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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 157-168页

作者： Lu-lu JIANG Liang LAN cheng-yan BAI Ru-yi XIN Shuang GAO Hao-yu WANG Bo HE Chao-yue chen Guo-xin LU Research Center of High-Temperature Alloy Precision Forming School of Materials Science and EngineeringShanghai University of Engineering ScienceShanghai 201620China State Key Laboratory of Advanced Special Steels School of Materials Science and EngineeringShanghai UniversityShanghai 200444China School of Materials Science and Engineering Shandong UniversityJinan 250061China

Laser shock peening(LSP)was used to enhance the high-temperature oxidation resistance of laser melting deposited Ti45Al8Nb *** microstructure and high-temperature oxidation behavior of the as-deposited Ti45Al8Nb alloy before and after LSP were investigated by scanning electron microscopy,X-ray diffraction,and electron backscatter *** results indicated that the rate of mass gain in the as-deposited sample after LSP exhibited a decrease when exposed to an oxidation temperature of 900℃,implying that LSP-treated samples exhibited superior oxidation resistance at high temperatures.A gradient structure with a fine-grain layer,a deformed-grain layer,and a coarse-grain layer was formed in the LSP-treated sample,which facilitated the diffusion of the Al atom during oxidation,leading to the formation of a dense Al_(2)O_(3)layer on the *** mechanism of improvement in the oxidation resistance of the as-deposited Ti45Al8Nb alloy via LSP was discussed.

关键词： TiAl alloy laser melting deposition laser shock peening additive manufacturing oxidation resistance

LFA-1基因对胶原诱导小鼠关节炎关节局部引流淋巴结T细胞活性的影响

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中国生物制品学杂志 2007年第12期20卷 877-879页

作者：王轶楠常非陈方方马迪霍德胜柳忠辉吉林大学基础医学院免疫学教研室吉林省神经免疫重点实验室长春130021 吉林大学中日联谊医院骨科长春130031

目的探讨淋巴细胞功能相关抗原1(LFA-1)在类风湿性关节炎形成中的作用。方法采用Ⅱ型胶原诱导小鼠关节炎模型,观察LFA-1基因敲除小鼠引流淋巴结T细胞增殖和细胞因子水平。结果LFA-1基因敲除小鼠在应用Ⅱ型胶原免疫后,引流淋巴结和关节局... 详细信息

目的探讨淋巴细胞功能相关抗原1(LFA-1)在类风湿性关节炎形成中的作用。方法采用Ⅱ型胶原诱导小鼠关节炎模型,观察LFA-1基因敲除小鼠引流淋巴结T细胞增殖和细胞因子水平。结果LFA-1基因敲除小鼠在应用Ⅱ型胶原免疫后,引流淋巴结和关节局部Th1型细胞因子IFN-γ和IL-12p40mRNA水平明显低于野生型对照小鼠,Th2型细胞因子IL-4mRNA水平无明显变化。LFA-1基因敲除小鼠引流淋巴结来源的CD4+T细胞在体外受Ⅱ型胶原刺激后,其特异性增殖和细胞因子IFN-γ的产生也明显低于野生型对照小鼠。结论LFA-1基因缺失抑制了辅助性T细胞的活化和向Th1方向的分化,进而抑制关节炎的发生。

关键词：淋巴细胞功能相关抗原1(LFA-1) 类风湿性关节炎引流淋巴结关节 T细胞活性

中老年人骨质疏松症药物使用——加拿大《骨质疏松症管理和骨折预防临床实践指南(2023版)》解读

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中华老年医学杂志 2025年第2期44卷 141-148页

作者：周轶史琛华中科技大学同济医学院附属协和医院药学部武汉430000

随着我国人口老龄化程度加深,骨质疏松症及由此引发的骨折愈发值得关注。2023年10月加拿大骨质疏松症指南更新小组在2010版基础上更新、制定并发布了加拿大《骨质疏松症管理和骨折预防临床实践指南(2023版)》,旨在帮助加拿大初级卫生保... 详细信息

