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Generating a dynamical M2 brane from super-gravitons in a pp-wave background

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Communications in Theoretical Physics 2022年第1期74卷 16-24页

作者： yi-fei chen J X Lu Nan Zhang Interdisciplinary Center for Theoretical Study University of Science and Technology of ChinaHefeiAnhui 230026China Peng Huanwu Center for Fundamental Theory HefeiAnhui 230026China

We present a detailed study of dynamically generating an M2 brane from super-gravitons(or DO branes)in a pp-wave background possessing maximal spacetime *** have three kinds of dynamical solutions depending on the excess energy which appears as an order parameter signalling a critical phenomenon about the *** the excess energy is below a critical value,we have two branches of the solution,one can have its size zero while the other cannot for each given excess *** there can be an instanton tunnelling between the *** the excess energy is above the critical value,we have a single solution whose dynamical behavior is basically independent of the background chosen and whose size can be zero at some instant.A by product of this study is that the size of particles or extended objects can grow once there is a non-zero excess energy even without the presence of a background flux,therefore lending support to the spacetime uncertainty principle.

关键词： M2 brane super-gravitons pp-wave background spacetime uncertainty principle

Constructing robust NiFe LDHs-NiFe alloy gradient hybrid bifunctional catalyst for overall water splitting:one-step electrodeposition and surface reconstruction

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Rare Metals 2023年第7期42卷 2272-2283页

作者： yi-fei chen Jia-Hong Li Tian-Tian Liu Si-Hang You Peng Liu Fu-Jin Li Meng-Qi Gao Shu-Guang chen fei-fei Zhang School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha410114China Faculty of Engineering Department of Materials Science and EngineeringNational University of SingaporeSingapore117576Singapore School of Materials Science and Engineering Jilin UniversityChangchun130022China

NiFe layered double hydroxides(NiFe LDHs)have been intensively developed for the oxygen evolution reaction(OER)in alkaline media;however,their unsatisfactory hydrogen evolution reaction(HER)performance limits their practical application in overall water ***,a simple and efficient one-step electrodeposition method is used to accomplish in situ growth of NiFe LDHsNiFe alloy gradient hybrid coatings on a carbon cloth(CC).Within the binder-free electrode,NiFe LDHs nanosheets with a low-crystalline nature exhibit highly active bifunctional OER/HER activities,and the NiFe alloy acts as a stable electron highway and strong skeleton bridge between NiFe LDHs and the *** the electrodes are simultaneously employed as the cathode and anode for overall water splitting,they require low cell potentials of 1.441 V at10 mA·cm^(-2)and 1.703 V at 100 mA·cm^(-2),respectively,and they demonstrate outstanding stability at a current density greater than 100 mA·cm^(-2)for more than 100 *** is one of the best bifunctional OER and HER catalysts for overall water *** lattice defects and surface reconstructions crucially contribute to the bifunctional OER/HER activities of NiFe *** simple and scalable synthesis approach presents an intriguing paradigm for industrial production,and the fabricated electrode has potential application in high-current-density water splitting.

关键词： Bifunctional Electrodeposition Gradient hybrid NiFe layered double hydroxides(NiFe LDHs) Overall water splitting

Electro-reductive carboxylation of acyclic C(sp^(3))–C(sp^(3))bonds in aromatic hydrocarbons with CO_(2)

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Science China Chemistry 2024年第10期67卷 3366-3372页

作者： Chuan-Kun Ran Quan Qu Yang-yi Tao yi-fei chen Li-Li Liao Jian-Heng Ye Da-Gang Yu Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610064China

Despite the recent advances in the selective functionalization of C–C bonds in specific substrates,cleavage and functionalization of C–C bonds in acyclic substrates,such as ethane derivatives,remains *** contrast to the well-developed functionalization of one carbon fragment after C–C bond cleavage,herein,we report a novel electro-reductive carboxylation of C(sp^(3))–C(sp^(3))bond in multi-aryl ethanes with carbon dioxide(CO_(2))by utilizing both carbon ***,this reaction exhibits an atom-,step-economic approach for the synthesis of carboxylic acids,fulfilling principal aspirations of organic ***,this method features mild reaction conditions,broad substrate scope,and good functional group *** and asymmetric substrates bearing primary,secondary,or tertiary C(sp^(3))–C(sp^(3))bonds are all amenable to this strategy,enabling one or two structurally different carboxylic acids to be facilely constructed at the same *** investigations indicate that carbanions might be the key intermediates in this reaction,which could be captured by CO_(2)efficiently.

关键词： carbon dioxide electrochemistry C(sp^(3))–C(sp^(3))bonds cleavage reductive carboxylation

OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma

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Journal of Molecular Cell Biology 2021年第6期13卷 409-421页

作者： Wei Shao Zhen-Yu Hao yi-fei chen Jun Du Qian He Liang-Liang Ren Yan Gao Nan Song Yan Song Hua He yi-Zheng Wang The Brain Science Center Beijing Institute of Basic Medical SciencesBeijing 100850China Department of Neurosurgery Changzheng HospitalSecond Military Medical UniversityShanghai 200003China

Transcription factors(TFs)control an array of expressed ***,the specifics of how a gene is expressed in time and space as controlled by a TF remain largely ***,in TRPC6-regulated proline oxidase 1(POX)transcription in human glioma,we report that OIP5-AS1,a long noncoding RNA,determines the specificity of p53-driven POX *** OIP5-AS1/p53 complex via its 24 nucleotides binds to the POX promoter and is necessary for POX expression but not for p21 *** O-site in the POX promoter to which OIP5-AS1 binds was identified that is required for OIP5-AS1/p53 binding and POX *** OIP5-AS1 binding to the O-site inhibits POX transcription and promotes glioma ***,the OIP5-AS1/O-site module decides p53-controlled POX expression as regulated by TRPC6 and affects glioma development.

