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RNF187 governs the maintenance of mouseGC-2 cell development by facilitating histone H3ubiquitination at K57/80

Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： Bing-Ya Xu Xiang-Ling Yu Wen-Xin Gao Ting-Ting Gao Hao-Yue Hu Tian-Tian wu Cong Shen Xiao-Yan Huang bo Zheng yi-bo wu Human Reproductive and Genetic Center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department ofHistology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and Child Health Care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction andGeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China.

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer cells.However,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline cells.To investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2 cells,a mouse spermatocyte-derived cell line.Our findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2 cells.Moreover,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular transcription.This is a study to report the role of RNF187 in maintaining the development of GC-2 cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of genetranscription.These discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2 cell histone H3 RNF187 ubiquitination

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Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis

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World Journal of Clinical Cases 2024年第9期12卷 1606-1621页

作者： Yu-yi Yuan Hui wu Qian-Yun Chen Heng Fan bo Shuai Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis(UC).METHODS We obtained gene expression profiles of circRNAs,miRNAs,and mRNAs in UC from the Gene Expression Omnibus dataset.The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions.Functional enrichment analysis was performed to identify the biological mechanisms involved in circRNAs.We identified the most relevant differential circRNAs for diagnosing UC and constructed a new predictive nomogram,whose efficacy was tested with the C-index,receiver operating characteristic curve(ROC),and decision curve analysis(DCA).RESULTS A circRNA-miRNA-mRNA regulatory network was obtained,containing 12 circRNAs,three miRNAs,and 38 mRNAs.Two optimal prognostic-related differentially expressed circRNAs,hsa_circ_0085323 and hsa_circ_0036906,were included to construct a predictive nomogram.The model showed good discrimination,with a C-index of 1(>0.9,high accuracy).ROC and DCA suggested that the nomogram had a beneficial diagnostic ability.CONCLUSION This novel predictive nomogram incorporating hsa_circ_0085323 and hsa_circ_0036906 can be conveniently used to predict the risk of UC.The circRNa-miRNA-mRNA network in UC could be more clinically significant.

关键词： Circular RNAs RNA regulatory network Ulcerative colitis New predictive model Bioinformatics Diagnose

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Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： yi Zhang Zhi-ying wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

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Significance of school greenspaces in preventing childhood myopia

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The Innovation 2024年第1期5卷 11-12页

作者： bo-yi Yang Department of Occupational and Environmental Health School of Public HealthSun Yat-Sen UniversityGuangzhou 510080China

THE BURDEN OF MYOPIA IN CHINESE CHILDREN Childhood myopia has emerged as a critical and underestimated public health issue globally,particularly in China and east Asian countries.The prevalence of myopia in Chinese children and adolescents is alarmingly high,with rates of 72%and 81%among middle school(ages 11–13 years)and high school(ages 14–17 years)students,respectively,resulting in an overall prevalence of approximately 54%.

关键词： globally myopia school

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Evolution of Cenozoic sedimentary architecture in Central and Southern South China Sea basins

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Journal of Palaeogeography 2024年第1期13卷 35-53页

作者： wu Tang Xiao-Jun Xie yi-bo Wang Lian-Qiao Xiong Jia Guo Xin Li China National Offshore Oil Corporation Research Institute Beijing 100028China

The Central and Southern South China Sea(CSSCS) has a complex tectonic dynamic background and abundant oil and gas resources, which has always been a hot topic of academic and industrial attention.However, systematic analyses are still lacking regarding its sediment filling structure and evolution, mostly due to limited borehole penetration and poor quality of seismic reflection data for deeply buried sequences. No consensus has been reached yet on the sedimentary infilling processes, which impeded the reconstruction of the palaeogeography of Southeast Asia and the oil-and-gas exploration undertakings. Here, we illustrate the Cenozoic sedimentary evolution of the CSSCS region by synthesizing relevant data from previous literature and our own observations and displaying the evolution of depositional systems in sequential reconstructions. Besides, the controlling factors of preferred sedimentary scenarios in the CSSCS incorporate the latest interpretations of the spreading of South China Sea(SCS) as well as the demise of the hypothetical Proto-South China Sea(PSCS). The results show that there are three types of sedimentary basins in the CSSCS(foreland,strike-slip, and rift basins) with different sedimentary filling structures. The foreland basins formed a depositional pattern of ‘transition from deep water to shallow water environments', dominated by deep-water depositional systems which were formed before the Early Oligocene with submarine fans developed. Later,the foreland basins were gradually dominated by shallow-water depositional systems with deltas and shallow marine facies. The strike-slip basins showed the depositional architecture of ‘transition from lake to marine environments', i.e. the basins were dominated by lacustrine deposits during the Eocene and evolved into the marine depositional environment since Oligocene with delta developed in the western part of the basin. The depositional evolution of rift basins illustrated the characteristics of 'transition from clastic to carbonate deposits', i.e., th

