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World Journal of Gastroenterology 2018年第10期24卷 4517-4518页

作者： yi-fan tong Xiu-Jun Cai Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

Correction to:tong YF,Meng N,Chen MQ,ying HN,Xu M,Lu B,Hong JJ,Wang YF,Cai *** of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model(World J Gastroenterol 2017;24(10):1107-1119)[1].Erratum:In the“Conclusion of Abstract”,“Core tip”,“Discussion”and“Research perspectives”,the description regarding the relationship between the volumetric and functional proliferation during ALPPS-derived liver regeneration should be ***,the sentence that reads“as the ALPPS-derived proliferation in volume lags behind the functional regeneration”should be revised to“as the ALPPS-derived functional regeneration lags behind the proliferation in volume”.

关键词： liver Cai tip be

Is Laparoscopic Hepatectomy a Safe, Feasible Procedure in Patients with a Previous Upper Abdominal Surgery？

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Chinese Medical Journal 2016年第4期129卷 399-404页

作者： Liu-Xin Cai yi-fan tong Hong Yu Xiao Liang Yue-Long Liang Xiu-jun Cai Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310016 China

Background： Laparoscopic liver resection has become an accepted treatment for liver tumors or intrahepatic bile duct stones, but its application in patients with previous upper abdominal surgery is *** aim of this study was to evaluate the feasibility and safety of laparoscopic hepatectomy in these ***： Three hundred and thirty-six patients who underwent laparoscopic hepatectomy at our hospital from March 2012 to June 2015 were enrolled in the retrospective *** were divided into two groups： Those with previous upper abdominal surgery （PS group, n =42） and a control group with no previous upper abdominal surgery （NS group, n =294）.Short-term outcomes including operating time, blood loss, hospital stay, morbidity, and mortality were compared among the ***： There was no significant difference in median operative duration between the PS group and the NS group （180 min vs.160 min, P =0.869）.Median intraoperative blood loss was same between the PS group and the control group （200 ml vs.200 ml, P =0.907）.The overall complication rate was significantly lower in the NS group than in the PS group （17.0% vs.31.0%, P =0.030）.Mortality and other short-term outcomes did not differ significantly between ***： Our study showed no significant difference between the PS group and NS group in term of short-term *** hepatectomy is a feasible and safe procedure for patients with previous upper abdominal surgery.

关键词： Hepatectomy: Laparoscopy Reoperation

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le tong Jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying Zhu Pu Chen tong Zhou Zhe-yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

自主研发的可调节环缩装置对肺动脉血流约束效果的初步实验研究

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中国医药 2018年第3期13卷 372-375页

作者：彭博王强蒋显超范凡奕桐中国医学科学院阜外医院小儿外科中心38病区北京100037

目的验证自主研发的可调节环缩装置对需肺血流约束作用的肺动脉的环缩效果。方法 20只实验用中华小型猪完全分为对照组和观察组,各10只。对照组手术置入环缩装置,术后不做环缩调整。观察组手术过程中不进行环缩加压,而在术后清醒状态下... 详细信息

目的验证自主研发的可调节环缩装置对需肺血流约束作用的肺动脉的环缩效果。方法 20只实验用中华小型猪完全分为对照组和观察组,各10只。对照组手术置入环缩装置,术后不做环缩调整。观察组手术过程中不进行环缩加压,而在术后清醒状态下,在超声监控下逐步环缩,设定环缩压差为30 mmHg(1 mmHg=0.133 kPa),观察血流动力学变化。结果与对照组相比,观察组在导管注水,环缩装置可产生30～35 mmHg压差,并使血氧饱和度降低到94%左右,在实验动物出现血流动力学剧烈变化时,可通过释放压力做出调整,该装置在缓解压差过大或不足时有效。观察组跨装置肺血流速度快于,压差大于,血氧饱和度低于对照组[(2.47±1.17)m/s比(0.40±0.11)m/s、(30.2±3.4)mmHg比(3.2±1.0)mmHg、(92.0±2.1)%比(100.0±0.0)%],差异均有统计学意义(均P<0.05)。结论该环缩装置在控制肺血流方面有效,能够根据需要设定环缩压力。

关键词：先天性心脏病肺动脉环缩术

Application of Eigenkets of Bosonic Creation Operator in Deriving Some New Formulas of Associated Laguerre Polynomials

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Communications in Theoretical Physics 2008年第8期50卷 315-320页

作者： fan Hong-yi WANG tong-tong Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

Using the resolution of unity composed of bosonic creation operator＇s eigenkets and annihilation operator＇s un-normalized eigenket, which is a new quantum mechanical representation in contour integration form, we derive new contour integration expression of associated Laguerre polynomials L^ρm （｜z｜^2） and its generalized generating function formula. A series of recursive relations regarding to L^ρm （｜z｜^2） are also deduced in the context of the Fock representation by algebraic method.

关键词： bosonic creation operator Laguerre polynomials contour integration

Generalized Wigner Operator and Bivariate Normal Distribution in p-q Phase Space

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Communications in Theoretical Physics 2008年第12期50卷 1299-1302页

We introduce a kind of generalized Wigner operator,whose normally ordered form can lead to the bivariatenormal distribution in p-q phase *** this bivariate normal distribution corresponds to the pure vacuum state inth... 详细信息

关键词： bivariate normal distribution generalized Wigner operator

Coordinate Eigenstate Representation in Noncommutative Space as a New Entangled State in Quantum Mechanics

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Communications in Theoretical Physics 2007年第4X期48卷 633-636页

作者： fan Hong-yi TANG Xu-Bing WANG tong-tong Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

For the first time we construct the eigenstate ｜τ〉 of noncommutatlve coordinate. It turns out that｜τ〉 is an entangled state in the ordinary space. Remarkably, its Schmidt decomposition has definite expression in the coordinate representation and the momentum representation. The 〈τ｜ representation can simplify some calculations for obtaining energy level of two-dimensional oscillator in noncommutative space.

关键词： noncommutative coordinate's eigenstates entangled states IWOP technique

On Bosonic Magnetic Flux Operator and Bosonic Faraday Operator Formula

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Communications in Theoretical Physics 2007年第6期47卷 1010-1012页

作者： fan Hong-yi WANG tong-tong WANG Ji-Suo Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics Liaocheng University Liaocheng 252059 China

In the literature about mesoscopic Josephson devices the magnetic flux is considered as an operator, the fundamental commutative relation between the magnetic flux operator and the Cooper-pair charge operator is usually preengaged. In this paper we show that such a relation can be deduced from the basic Bose operators＇ commutative relation through the entangled state representation. The Faraday formula in bosonic form is then equivalent to the second Josephson equation. The current operator equation for LC mesoscopic circuit is also derived.

关键词： magneticflux operator Faraday operator mesoscopic Josephson junction LC mesoscopic circuit entangled state representation