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Fully Automatic Scar Segmentation for Late Gadolinium Enhancement MRI Images in Left Ventricle with Myocardial Infarction

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Current Medical Science 2021年第2期41卷 398-404页

作者： Zheng-hong WU Li-ping sun Yun-long LIU Dian-dian DONG Lv TONG Dong-dong DENG yi HE Hui WANG yi-bo sun Jian-zeng DONG Ling XIA College of Biomedical Engineering&Instrument Science Zhejiang UniversiryHangzhou 310027China Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversiryZhengzhou 450052China School of Biomedical Engineering Dalian University of TechnologyDalian 116024China Department of Cardiology Beijing Anzhen HospitalCapital Medical University and National Clinical Research Center for Cardiovascular DiseasesBeijing 100029China Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Numerous methods have been published to segment the infarct tissue in theleft ventricle, most of them either need manual work, post-processing, or suffer from poorreproducibility. We proposed an automatic segmentation method for segmenting the infarct tissue irleft ventricle with myocardial infarction. Cardiac images of a total of 60 diseased hearts (55 humanhearts and 5 porcine hearts) were used in this study. The epicardial and endocardial boundariesof the ventricles in every 2D slice of the cardiac magnetic resonance with late gadoliniumenhancement images were manually segmented. The subsequent pipeline of infarct tissuesegmentation is fully automatic. The segmentation results with the automatic algorithm proposed inthis paper were compared to the consensus ground truth. The median of Dice overlap between ourautomatic method and the consensus ground truth is 0.79. We also compared the automatic methodwith the consensus ground truth using different image sources from diferent centers with diferentscan parameters and different scan machines. The results showed that the Dice overlap with thepublic dataset was 0.83, and the overall Dice overlap was 0.79. The results show that our method isrobust with respect to different MRI image sources, which were scanned by different centers withdifferent image collection parameters. The segmentation accuracy we obtained is comparable toor better than that of the conventional semi-automatic methods. Our segmentation method may beuseful for processing large amount of dataset in clinic.

关键词： myocardial infarction cardiac magnetic resonance with late gadolinium enhancement automatic scar segmentation

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Analyses and Solutions of Specific Cases in Spatial Angles Calculation

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Computer Aided Drafting,Design and Manufacturing 2006年第1期16卷 57-62页

作者： ZHANG Ai-mei QIU yi sun bo-lu FANG Dong-yang School of Mechanical Engineering Zhengzhou University Zhengzhou 450002 China

Aiming at the specific cases existing in spatial angles calculation the paper investigates five types of them： lines in specific orientations, planes in specific orientations, two lines defining a plane and angles between them, orientations and relevant parameters of a line lying on a plane, and orientations and relevant parameters of a plane passing through a line. The results are presented. The strategy presented provides a firm theoretic basis for the application of the new method of spatial angles calculations.

关键词： engineering graphics spatial angles automatic calculation specific cases

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai bo sun Huijun Wang yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(Dbo)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with Dbo show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original Dbo,the R and RPD of models with the improved Dbo increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Rose without prickle: genomic insights linked to moisture adaptation

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National Science Review 2021年第12期8卷 74-85页

作者： Mi-Cai Zhong Xiao-Dong Jiang Guo-Qian Yang Wei-Hua Cui Zhi-Quan Suo Wei-Jia Wang yi-bo sun Dan Wang Xin-Chao Cheng Xu-Ming Li Xue Dong Kai-Xue Tang De-Zhu Li Jin-Yong Hu CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences University of Chinese Academy of Sciences Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of Sciences Flower Research Institute Yunnan Agricultural Academy of Sciences Biomarker Technologies Corporation

Prickles act against herbivores, pathogens or mechanical injury, while also preventing water loss. However,whether prickles have new function and the molecular genetics of prickle patterning remain poorly explored. Here, we generated a high-quality reference genome assembly for ‘Basye’s Thornless’(BT), a prickle-free cultivar of Rosa wichuraiana, to identify genetic elements related to stem prickle *** BT genome harbors a high level of sequence diversity in itself and with cultivar ‘Old Blush’(R. chinensis), a founder genotype in rose domestication. Inheritance of stem prickle density was determined and two QTL were identified. Differentially expressed genes in QTL were involved in water-related functions, suggesting that prickle density may hitchhike with adaptations to moist environments. While the prickle-related gene-regulatory-network(GRN) was highly conserved, the expression variation of key candidate genes was associated with prickle density. Our study provides fundamental resources and insights for genome evolution in the Rosaceae. Ongoing efforts on identification of the molecular bases for key rose traits may lead to improvements for horticultural markets.