关键词： DNA‒RNA hybrid glioma lncRNA p53 transcription

Pemetrexed monotherapy versus pemetrexed plus platinum combination as second-line treatment for advanced non-small cell lung cancer

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Chinese Medical Journal 2009年第20期122卷 2472-2476页

作者： ZHANG yi-fei chen Zhi-wei LU Shun Shanghai Lung Tumor Clinical Medical Center Chest Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200030 China

Background Pemetrexed is a novel folic acid antagonist with multiple targets, which has been widely used in the treatment of non-small cell lung cancer （NSCLC）. The objective of this study was to compare the effects and toxicities in NSCLC patients treated with pemetrexed monotherapy versus pemetrexed plus a platinum combination agent, so as to provide a basis for standard second-line chemotherapy. Methods The clinical data of 52 patients with NSCLC who were admitted to Shanghai Chest Hospital from August 2006 to October 2008 were retrospectively analyzed. Ten of the 52 patients received pemetrexed monotherapy, and the other 42 patients received the pemetrexed plus platinum regimen. The primary end point was overall survival （OS）. The progression-free survival time （PFS） was analyzed and the effects and toxicities were assessed. Survival analysis was evaluated by Kaplan-Meier method. Single factor analysis and the COX regression model were done to analyze the relationship between the influential factors and the prognosis of disease. The elderly patients （〉60 years old） were analyzed separately as a subgroup. Results No statistically significant increase in OS （x^2=0.09, P=0.76）, PFS （x^2=0.15, P=0.70）, disease control rate （DCR）（x^2=0.06, P=0.81） or 1-year survival rate （x^2=0.33, P=0.57） was found between the two regimens. Single factor analysis showed that the factors including surgery history, PS score before treatment, clinical stage, and response to second-line treatment influenced the prognosis of NSCLC （all P 〈0.05）. COX regression analysis demonstrated that surgery history （P=-0.041） and performance status （PS） score before treatment （P=0.043） may be associated with survival. The toxicity of the two regimens was similar. In the subgroup of elderly patients, no significant difference in OS （x^2=0.01, P=0.94）, PFS （x^2=0.14, P=0.70）, DCR （x^2=0.004, P=-0.95）, or 1-year survival rate （x^2=0.03, P=0.87） was found between the two regimens. The toxicity of combin

关键词： carcinoma, non-small-cell lung antineoplastic agents pemetrexed

碟式太阳能光热发电系统机架结构风振响应的时域分析

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振动与冲击 2016年第7期35卷 177-185页

作者：颜健彭佑多易陈斐湖南科技大学机械设备健康维护省重点实验室湖南湘潭411201

针对大型碟式光热系统抗风运行的机架风致振动问题,以研制的25 k W级碟式机架为对象,阐述了复杂机架结构的有限元建模方法,并通过静力承载和机构传动角的分析,指出了高度角驱动机构的不足并予以改进,进而对比分析了改进前后机架多高度... 详细信息

针对大型碟式光热系统抗风运行的机架风致振动问题,以研制的25 k W级碟式机架为对象,阐述了复杂机架结构的有限元建模方法,并通过静力承载和机构传动角的分析,指出了高度角驱动机构的不足并予以改进,进而对比分析了改进前后机架多高度角工况的自振特性;基于线性滤波AR法模拟得到25组工况的脉动风载荷(平均风速16.0m/s),开展了改进机架的风振时域求解。分析了机架关键节点的位移响应均方根和峰值分布特征,并对典型工况的机架位移响应进行频谱分析,给出了各工况机架关键节点的位移风振系数,为机架结构设计提供参考。结果表明,机架结构位移响应是以脉动载荷的强迫振动为主,并伴有多阶振型参与的共振响应;机架控制点的位移峰值和位移均方根的分布特征相似,且沿焦轴的响应分量均占主导地位,机架振动主要为机架视日部分绕高度角轴线的旋转运动。

关键词：碟式光热发电机架结构脉动风场模拟风振响应时域分析机构传动角

Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-yi Zhan Jie chen Jin-Zhong Yu fei-Peng Xu fei-fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang Yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

Application of BP Neural Network in Classification and Prediction of Blended Learning Achievements

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Journal on Artificial Intelligence 2022年第1期4卷 15-26页

作者： Liu Zhang yi-fei chen Zi-Quan Pei Jia-Wei Yuan Nai-Qiao Tang School of Automation Nanjing University of Information Science&TechnologyNanjing210044China School of Automation Wuxi UniversityWuxi214105China

Analyzing and predicting the learning behavior data of students in blended teaching can provide reference basis for *** at weak generalization ability of existing algorithm models in performance prediction,a BP neural network is introduced to classify and predict the grades of students in the blended teaching.L2 regularization term is added to construct the BP neural network model in order to reduce the risk of *** with Pearson coefficient,effective feature data are selected as the validation dataset of the model by mining the data of Chao-Xing *** performance of common machine learning algorithms and the BP neural network are compared on the *** show that BP neural network model has stronger generalizability than common machine learning *** BP neural network with L2 regularization has better fitting ability than the original BP neural network *** achieves better performance with improved accuracy.

关键词： Blended teaching student performance prediction BP neural network binary prediction

Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and proliferation of airway smooth muscle cells

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Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and pro...