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Chinese Physics B 2024年第5期33卷 722-735页

作者： Charles Omotomide Apata 唐浥瑞周祎凡蒋龙裴启明 School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434023China

The FitzHugh–Nagumo neuron circuit integrates a piezoelectric ceramic to form a piezoelectric sensing neuron,which can capture external sound signals and simulate the auditory neuron *** piezoelectric sensing neurons are coupled by a parallel circuit consisting of a Josephson junction and a linear resistor,and a binaural auditory system is *** the non-singleness of external sound sources,the high–low frequency signal is used as the input signal to study the firing mode transition and synchronization of this *** is found that the angular frequency of the high–low frequency signal is a key factor in determining whether the dynamic behaviors of two coupled neurons are *** they are in synchronization at a specific angular frequency,the changes in physical parameters of the input signal and the coupling strength between them will not destroy their *** addition,the firing mode of two coupled auditory neurons in synchronization is affected by the characteristic parameters of the high–low frequency signal rather than the coupling *** asynchronous dynamic behavior and variations in firing modes will harm the auditory *** findings could help determine the causes of hearing loss and devise functional assistive devices for patients.

关键词： piezoelectric ceramic Josephson junction auditory neuron synchronization

A case report of retrograde laparoscopic Spiegel lobectomy： an alternative surgical procedure

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Chinese Medical Journal 2009年第5期122卷 596-598页

作者： CAI Xiu-jun DAI yi YU Hong LIANG Xiao WANG yi-fan zhou Wei PENG Shu-you Department of General Surgery Sir Run Run Shaw Hospital College of Medicine Minimally Invasive Surgery Institute of Zhejiang University Hangzhou Zhejiang 310016 China

The first laparoscopic hepatectomy case was reported by Reich et al in 1991. Initially the laparoscope was utilized diagnostically for resection and biopsy of superficial liver lesions. Recently due to the technological advancement and instrumental improvement, the laparoscopic hepatic resection procedures have evolved significantly.

关键词： laparoscopic Spiegel lobectomy retrograde procedure

Emerging roles of exosomes in oral diseases progression

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International Journal of Oral Science 2024年第1期16卷 36-51页

作者： Jiayi Wang Junjun Jing Chenchen zhou yi fan State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine.

关键词： diseases diagnosis salivary

Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2362-2379页

作者： yi zhou Shuang Wu fan-Jie Qu Department of Oncology Affiliated Dalian Third People’s Hospital of Dalian Medical UniversityDalian 116033Liaoning ProvinceChina

More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and ***,colorectal ranks third in incidence,but second in *** than half of the patients are in advanced stages at *** options are complex because of the heterogeneity of the patient population,including different molecular *** have included conventional fluorouracil-based chemotherapy,targeted therapy,immunotherapy,*** recent years,with the development of genetic testing technology,more and more targeted drugs have been applied to the treatment of CRC,which has further prolonged the survival of metastatic CRC patients.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor B-type RAF mutation Kirsten rat sarcoma viral oncogene wild type Kirsten rat sarcoma viral oncogene G12C mutation Human epidermal growth factor receptor 2 overexpression/amplification

Evolution of tribo-magnetization during sliding of ferromagnetic materials

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Friction 2024年第5期12卷 906-918页

作者： Fumin GAO Laibin ZHANG Jin zhou yi XIONG Jing WU Jianchun fan China University of Petroleum-Beijing Beijing102249China Key Laboratory of Oil and Gas Safety and Emergency Technology Ministry of Emergency ManagementBeijing102249China

Sliding-induced subsurface microstructure evolution is believed to be decisive for determining the friction and wear performance of metallic contacts as well as the development of *** expects to develop a new prediction method of wear state by elucidating the correlation between subsurface microstructure evolution and corresponding magnetic domain ***,subsurface microstructure evolution including crystal and magnetic domain under tribological action is investigated *** results demonstrate that dislocation mediated plastic deformation decisively influences microstructural changes during tribological contact,further determining the magnetic domain ***,sliding-induced plastic deformation causes an increase in the width of magnetic domains,but depth-dependent derived microstructure formed under severe plastic deformation such as the refined grains and sub-grains,in turn,promoted the refinement of magnetic domains and their discontinuity,forming depth-dependent magnetic domain *** results are helpful to clarify the evolution of tribo-magnetization and the pinning effect of dislocations on magnetic domains.

