58)recombinant vaccine(Escherichia coli)

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Chinese Medical Journal 2021年第24期134卷 3020-3022页

作者： Yu-ying Liu Hai-Jiang Zhang Er-Cui shen Dan Chen Yan Wang Si-Jia Fu Fei yin Gui-Feng Zhang yi-guo shen Yong-Jiang Liu Quality Department of Beijing Health Guard Biotechnology Inc. BDADaxing DistrictBeijing 100176China National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China Research and Development Department of Beijing Health Guard Biotechnology Inc. BDADaxing DistrictBeijing 100176China

To the Editor:There are 530,000 new cases of cervical cancer and 270,000 deaths annually in the world,85%occur in developing countries.Among them,about 150,000 new cases of cervical cancer are in China each year,accounting for one-third of the total patients worldwide.[1]Vaccines are the most economical and effective ways of preventing infectious diseases.To stop the transmission of human papillomavirus(HPV)fundamentally,the most effective measure is to vaccinate safe and effective HPV vaccines.[2,3]Numerous studies have shown that vaccines based on HPV L1 virus-like particles(VLPs)have good safety and protective efficacy.[4]Infection of HPV16,HPV18,and HPV58 viruses is the main cause of cervical cancer in Chinese women.By preventing the infection of HPV16,HPV18,and HPV58 viruses,85.0%to 93.7%of cervical cancers can be prevented.[5].

关键词： papillomavirus protective cervical

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing Huang Xiaohan guo yi Wu Xingyu Chen Lixiang Feng Na Xie guobo shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging population.Despite rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory therapies.In recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated diseases.Various types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability.NPs can also directly combat pathogens and inflammation.In addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases.This review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory diseases.It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects.In conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

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Evaluation of water management on arsenic methylation and volatilization in arsenic-contaminated soils strengthened by bioaugmentation and biostimulation

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Journal of Environmental Sciences 2024年第3期137卷 515-526页

作者： Peng Chen yi Liu guo-Xin Sun State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under fooded conditions. However,no attempt was done to explore As methylation and volatilization under non-fooded conditions. Herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with strawderived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440(GE P. putida). Under fooded conditions, the application of biochar(BC), rice straw(RS)and their combination(BC+RS) increased total As in porewater. However, these effects were greatly attenuated under non-fooded conditions. Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization,and the promotion percentage under non-fooded conditions were significantly higher than that under fooded conditions. The combined GE P. putida and RS showed the highest efficiency in As methylation(88 μg/L) and volatilization(415.4 μg/(kg·year)) in the non-fooded soil with moderate As contamination. Finally, stepwise multiple linear regression analysis presented that methylated As, DOC and p H in porewater were the most important factors contributing to As volatilization. Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-fooded conditions.

关键词： Arsenic methylation Arsenic volatilization Water management Straw incorporation Bioaugmentation

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Research progress on metal-organic framework compounds(MOFs)in electrocatalysis

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Journal of Environmental Sciences 2024年第7期141卷 261-276页

作者： Yutong guo Shunzheng Zhao Xiaolong Tang Honghong yi Department of Environmental Science and Engineering School of Energy and Environmental EngineeringUniversity of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

Metal-organic frameworks(MOFs)have favorable characteristics such as large specific surface area,high porosity,structural diversity,and pore surface modification,giving them great potential for development and attractive prospects in the research area of modern materials electrocatalysis.However,unsatisfactory catalytic activity and poor electronic conductivity are the main challenges facing MOFs.This review focuses on MOF-based materials used in electrocatalysis,based on the types of catalytic reactions that have used MOF-based materials in recent years along with their applications,and also looks at some new electrocatalytic materials and their future development prospects.

关键词： Metal-organic frame compounds Electrocatalysis Oxidation-reduction Nitrogen fixation to synthesize ammonia Carbon dioxide reduction

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Recent advances in nickel-based catalysts in eCO_(2)RR for carbon neutrality

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Carbon Energy 2024年第2期6卷 61-91页

作者： Weikang Peng Fengfeng Li Shuyi Kong Chenxi guo Haotian Wu Jiacheng Wang yi shen Xianguang Meng Mingxi Zhang Hebei Key Laboratory of Inorganic Nonmetallic Materials School of Materials Science and EngineeringNorth China University of Science and TechnologyTangshanHebeiChina Hebei Iron and Steel Laboratory North China University of Science and TechnologyTangshanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina School of Materials Science and Engineering Taizhou UniversityZhejiangChina

The excessive use of nonrenewable energy has brought about serious greenhouse effect.Converting CO_(2) into high-value-added chemicals is undoubtedly the best choice to solve energy problems.Due to the excellent cost-effectiveness and dramatic catalytic performance,nickel-based catalysts have been considered as the most promising candidates for the electrocatalytic CO_(2) reduction reaction(eCO_(2)RR).In this work,the electrocatalytic reduction mechanism of CO_(2) over Ni-based materials is reviewed.The strategies to improve the eCO_(2)RR performance are emphasized.Moreover,the research on Ni-based materials for syngas generation is briefly summarized.Finally,the prospects of nickel-based materials in the eCO_(2)RR are provided with the hope of improving transition-metal-based electrocatalysts for eCO_(2)RR in the future.

