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Expression of IL-4 in a rat model of chronic pulmonary infection with biofilm formation induced by Pseudomonas aeruginosa

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Journal of Microbiology and Immunology 2007年第1期5卷 23-28页

作者： PING YAN yi QIANG chen JIN liang KONG ZHI JUN SONG HONG WU Geriatric Respiratory Disease Ward the First Affiliated Hospital of Guangxi Medical University Nanning P. R. China

The expression of IL-4 in a rat model of chronic pulmonary infection biofilm formation induced by Pseudomonas aeruginosa was investigated, in which SPF Wister rats were infected via trachea with 0.1 ml P. aeruginosa strain PAO579 （ 10^9 CFU/ml） in alginate beads or the planktonic form of this bacterial strain （109 CFU/ml）, and on 3, 7 and 14 d after infection, the bacteriological and pathological changes were observed as well as the expression of the cytokine IL-4 was determined. It was demonstrated that the count of CFU per lung tissue in case of bacteria in alginate beads was significantly higher than that of bacteria in planktonic form, with more severe gross pathologic changes and inflammatory reactions in the alginate bead group in comparison with that of the planktonic forms （ P = 0. 002, P = 0. 004 and P = 0. 002, respectively）. In addition, the expression of IL-4 in the alginate bead group was also higher than that in the planktonic form （P = 0.02, P = 0.02 and P = 0.022, respectively）. A positive correlation between the level of IL-4 expression and the gross lung pathology in alginate bead group existed as demonstrated by simple regression analysis （r = 0.78, P 〈 0.02）. It is concluded that the chronic pulmonary infection with biofilm formation induced by P. aeruginosa tends to have the priority to the Th2 immune response.

关键词： P. aeruginosa Biofilm Pulmonary infection Interleukin-4

Superoxide Dismutase Mutant Accelerates Aggregation of Wild-type Superoxide Dismutase:SOD1 Could Gain Toxic Function Via Inducement

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Superoxide Dismutase Mutant Accelerates Aggregation of Wild-...

2008年全国生物化学与分子生物学学术大会

作者： Jun-ming Liao Hong-tao Li Jie chen yi liang (State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan 430072,China)

Misfolding and aggregation of mutant human copper,zinc superoxide dismutase (SOD1) is associated with the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS).Recent studies have shown that the co- expr...

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惰性多孔介质内过滤燃烧特性分析

工程热物理学报 2007年第1期28卷 157-160页

作者：张根烜刘明侯陈义良赵平辉中国电子科技集团公司第三十八研究所安徽合肥230031 中国科学技术大学热科学和能源工程系安徽合肥230027

以惰性堆积床内甲烷／空气低速过滤燃烧为例,因次分析系统特征尺度,基于修正的单温度模型,提出一种封闭的耦合解析方法,对燃烧过程进行理论分析。研究了燃烧波波速、火焰传播速率、最高燃烧温度等燃烧特性参数,将计算结果与实验结果以... 详细信息

以惰性堆积床内甲烷／空气低速过滤燃烧为例,因次分析系统特征尺度,基于修正的单温度模型,提出一种封闭的耦合解析方法,对燃烧过程进行理论分析。研究了燃烧波波速、火焰传播速率、最高燃烧温度等燃烧特性参数,将计算结果与实验结果以及前人的理论结果进行对比。

关键词：多孔介质过滤燃烧燃烧波火焰传播速率超绝热火焰温度燃烧

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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氮化物催化剂的制备、结构特性和应用

石油化工 1999年第12期28卷 841-845页

作者：李永峰詹予忠陈宜郭士岭郑州工业大学化工学院郑州450002

传统的金属硫化物和金属氧化物催化剂,由于其自身结构和性能方面的原因,存在许多不尽人意的地方.如金属硫化物催化剂在加氢精制的活性和选择性方面存在不足;金属氧化物催化剂比表面积较小,且活性中心多数来源于表面的氧负离子或者碱性的... 详细信息

传统的金属硫化物和金属氧化物催化剂,由于其自身结构和性能方面的原因,存在许多不尽人意的地方.如金属硫化物催化剂在加氢精制的活性和选择性方面存在不足;金属氧化物催化剂比表面积较小,且活性中心多数来源于表面的氧负离子或者碱性的OH-.与固体酸相比,其活性中心的多样性较差.目前急需开发新型催化材料,其中的一个方向是探索制备氮化物催化剂.

