检索结果-南通市图书馆

Plasma levels of Elabela are associated with coronary angiographic severity in patients with acute coronary syndrome

引用

Journal of Geriatric Cardiology 2020年第11期17卷 674-679页

作者： Sheng-Li DU Xin-Chun yang Jiu-Chang ZHONG Le-Feng WANG yi-fan fan Heart Center and Beijing Key Laboratory of Hypertension Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina

Background Elabela(ELA) was newly discovered as a novel endogenous ligand of the apelin receptor(APJ) which has demonstrated to be crucial for cardiovascular disease such as myocardial infarction, hypertension and heart failure. Previous experiments have revealed that ELA reduced arterial pressure and exerted positive inotropic effects on the heart. However, the role of plasma ELA levels in patients with acute coronary syndrome(ACS) and its relationship with severity of coronary arteries have not been investigated. Methods Two hundred and one subjects who were hospitalized for chest pain and underwent coronary angiography were recruited in this study. One hundred and seventy five patients were diagnosed with ACS and twenty-six subjects with negative coronary angiography were included in the control group. Plasma ELA levels, routine blood test, blood lipid, liver and kidney functions were measured. The number of coronary arteries and SYNTAX(Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score of coronary lesions were used to evaluate the extent of coronary artery stenosis. Results ELA in patients with ACS was significantly higher than that in the control group(P < 0.01). There was no significant difference in plasma ELA levels among patients with single-, double-and triple-vessel diseases. However, in the generalized additive model(GAM), there was a threshold nonlinear correlation between the ELA levels and Syntax I score(P < 0.001). Plasma ELA levels were positively correlated with the Syntax I score when the ELA levels ranged from 63.47 to 85.49 ng/m L. There was no significant association between the plasma ELA levels and the extent of coronary artery stenosis when the ELA levels were less than 63.47 ng/m L or higher than 85.49 ng/m L. Conclusion The present study demonstrates for the first time that plasma ELA levels are increased in patients with ACS. The rise in endogenous ELA levels was associated with severity of coronary s

关键词： Acute coronary syndrome Coronary artery stenosis Elabela

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fas-670 A/G polymorphism predicts prognosis of hepatocellular carcinoma after curative resection in Chinese Han population

引用

Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 33-40页

作者： Xin-yi Guo yi-Lin Xia Zhi-yang Li Ran Li yang fan Wen-Mo Yao Fei Liu West China School of Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Liver Surgery&Liver Transplantation Center West China HospitalSichuan UniversityChengdu 610041China

Background:Apoptosis,also called programmed cell death,is a genetically controlled process against hyperproliferation and *** Fas-Fas ligand(FasL)system is considered a major pathway for apoptosis in cells and ***,this study aimed to investigate whether single nucleotide polymor-phisms(SNPs)in Fas and FasL gene may have effects on the recurrence and survival of patients with hepatocellular carcinoma(HCC)after curative ***:We investigated the relationship between Fas rs1800682,rs2234767 and FasL rs763110 poly-morphisms and recurrence-free survival(RFS)as well as overall survival(OS)in 117 Chinese Han patients with HCC who underwent ***:In Kaplan-Meier survival analysis,only Fas rs1800682(-670 A/G)was associated with RFS and *** with AA genotype,the AG/GG genotype was significantly associated with better RFS(P=0.008)and OS(P=0.020).Moreover,multivariate Cox regression analysis showed that Fas rs1800682 remained as a significant independent predictor of RFS for HCC patients with hepatectomy[AG/GG ***:adjusted hazard ratio=0.464,95%confidence interval:0.275-0.782,P=0.004],but was not an independent predictor of OS(P=0.395).Conclusions:This study demonstrated that Fas-670 G allele may play a protective role in the recurrence and survival of HCC patients with ***,Fas rs1800682 polymorphism might be a promising biomarker for HCC patients after hepatectomy.

关键词： Hepatocellular carcinoma Single nucleotide polymorphism Cell apoptosis Prognosis Resection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decontamination Efficacy of Disinfection and Doffing of Medical Protective Clothing:A Combined Mannequin and Personnel Study

引用

Biomedical and Environmental Sciences 2023年第11期36卷 1105-1109页

作者： XIE Zhong yi LU Long Xi LI Ye fan Ling Feng yang fan fan LU Ye Department of Environmental Health Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310000ZhejiangChina Zhejiang TAILIN Bioengineering Company Limited Hangzhou 310000ZhejiangChina Department of Microorganism Examination Ningbo Center for Disease Control and PreventionNingbo 315000ZhejiangChina

Personal protective equipment(PPE)plays a key role in protecting healthcare workers(HCWs)from highly infectious *** use of PPE based on the level of exposure can prevent severe acute respiratory syndrome coronavirus 2... 详细信息