关键词： Central and Southern South China Sea Sedimentary filling Main controlling factors Proto-South China Sea South China Sea

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Liquid-metal microgrid stretchable electronics based on bionic leaf veins with ultra-stretchability and high conductivity

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Rare Metals 2024年第6期43卷 2747-2757页

作者： Xi-Di Sun Jun-Yang An yi-Qi Sun Xin Guo Jing wu Jiang-bo Hua Meng-Rui Su yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing University

Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare applications.Such devices can be seamlessly integrated with human skin.However,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical conditions.Here,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex microstructures.The systems are ultra-high tensile(800% tensile strain),environmentally stable(20 days) and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture signals.At the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm) with the system interconnects for a stretchable and wearable light source.

关键词： Stretchable electronics Liquid metal Stretchable conductor Vein Bionicist electronics

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Almost Periodic Type Group Actions on Compact Quantum Metric Spaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 568-594页

作者： bo Tao LONG Wei wu College of Mathematics MIIT Key Laboratory of Mathematical Modelling and High Performance Computing of Air VehiclesNanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China School of Mathematical Sciences Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200241P.R.China

A compact quantum metric space is a complete order unit space A endowed with a Lipnorm L.We give some characterizations of almost periodic type group actions on a compact quantum metric space(A,L)by means of several kinds of subsets of A,its induced equicontinuous actions on several important subsets of the dual Banach space A*,and the Lip-norm L with its induced metric space structures on the state space S(A)of A.

关键词： Lip-norm compact quantum metric space Lipschitz isomorphism almost periodicity Arzela-Ascoli theorem metric set

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Regulating electrochemical performances of lithium battery by external physical field

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Rare Metals 2024年第6期43卷 2391-2417页

作者： Shi-Kang Wang Shuai wu yi-Cheng Song Hassanien Gomaa Cui-Hua An Qi-bo Deng Ning Hu School of Mechanical Engineering School of Materials Science and EngineeringHebei University of Technology Shanghai Key Laboratory of Mechanics in Energy Engineering Department of Chemistry Faculty of ScienceAl-Azhar University Tianjin Key Laboratory of Power Transmission and Safety Technology for New Energy Vehicles State Key Laboratory of Reliability and Intelligence Electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of EducationHebei University of Technology

Lithium batteries have always played a key role in the field of new energy sources.However,non-controllable lithium dendrites and volume dilatation of metallic lithium in batteries with lithium metal as anodes have limited their development.Recently,a large number of studies have shown that the electrochemical performances of lithium batteries can be enhanced through the regulation of external physical fields.Especially,it significantly hinders the growth of lithium dendrites and promoting the reaction kinetics.This review summarizes recent innovations in the investigation of various physical fields of lithium batteries.The application of magnetic field in the synthesis of lithium battery electrode materials is introduced.The influence factors and regulation mechanism of various physical fields on the electrochemical performance of lithium batteries are reviewed emphatically.In addition,the current research status and existing challenges,along with future directions for the evolution of lithium batteries,are minutely discussed and prospected.New strategies for the further evolution of lithium batteries have also been provided.

关键词： Lithium battery External field assist Reaction kinetics Lithium dendrite

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Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1514-1531页

作者： Yong Pan yi-Ru Zhang Ling-Yun Wang Li-Na wu ying-Qiu Ma Zhou Fang Shi-bo Li Department of Infectious Disease Zhoushan HospitalWenzhou Medical UniversityZhoushan 316021Zhejiang ProvinceChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

关键词： Hepatocellular carcinoma Competitive endogenous RNA Molecular mechanism Prognosis Biomarker

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Some Convergence Properties for Weighted Sums of Martingale Difference Random Vectors

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1127-1142页

作者： yi wu Xue Jun WANG School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000P.R.China School of Big Data and Statistics Anhui UniversityHefei 230601P.R.China

Let{X_(ni),F_(ni);1≤i≤n,n≥1}be an array of R^(d)martingale difference random vectors and{A_(ni),1≤i≤n,n≥1}be an array of m×d matrices of real numbers.In this paper,the Marcinkiewicz-Zygmund type weak law of large numbers for maximal weighted sums of martingale difference random vectors is obtained with not necessarily finite p-th(1

关键词： Martingale difference random vectors weighted sums Marcinkiewicz–Zygmund type weak law of large numbers complete convergence strong law of large numbers multivariate simple linear regression model

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