关键词：氮化物催化剂制备特性结构

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多孔介质燃烧的二维数值模拟

中国科学技术大学学报 2009年第4期39卷 385-390页

作者：姜海赵平辉徐侃陈义良中国科学技术大学热科学和能源工程系安徽合肥230027

利用商业软件FLUENT6.2结合用户自定义标量和用户自定义函数,采用二维稳态模型和简单化学反应机理,对堆积床内丙烷/空气预混燃烧进行了数值模拟,并与实验结果进行对比.结果表明,由于壁面粘性和壁面散热的影响,多孔介质燃烧火焰呈现明显... 详细信息

利用商业软件FLUENT6.2结合用户自定义标量和用户自定义函数,采用二维稳态模型和简单化学反应机理,对堆积床内丙烷/空气预混燃烧进行了数值模拟,并与实验结果进行对比.结果表明,由于壁面粘性和壁面散热的影响,多孔介质燃烧火焰呈现明显的二维结构.所以在实际的燃烧器设计中应考虑壁面带来的影响.

关键词：多孔介质预混燃烧二维数值模拟

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming liang Huayi Wang Junjie Yang Ganggang Zhang chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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微喷管数值模拟

工程热物理学报 2005年第z1期26卷 199-202页

作者：刘明侯孙建威李志亮陈义良中国科学技术大学热科学与能源工程系安徽合肥230026

本文数值模拟喉部半高为34μm的二维微喷管,分别分析了固定进口及固定喉部尺度下扩张角、扩张比以及滑移边界条件对微喷管性能的影响,发现最佳半扩张角在20°-22°之间,而最佳扩张比为7。为了比较壁面滑移条件对计算结果影响,分别数值... 详细信息

本文数值模拟喉部半高为34μm的二维微喷管,分别分析了固定进口及固定喉部尺度下扩张角、扩张比以及滑移边界条件对微喷管性能的影响,发现最佳半扩张角在20°-22°之间,而最佳扩张比为7。为了比较壁面滑移条件对计算结果影响,分别数值模拟了喉部尺寸为68μm和6.8μm的微喷管,发现Kn<0.001时,滑移边界条件对数值模拟结果较小;而0.002

关键词：微喷管数值模拟推力扩张角扩张比

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多孔介质燃烧器的辐射输出效率和污染物

燃烧科学与技术 2007年第6期13卷 549-553页

作者：赵平辉叶桃红丁敏陈义良刘明侯中国科学技术大学热科学与能源工程系合肥230027

使用双温度体积平均模型、详细化学反应机理GRI3.0,对甲烷/空气预混气在多孔介质燃烧器内的预混火焰进行模拟.分析不同当量比和质量流量下的预热效率、辐射输出效率以及污染物排放情况,并对辐射输出效率随多孔介质热物性参数的变化进行... 详细信息

使用双温度体积平均模型、详细化学反应机理GRI3.0,对甲烷/空气预混气在多孔介质燃烧器内的预混火焰进行模拟.分析不同当量比和质量流量下的预热效率、辐射输出效率以及污染物排放情况,并对辐射输出效率随多孔介质热物性参数的变化进行敏感性分析.结果表明,增大相间对流换热系数或减小当量比、质量流量及固相消光系数都可以提高辐射输出效率,减小当量比或质量流量可以减少污染物排放.在所有的影响因素中,当量比的影响最大,发展超贫燃燃烧技术是获得高效低污染多孔介质燃烧器的关键.

关键词：多孔介质燃烧器辐射输出效率污染物排放预热效率