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Large yellow croaker(Larimichthys crocea)mitofusin 2 inhibits type I IFN responses by degrading MAVS via enhanced K48‑linked ubiquitination

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Marine Life Science & Technology 2023年第3期5卷 359-372页

作者： Wen-Xing Li Xiao-Hong Wang yi-Jun Lin yuan-yuan Zhou Jun Li Xiang-Yang Zhang Xin-Hua Chen State Key Laboratory of Mariculture Breeding Key Laboratory of Marine Biotechnology of Fujian ProvinceCollege of Life SciencesCollege of Marine SciencesFujian Agriculture and Forestry UniversityFuzhou 350002China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China School of Science and Medicine Lake Superior State UniversitySault Ste.MarieMI 49783USA

In mammals,mitofusin 2(MFN2)is involved in mitochondrial fusion,and suppresses the virus-induced RIG-I-like receptor(RLR)signaling ***,little is known about the function of MFN2 in non-mammalian *** the present study,we cloned an MFN2 ortholog(LcMFN2)in large yellow croaker(Larimichthys crocea).Phylogenetic analysis showed that MFN2 emerged after the divergence of amphioxus and *** protein sequences of MFN2 were well conserved from fsh to ***2 was expressed in all the tissues/organs examined at diferent levels,and its expression was upregulated in response to poly(I:C)*** of LcMFN2 inhibited MAVS-induced type I interferon(IFN)promoter activation and antiviral gene *** contrast,knockdown of endogenous LcMFN2 enhanced poly(I:C)induced production of type I ***,LcMFN2 enhanced K48-linked polyubiquitination of MAVS,promoting its ***,overexpression of LcMFN2 impaired the cellular antiviral response,as evidenced by the increased expression of viral genes and more severe cytopathic efects(CPE)in cells infected with spring viremia of carp virus(SVCV).These results indicated that LcMFN2 inhibited type I IFN response by degrading MAVS,suggesting its negative regulatory role in cellular antiviral ***,our study sheds a new light on the regulatory mechanisms of the cellular antiviral response in teleosts.

关键词： Large yellow croaker Larimichthys crocea MFN2 MAVS Type I IFN response Ubiquitin-proteasome pathway

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智能互联时代的基础教育网络舆情治理

教学与管理 2024年第7期 6-10页

作者：林玮王博源浙江大学哲学学院杭州310007 浙江大学传媒与国际文化学院杭州310007

教育治理现代化要求高度关注基础教育的网络舆情。基础教育网络舆情一般以校园事件为生发点,利用监管盲区为蔓延空间,以公众对公平正义的朴素追求为内驱动力,并以社交媒体作为存续场域,具有全方位扩散和裂变式传播的特点。这带来了助推... 详细信息

教育治理现代化要求高度关注基础教育的网络舆情。基础教育网络舆情一般以校园事件为生发点,利用监管盲区为蔓延空间,以公众对公平正义的朴素追求为内驱动力,并以社交媒体作为存续场域,具有全方位扩散和裂变式传播的特点。这带来了助推维权活动的正面影响,也造成了一些恶意煽动民意的乱象。基础教育网络舆情的处置要坚守应对原则,确保过程完整,善用应对策略,使网络舆情危机内化为治理体系中的重要一环。

关键词：教育治理管办评分离网络舆情舆情应对

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二冬二母二草汤的化痰作用研究

中国实用医药 2024年第17期19卷 177-180页

作者：李惠惠袁维蔚陈奕涛陈洪惠州市中医医院 516000

目的研究二冬二母二草汤的化痰作用。方法选择50只KM小鼠,以10只为1组,随机分成5组,根据其给药不同将组名命名为空白对照组(蒸馏水);盐酸溴己新组(9.6 mg/kg);二冬二母二草汤组高剂量组(18.6 g生药/kg)、中剂量组(9.3 g生药/kg)、低剂量... 详细信息

