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Advanced Role of Hippo Signaling in Endometrial Fibrosis： Implications for Intrauterine Adhesion

Chinese Medical Journal 2017年第22期130卷 2732-2737页

作者： Hai-Yan Zhu Tian-Xiang Ge yi-bin pan Song-ying Zhang Assisted Reproduction Unit Department of Obstetrics and Gynecology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310016 China

Objective： Intrauterine adhesion （IUA） is a major health problem that causes infertility, menstrual irregularities, and recurrent pregnancy losses in women. Unfortunately, treatments for IUA are limited, and there are currently no effective strategies for preventing IUA recurrence. In this review, we introduced the role of Hippo signaling in the normal endometrium and IUA and described the mechanisms by which the Hippo pathway integrates with the Wnt and transforming growth factor-β （TGF-β） signaling pathways to form an intricate network governing the development of fibrosis. Data Sources： Original research articles in English that were published until July 2017 were collected from the PubMed database. Study Selection： Literature search was conducted using the search terms ＂endometrial fibrosis OR fibrosis AND or OR intrauterine adhesion OR Asherman syndrome OR IUA,＂＂Hippo AND or OR Hippo/TAZ,＂＂TGF-β,＂ and ＂Wnt.＂ Related original research articles were included in the comprehensive analysis. Results： Endometrial fibrosis is recognized as a key pathological event in the development of IUA, which is characterized by epithelial/fibroblast-myofibroblast transition. Myofibroblasts play crucial roles in the pathogenesis of fibrous scarring, and myofibroblast differentiation can be triggered by multiple signaling pathways. H ippo signaling is a critical regulator of the epithelial/fibroblast-myofibroblast transition and α-smooth muscle actin, which exhibits a specific spatiotemporal expression in the endometrium. Conclusions： Hippo signaling plays a critical role in fibrous diseases and participates in cross talks with Wnt and TGF-β signaling. Our findings not only contributed to knowledge on the pathogenesis of endometrial fibrosis, but can also serve as a useful resource for developing specific molecular inhibitors for IUA treatment and prevention.

关键词： Endometrial Fibrosis: Hippo Signaling Intrauterine Adhesion Transforming Growth Factor-β Wnt Signaling

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Rare rectal gastrointestinal stromal tumor case:A case report and review of the literature

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World Journal of Clinical Cases 2023年第28期11卷 6797-6805页

作者： Ruo-Xi Dong Chen Wang Hao Zhou Hao-Qiang yin Yang Liu Hong-Tao Liang yi-bin pan Jia-Wen Wang Yong-Qing Cao Department of Anorectal Surgery LongHua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Department of Ultrasound LongHua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare tumors of the gastrointestinal tract accounting for less than 1%of all gut *** occurring in the rectum are extremely rare,and these usually present at an advanced stage compared with other *** SUMMARY A 60-year-old male who presented with features of sensations of rectal tenesmus was referred to our department with a mass in the lower rectum that was detected during a routine ***,transrectal ultrasound,perianal magnetic resonance imaging and ultrasonic contrast were used to diagnose the rectum GIST,and then the patient underwent complete transanal resection using the ultrasonic *** patient was discharged ten days after the operation and was defined as low ***,he had no need to receive subsequent adjuvant therapies,and he had not suffered any anal dysfunction or had any evidence of recurrence at follow *** Surgical resection with histologically negative margins is the standard curative treatment for rectal *** surgical techniques based on the location,size,and resectability of the tumor should attract great attention from clinicians.

