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Molecular evolution of Toll-like receptors in rodents

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Integrative Zoology 2024年第3期19卷 371-386页

作者： Qianqian SU yi chen Hongxuan HE College of Forestry Central South University of Forestry and TechnologyChangshaChina National Research Center for Wildlife-Borne Diseases Institute of ZoologyChinese Academy of SciencesBeijingChina

Toll-like receptors(TLRs),the key sensor molecules in vertebrates,trigger the innate immunity and prime the adaptive immune *** TLR family of rodents,the largest order of mammals,typically contains 13 TLR ***,a clear picture of the evolution of the rodent TLR family has not yet emerged and the TLR evolutionary patterns are unclear in rodent ***,we analyzed the natural variation and the evolutionary processes acting on the TLR family in rodents at both the interspecific and population *** results showed that rodent TLRs were dominated by purifying selection,but a series of positively selected sites(PSSs)primarily located in the ligand-binding domain was also *** numbers of PSSs differed among TLRs,and nonviralsensing TLRs had more PSSs than those in viral-sensing ***-conversion events were found between TLR1 and TLR6 in most rodent *** genetic analyses showed that TLR2,TLR8,and TLR12 were under positive selection in Rattus norvegicus and ***,whereas positive selection also acted on TLR5 and TLR9 in the former species,as well as TLR1 and TLR7 in the latter ***,we found that the proportion of polymorphisms with potentially functional change was much lower in viral-sensing TLRs than in nonviral-sensing TLRs in both of these rat *** findings revealed the first thorough insight into the evolution of the rodent TLR genetic variability and provided important novel insights into the evolutionary history of TLRs over long and short timescales.

关键词： adaptive evolution gene conversion positive selection rodents Toll-like receptors

Effects of the properties of Mg(OH)2 precursor on the hydrothermal synthesis of magnesium oxysulfate whiskers

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颗粒学报（英文版） 2024年第9期92卷 13-23页

作者： Thanayos Boonrit Mei yang Guangwen chen Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences Beijing100049China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian116023China

Magnesium oxysulfate(MOS)whiskers are commonly synthesized through a dissolution-precipitation mechanism,wherein Mg(OH)2 dissolves to form Mg(OH)64-,followed by reactions with SO4-and H2O to yield MOS ***,the impact of Mg(OH)2 precursor properties on the formation process of MOS whiskers has been insufficiently explored,and sector-like and needle-like morphologies were both observed in previous *** this study,we systematically investigated how the properties of Mg(OH)2 precursors influenced the crystalline structure and morphology of MOS *** various experimental conditions,MgSO4·5Mg(OH)2·2H2O(152MOS)whiskers were consistently ob-tained,regardless of Mg(OH)2 morphology and *** size of Mg(OH)2 emerged as a critical factor in shaping the morphology of 152MOS ***-sized Mg(OH)2(≤106±37 nm)favored the formation of sector-like whiskers,while larger-sized Mg(OH)2(≥206±98 nm)encouraged the devel-opment of needle-like *** distinction was attributed to the slower dissolution rate exhibited by larger-sized Mg(OH)2,maintaining a smaller number of 152MOS nuclei and promoting the growth of needle-like whiskers instead of the aggregation of 152MOS nuclei into sector-like *** addition,the effects of the molar ratio of Mg2+to SO4-and hydrothermal temperature were also *** average length and diameter of the needle-like whiskers prepared with Mg(OH)2 of 331±145 nm under optimized conditions were 77±32 and 0.39±0.10 μm,*** study presented an effective strategy for controlling the morphology of 152MOS whiskers.

关键词： Magnesium oxysulfate whiskers Microreactor Morphology control Precursor

Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 1-17页

作者： Jiafeng Zou Zeting Yuan Xiaojie chen You chen Min Yao yang chen Xiang Li yi chen Wenxing Ding Chuanhe Xia Yuzheng Zhao Feng Gao Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism School of PharmacyEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Optogenetics and Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237China CAS Center for Excellence in Brain Science Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Research Unit of New Techniques for Live-cell Metabolic Imaging Chinese Academy of Medical SciencesBeijing 100050China

Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas *** studies have mainly focused on the production and pharmacological side effects caused by H_(2)***,effective strategies to remove H_(2)S has become a key research ***,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)*** paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and ***,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were *** only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this ***,this review provided in-depth analysis of the potential of HRNs about treatment or detection in ***,potential challenges of HRNs were *** study demonstrates the excellent potential of HRNs for biomedical applications.