关键词： tribology magnetic domain microstructure tribo-magnetization dislocations

Identification of a Homozygous Missense Mutation in the TYR Gene in a Chinese Family with OCA1

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Current Medical Science 2018年第5期38卷 932-936页

作者： Yan WANG yi-fan zhou Na SHEN Yao-wu ZHU Kun TAN Xiong WANG Department of Neurosurgery Tongii Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Reproductive Medicine Center Tongii Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongii Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Infection Control Tongii Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Oculocutaneous albinism (OCA)is an autosomal recessive pigmentation abnormality,characterized by variable hair,skin,and ocular ***1 is the most frequent subtype of OCA,caused by mutations in the tyrosinase gene (TYR). In this study,we investigated the genetic mutation of a Chinese family with a female OCA patient who came for genetic counseling before *** physical examination was performed,and DNA from blood samples was collected from the family *** of TYR,OCA2,and SLC45A2 genes were examined in the proband, and verified in her parents by Sanger *** deletion or duplication of TYR and OCA2 genes was detected by multiplex ligation-dependent probe amplification (MLPA).A homozygous TYR c.307T>C (***103Arg)missense mutation was identified in the proband,and both parents were heterozygous *** large deletion or duplication was found in the *** mutation was absent in 1000G,ExAC,or HGMD database,and multiple lines of in silico tools supported a deleterious *** results suggest that TYR c.307T>C mutation might be responsible for OCA1,and our study further expands the mutation spectrum of OCA1 in the Chinese population.

关键词： oculocutaneous albinism TYR mutation multiplex ligation-dependent probe amplification

Influence of Different Gonadotropin-releasing Hormone Agonist Administration Methods on Pregnancy Outcomes of Patients Undergoing In-vitro Fertilization-embryo Transfer

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Current Medical Science 2019年第3期39卷 437-441页

作者： Li WU Xin-ling REN Wen CHEN Bo HUANG yi-fan zhou Lei JIN Reproductive Medicine Center Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

This study aimed to investigate the effect of different gonadotropin-releasing hormone agonist (GnRH-a) administration methods on pregnancy outcomes of patients undergoing in-vitro fertilization-embryo transfer (IVF-ET). Clinical data of 5217 patients who underwent IVF-ET were retrospectively analyzed. Patients were divided into the long-acting GnRH-a group (n=1330) and the short-acting GnRH-a group (w=3887) based on their various treatment plans. The clinical and laboratory embryo data and clinical pregnancy outcomes were compared between the two groups. The results showed that there were no significant differences in the age, infertility, primary/secondary infertility rate, IVF rate, body mass index (BMI), antral follicle counting (AFC), folliclestimulating hormone (FSH) level, and the number of transplanted embryos between the two groups (P>0.05). There were no significant differences in the oocyte numbers, M II rate, fertilization rate, cleavage rate and blastocyst formation rate (P>0.05) between the two groups. The gonadotropin (Gn) using days, Gn dose and endometrial thickness were significantly greater in the long-acting GnRH-a group than those in the short-acting GnRH-a group (P<0.01). Additionally, the estradiol (E2) levels, blastocyst freezing rate, embryo utilization rate, transplant cancellation rate and abortion rate were significantly lower in the long-acting GnRH-a group than those in the shortacting GnRH-a group (P<0.01). The clinical pregnancy rate and embryo implantation rate were significantly higher in the long-acting GnRH-a group than in the short-acting GnRH-a group (P<***). It was concluded that use of long-acting GnRH-a can effectively reduce the transplant cancellation rate and improve the clinical pregnancy rate of the fresh cycle.

关键词： gonadotropin-releasing hormone agonist long-acting short-acting in-vitro fertilization-embryo transfer clinical pregnancy rate

Biodegradation,hemocompatibility and covalent bonding mechanism of electrografting polyethylacrylate coating on Mg alloy for cardiovascular stent

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Journal of Materials Science & Technology 2020年第11期42卷 114-126页

作者： Yong-Xin Yang Zhe fang yi-Hao Liu Ya-Chen Hou Li-Guo Wang yi-fan zhou Shi-Jie Zhu Rong-Chang Zeng Yu-Feng Zheng Shao-Kang Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China Henan Key Laboratory of Advanced Magnesium Alloys Zhengzhou450002China Key Laboratory of Advanced Materials Processing&Mold Ministry of Education Zhengzhou450002China Corrosion Laboratory of Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