关键词： Gastrointestinal stromal tumor Rectum Ultrasonic scalpel resection Case report

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100 TeV diffuse γ-rays observation by YangBaJing Hybrid Array

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Radiation Detection Technology and Methods 2020年第3期4卷 392-398页

作者： Jian-Cheng He Yu-Hua Yao Zhen Wang Tian-Lu Chen Dan-Zeng-Luo-Bu Cun-Feng Feng Youliang Feng Qi Gao yi-Qin Guo ying-ying Guo Hong-Bo Hu Xing-Tao Huang Cheng Liu Mao-Yuan Liu yi-bin pan bing-Qiang Qiao Guang-Guang Xin Xue-Yao Zhang yi Zhang Shi-Ping Zhao Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences(UCAS) Beijing 100049China College of Physics Sichuan UniversityChengdu 610064China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Physics Department of Science School Tibet UniversityLhasa 850000China Institute of Frontier and Interdisciplinary Science Shandong UniversityJinan 250100China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences(CAS)Nanjing 210008China Department of Physics University of Wisconsin-Madison1150 University ave MadisonMadisonWI 53706USA School of Physics and Technology Wuhan UniversityWuhan 430072China

Purpose Cosmic rays up to PeV energy are believed to be generated in our galaxy.γ-rays at 100TeV energies are important probe to identify ***,γ-rays contain additional information on the propagation of the galactic cosmic *** Diffuseγ-rays originating from the Galactic plane from 20 to 200 TeV region are studied with early 160-day data collected by YangBaJing Hybrid Array(YBJ-HA),which is a hybrid array and consists of scintillation detectors and underground muon ***-distance equi-zenith angle and time-swapping methods are used to analyze the number ofγ-rays *** and conclusion Because of no significant observation onγ-ray emission,Helene's method is adopted to derive the 90%confidence level upper limits on the flux of diffuse galacticγ-*** the limit to the ratio of the flux ofγ-rays to CRs is obtained at the order of 10^(-4),which is the current best result at these energies.

关键词： Cosmic rays Diffuse y-rays YBJ-HA EAS

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Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang pan yihuang Chen Qiong Liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Rubidium atom coordination Biomass valorization

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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兵力损耗仿真相关问题的探讨

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系统仿真学报 2009年第S1期21卷 32-34页

作者：黄一斌潘高田彭文成薛青装甲兵工程学院北京100072

兵力损耗模拟是作战仿真领域中的一个重要内容,其计算过程中有一些细节问题需要认真考虑。通过对损耗系数的量纲和求解过程进行探讨,找到了武器系统效能与作战效能的关系。并针对兵力损耗实现过程中存在的误区,指出了瞬时的交火兵力才... 详细信息

兵力损耗模拟是作战仿真领域中的一个重要内容,其计算过程中有一些细节问题需要认真考虑。通过对损耗系数的量纲和求解过程进行探讨,找到了武器系统效能与作战效能的关系。并针对兵力损耗实现过程中存在的误区,指出了瞬时的交火兵力才是瞬时战斗力的计算依据,而非所有参战兵力。

关键词：损耗系数瞬时战斗力交火兵力参战兵力

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Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei Lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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Research on cubic polynomial acceleration and deceleration control model for high speed NC machining

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 358-365页

作者： Hong-bin LENG yi-jie WU Xiao-hong pan Institute of Modern Manufacture Engineering Zhejiang University Hangzhou 310027 China

To satisfy the need of high speed NC (numerical control) machining, an acceleration and deceleration (acc/dec) control model is proposed, and the speed curve is also constructed by the cubic polynomial. The proposed control model provides continuity of acceleration, which avoids the intense vibration in high speed NC machining. Based on the discrete characteristic of the data sampling interpolation, the acc/dec control discrete mathematical model is also set up and the discrete expression of the theoretical deceleration length is obtained furthermore. Aiming at the question of hardly predetermining the deceleration point in acc/dec control before interpolation, the adaptive acc/dec control algorithm is deduced from the expressions of the theoretical deceleration length. The experimental result proves that the acc/dec control model has the characteristic of easy implementation, stable movement and low impact. The model has been applied in multi-axes high speed micro fabrication machining successfully.

关键词： High speed NC machining Acceleration and deceleration (acc/dec) control model Cubic speed curve Discrete mathematical model Adaptive acceleration and deceleration control algorithm

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Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： pan Guo Hong-Bo Jin Cong-Feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期 297-307页

作者： bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding pan pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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