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Synthesis and Crystal Structure of a Novel Manganese Coordination Polymer: 2,5-Bis(4-pyridyl)-3,4-diaza-2,4-hexadiene

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Chinese Journal of Structural Chemistry 2007年第2期26卷 219-223页

作者： CHEN Man-Sheng DENG yi-Fang zhang chun-Hua KUANG Dai-Zhi FENG Yong-Lan PENG Yun-Lin Department of Chemistry and Materials Science Hen gyan g Normal University Hen gyan g 421008 China

A new manganese coordination polymer 1, [Mn（H2O）4（L）]n（ClO4）2n.2nH2O.3nL （L = 2,5-bis（4-pyridyl）-3,4-diaza-2,4-hexadiene）, has been synthesized and structurally characterized. The crystal structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group Pn with a = 13.9176（8）, b = 15.4754（9）, c = 15.9670（9） A, β = 99.5010（10）°, V = 3391.8（3） ]k3, Z = 2, C56H68C12MnN16O14, Mr= 1315.10, Dc = 1.288 g/cm^3,μ = 0.344 mm^-1, F（000） = 1374, R = 0.0733 and wR = 0.2035. In the crystal the manganese atom is six-coordinated by two nitrogen atoms from 2,5-bis（4-pyridyl）-3,4-diaza-2,4-hexadiene and four oxygen atoms from water molecules, completing an octahedral geometry. The title complex exhibits a novel supramolecular layer architecture sustained by the concurrence of coordination bonds, hydrogen bonds, and π-π stacking interactions.

关键词： manganese complex Schiff bases crystal structure

Effects of Triptolide on Histone Acetylation and HDAC8 Expression in Multiple Myeloma in vitro

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Chinese Journal of Cancer Research 2010年第2期22卷 148-155页

作者： Fei Zhao Ling-lan Zeng Yan Chen Rui Li Yuan Liu Lu Wen yi-quan Cheng chun zhang Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： Multiple myeloma is a kind of malignant plasma cell disease that originated from B lymphocyte and secrete great amount of monoclonal immunoglobulin. It is still one of the refractory diseases at present. Numerous studies show that there is an intensive relationship between the disequilibrium of histone acetylation and the occurance of multiple myeloma. Here we investigated the effect of triptolide（TPL） on the proliferation, apoptosis, histone H3 and H4 acetylation and expression of histone deacetylase 8 （HDAC8） in vitro, to explore its anti- myeloma mechanism. Methods： The effect of triptolide on the growth of RPMI8226 was studied by 3-（4,5-Dimethyl-2-thiazolyl） -2,5-diphenyl-2H-tetrazolium（MTT） assay. Apoptosis was detected by Hoechst 33258 staining. The protein expressions of acetyl-histone H3 and H4 were determined by Western blot, and the expression of HDAC8 was assessed by RT-PCR, Western blot and confocal microscopy. Results： Triptolide inhibited the proliferation of RPMI8226 and induced apoptosis in a time- and dosedependent manner. The 36h IC50 value was （105.370 ± 0.189）nmol/L. Triptolide increased the acetylation of histone H3 and H4 greatly. Furthermore, triptolide significantly down-regulated the mRNA and protein expression of HDAC8. Conclusion： Triptolide can inhibit proliferation and induce apoptosis of RPMI8226 significantly. Triptolide reduces the expression of HDAC8 in order to increase the histone H3 and H4 acetylation, which is possibly the anti-myeloma mechanism of triptolide.