目的研究二冬二母二草汤的化痰作用。方法选择50只KM小鼠,以10只为1组,随机分成5组,根据其给药不同将组名命名为空白对照组(蒸馏水);盐酸溴己新组(9.6 mg/kg);二冬二母二草汤组高剂量组(18.6 g生药/kg)、中剂量组(9.3 g生药/kg)、低剂量组(4.65 g生药/kg),分析二冬二母二草汤对小鼠气管酚红排泌的影响。选择50只英国种豚大鼠,以10只为1组,随机分成5组,根据其给药不同将组名命名为空白对照组(蒸馏水);盐酸溴己新组(5.6 mg/kg);二冬二母二草汤组高剂量组(18.6 g生药/kg)、中剂量组(9.3 g生药/kg)、低剂量组(4.65 g生药/kg),分析二冬二母二草汤对大鼠痰液的影响。结果KM小鼠实验中,二冬二母二草汤中剂量组、低剂量组和盐酸溴己新组的小鼠酚红浓度分别为(0.88±0.17)、(1.21±0.18)、(0.91±0.31)μg/ml,对比空白对照组的(0.71±0.16)μg/ml显著升高,差异具有统计学意义(P<0.05或<0.01或<0.001)。英国种豚大鼠实验中,二冬二母二草汤高剂量组、中剂量组、低剂量组和盐酸溴己新组的痰液长度分别为(13.95±6.05)、(19.61±7.83)、(17.02±5.20)、(16.12±5.03)cm,对比空白对照组的(7.09±2.87)cm显著延长,差异具有统计学意义(P<0.05或<0.01或<0.001)。结论二冬二母二草汤的化痰效果显著,可广泛用于治疗肺阴亏虚型咳嗽。

关键词：二冬二母二草汤化痰小鼠气管酚红排泌法大鼠毛细玻管法肺阴亏虚咳嗽

第三次分配中的互益性分配:现实价值、逻辑关系与治理路径

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华南师范大学学报（社会科学版） 2024年第1期 117-126,207页

作者：徐家良袁君翱上海交通大学国际与公共事务学院/中国城市治理研究院/中国公益发展研究院上海200030

第三次分配是实现共同富裕的重要作用机制之一,但是关于第三次分配的研究着重强调了公益性分配的重要意义,忽视了互益性分配的价值。公益性分配立足于更高的道德维度,对社会价值有引领示范作用,但盲目追求纯粹公益只会限制第三次分配的... 详细信息

第三次分配是实现共同富裕的重要作用机制之一,但是关于第三次分配的研究着重强调了公益性分配的重要意义,忽视了互益性分配的价值。公益性分配立足于更高的道德维度,对社会价值有引领示范作用,但盲目追求纯粹公益只会限制第三次分配的规模;而承认互益性分配的重要性,有助于扩大第三次分配的覆盖范围,让更多群体共享发展成果。从推动共同富裕的进程看,互益性分配有助于扩大参与主体、夯实文化基础、廓清思想障碍。从第三次分配本身的制度化建设来看,互益性分配和公益性分配形成耦合关系,前者为后者的发展提供了动力,后者为前者的深化构建了平台,两者共同从规范化、持续化、通约化层面推动第三次分配的制度化。实践中,可从加强党建引领、打造熟人社区、加大政策支持、弘扬利他文化等方向打通路径,更好地发挥互益性分配的作用,助力共同富裕目标的实现。

关键词：互益性分配公益性分配第三次分配共同富裕

A method for identifying coalbed methane co-production interference based on production characteristic curves: A case study of the Zhijin block, western Guizhou, China

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Petroleum Exploration and development 2022年第5期49卷 1126-1137页