随着我国人口老龄化程度加深,骨质疏松症及由此引发的骨折愈发值得关注。2023年10月加拿大骨质疏松症指南更新小组在2010版基础上更新、制定并发布了加拿大《骨质疏松症管理和骨折预防临床实践指南(2023版)》,旨在帮助加拿大初级卫生保健专业人员筛查居住在社区的中老年人是否存在骨质疏松症和骨折的危险因素,并提供干预措施以优化骨骼健康和骨折预防。本文将结合指南的要点、循证医学证据以及最新临床实践,对新版指南中关于中老年人骨质疏松症的运动锻炼、营养补充及药物治疗相关临床问题进行解读。

关键词：骨质疏松骨折药物疗法

大深宽比矩形高层建筑表面脉动风压非高斯特性

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哈尔滨工业大学学报 2025年第1期57卷 46-55页

作者：袁家辉陈水福刘奕中冶南方城市建设工程技术有限公司武汉430063 浙江大学建筑工程学院杭州310058

为探究大深宽比矩形高层建筑表面脉动风压的非高斯特性,本文对深宽比为1/9~9的矩形高层建筑进行了同步测压风洞试验。基于试验结果,分析了建筑表面风压的三阶和四阶统计矩分布特性,对高层建筑各立面风压进行高斯与非高斯分布的分区;研... 详细信息

为探究大深宽比矩形高层建筑表面脉动风压的非高斯特性,本文对深宽比为1/9~9的矩形高层建筑进行了同步测压风洞试验。基于试验结果,分析了建筑表面风压的三阶和四阶统计矩分布特性,对高层建筑各立面风压进行高斯与非高斯分布的分区;研究了风压的空间相关系数与非高斯性强度的关系,提出了一种新的估算建筑侧风面平均再附长度的计算方法。结果表明:在建筑侧风面上,脉动风压服从高斯还是非高斯分布取决于测点到迎风前缘的距离;除了以往文献指出的迎风面角部、侧风面分离区和背风面风压呈现非高斯性外,再附区后面的风压也呈现出高度的非高斯性;本文提出的相关系数法在计算平均再附长度时具有良好的准确性,利用该方法获得了矩形高层建筑侧风面的平均再附长度沿高度的变化呈抛物线形状。

关键词：矩形高层建筑非高斯特性风洞试验相关系数平均再附长度

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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犬猫致伤伤口感染预防及治疗研究进展

中华预防医学杂志 2025年第1期59卷 110-115页

作者：陈召阳陈瑞丰单毅解放军总医院第六医学中心急诊医学科北京100048

犬猫致伤在动物致伤中最为常见,除可致多种类型的组织损伤外,还具有伤口感染发生率高的特点,且常为多种微生物的混合感染,具有其特殊性和复杂性,选择适宜的抗菌药物进行预防和治疗,有助于预防感染发生和提高感染治疗效果。为更好地防治... 详细信息

犬猫致伤在动物致伤中最为常见,除可致多种类型的组织损伤外,还具有伤口感染发生率高的特点,且常为多种微生物的混合感染,具有其特殊性和复杂性,选择适宜的抗菌药物进行预防和治疗,有助于预防感染发生和提高感染治疗效果。为更好地防治犬猫致伤伤口感染,本文综述了犬猫致伤的流行病学、伤口特点、伤口感染发生率、感染类型、常见致病菌、感染的评估和抗菌治疗等方面的研究进展,以期为犬猫致伤伤口感染的抗菌药物选择提供参考。

关键词：咬伤,人狗猫伤口感染抗菌药物

Ancient genomes shed light on the long-term genetic stability in the Central Plain of China

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Science Bulletin 2025年第3期70卷 333-337页

作者： Hao Ma Yawei Zhou Rui Wang fei Yan Haodong chen Limin Qiu Jing Zhao Li Jin Chuan-Chao Wang State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361102China School of Archaeology and Cultural Heritage Zhengzhou UniversityZhengzhou 450001China Institute of Cultural Relics and Archaeology of Sanmenxia Sanmenxia 472001China Department of Anthropology and Ethnology Institute of AnthropologyFujian Provincial Key Laboratory of Philosophy and Social Sciences in BioanthropologySchool of Sociology and AnthropologyXiamen UniversityXiamen 361005China Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200433China

The Central Plain of China,or Zhongyuan(中原),refers to a part of the North China Plain surrounding the middle and lower reaches of the Yellow River(YR),with Henan Province as the *** archaeological records suggest that the Central Plain was one of the world’s earliest independent Neolithic agricultural revolution centers and played a major role in the formation and development of Chinese civilization[1],[2].