关键词： carbon energy carbon neutrality CO_(2)reduction electrocatalysis nickel-based materials

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Manufacturing CAR-NK against tumors: Who is the ideal supplier?

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Chinese Journal of Cancer Research 2024年第1期36卷 1-16页

作者： Feifei guo yi Zhang Jiuwei Cui The First Hospital of Jilin University Cancer CenterChangchun 133021China

Chimeric antigen receptor-natural killer(CAR-NK) cells have emerged as another prominent player in the realm of tumor immunotherapy following CAR-T cells. The unique features of CAR-NK cells make it possible to compensate for deficiencies in CAR-T therapy, such as the complexity of the manufacturing process, clinical adverse events, and solid tumor challenges. To date, CAR-NK products from different allogeneic sources have exhibited remarkable anti-tumor effects on preclinical studies and have gradually been applied in clinical practice.However, each source has advantages and disadvantages. Selecting a suitable source may help maximize CAR-NK cell efficacy and increase the feasibility of clinical transformation. Therefore, this review discusses the development and challenges of CAR-NK cells from different sources to provide a reference for future exploration.

关键词： CAR-NK cells cord blood iPSC NK-92 cells peripheral blood

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An Encoding-Decoding Framework Based on CNN for circ RNA-RBP Binding Sites Prediction

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Chinese Journal of Electronics 2024年第1期33卷 256-263页

作者： Yajing guo Xiujuan LEI yi PAN School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Department of Computer Science Georgia State University

Predicting RNA binding protein(RBP) binding sites on circular RNAs(circ RNAs) is a fundamental step to understand their interaction mechanism. Numerous computational methods are developed to solve this problem, but they cannot fully learn the features. Therefore, we propose circ-CNNED, a convolutional neural network(CNN)-based encoding and decoding framework. We first adopt two encoding methods to obtain two original matrices. We preprocess them using CNN before fusion. To capture the feature dependencies, we utilize temporal convolutional network(TCN) and CNN to construct encoding and decoding blocks, respectively. Then we introduce global expectation pooling to learn latent information and enhance the robustness of circ-CNNED. We perform circ-CNNED across 37 datasets to evaluate its effect. The comparison and ablation experiments demonstrate that our method is superior. In addition, motif enrichment analysis on four datasets helps us to explore the reason for performance improvement of circ-CNNED.

关键词： Circular RNAs (circRNAs) RNA binding proteins Convolutional neural network Temporal convolutional network Encoder-decoder network

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Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 405-417页

作者： yi Yu guo-Ping Liu yi Huang Peng Shi IEEE shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and TechnologyShenzhen 518055China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China School of Electrical and Mechanical Engineering the University of AdelaideSA 5005Australia Research and Innovation Centre Obuda University1034 BudapestHungary

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.

关键词： DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control

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Optimizing the Diameter of Plugging Balls in Deep Shale Gas Wells

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Fluid Dynamics & Materials Processing 2024年第3期20卷 609-624页

作者： yi Song Zheyu Hu Cheng shen Lan Ren Xingwu guo Ran Lin Kun Wang Zhiyong Zhao Shale Gas Research Institute PetroChina Southwest Oil&Gasfield CompanyChengdu610056China State Key Laboratory of Oil&Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China National Pipe Network Group Sichuan East Natural Gas Transmission Pipeline Co. Ltd.Wuhan430205China Fracturing Acidizing Company Downhole Operation Company of Chuanqing Drilling Engineering Co.Ltd.Chengdu610213China

Deep shale gas reserves that have been fractured typically have many relatively close perforation holes. Due to theproximity of each fracture during the formation of the fracture network, there is significant stress interference,which results in uneven fracture propagation. It is common practice to use “balls” to temporarily plug fractureopenings in order to lessen liquid intake and achieve uniform propagation in each cluster. In this study, a diameteroptimization model is introduced for these plugging balls based on a multi-cluster fracture propagationmodel and a perforation dynamic abrasion model. This approach relies on proper consideration of the multiphasenature of the considered problem and the interaction force between the involved fluid and solid phases. Accordingly,it can take into account the behavior of the gradually changing hole diameter due to proppant continuousperforation erosion. Moreover, it can provide useful information about the fluid-dynamic behavior of the consideredsystem before and after plugging. It is shown that when the diameter of the temporary plugging ball is1.2 times that of the perforation hole, the perforation holes of each cluster can be effectively blocked.

关键词： Deep shale gas fracture propagation fluid mechanics fluid-solid coupling perforation hole abrasion

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