作者： GUO Chen QIN Yong yi Tongsheng CHEN Zhenlong yuan Hang GAO Junzhe GOU Jiang College of Geology and Environment Xi'an University of Science and TechnologyXi'an 710054China Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation Xi'an 710054China Geological Research Institute for Coal Green Mining Xi'an University of Science and TechnologyXi'an 710054China Key Laboratory of CBM Resources and Reservoir Formation Process Ministry of EducationChina University of Mining and TechnologyXuzhou 221116China Guizhou Bureau of Coal Geological Exploration Guiyang 550008China East China Oil&Gas Company SinopecNanjing 210011China

Efficient detection of coalbed methane(CBM) co-production interference is the key to timely adjusting the development plan and improving the co-production efficiency. Based on production data of six typical CBM co-production wells in the Zhijin block of western Guizhou Province, China, the production characteristic curves, including production indication curve, curve of daily water production per unit drawdown of producing fluid level with time, and curve of water production per unit differential pressure with time have been analyzed to explore the response characteristics of co-production interference on the production characteristic curves. Based on the unit water inflow data of pumping test in coal measures, the critical value of in-situ water production of the CBM wells is 2 m^(3)/(d·m). The form and the slope of the initial linear section of the production indication curves have clear responses to the interference, which can be used to discriminate internal water source from external water source based on the critical slope value of 200 m^(3)/MPa in the initial linear section of the production indication curve. The time variation curves of water production per unit differential pressure can be divided into two morphological types: up-concave curve and down-concave curve. The former is represented by producing internal water with average daily gas production greater than 800 m^(3)/d, and the latter produces external water with average daily gas production smaller than 400 m^(3)/d. The method and critical indexes for recognition of CBM co-production interference based on the production characteristic curve are constructed. A template for discriminating interference of CBM co-production was constructed combined with the gas production efficiency analysis, which can provide reference for optimizing co-production engineering design and exploring economic and efficient co-production mode.

关键词： coalbed methane multi-seam co-production interlayer interference production indication curve external water internal water discrimination template

On-site low-power sensing nodes for distributed monitoring of heavy metal ions in water

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Nanotechnology and Precision Engineering 2021年第1期4卷 36-43页

作者： Menglun Zhang Xi Zhang Pengfei Niu Tao Shen yi yuan yuantao Bai Zhilin Wang State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China School of Precision Instrument and Opto-Electronics Engineering Tianjin UniversityTianjin 300072China

Heavy metal pollution in water environments poses a great threat to public health and to the ecological environment due to its high toxicity and ***,many existing detection methods require laboratory-based bulky instruments and time-consuming manual *** some on-site systems exist,they are difficult to deploy on a large scale owing to their large size and high ***,we report a sensing node featuring low power consumption and low cost,achieved by integrating microsensor,microfluidic,and electronic modules into a compact size for automatic and scalable heavy metal pollution *** microfluidic and electrochemical sensing modules are integrated on a chip,thereby combining the procedures of sample pretreatment,electrochemical sensing,and waste removal for automatic and continuous *** feasibility of the platform is demonstrated by Pb2+detection in tap *** a 3500 mA􀀀h battery,the compact sensing node could work for several years in *** is scope for further improvements to the system in terms of wider functionality and reductions in size,power consumption,and *** sensing node presented here is a strong candidate for distributed monitoring of water quality as an Internet-of-Things application.

关键词： Digital microfluidics Electrochemical sensor Heavy metal Node

Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions

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Journal of Molecular Cell Biology 2021年第9期13卷 636-645页

作者： yi Jiang Linlin Li Xi Chen Jiazheng Liu Jingbin yuan Qiwei Xie Hua Han National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 101408China School of Future Technology University of Chinese Academy of SciencesBeijing 101408China Data Mining Lab Beijing University of TechnologyBeijing 100124China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