关键词： Rosa wichuraiana ‘Basye's Thornless’ prickle-free water storage gene-regulatory-network (GRN) QTL

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颈内动脉和椎动脉颅外段迂曲与急性缺血性卒中相关性分析

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中国现代神经疾病杂志 2017年第4期17卷 290-299页

作者：曹益瑞吴波孙家瑜四川大学华西医院神经内科成都610041 四川省成都市温江区人民医院重症医学科 611130 四川大学华西医院放射科 611130

目的分析颈内动脉颅外段(EICA)和椎动脉颅外段(EVA)迂曲与急性缺血性卒中的相关性,以探讨血管迂曲原因及其诱发脑卒中的作用机制。方法采用CTA测量103例急性缺血性卒中患者和103例非缺血性卒中致头晕和头痛患者EICA和EVA迂曲指数、偏离... 详细信息

目的分析颈内动脉颅外段(EICA)和椎动脉颅外段(EVA)迂曲与急性缺血性卒中的相关性,以探讨血管迂曲原因及其诱发脑卒中的作用机制。方法采用CTA测量103例急性缺血性卒中患者和103例非缺血性卒中致头晕和头痛患者EICA和EVA迂曲指数、偏离度、迂曲度和成角个数,Pearson相关分析和Spearman秩相关分析EICA和EVA迂曲指数与缺血性卒中危险因素和其他血管形态学指标的相关性,单因素和多因素逐步法Logistic回归分析筛查EICA和EVA迂曲相关危险因素。结果脑卒中组患者EICA和EVA迂曲指数(P=0.000,0.000)、偏离度(P=0.000,0.000)、迂曲度(P=0.002,0.000)和成角个数(P=0.019,0.000)均高于对照组。根据梗死灶部位,进一步将脑卒中组分为前循环梗死亚组(73例)和后循环梗死亚组(30例),两亚组内(梗死侧与非梗死侧EICA,左侧与右侧EVA)和两亚组间血管形态学指标差异均无统计学意义(P>0.05);而前循环梗死亚组EICA迂曲指数(P=0.000)、偏离度(P=0.000)和迂曲度(P=0.045),以及后循环梗死亚组EVA迂曲指数(P=0.000)、偏离度(P=0.000)、迂曲度(P=0.000)和成角个数(P=0.046)均高于对照组。选择二者迂曲指数较高的一侧,相关分析显示,缺血性卒中患者EICA迂曲指数与年龄、颈动脉粥样硬化、EICA和EVA形态学指标(除外EVA偏离度)均呈正相关(P<0.05),而与男性呈负相关(rs=-0.253,P=0.010);EVA迂曲指数与年龄、高血压、EICA和EVA形态学指标均呈正相关(P<0.05),而与男性呈负相关(rs=-0.276,P=0.005)。单因素和多因素逐步法Logistic回归分析显示,女性(EICA:OR=1.458,95%CI:1.111~5.166,P=0.016;EVA:OR=9.092,95%CI:1.294~63.872,P=0.026)和年龄(EICA:OR=1.050,95%CI:1.013~1.088,P=0.007;EVA:OR=1.084,95%CI:1.003~1.138,P=0.001)是EICA和EVA迂曲的独立危险因素。结论缺血性卒中患者EICA和EVA迂曲无侧别、前后循环分布的差异。缺血性卒中患者EICA和EVA形态学指标显著高于非脑卒中患者。女性和高龄是EICA和EVA迂曲的独立危险因素。

关键词：颈内动脉椎动脉血管畸形卒中脑缺血危险因素回归分析

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Traffic safety helmet wear detection based on improved YOLOv5 network