关键词： Central centers Ancient

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基于改进变色龙算法的交通控制子区划分方法

计算机工程与设计 2025年第1期46卷 15-22页

作者：张添翼闫飞太原理工大学电气与动力工程学院山西太原030024 西安理工大学自动化与信息工程学院陕西西安710048

为缓解城市拥堵情况,提出一种基于改进变色龙(Chameleon)算法的交通控制子区划分方法。综合考虑交叉口间距、交通车流量等因素影响,计算各相邻交叉口的流量关联度,构建相似性矩阵;引入密度峰值聚类算法改进变色龙算法,通过度量公式得到... 详细信息

为缓解城市拥堵情况,提出一种基于改进变色龙(Chameleon)算法的交通控制子区划分方法。综合考虑交叉口间距、交通车流量等因素影响,计算各相邻交叉口的流量关联度,构建相似性矩阵;引入密度峰值聚类算法改进变色龙算法,通过度量公式得到子区划分结果。选取义乌市某区域路网进行模型验证分析,结果表明该方法与常用的固定配时法及谱聚类法相比在平均排队长度上降低7.9%和6.2%,停车次数降低32.6%和16.5%,平均延误时间降低17.8%和11.9%,该划分方法能使城市路网子区划分合理,控制效果显著。

关键词：城市交通信号控制交叉口关联度控制子区变色龙算法密度峰值聚类模型验证

Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2 diabetes mellitus

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World Journal of Diabetes 2025年第2期16卷 71-80页

作者： Si-Jia fei Jing-yi Luo Wei-Hao Wang Li-Xin Guo Qi Pan Department of Endocrinology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Diabetic peripheral neuropathy(DPN)is a common complication of type 2 diabetes mellitus(T2DM),significantly affecting patients’quality of life and imposing a substantial economic *** studies have highlighted the role of thyroid hormones in diabetes complications,particularly in elderly patients with ***,the relationship between thyroid hormone sensitivity and DPN remains *** To investigate the correlation between thyroid hormone sensitivity and DPN in elderly patients with *** In a cohort of 256 elderly patients with T2DM,propensity score matching was used to balance age,sex,and diabetes *** data were collected to calculate thyroid hormone sensitivity and analyze its correlation with DPN.A random forest model was used to evaluate the diagnostic value of free triiodothyronine/free thyroxine(FT_(3)/FT_(4))for *** Patients with DPN had a lower FT_(3)/FT_(4) ratio[(0.302±0.053)vs(0.316±0.049),P=0.040].Quartile stratification showed decreasing DPN prevalence with higher FT_(3)/FT_(4) ***’s correlation analysis showed that a lower FT_(3)/FT_(4) ratio was associated with higher glycated hemoglobin,fasting blood glucose,reduced nerve conduction velocity,and electrical skin *** regression indicated a positive relationship between the median FT_(3)/FT_(4) ratio and bilateral foot electrochemical skin conductance[odds ratio(OR):1.019;95%CI:1.005-1.034;P=0.007]and sural nerve sensory amplitude(OR:1.310;95%CI:1.008-1.703;P=0.043).Receiver operating characteristic analysis using a random forest model showed that incorporating FT_(3)/FT_(4) improved predictive performance for DPN,with an area under the curve of 0.74,sensitivity of 0.79,specificity of 0.64,and accuracy of *** In elderly patients with T2DM with euthyroidism,a lower FT_(3)/FT_(4) ratio is correlated with increased DPN incidence,affecting both large and small nerve ***_(3)/FT_(4) is an effective predicto

关键词： Diabetic peripheral neuropathy Thyroid hormone sensitivity Type 2 diabetes mellitus Elderly Free triiodothyronine/free thyroxine ratio

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu ying-Tong Di Man-cheng Tang Ding-Kang chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids