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Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai Yu Peng Wen Hu yi liu Hui Wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

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Photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na

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Science China Chemistry 2024年第2期67卷 587-594页

作者： fangming Chen Lvqi Jiang Chunyang Hu Jie liu Wenbin yi School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Organofluorine Chemistry Shanghai Institute Organic ChemistryChinese Academy of SciencesShanghai200032China

Since the first report of sodium trifluoromethanesulfinate(CF_(3)SO_(2)Na) as an electrophilic trifluoromethylthiolation reagent in 2015,there has been no breakthrough in research in this ***,we disclose an unprecedented usage of CF_(3)SO_(2)Na as a radical trifluoromethylthiolation reagent.A photocatalyzed ditrifluoromethylthiolation of alkenes with CF_(3)SO_(2)Na in the presence of PPh_(3) and catalytic copper has been ***,either Ir[(p-Fppy)_(2)(bpy)]PF_6 or Ir(ppy)_(3) could facilitate this *** studies indicate that initiation of the radical chain proceeded via two different photocatalytic quenching *** protocol provides a practical method for the construction of diverse vicinal ditrifluoromethylthiolated compounds.

关键词： trifluoromethylthiolation photocatalysis radical difunctionalization alkenes

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IoV environment exploring coordination:A federated learning approach

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Digital Communications and Networks 2024年第1期10卷 135-141页

作者： Tong Ding Lei liu yi Zhu Lizhen Cui Zhongmin Yan School of Software Shandong UniversityJinan250101China

Exploring open fields with coordinated unmanned vehicles is popular in academia and *** of the most impressive applicable approaches is the Internet of Vehicles(lov).The IoV connects vehicles,road infrastructures and communication facilities to provide solutions for exploration ***,the coordination of acquiring information from multi-vehicles may risk data *** this end,sharing high-quality experiences instead of raw data has become an urgent *** paper employs a Deep Reinforcement Learning(DRL)method to enable IoVs to generate training data with prioritized experience and states,which can support the IoV to explore the environment more ***,a Federated Learning(FL)experience sharing model is established to guarantee the vehicles'*** numerical results show that the proposed method presents a better successful sharing rate and a more stable convergence within the comparison of fundamental *** experiments also suggest that the proposed method could support agents without full information to achieve the tasks.

关键词： Internet of vehicle Deep reinforcement learning Federated learning Data privacy

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Vibration Control of the Rail Grinding Vehicle with Abrasive Belt Based on Structural Optimization and Lightweight Design

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 311-337页

作者： Wengang Fan Shuai Zhang Zhiwei Wu yi liu Jiangnan Yu School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Key Laboratory of Vehicle Advanced Manufacturing Measuring and Control TechnologyMinistry of EducationBeijing 100044China China Railway Materials Operation and Maintenance Technology Co. LtdBeijing 100036China

As a new grinding and maintenance technology,rail belt grinding shows significant advantages in many applications The dynamic characteristics of the rail belt grinding vehicle largely determines its grinding performance and service *** order to explore the vibration control method of the rail grinding vehicle with abrasive belt,the vibration response changes in structural optimization and lightweight design are respectively analyzed through transient response and random vibration simulations in this ***,the transient response simulation analysis of the rail grinding vehicle with abrasive belt is carried out under operating conditions and non-operating ***,the vibration control of the grinding vehicle is implemented by setting vibration isolation elements,optimizing the structure,and increasing ***,in order to further explore the dynamic characteristics of the rail grinding vehicle,the random vibration simulation analysis of the grinding vehicle is carried out under the condition of the horizontal irregularity of the American AAR6 ***,by replacing the Q235 steel frame material with 7075 aluminum alloy and LA43M magnesium alloy,both vibration control and lightweight design can be achieved *** results of transient dynamic response analysis show that the acceleration of most positions in the two working conditions exceeds the standard value in GB/T 17426-1998 *** optimizing the structure of the grinding vehicle in three ways,the average vibration acceleration of the whole car is reduced by about 55.1%from 15.6 m/s^(2) to 7.0 m/s^(2).The results of random vibration analysis show that the grinding vehicle with Q235 steel frame does not meet the safety conditions of 3σ.By changing frame material,the maximum vibration stress of the vehicle can be reduced from 240.7 MPa to 160.0 MPa and the weight of the grinding vehicle is reduced by about 21.7%from 1500 kg to 1175 *** modal analysis results indic

关键词： Vibration control Dynamic characteristics Structural optimization Lightweight design Modal analysis

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Influence of vibration on the lubrication effect of a splash-lubricated gearbox

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 324-339页

作者： yi liu Kailin ZHANG Shuai SHAO Hongxu XIANG Zhijian YE State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China

In this study,we investigate the effect of rail vibrations on the lubrication and efficiency of a splash-lubricated gearbox;specifically,the gearbox of a rail-transit vehicle.A high-fidelity 3D numerical model of the gearbox in a moving reference system is described,as well as computational fluid dynamics(CFD)simulations of the gearbox with different vibration *** effects of rotational speed,oil-immersion depth,and different oil-injection volume rates on lubrication and efficiency are *** propose a method of evaluating the internal lubrication condition of a splash-lubricated gearbox and quantitatively compare the effects of different operating parameters on lubrication and ***,our experiment to verify the feasibility of the simulation method is *** results show that with vibration,the churning loss and oil supply for the bearings are significantly higher than those under static *** addition,among different vibrational directions,lateral vibration has the greatest influence on the lubrication condition and efficiency of the *** the studied railway-vehicle gearbox,the best lubrication condition is achieved at a rotational speed of 1600 r/min and an oil-immersion depth of two times the tooth height(***).Rotational speed is the operating parameter that has the most significant effect on the lubrication and efficiencyofthegearbox.

关键词： Comprehensive lubrication evaluation Churning loss Moving reference system Splash lubrication Vibrational excitation Gearbox

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1.42-fold enhancement of formate selectivity by linker conversion on the Zn-based metal organic framework catalyst

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Journal of Energy Chemistry 2024年第3期90卷 183-190,I0006页

作者： Yayu Guan Yuyu liu fanghua Ning Jin yi Jiujun Zhang Institute for Sustainable Energy College of SciencesShanghai UniversityShanghai 200444China

Electro-reduction of carbon dioxide(ERCO_(2)) is considered an effective method to alleviate the greenhouse effect and produce value-added *** the dominant selectivity of Zn-based catalysts for formate remains a *** this article,the ZnIn-E_(12) catalyst is successfully prepared by solvent assisted ligand exchange(SALE) method to convert organic ligands,achieving a Faradaic efficiency of 72.28% for formate at-1.26 V ***(V_(RHE)),which is 1.42 times higher than the original *** shows that the successful conversion of organic ligands can transform the catalyst from the original large size polyhedron to cross-linked network of particles with a diameter of about 30 *** increased specific surface area can expose more active sites and facilitate the electrocatalytic conversion of CO_(2) to *** work is expected to provide inspiration for the regulation of formate selectivity and catalyst size in Zn-based catalysts.

关键词： Electrocatalyst Carbon dioxide Formate Linker conversion

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Trace Cobalt Doping and Defect Engineering of High Surface Area α-Ni(OH)_(2) for Electrocatalytic Urea Oxidation

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Energy & Environmental Materials 2024年第2期7卷 111-118页

作者： yi liu Zhihui Yang Yuqin Zou Shuangyin Wang Junying He School of Metallurgy and Environment Central South UniversityChangsha 410083China State Key Laboratory of Chem/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Owing to the intrinsically sluggish kinetics of urea oxidation reaction(UOR)involving a six-electron transfer process,developing efficient UOR electrocatalyst is a great challenge remained to be ***,by taking advantage of 2-Methylimidazole,of which is a kind of alkali in water and owns strong coordination ability to Co^(2+)in methanol,trace Co(1.0 mol%)addition was found to induce defect engineering onα-Ni(OH)_(2)in a dual-solvent system of water and *** characterization results revealed that the synthesized electrocatalyst(WM-Ni_(0.99)Co_(0.01)(OH)_(2))was a kind of defective nanosheet with thickness around 5-6 nm,attributing to the synergistic effect of Co doping and defect engineering,its electron structure was finely altered,and its specific surface a rea was tremendously enlarged from 68 to 172.3 m^(2)g^(-1).With all these merits,its overpotential to drive 10 mA cm^(-2)was reduced by 110 ***,the interfacial behavior of UOR was also well deciphered by operando electrochemical impedance spectroscopy.