关键词： protective acute respiratory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial distribution and influencing factors of Surface Nibble Degree index in the severe gully erosion region of China’s Loess Plateau

引用

Journal of Geographical Sciences 2021年第11期31卷 1575-1597页

作者： ZHOU yi yang Caiqin LI fan CHEN Rong School of Geography and Tourism Shaanxi Normal UniversityXi'an 710119China National Experiment and Teaching Demonstration Center for Geography Xi'an 710119China

In China’s Loess Plateau severe gully erosion(LPGE)region,the shoulder-line is the most intuitive and unique manifestation of the loess landform,which divides a landform into positive and negative terrains(PNTs).The spatial combination model of PNTs is of great significance for revealing the evolution of the loess *** study modeled and proposed the Surface Nibble Degree(SND),which is a new index that reflects the comparison of the areas of *** on 5 m DEMs and matched high-resolution remote sensing images,the PNTs of 164 complete watersheds in the LPGE were extracted accurately,and the SND index was *** spatial distribution trend of SND was discussed,and the relationship between SND and the factors that affect the evolution mechanism of regional landform was explored *** show that:(1)The SND can be calculated *** can quantify the development of the loess landform well.(2)The SND of the LPGE has evident spatial differentiation that increases from southwest to *** values appear in Shenmu of Shaanxi,Shilou of Shanxi,and northern Yanhe River,whereas the low values are mainly distributed in the southern loess tableland and the inclined elongated ridge area of Pingliang in Gansu and Guyuan in Ningxia.(3)In the Wuding River and Yanhe River,the SND decreases with the increase in flow length(FL).In the North-Luohe River and Jinghe River,the SND increases with FL.(4)SND is significantly correlated with gully density and sediment modulus and moderately correlated with hypsometric *** for the mechanism factors analysis,the relationship between loess thickness and SND is not obvious,but SND increased first and then decreased with the increase of precipitation and vegetation in each geographical division,and we found that the land use type of low coverage grassland has greater erosion potential.

关键词： digital elevation model shoulder-line Surface Nibble Decree spatial distribution terrain factor digital terrain analysis Loess Plateau gully erosion region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ambipolar Transport Compact Models for Two-Dimensional Materials Based Field-Effect Transistors

引用

Tsinghua Science and Technology 2021年第5期26卷 574-591页

作者： Zhaoyi Yan Guangyang Gou Jie Ren fan Wu yang Shen He Tian yi yang Tian-Ling Ren the Institute of Microelectronics Tsinghua UniversityBeijing 100084China the Institute of Microelectronics and Tsinghua National Laboratory for Information Science and TechnologyTsinghua UniversityBeijing 100084China

Three main ambipolar compact models for Two-Dimensional(2D)materials based Field-Effect Transistors(2D-FETs)are reviewed:(1)Landauer model,(2)2D Pao-Sah model,and(3)virtual Source Emission-Diffusion(VSED)*** the Landauer model,the Gauss quadrature method is applied,and it summarizes all kinds of variants,exhibiting its *** the 2D Pao-Sah model,the aspects of its theoretical fundamentals are rederived,and the electrostatic potentials of electrons and holes are clarified.A brief development history is compiled for the VSED *** summary,the Landauer model is naturally appropriate for the ballistic transport of short channels,and the 2D Pao-Sah model is applicable to long-channel *** contrast,the VSED model offers a smooth transition between ultimate *** three models cover a fairly completed channel length range,which enables researchers to choose the appropriate compact model for their works.

关键词： Field-Effect Transistor(FET) compact model ambipolar transport Landauer formula Pao-Sah model virtual source

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma:A case report

引用

World Journal of Gastroenterology 2024年第38期30卷 4232-4238页

作者： yi-fan Jia Fei-fan Chen Li yang Yun-Xia Ye yi-Zhu Gao Wen-Yan Zhang Jin-Lin yang Department of Gastroenterology and Hepatology University of Oxford Huaxi Joint Centre for Gastrointestinal CancerFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Emergency West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Composite tumors are neoplasms comprising two distinct,yet intermingling,cell *** paper reports a rare phenomenon where early gastric signet-ring cell carcinoma(SRCC)and gastric mucosa-associated lymphoid tissue(MALT)lymphoma coexist within the same *** SUMMARY A 40-year-old woman presented to the West China Hospital for examination,which revealed a whitish,shallow,and uneven mucosal lesion in the *** lesion was diagnosed as a poorly differentiated adenocarcinoma,including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection,based on histopathological examination of the biopsy *** lesion was excised using segmental ***,histological exami-nation of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT *** two entities were stage I and coexisted in the same *** It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct *** resection is effective for these lesions.