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Optoelectronics Letters 2025年第1期21卷 35-42页

作者： GUI Dongdong sun bo College of Software Southeast University Quanzhou Equipment Research Centre Haixi Institute Chinese Academy of Sciences

Aiming at the problem that the current traffic safety helmet detection model can't balance the accuracy of detection with the size of the model and the poor generalization of the model, a method based on improving you only look once version 5(YOLOv5) is proposed. By incorporating the lightweight Ghost Net module into the YOLOv5 backbone network, we effectively reduce the model size. The addition of the receptive fields block(RFB) module enhances feature extraction and improves the feature acquisition capability of the lightweight model. Subsequently, the high-performance lightweight convolution, GSConv, is integrated into the neck structure for further model size compression. Moreover, the baseline model's loss function is substituted with efficient insertion over union(EIoU), accelerating network convergence and enhancing detection precision. Experimental results corroborate the effectiveness of this improved algorithm in real-world traffic scenarios.

关键词： Traffic control

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Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures

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World Journal of Psychiatry 2025年第1期15卷 83-92页

作者： bo Wang Da Shi yin-Di sun bo Dong Joint Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Pain Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar *** kind of fracture is easily combined with serious injuries to peripheral nerves and soft tissues,which causes paralysis of the lower limbs if there is no timely rehabilitation *** patients with thoracolumbar fractures find it difficult to recover after the operation,and they are prone to depression,low self-esteem,and other negative *** To investigate the association between anxiety,depression,and social stress in young patients with thoracolumbar spine fractures and the effect on rehabilitation *** This study retrospectively analyzed 100 patients admitted to the orthopedic department of Honghui Hospital,Xi’an Jiaotong University who underwent thoracolumbar spine fracture surgery from January 2022 to June *** general data of the patients were assessed with the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),life events scale,and social support rating scale(SSRS)to identify the correlation between anxiety,depression scores,and social stress and social *** Japanese Orthopedic Association(JOA)was utilized to evaluate the rehabilitation outcomes of the patients and to analyze the effects of anxiety and depression scores on *** According to the scores of HAMD and HAMA in all patients,the prevalence of depression in patients was 39%(39/100),and the prevalence of anxiety was 49%(49/100).Patients were categorized into non-depression(n=61)and depression(n=39),non-anxiety(n=51),and anxiety(n=49)*** significant differences in gender,occupation,Pittsburgh Sleep Quality Index(PSQI)score,and monthly family income were observed between the non-depression and depression groups(P<0.05).A significant difference in occupation and PSQI score was found between the non-anxiety and anxiety *** depression(r=0

关键词： Patients with thoracolumbar fractures Anxiety Depression Social pressure Social support

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Targets capture by distributed active swarms via bio-inspired reinforcement learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu Yue Li Jun sun Shuyuan Du Xinpeng Di Yuguang Yang bo Li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

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复杂产品研制过程技术风险的仿真评估

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系统仿真学报 2009年第16期21卷 5207-5211页

作者：冯强曾声奎任羿孙博北京航空航天大学工程系统工程系北京100083

探讨了复杂产品研制过程中技术风险的内涵,建立了费用风险、进度风险、性能风险等三类技术风险之间的关系模型。考虑复杂产品研制过程的并行迭代特征,提出了一种基于设计结构矩阵的多层技术风险仿真评估模型。系统分析了性能风险对进度... 详细信息

探讨了复杂产品研制过程中技术风险的内涵,建立了费用风险、进度风险、性能风险等三类技术风险之间的关系模型。考虑复杂产品研制过程的并行迭代特征,提出了一种基于设计结构矩阵的多层技术风险仿真评估模型。系统分析了性能风险对进度、费用风险的影响,并依此给出了一种两层抽样机制的仿真算法修正了传统仿真中仅考虑费用风险和进度风险的仿真偏差。在此基础上,给出了定量评估子项目或活动技术风险的似然估计值的方法,为复杂产品研制过程的风险控制提供了依据。

关键词：产品研制过程仿真风险评估设计结构矩阵

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying sun Zhen-Ni Guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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