关键词： Hydrogen sulfide Disease mechanisms Removal of hydrogen sulfide Responsive nanoplatforms Challenges Biomedical applications

Understanding the Interfacial Energy Structure and Electron Extraction Process in Inverted Organic Solar Cells with Phosphine-Doped Cathode Interlayers

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Chinese Journal of Chemistry 2024年第12期42卷 1347-1354页

作者： yi yang Jingwen Wang yang Xiao Bowei Xu Jianhui Hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Chemical Resource Engineering College of Materials Science and EngineeringBeijing University of Chemical TechnologyBejing 100029China University of Chinese Academy of Sciences Beijing 100049China

Comprehensive Summary Cathode interlayers(CILs)play an essential role in achieving efficient organic solar cells(OSCs).However,the electronic structure at the electrode/CIL/active layer interfaces and the underlying mechanisms for electron collection remain unclear,which becomes a major obstacle to develop high-performance ***,we investigate the relationship of the electron collection abilities of four cross-linked and n-doped CILs(c-NDI:P0,c-NDI:P1,c-NDI:P2,c-NDI:P3)with their electronic structure of space charge region at heterojunction *** accurately calculating the depletion region width according to the barrier height,doping density and permittivity,we put forward that the optimal thickness of CIL should be consistent with the depletion region width to realize the minimum energy *** a result,the depletion region width is largely reduced from 13 nm to 0.8 nm at the indium tin oxide(ITO)/c-NDI:P0 interface,resulting in a decent PCE of 17.7%for the corresponding inverted OSCs.

关键词： Organic solar cells Cathode interlayer Depletion region width Electric conductivity Electron transport Electron transfer Electron extraction process

Superhydrophobic melamine sponge prepared by radiation-induced grafting technology for efficient oil-water separation

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第9期35卷 1-12页

作者： Sun, ying Wang, Wen-Rui Li, Dan-yi Xu, Si-yi Lin, Lin Lu, Man-Li Fan, Kai Xing, chen-yang Li, Lin-Fan Li, Ji-Hao Chinese Acad Sci Shanghai Inst Appl Phys Shanghai 201800 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Chongqing Coll Elect Engn Sch Architecture & Mat Chongqing 401331 Peoples R China Shenzhen Univ Coll Phys & Optoelect Engn Ctr Stretchable Elect & NanoSensors Key Lab Optoelect Devices & SystMinist Educ Shenzhen 518060 Peoples R China

This paper presents a superhydrophobic melamine (ME) sponge (ME-g-PLMA) prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate (LMA) onto an ME sponge for efficient oil-water separation. The obtained ME-g-PLMA sponge had an excellent pore structure with superhydrophobic (water contact angle of 154 degrees\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$154\circ$$\end{document}) and superoleophilic properties. It can absorb various types of oils up to 66-168 times its mass. The ME-g-PLMA sponge can continuously separate oil slicks in water by connecting a pump or separating oil underwater with a gravity-driven device. In addition, it maintained its highly hydrophobic properties even after long-term immersion in different corrosive solutions and repeated oil adsorption. The modified ME-g-PLMA sponge exhibited excellent separation properties and potential for oil spill cleanup.

关键词： Radiation-induced graft polymerization Oil-water separation Sponge Superhydrophobic OIL/WATER SEPARATION LAURYL METHACRYLATE POLYURETHANE SPONGE ABSORPTION ABSORBENT STRATEGY REMOVAL AEROGEL SPILL FOAM

Stem Cell Transplantation Represents a New Strategy for the Treatment of Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 673-676页

作者： Yuan Zhou yi Wang Lin yang Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical Sciences and First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou310053China Zhejiang Rehabilitation Medical Center Department The Third Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou310013China

Epilepsy is a neurological disorder characterized by faulty neuronal synchronization and repeated *** balance between glutamatergic excitatory neurons and gammaaminobutyric acid inhibitory neurons is critical for opti... 详细信息

关键词： epilepsy Transplantation Strategy

GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 680-682页

作者： Junzi chen Zhongxia Li yi Wang Liying chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province First Affiliated Hospital and School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou310053China Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Epilepsy,one of the most common central nervous system disorders,affects about 70 million people of all ages worldwide[1].It is characterized by hyperactive neuronal networks,resulting from imbalanced excitatory and inhibitory *** the development of multiple next-generation anti-seizure medicines,one-third of epilepsy patients are still drug-resistant[2].

关键词： epilepsy Therapy seizure

Temperature inversion enables superior stability for low-temperature Zn-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian yi Rui-yang Li Wei-Hao Lin Jie chen Xiao-Yue chen yi-Ming Xie Ji-Huai Wu Zhang Lan Lan-Fang Que Bao-Sheng Liu Hao Luo Zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

Double Moving Extremes Ranked Set Sampling Design

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 75-90页

作者： Meng chen Wang-xue chen Rui yang Department of Mathematics and Statistics Jishou UniversityJishou416000China

The traditional simple random sampling(SRS)design method is inefficient in many *** proposed some new designs to increase *** this paper,as a variation of moving extremes ranked set sampling(MERSS),double MERSS(DMERSS)is proposed and its properties for estimating the population mean are *** turns out that,when the underlying distribution is symmetric,DMERSS gives unbiased estimators of the population ***,it is found that DMERSS is more efficient than the SRS and MERSS methods for usual symmetric distributions(normal and uniform).For asymmetric distributions considered in this study,the DMERSS has a small bias and it is more efficient than SRS for usual asymmetric distribution(exponential)for small sample sizes.

关键词： double moving extremes ranked set sampling symmetric distribution efficiency