关键词： Gastric cancer Composite tumors Early stage Signet-ring cell carcinoma Mucosa-associated lymphoid tissue lymphoma Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic hepatitis B infection with concomitant hepatic steatosis:Current evidence and opinion

引用

World Journal of Gastroenterology 2021年第26期27卷 3971-3983页

作者： yi-Wen Shi Rui-Xu yang Jian-Gao fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China

With the increasing incidence of obesity and metabolic syndrome worldwide,concomitant nonalcoholic fatty liver disease(NAFLD)in patients with chronic hepatitis B(CHB)has become highly *** risk of dual etiologies,outcome,and mechanism of CHB with concomitant NAFLD have not been fully *** this review,we assessed the overlapping prevalence of metabolic disorders and CHB,assessed the risk of advanced fibrosis/hepatocellular carcinoma in CHB patients concomitant with NAFLD,and discussed the remaining clinical issues to be addressed in the outcome of such *** also explored the possible roles of hepatitis B virus in the development of steatosis and discussed difficultiesof histological *** CHB patients,it is important to address concomitant NAFLD through lifestyle management and disease screening to achieve better *** assessment of progressive changes and novel therapies for CHB patients concomitant with NAFLD deserve further research.

关键词： Nonalcoholic fatty liver disease Hepatitis B Metabolic disorders Steatosis Mechanism Disease burden

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel restricted-flow etching method for glass

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第11期10卷 1601-1608页

作者： Hai-bo XIE yi ZHENG Yu-run fan Xin FU Hua-yong yang State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

This paper presents a novel micro fabrication method based on the laminar characteristics of micro-scale flows. Therein the separator and etchant are alternatively arranged in micro channels to form multiple laminar streams, and the etchant is located at the site where the reaction is supposed to occur. This new micro fabrication process can be used for the high aspect ratio etching inside a microchannel on glass substrates. Furthermore, the topography of microstructure patterned by this method can be controlled by changing the flow parameters of the separator and etchant. Experiments on the effects of flow parameters on the aspect ratio, side wall profile and etching rate were carried out on a glass substrate. The effect of flow rates on the etching rate and the micro topography was analyzed. In addition, experiments with dynamical changes of the flow rate ratio of the separator and etchant showed that the verticality of the side walls of microstructures can be significantly improved. The restricted flowing etching technique not only abates the isotropic effect in the traditional wet etching but also significantly reduces the dependence on expensive photolithographic equipment.

关键词： Microfluidics Micro fabrication Etching Laminar flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multifunctional Cholesterol-modified Dendrimers for Targeted Drug Delivery to Cancer Cells Expressing Folate Receptors

引用

Chinese Journal of Polymer Science 2019年第2期37卷 129-135页

作者： fan-fan Fu Ben-Qing Zhou Zhi-Jun Ouyang yi-Lun Wu Jing-yi Zhu Ming-Wu Shen Jin-Dong Xia Xiang-yang Shi Key Laboratory of Science & Technology of Eco-Textile Ministry of Education College of Chemistry Chemical Engineering and Biotechnology Donghua University Department of Radiology Shanghai Songjiang District Central Hospital

We present here the development of cholesterol(Chol)-modified dendrimer system for targeted chemotherapy of folate(FA)receptor-expressing cancer cells. In our study, poly(amidoamine)(PAMAM) dendrimers of generation 5(G5) were functionalized stepby-step with Chol, fluorescein isothiocyanate(FI), and FA via a poly(ethylene glycol)(PEG) spacer(PEG-FA), and then acetamide to shield their remaining surface amines. The synthesized ***-Chol-FI-PEG-FA(for short, G5-CFPF) dendrimers were utilized to encapsulate 10-hydroxycamptothecin(HCP), a hydrophobic anticancer drug. We find that each G5-CFPF dendrimer can encapsulate 13.8 HCP molecules. The complexes show a slower release profiles of HCP in a pH-dependent manner than the control complexes formed using the same dendrimers without Chol under the same conditions. Thanks to the targeting role played by FA, the complexes display a specific inhibition efficacy to FA receptor-expressing cervical cancer cells. The designed Chol-modified dendrimers may be adopted as a promising carrier for application in targeted cancer therapy.

关键词： PAMAM dendrimers Folate Cholesterol 10-Hydroxycamptothecin Targeted cancer therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

某学生宿舍楼裂缝压力灌胶及粘碳纤维综合加固施工

引用

特种结构 2003年第4期20卷 64-65页

作者：肖毅范世平杨文义王群天地金草田(北京)科技有限公司天地金草田(北京)科技有限公司 100013

本文介绍了某学生宿舍楼裂缝采用压力自动灌胶和粘碳纤维综合加固,施工简便、适应性强、效果可靠。

关键词：裂缝压力灌胶粘碳纤维

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：