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N^(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance

Military Medical Research 2022年第5期9卷 576-591页

作者： Xian lin Feng Wang Jian Chen Jing Liu yi-bin lin Li Li Chuan-Ben Chen Qin Xu Departments of Gynecology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Department of Radiation Oncology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Shenzhen Key Laboratory of Immunity and Inflammatory Diseases Peking University Shenzhen HospitalShenzhen Peking University?the Hong Kong University of Science and Technology Medical CenterShenzhen 518036GuangdongChina Outpatient Department Fujian Hospital of People's Armed PoliceFujian Medical UniversityFuzhou 350014China

Background:Stemness and chemoresistance contribute to cervical cancer recurrence and *** the current study,we determined the relevant players and role of N^(6)-methyladenine(m^(6)A)RNA methylation in cervical cancer ***:The roles of m^(6)A RNA methylation and centromere protein K(CENPK)in cervical cancer were analyzed using bioinformatics *** RNA immunoprecipitation was adopted to detect m^(6)A modification of CENPK *** cervical cancer clinical samples,cell lines,and xenografts were used for analyzing gene expression and *** staining and the tumorsphere formation,clonogenic,MTT,and EdU assays were performed to determine cell stemness,chemoresistance,migration,invasion,and proliferation in HeLa and SiHa cells,*** blot analysis,co-immunoprecipitation,chromatin immunoprecipitation,and luciferase reporter,cycloheximide chase,and cell fractionation assays were performed to elucidate the underlying ***:Bioinformatics analysis of public cancer datasets revealed firm links between m^(6)A modification patterns and cervical cancer prognosis,especially through ZC3H13-mediated m^(6)A modification of CENPK *** expression was elevated in cervical cancer,associated with cancer recurrence,and independently predicts poor patient prognosis[hazard ratio=1.413,95%confidence interval=1.078−1.853,P=0.012].Silencing of CENPK prolonged the overall survival time of cervical cancer-bearing mice and improved the response of cervical cancer tumors to chemotherapy in vivo(Pling,but suppression of the p53 *** dysregulation ultimately enhanced the tumorigenic pathways required for cell stemness,DNA damage repair pathways necessary f

关键词： N^(6)-methyladenosine Centromere protein K Cervical cancer Stemness Chemoresistance

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Modification of the Recovery Behavior of TiNi Shape Memory Alloy(SMA)by Chemical Heat Treatment

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材料热处理学报 2004年第5期25卷 122-125页

作者： WANGGao-chao YANGGang HUANGyi-bin MINSi-lin CollegeofMaterialsScienceandEngineering NanchangInstituteofAeronauticalTechnologyNanchangChina

In order to improve the linear recovery behavior, TiNi shape memory alloy springs were samariumed at 550°C for 4 hours with SmH3 as samarium source, in a vacuum furnace. The phase of samariumed layer was determined by X-ray diffractometer (XRD). The fracture surface of TiNi SMA spring was investigated by scanning electronic microscope (SEM). The experimental results indicate that a thick samariumed layer composed of NiSm intermetallics existed on the fracture surface. Additionally, a new idea of linear recovery behavior in shape memory alloy (SMA) has been proposed, and its properties have been defined. The reversion measurements show that the linear recovery properties of TiNi SMA were obviously improved. The temperature range of the linear reversion (Tw) was enlarged from 4°C to 8’C, The ratio of linear reversion was increased from 54% to 75%, the proportion of linear reversion (PL) was increased from 56% to 70%, and the proportion of non-linear reversion (Ps) was decreased from 44% to 10%, but the proportion of total reversion (PT) has a little decrease. These results were attributed to the strengthening effect of NiSm intermetallics.