关键词： Triptolide Histone acetylation HDAC8 Multiple myeloma

Problem identification and revitalization strategies for the recovery and reconstruction of traditional villages in the Ms 6.8 Luding Earthquake

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Journal of Mountain Science 2024年第2期21卷 361-379页

作者： HUANG Chao QIU Jian LIU chun JIANG Rui ZHAO Chuanrong zhang yi School of Architecture and Research Center of Space Planning and Engineering Design Southwest Jiaotong UniversityChengdu 611756China Sichuan Provincial Rural Construction and Development Center Chengdu 610041China Sichuan Institute of Urban and Rural Construction Chengdu 610043China China Association for Promoting Democracy(CAPD)Sichuan Provincial Committee Chengdu 610016China Sichuan Provincial Architectural Design and Research Institute(SADI) Chengdu 610095China

Post-disaster reconstruction is a topic of global concern,and traditional villages have special heritage attributes and need to face more requirements and obstacles in post-disaster *** paper summarizes four concepts based on the research on post-disaster reconstruction both domestically and internationally,as well as the recovery and reconstruction of cultural *** a field survey of traditional villages in the Ms 6.8 Luding earthquake-stricken area,it is found that there are problems such as insufficient awareness of heritage value,misalignment of scientific reconstruction technology,and insufficient protection of reconstruction elements during the reconstruction *** villages face the risk of declining or even loss of heritage *** order to effectively protect traditional villages and inherit the carrier of regional culture,four targeted reconstruction response strategies are proposed,i.e.,to"establish special planning for traditional village preservation","emphasize recovery of the authenticity of village heritage","ensure elements for village heritage recovery"and"promote the activation and utilization of village heritage",based on the problems discovered during the survey and the four concepts summarized in the research on post-disaster reconstruction of traditional *** research results hope to provide useful reference for ancient cultural areas affected by earthquakes on how to protect cultural heritage during the post-disaster reconstruction process.

关键词： Seismic hazard Decision making Traditional village Cultural heritage protection Post-earthquake recovery and reconstruction Revitalization strategy

Silurian ostracods from the Nyalam region,southern Tibet,China and their implications on palaeoenvironment and palaeobiogeography

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Journal of Palaeogeography 2022年第1期11卷 85-96页

作者： Jun-Jun Song Wen Guo Jia-Yuan Huang yi-chun zhang Zhong-Yang Chen Yu-Cong Sun Juan Ma Wen-Kun Qie State Key Laboratory of Paleobiology and Stratigraphy Nanjing Institute of Geology and Paleontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of Geosciences(Wuhan)Wuhan 430074Hubei ProvinceChina

The overall occurrence,stratigraphical distribution,palaeoenvironmental and palaeobiogeographical significances of the ostracod faunas from the Silurian Pulu Formation in the Yalai West Ⅱ section,Nyalam region,southern Tibet,China,are documented for the first ***-two species belonging to 19 genera are identified and figured *** ostracod fauna in the Pulu Formation indicates an age of the late *** ostracods belong to a podocope-rich association,which suggests an offshore environment for the Yalai West II *** ostracods of the Pulu Formation have strong affinities with the South China taxa and also share some similarities with those from *** implies that ostracods could probably benefit from sea-level changes to facilitate faunal exchanges between peri-Gondwana and *** isolation and global sea-level changes are proposed as the primary factors controlling the palaeobiogeographical distribution of ostracods during the Silurian.

关键词： Ostracods Silurian Pulu Formation Tethyan Himalaya terrane South Tibet Paleobiogeography

Towards full-stack deep learning-empowered data processing pipeline for synchrotron tomography experiments

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The Innovation 2024年第1期5卷 127-138页

作者： Zhen zhang chun Li Wenhui Wang Zheng Dong Gongfa Liu Yuhui Dong yi zhang National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Synchrotron tomography experiments are transitioning into multifunctional,cross-scale,and dynamic characterizations,enabled by new-generation synchrotron light sources and fast developments in beamline ***,with the spatial and temporal resolving power entering a new era,this transition generates vast amounts of data,which imposes a significant burden on the data processing ***,as a highly accurate and efficient data processing method,deep learning shows great potential to address the big data challenge being encountered at future synchrotron *** this review,we discuss recent advances employing deep learning at different stages of the synchrotron tomography data processing *** also highlight how applications in other data-intensive fields,such as medical imaging and electron tomography,can be migrated to synchrotron ***,we provide our thoughts on possible challenges and opportunities as well as the outlook,envisioning selected deep learning methods,curated big models,and customized learning strategies,all through an intelligent scheduling solution.

