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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan huang yin YANG Hua WANG Xintian SHI Jianping LIU Lixia FU Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

Nitrogen addition promotes soil carbon accumulation globally

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Science China Life Sciences 2025年第1期68卷 284-293页

作者： Xuemei Yang Suhui Ma Erhan huang Danhua Zhang Guoping Chen Jiangling Zhu Chengjun Ji Biao Zhu Lingli Liu Jingyun Fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

关键词： meta-analysis nitrogen enrichment soil organic carbon carbon accumulation carbon stability

Convergence in Conformal Field Theory

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Chinese Annals of Mathematics,Series B 2022年第6期43卷 1101-1124页

作者： yi-Zhi huang Department of Mathematics Rutgers UniversityPiscatawayNJ 08854USA

Convergence and analytic extension are of fundamental importance in the mathematical construction and study of conformal field *** author reviews some main convergence results,conjectures and problems in the construction and study of conformal field theories using the representation theory of vertex operator *** also reviews the related analytic extension results,conjectures and *** discusses the convergence and analytic extensions of products of intertwining operators(chiral conformal fields)and of q-traces and pseudo-q-traces of products of intertwining *** also discusses the convergence results related to the sewing operation and the determinant line bundle and a higher-genus convergence *** then explains conjectures and problems on the convergence and analytic extensions in orbifold conformal field theory and in the cohomology theory of vertex operator algebras.

关键词： Conformal field theory Vertex operator algebras Representation theory Convergence Analytic extension

模因论教学法对大学英语低级别学生产出性词汇学习的影响

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肇庆学院学报 2025年第1期46卷 66-72页

作者：陈宜黄洪志福建医科大学文理艺术学院福建福州350122

本研究探讨了基于模因论的英语教学方法对大学英语低级别学生产出性词汇学习效果的影响。研究选取两个英语低级别班级作为实验对象,随机分为实验组(n=51)和对照组(n=51)。实验组接受基于模因论的词汇教学,而对照组则采用传统教学方法。... 详细信息

本研究探讨了基于模因论的英语教学方法对大学英语低级别学生产出性词汇学习效果的影响。研究选取两个英语低级别班级作为实验对象,随机分为实验组(n=51)和对照组(n=51)。实验组接受基于模因论的词汇教学,而对照组则采用传统教学方法。研究通过前测和两次后测收集数据,使用独立样本t检验分析每次测试中两组学生在产出性词汇掌握程度上的差异。结果显示,实验组在两次后测中的词汇学习成绩均显著优于对照组,表明基于模因论的教学方法能有效提高大学英语低级别学生的产出性词汇能力。本研究为英语词汇教学,特别是针对低级别学习者的教学策略提供了新的思路和实证依据,对提升学生的英语表达能力具有一定意义。

关键词：模因论大学英语低级别学生产出性词汇

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Observability Analysis and Navigation Algorithm for Distributed Satellites System Using Relative Range Measurements

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Journal of Systems Science & Complexity 2018年第5期31卷 1206-1226页

作者： SU Qiya huang yi Beijing Institute of Remote Sensing Equipment Beijing 100854 China Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049 China

The problem of navigation for the distributed satellites system using relative range mea- surements is investigated. Firstly, observability for every participating satellites is analyzed based on the nonlinear Keplerian model containing J2 perturbation and the nonlinear measurements. It is proven that the minimum number of tracking satellites to assure the observability of the distributed satellites system is three. Additionally, the analysis shows that the J2 perturbation and the nonlinearity make little contribution to improve the observability for the navigation. Then, a quasi-consistent extended Kalman filter based navigation algorithm is proposed, which is quasi-consistent and can provide an on- line evaluation of the navigation precision. The simulation illustrates the feasibility and effectiveness of the proposed navigation algorithm for the distributed satellites system.

关键词： Distributed satellites system (DSS) navigation observability quasi-consistent extendedKalman filter (QCEKF) relative range.

Delayed ischemic gangrene change of distal limb despite optimal decompressed colostomy constructed in obstructedsigmoid colon cancer:A case report

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World Journal of Gastroenterology 2006年第6期12卷 993-995页

作者： Wen-Shih huang Kuang-Wen Liu Paul Y Lin ching-Chuan Hsieh Jeng-yi Wang Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial Hospital ChiayiTaiwan Graduate Institute of Clinical Medicine Chang Gung UniversityTaoyuanTaiwanChina Department of Surgery E-Da Hospital/Ⅰ-Shou University KaohsiungTaiwanChina Division of Anatomical Pathology Department of Pathology Chang Gung Memorial HospitalChiayiTaiwanChina Division of General Surgery Department of Surgery Chang Gung Memorial HospitalChiayiTaiwanChina Division of Colon and Rectal Surgery Department of Surgery Chang Gung Memorial HospitalChiayiTaiwanChina

Creating blow-hole colostomy for decompression could provide a time-saving and efficient surgical procedure for a severely debilitated case with a completely obstructed colorectal cancer. Complications are reported as prolapse, retraction, and paracolostomal abscess. However, complication with an ischemic distal limb has not been reported. We report a case of critical intra-abdominal disease after decompressed colostomy for relieving malignant sigmoid colon obstruction; a potential fatal condition should be alerted. A 76-year-old male visited our emergency department for symptoms related to obstructed sigmoid colon tumor with foul-odor vomitus containing fecal-like materials. An emergent blow-hole colostomy proximal to an obstructed sigmoid lesion was created, and resolution of complete colon obstruction was pursued. Unfortunately, extensive abdominal painful distention with board-like abdomen and sudden onset of high fever with leukocytopenia developed subsequently. Such surgical abdomen rendered a secondary laparotomy with resection of the sigmoid tumor along with an ischemic colon segment located proximally up to the previously created colostomy. Eventually, the patient had an uneventful postoperative hospital stay. In the present article, we have described an emergent condition of sudden onset of distal limb ischemia after blow-hole colostomy and concluded that despite the decompressed colostomy would resolve acute malignant colon obstruction efficiently; impending ischemic bowel may progress with a possible irreversible peritonitis. Any patient, who undergoes a decompressed colostomy without resection of the obstructed lesion, should be monitored with leukocyte count and abdominal condition survey frequently.

关键词： Colorectal cancer obstruction Colostomy IschemJc colitis Laparotomy

ADRC BASED INPUT DISTURBANCE REJECTION FOR MINIMUM-PHASE PLANTS WITH UNKNOWN ORDERS AND/OR UNCERTAIN RELATIVE DEGREES

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Journal of Systems Science & Complexity 2012年第4期25卷 625-640页

作者： Chunzhe ZHAO yi huang School of Computer Science and Engineering Chongqing Three Gorges University Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of Sciences

The capability of ADRC is studied for linear time-invariant SISO minimum-phase systems with unknown orders, uncertain relative degrees, and unknown input disturbances. It is proved that ADRC can reject the unknown input disturbance and guarantee the close-loop stability for the plants with unknown but bounded relative degrees. Meanwhile, some close-loop performances can be achieved. The influence of the sensor noise is also discussed. And it is demonstrated by numerical examples that one ADRC with fixed parameters can be applied to a group of plants of different orders, relative degrees, and parameters.

关键词： ADRC frequency performance sensor noise uncertain relative degree unknown input disturbance unknown order.