关键词： TiNi形状记忆合金化学热处理钐线性反转

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Liver protection strategies in liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 34-42页

作者： Jun-Jun Jia Jian-Hui Li Li Jiang bin-yi lin Li Wang Rong Su lin Zhou Shu-Sen Zheng Key Laboratory of Combined Multi-organ Transplantation Ministry of Health Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND： Liver transplantation is the therapy of choice for patients with end-stage liver diseases. However, the gap between the low availability of organs and high demand is continuously increasing. Innovative strategies for organ protection are necessary to expand donor pool and to achieve better outcomes for liver transplantation. The present review analyzed and compared various strategies of liver *** SOURCES： Databases such as PubM ed, Embase and Ovid were searched for the literature related to donor liver protection strategies using following key words：＂ischemia reperfusion injury＂, ＂graft preservation＂, ＂liver transplantation＂, ＂machine perfusion＂ and ＂conditioning＂. Of the 146 studies identified,only those with cutting edge strategies were ***： A variety of therapeutic approaches were proposed to alleviate graft ischemia/reperfusion injury, which included static cold storage, machine perfusion （hypothermic, normothermic and subnormothermic）, manual conditioning （pre,post and remote）, and pharmacological conditioning. Evidences from animal experiments and clinical trials suggested that all these strategies could potentially protect liver graft; however, their clinical applications are limited partially due to their own ***： There are a plenty of methods suggested to decrease the degree of donor liver transplantation-related injury. However, none of these approaches is perfect in clinical practice. More translational researches （molecular and clinical studies） are needed to improve the techniques in liver graft protection.

关键词： ischemia reperfusion injury liver transplantation organ protection conditioning

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''Minimizing tacrolimus' ' strategy and long-term survival after liver transplantation

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World Journal of Gastroenterology 2014年第32期20卷 11363-11369页

作者： Jun-Jun Jia bin-yi lin Jiang-Juan He Lei Geng Dhruba Kadel Li Wang Dong-Dong Yu Tian Shen Zhe Yang Yu-Fu Ye lin Zhou Shu-Sen Zheng Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public Health Depart-ment of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital of Zhejiang University School of Medicine

AIM: To investigate the effect of the ‘‘minimizing tacrolimus' ' strategy on long-term survival of patients after liver transplantation(LT).METHODS: We conducted a retrospective study of 319 patients who received LT between January 2009 and December 2011 at the First Affiliated Hospital of Zhejiang University School of Medicine. Following elimination of ineligible patients, 235 patients were included in the study. The relationship between early tacrolimus(TAC)exposure and survival period was analyzed by Kaplan Meier curves. Adverse effects related to TAC were eval-uated by the χ2 test. Routine monitoring of blood TAC concentration(TC) was performed using the PRO-TracTM Ⅱ Tacrolimus Elisa Kit(Diasorin, United States). RESULTS: Of 235 subjects enrolled in the study, 124(52.8%) experienced adverse effects due to TAC. When evaluating mean TC, the survival time of patients with a mean TC 4, the survival time was not statistically different. Adverse effects experienced in all three groups were not statistically different. In Cox regression analysis, male patients and those with a primary diagnosis of benign disease, mean TC > 5 ng/mL and TC SD 2-4 had better ***: The early ‘‘minimizing tacrolimus' ' strategy with a mean TC of 5-10 ng/mL and SD of 2-4 was beneficial in terms of long-term survival after LT.

关键词： Tacrolimus Liver transplantation Outcome Minimizing tacrolimus Immunosuppressive drug

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Slicing Method for Reverse Engineering Based on Image Mosaic

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Computer Aided Drafting,Design and Manufacturing 2008年第2期18卷 33-38页

作者： ZHAN yi-bin,lin Da-jun,AN Qi (School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China)

Reverse engineering dealing with images is traditionally based on image processing and contour recognition. A new method is presented based on the combination of sectional slicing with image mosaic. Sectional contours of the target object are generated by colorful liquid or laser scanning, these images from different views are fused into a set of complete cross-sectional images, thereby the whole practical model is reconstructed in 3D space.