关键词： processing pipeline outlook

Self-assembly of perovskite nanocrystals:From driving forces to applications

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Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： yi Li Fei zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi zhang Qian Chen Pan Cao chun-Xia Shi Lu-yi zhang Lu-Wen Wang Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP homologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： SIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis

The role of innate immunity in diabetic nephropathy and their therapeutic consequences

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Journal of Pharmaceutical Analysis 2024年第1期14卷 39-51页

作者： Min Yang chun zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Diabetic nephropathy (DN) is an enduring condition that leads to inflammation and affects a substantial number of individuals with diabetes worldwide. A gradual reduction in glomerular filtration and emergence of proteins in the urine are typical aspects of DN, ultimately resulting in renal failure. Mounting evidence suggests that immunological and inflammatory factors are crucial for the development of DN. Therefore, the activation of innate immunity by resident renal and immune cells is critical for initiating and perpetuating inflammation. Toll-like receptors (TLRs) are an important group of receptors that identify patterns and activate immune responses and inflammation. Meanwhile, inflammatory responses in the liver, pancreatic islets, and kidneys involve inflammasomes and chemokines that generate pro-inflammatory cytokines. Moreover, the activation of the complement cascade can be triggered by glycated proteins. This review highlights recent findings elucidating how the innate immune system contributes to tissue fibrosis and organ dysfunction, ultimately leading to renal failure. This review also discusses innovative approaches that can be utilized to modulate the innate immune responses in DN for therapeutic purposes.

关键词： Innate immunity Diabetic nephropathy Inflammation Toll-like receptor Inflammasomes

Regulating metal-acid double site balance on mesoporous SiO2-Al2O3 composite oxide for supercritical n-decane cracking

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Petroleum Science 2024年第4期21卷 2881-2891页

作者： Liu-Ling Chen Jun zhang chun-Guang Li Li-Qun Fei Bo Wang Chen-Qi zhang yi Jiao Jian-Li Wang Institute of New Energy and Low-Carbon Technology Sichuan University Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of Education School of Chemical Engineering Sichuan University State Key Laboratory of Industrial Vent Gas Reuse Southwest Institute of Chemical Co. Ltd Science and Technology on Scramjet Laboratory Beijing Power Machinery Research Institute

The balance between metal and acid sites directly affects the preparation of high-performance cracking catalysts with high heat sink and low ***,how to control acid-metal sites balance and its relationship with cracking performance are reported *** this work,a series of Pt/Al2O3-SiO2dual sites catalysts with different metal to acid active sites ratio(CM/CSA) were constructed by ethanolassisted impregnation method and the impact on n-decane cracking under supercritical conditions was systematically and deeply *** results showed that the conversion and carbon deposition increased gradually with varied CM/CSAand reached the balance at CM/CSAof *** proper ratio CM/CSA（0.13） can balance the deep dehydrogenation coking over metal active sites and high heat sink of cracking over acid active sites,the chemical heat sink reaches amazing 1.75 MJ/kg and carbon deposition is only22.03 mg/cm2at 750℃.Meanwhile,the few metal sites at low CM/CSAand the few strong acid sites at high CM/CSAare the main factors limiting the cracking *** CM/CSAlimit the activation of C-H bond and deep dehydrogenation of coking precursor,resulting in relative low cracking activity and carbon deposition,while high CM/CSAlimit the activation of C-C bond and increase the deep *** this contribution,design and construction of metal-acid dual sites can not only provide the technical solution for the preparation of high heat sink and low coking cracking catalyst,but also deepen the understanding of the cracking path of hydrocarbon fuel.

关键词： Metal-acid dual sites balance Catalytic cracking Hydrocarbon fuels Chemical heat sink Carbon deposition