关键词： defect engineering electrocatalysis small molecule oxidation

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Spheroid construction strategies and application in 3D bioprinting

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Bio-Design and Manufacturing 2024年第5期7卷 800-818页

作者： Chunxiang Lu Chuang Gao Hao Qiao yi Zhang Huazhen liu Aoxiang Jin Yuanyuan liu School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China School of Medicine Shanghai UniversityShanghai 200444China

Tissue engineering has been striving toward designing and producing natural and functional human *** are the fundamental building blocks of *** with traditional two-dimensional cultured cells,cell spheres are threedimensional(3D)structures that can naturally form complex cell–cell and cell–matrix *** structure is close to the natural environment of cells in living *** addition to being used in disease modeling and drug screening,spheroids have significant potential in tissue *** 3D bioprinting is an advanced biofabrication *** accurately deposits bioinks into predesigned 3D shapes to create complex tissue *** 3D bioprinting is efficient,the time required for cells to develop into complex tissue structures can be *** 3D bioprinting of spheroids significantly reduces the time required for their development into large tissues/organs during later cultivation stages by printing them with high cell *** spheroid fabrication and bioprinting technology should provide a new solution to many problems in regenerative *** paper systematically elaborates and analyzes the spheroid fabrication methods and 3D bioprinting strategies by introducing spheroids as building ***,we present the primary challenges faced by spheroid fabrication and 3D bioprinting with future requirements and some recommendations.

关键词： Spheroids Strategies 3D bioprinting Biofabrication

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A survey on federated learning:a perspective from multi-party computation

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Frontiers of Computer Science 2024年第1期18卷 93-103页

作者： Fengxia liu Zhiming ZHENG Yexuan SHI Yongxin TONG yi ZHANG Institute of Artificial Intelligence and Key Laboratory of Mathematics Informatics Behavioral Semantics Beihang UniversityBeijing 100191China State Key Laboratory of Software Development Environment and Advanced Innovation Center for Future Blockchain and Privacy Computing Beihang UniversityBeijing 100191China Pengcheng Laboratory Shenzhen 518055China Zhongguancun Laboratory Beijing 100190China Institute for Mathematical Sciences and Engineering Research Center of Financial Computing and Digital Engineering Renmin University of ChinaBeijing 100872China

Federated learning is a promising learning paradigm that allows collaborative training of models across multiple data owners without sharing their raw *** enhance privacy in federated learning,multi-party computation can be leveraged for secure communication and computation during model *** survey provides a comprehensive review on how to integrate mainstream multi-party computation techniques into diverse federated learning setups for guaranteed privacy,as well as the corresponding optimization techniques to improve model accuracy and training *** also pinpoint future directions to deploy federated learning to a wider range of applications.

关键词： sfederated learning multi-party ycomputation privacy-preserving data mining distributed learning

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Multi-UAVs Collaborative Path Planning in the Cramped Environment

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 529-538页

作者： Siyuan Feng Linzhi Zeng Jining liu yi Yang Wenjie Song School of Automation Beijing Institute of TechnologyNanjing 210039China Nanjing Research Institute of Electronics Technology Nanjing 210039China yichang Testing Technique Research Institute Yichang 443003China IEEE

Due to its flexibility and complementarity, the multiUAVs system is well adapted to complex and cramped workspaces, with great application potential in the search and rescue(SAR) and indoor goods delivery fields. However, safe and effective path planning of multiple unmanned aerial vehicles(UAVs)in the cramped environment is always challenging: conflicts with each other are frequent because of high-density flight paths, collision probability increases because of space constraints, and the search space increases significantly, including time scale, 3D scale and model scale. Thus, this paper proposes a hierarchical collaborative planning framework with a conflict avoidance module at the high level and a path generation module at the low level. The enhanced conflict-base search(ECBS) in our framework is improved to handle the conflicts in the global path planning and avoid the occurrence of local deadlock. And both the collision and kinematic models of UAVs are considered to improve path smoothness and flight safety. Moreover, we specifically designed and published the cramped environment test set containing various unique obstacles to evaluating our framework performance thoroughly. Experiments are carried out relying on Rviz, with multiple flight missions: random, opposite, and staggered, which showed that the proposed method can generate smooth cooperative paths without conflict for at least 60 UAVs in a few *** benchmark and source code are released in https://***/inin-xingtian/multi-UAVs-path-planner.

关键词： Collision avoidance conflict resolution multi-unmanned aerial vehicles(UAVs)system path planning

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