The endoplasmic reticulum(ER)is a contiguous and complicated membrane network in eukaryotic cells,and membrane contact sites(MCSs)between the ER and other organelles perform vital cellular functions,including lipid homeostasis,metabolite exchange,calcium level regulation,and organelle ***,we establish a whole pipeline to reconstruct all ER,mitochondria,lipid droplets,lysosomes,peroxisomes,and nuclei by automated tape-collecting ultramicrotome scanning electron microscopy and deep learning techniques,which generates an unprecedented 3D model for mapping liver ***,the morphology of various organelles and the MCSs between the ER and other organelles are systematically *** found that the ER presents with predominantly flat cisternae and is knitted tightly all throughout the intracellular space and around other *** addition,the ER has a smaller volume-to-membrane surface area ratio than other organelles,which suggests that the ER could be more suited for functions that require a large membrane surface *** data also indicate that ER-mitochondria contacts are particularly abundant,especially for branched *** study provides 3D reconstructions of various organelles in liver samples together with important fundamental information for biochemical and functional studies in the liver.

关键词： 3D reconstruction ATUM-SEM deep learning liver ER MCSs

数据要素对区域协调发展的影响研究——基于中国279个地级市面板数据的实证分析

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城市问题 2024年第6期 35-44页

作者：何伟董影孙中原北京邮电大学经济管理学院西安邮电大学经济与管理学院

基于中国2011—2021年279个城市的面板数据,采用双固定效应回归分析法实证检验数据要素对区域协调发展的影响效应及作用机制。研究结果表明,数据要素能够显著缩小区域经济发展差距,促进区域协调发展。就影响机制而言,数据要素能够通过... 详细信息

基于中国2011—2021年279个城市的面板数据,采用双固定效应回归分析法实证检验数据要素对区域协调发展的影响效应及作用机制。研究结果表明,数据要素能够显著缩小区域经济发展差距,促进区域协调发展。就影响机制而言,数据要素能够通过缩小房地产价格差距、人口资源禀赋差距、金融资源禀赋差距以及提高城市数字普惠金融水平来缩小区域经济发展差距,从而实现区域协调发展。异质性分析结果表明,数据要素对中部地区及较发达地区经济协调发展的促进作用最为显著。研究结果可为进一步完善数据要素流通机制、培育经济发展新动能、加快实现共同富裕提供政策启示。

关键词：数据要素区域协调发展资源禀赋差距数字普惠金融

Eight-year trajectories of malalignment progression in symptomatic knee osteoarthritis

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Chinese Medical Journal 2022年第21期135卷 2570-2576页

作者： Mingyang Li Yong Nie yi Zeng yuangang Wu Limin Wu yuan Liu Bin Shen department of Orthopedics Orthopedic Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China.

Background: Although various therapies have been developed to treat malalignment in osteoarthritic knees, the pattern of malalignment progression is still unclear. This study aimed to identify homogeneous subgroups with distinct trajectories of malalignment progression in subjects with symptomatic knee osteoarthritis (KOA) and to determine corresponding risk ***: Eight-year follow-up (from 2004 to 2012) data on 1252 participants with symptomatic KOA from the Osteoarthritis Initiative were included. Varus/valgus angle progression was characterized by group-based trajectory models. Time-varying covariates were introduced into the model to investigate how they affected trajectories. Multinomial logistic regression for trajectory group membership was applied to ascertain risk ***: Five subgroups were identified. Participants in the varus worsening trajectory (n = 166) or valgus worsening trajectory (n = 118) proceeded to worsen malalignment over time. The neutral trajectory (n = 378), varus stable trajectory (n = 328), and valgus stable trajectory (n = 262) maintained close to the initial varus/valgus angle over 8 years. Higher baseline Kellgren and Lawrence grade (odds ratio [OR] = 4.35,P dentified the malalignment progression pattern - minor malalignment (-4.5° to +3.6°) tends to remain stable, while major baseline malalignment is likely to progress. This provides a reference for therapy to prevent malalignment from deteriorating and emphasizes the necessity of determining the trigger factors for malalignment onset.

关键词： Malalignment Knee osteoarthritis Group-based trajectory modeling