Organic coatings are the most widely employed approach for the promotion of corrosion resistance of magnesium(Mg)***,traditional organic coatings are weakly bonded to Mg substrates due to physical ***,a polyethylacrylate(PEA)coating was fabricated on Mg-Zn-YNd alloy via *** surface structure and chemical composition were characterized by means of scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDS),atomic force microscope(AFM)and Fourier transform infrared(FTIR)as well as time of flight-secondary ion mass spectrometer(To F-SIMS).The results showed that the surface roughness of PEA coating was dominated by scan rate;while the coverage and integrity of PEA coating were mainly affected by the monomer concentration and sweep *** F-SIMS results indicated that PEA coating was wholly covered on Mg alloy,and the presence of C2H3Mg-fragment confirmed the covalent bond between PEA coating and Mg *** addition,DFT calculation results of the adsorption of EA molecules with Mg substrate agree well with the experimental phenomena and observation,suggesting that the electrons in 3s orbit of Mg atoms and 2pz orbit of C1 atom participated in the formation of covalent bond between PEA coating and Mg *** polarization curves and immersion test demonstrated that the PEA coatings could effectively enhance the corrosion resistance of Mg *** platelet adhesion results designated that platelets were barely visible on PEA coating,which implied that PEA coating could effectively prevent the thrombosis and coagulation of *** coating might be a promising candidate coating of Mg alloy for cardiovascular stent.

关键词： Magnesium alloy Organic coating Electro-grafting Covalent bond Density functional theory Biomaterial

Systematic and long-term technical validity of toxicity determination and early warning of heavy metal pollution based on an automatic water-toxicity-determination-system

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 59-71页

作者： Yue yi Baoguo Wang Xuemei yi fan Zha Haisen Lin Zhijun zhou Yanhong Ge Hong Liu School of Life Science Beijing Institute of TechnologyBeijing 100081China Institute of Environmental Biology and Life Support Technology School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Infore Environment Technology Group Foshan 528000China Jiangmen Ecological Environment Monitoring Station Jiangmen 529000China Guangzhou Sub-branch of Guangdong Ecological and Environmental Monitoring Center Guangzhou 510000China

Water toxicity determination with electrochemically active bacteria(EAB)shows promise for providing early warnings for heavy metal pollution in ***,thus far,only idealized tests with a few types of heavy metals have been *** this study,an automatic water-toxicitydetermination system with high technical maturity was established,and the toxicological properties of common heavy metals were systematically *** results demonstrated that the common heavy metals linearly inhibited EAB currents in the range of 0.1 mg/L to 0.5 mg/*** toxicity ranking of the tested heavy metals was Pb^(2+)>Tl^(3+)>Cu^(2+)>Cd^(2+)>Zn^(2+)>Ni^(2+)>Hg^(2+)>As^(3+).The toxicity interaction mainly exhibited an antagonistic effect in binary heavy metal *** system can accurately determine surface water toxicity and rapidly monitor heavy metal pollution,with good repeatability and a long ***,this study demonstrates that EAB are capable of long-term(>60 d)surface water quality monitoring and on-site early warning of heavy metal pollution.

关键词： Biological early warning system Electrochemically active bacteria Water toxicity determination Biosensor Heavy metal pollution Early warning

PVDF-HFP binder for advanced zinc−manganese batteries

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Transactions of Nonferrous Metals Society of China 2022年第9期32卷 3005-3014页

作者： Shu-ci MA Xiao-dong SHI Zhe-xuan LIU yi-fan zhou Pin-ji WANG Jiang zhou Shu-quan LIANG Hunan Provincial Key Laboratory of Electronic Packaging and Advanced Functional Materials School of Materials Science and EngineeringCentral South UniversityChangsha 410083China

In order to optimize and select the appropriate binder to improve the electrochemical performance of aqueous zinc-manganese batteries,the influences of water-soluble binders and oil-based binders on the zinc storage performance of manganese-based cathode materials were systematically *** results show that the water-soluble binders with large numbers of hydroxyl and carboxyl groups are easily soluble in aqueous electrolytes,leading to poor electrochemical ***,the cathodes with polyvinylidene fluoride-hexafluoropropylene(PVDF-HFP)binder display high specific capacity of 264.9 mA·h/g and good capacity retention of 92%after 90 cycles at 100 mA/***,PVDF-HFP binder with plenty of hydrophobic groups presents excellent ability in inhibiting cracks on the surface of electrode,reducing voltage polarization and charge transfer resistance,as well as maintaining electrode integrity.

关键词： aqueous zinc−manganese batteries binders PVDF-HFP cycling stability