关键词： reverse engineering image mosaic slicing contour 3D reconstruction

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen Liu Xuliang lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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基于长短期记忆网络的换道意图识别方法

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中国公路学报 2021年第11期34卷 236-245页

作者：宋晓琳曾艳兵曹昊天李明俊易滨林湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

准确识别周围车辆的换道意图将有助于自动驾驶系统决策,从而提升安全性和舒适性。提出一种基于长短期记忆(Long Short-term Memory,LSTM)网络的换道意图识别方法,能够较为准确地识别周围车辆的换道意图。该方法先通过构造收益函数来描... 详细信息

准确识别周围车辆的换道意图将有助于自动驾驶系统决策,从而提升安全性和舒适性。提出一种基于长短期记忆(Long Short-term Memory,LSTM)网络的换道意图识别方法,能够较为准确地识别周围车辆的换道意图。该方法先通过构造收益函数来描述目标车辆(被预测的车辆)与其邻域车辆之间的交互关系,得到目标车辆左换道、右换道和车道保持的收益值,并将该收益值作为交互特征输入到意图识别网络;在意图识别网络中,引入注意力机制,通过网络自学习得到的权重对LSTM层各个时刻的输出加权求和,能够对编码信息进行有效利用,提高换道意图的识别性能;由于车辆的换道意图存在较强的前后依赖性,引入条件随机场(Conditional Random Field,CRF),采用意图转移特征函数对各个时刻换道意图进行联合建模,并构建负对数似然损失函数作为整个网络的损失。为了验证所提方法的有效性,基于NGSIM数据集训练并评估模型。结果表明:所提方法对换道意图识别的准确率、宏观F1分数、测试集损失分别为0.916 4、0.874 6和0.168 3,均优于支持向量机(SVM)、隐马尔可夫模型(HMM)和LSTM模型。同时,所提模型对左换道和右换道的平均换道提前识别时间分别为3.08、2.33 s,综合换道提前识别时间为2.81 s,优于基线模型,能够为主车的决策提供充足的冗余时间。通过消融分析可知,引入的交互作用模块、注意力机制和条件随机场对准确率的贡献分别为0.012 2、0.004 3和0.011 0,印证了相关模块的有效性。最后由场景验证的案例可以得出,所提方法在准确率、稳定性和换道提前识别时间等指标上优于对比模型。

关键词：交通工程换道意图识别收益函数自动驾驶长短期记忆网络交互作用注意力机制条件随机场

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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收运车机械手执行机构多目标优化设计

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机械设计 2018年第3期35卷 20-26页

作者：易滨林刘江南张文博桂科湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

收运车机械手执行机构的关键点轨迹偏差、运动平稳性是影响收运车上料过程中垃圾漂、撒、遗的关键因素。为提高关键点轨迹精度及运动平稳性,建立了收运车机械手执行机构优化设计数学模型。以各杆长及短连架杆初始角度等参数为设计变量,... 详细信息

收运车机械手执行机构的关键点轨迹偏差、运动平稳性是影响收运车上料过程中垃圾漂、撒、遗的关键因素。为提高关键点轨迹精度及运动平稳性,建立了收运车机械手执行机构优化设计数学模型。以各杆长及短连架杆初始角度等参数为设计变量,以关键点轨迹偏差、输出角速度标准差为优化目标,根据收运车机械手执行机构参数的约束条件,建立机构的关键点轨迹与运动平稳性优化数学模型。采用基于内点算法的优化方法进行求解,最后利用仿真试验对优化结果进行验证。结果表明,优化后收运车机械手执行机构的运动性能得到较大改善。

关键词：机械手关键点轨迹运动平稳性多目标优化

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气枪信号触发台站的自动快速识别

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地震工程学报 2017年第2期39卷 234-239页

作者：黄艳丹李军金星邱毅林彬华福建省地震局福建福州350003 中国地震局工程力学研究所黑龙江哈尔滨150080 福州大学福建福州350018

气枪震源是高度可重复的人工震源,在深部探测工作中应用广泛。以福建省地震局组织开展的水库气枪实验为研究对象,面向未来技术的发展,提出基于气枪激发波形的相关性计算,自动获取气枪信号触发台站情况,并绘制触发台站的分布图。对处理... 详细信息

气枪震源是高度可重复的人工震源,在深部探测工作中应用广泛。以福建省地震局组织开展的水库气枪实验为研究对象,面向未来技术的发展,提出基于气枪激发波形的相关性计算,自动获取气枪信号触发台站情况,并绘制触发台站的分布图。对处理结果分析认为:该方法能快速准确识别触发台站,可迅速作出分布图,直观地反应气枪激发效果,较好地为实验现场实验条件的调整提供依据。

关键词：气枪激发波形相关性触发台站分布图

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