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Simultaneous prestack inversion of variable-depth streamer seismic data

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Applied Geophysics 2019年第1期16卷 92-100页

作者： Zhang Zhen-Bo xuan yi-Hua Deng Yong CNOOC China Limited Shenzhen BranchShenzhen 518000China

Variable-depth streamer seismic data are characterized by low and high frequencies and can be used to obtain high-quality and resolution images of complex subsurface structures. Taking advantage of the frequency range in the variable-depth streamer data, we propose the simultaneous inversion of prestack data from variable-offset stack gathers to obtain the P-wave impedance, S-wave impedance, and density. Next, we validate the method by using model and actual variable-depth streamer data from the Huizhou block. The results suggest that the broadband data recorded by variable-depth streamers improve the signal-to-noise ratio and quality of the inversion results and outperform the constant-depth streamer data in delineating the underground stratigraphy.

关键词： streamer prestack variable inversion reservoir frequency

Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19:A review

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Journal of Integrative Medicine 2022年第6期20卷 477-487页

作者： yi-xuan Wang Zhen Yang Wen-xiao Wang Yu-xi Huang Qiao Zhang Jia-jia Li Yu-ping Tang Shi-jun Yue Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046Shaanxi ProvinceChina Department of Scientific Research Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

Traditional Chinese medicine,as a complementary and alternative medicine,has been practiced for thousands of years in China and possesses remarkable clinical ***,systematic analysis and examination of the mechanistic links between Chinese herbal medicine(CHM)and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative *** increasing attention,the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of“herb-compound-target-pathway,”which corresponds to the holistic mechanisms of *** integrating computational techniques into network pharmacology,the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented *** review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it.

关键词： Chinese traditional medicine Herbal medicine Network pharmacology Compound identification COVID-19

Electrospun N-halamine/ZnO-based platform eradicates bacteria through multimodal antimicrobial mechanism of action

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Rare Metals 2023年第1期42卷 222-233页

作者： Hui-Hui Qu Cong Wang yi-xuan Guo Zi-ying Zhao Long Qiao Jie-Bing Yang Hai-Xia Wu Quan-Shun Li Alideertu Dong College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control TechnologyMinistry of EducationInner Mongolia UniversityHohhot010021China Center of Experimental Instrument School of Food Science and TechnologyDalian Polytechnic UniversityDalian116034China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun130012China

The emergence and prevalence of antibiotic-resistant bacteria demands powerful antibacterial tactics to combat infectious *** combinational therapy based on synergistic hybrid antibacterial materials is a promising approach to realize effective sterilization through the rational integration of distinct bactericides into one compact *** this work,we constructed a microfiber-based antibacterial platform(PAM-Cl/ZnO MFs)by electrospinning N-halamine polymers(PAM-Cl)loaded with zinc oxide(ZnO)*** as-designed PAM-Cl/ZnO MFs inherited the intrinsic antibacterial effects of both PAM-Cl microfibers(PAM-Cl MFs)and ZnO microfibers(ZnO MFs),and the material exhibited enhanced synergistic antibacterial performance against Staphylococcus aureus(***)and Escherichia coli(***)in *** bactericidal effect was multimodal and included contact killing based on the N-Cl bond of N-halamine,multiple-release killing,such as reactive oxygen species(ROS)under light irritation,and Zn^(2+)and Cl^(+)acting as antibacterial ***,PAM-Cl/Zno MFs worked on inactivate bacteria even under harsh temperatures and atmospheric ***,PAM-Cl/ZnO MFs exhibited good biocompatibility and performed outstanding acceleration of wound healing with in vivo mouse skin defect models using *** work advances the design of antibacterial hybrid materials with the potency to eradicate bacteria in biological systems in multiple settings through the superiority of multimodal synergistic therapy.

关键词： N-halamine ZnO nanoparticles Electrospinning Synergistic antibacterial therapy Various scenarios

Fecal microbiota transplantation and prednisone for severe eosinophilic gastroenteritis

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World Journal of Gastroenterology 2014年第43期20卷 16368-16371页

作者： yi-xuan Dai Chuan-Bing Shi Bo-Ta Cui Min Wang Guo-Zhong Ji Fa-Ming Zhang Department of Digestive Endoscopy and Medical Center for Digestive Diseases Second Affiliated Hospital of Nanjing Medical University

Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by patchy or diffuse eosinophilic infiltration of the bowel wall to a variable depth and various gastrointestinal manifestations. We describe a case of severe eosinophilic gastroenteritis presenting as frequent bowel obstruction and diarrhea in a 35-year-old man. The patient was misdiagnosed and underwent surgery because of intestinal obstruction when he was first admitted to a local hospital. Then he was misdiagnosed as having Crohn’s disease in another university teaching hospital. Finally, the patient asked for further treatment from our hospital because of the on-going clinical trial for treating refractory Crohn’s disease by fecal microbiota transplantation. Physical examination revealed a slight distended abdomen with diffuse tenderness. Laboratory investigation showed the total number of normal leukocytes with neutrophilia as 90.5%, as well as eosinopenia, monocytopenia and lymphocytopenia. Barium radiography and sigmoidoscopy confirmed inflammatory stenosis of the sigmoid colon. We diagnosed the patient as having eosinophilic gastroenteritis by multi-examinations. The patient was treated by fecal microbiota transplantation combined with oral prednisone, and was free from gastrointestinal symptoms at the time when we reported his disease. This case highlights the importance of awareness of manifestations of a rare disease like eosinophilic gastroenteritis.

关键词： Eosinophilic gastroenteritis Bowel obstruction Diarrhea Fecal microbiota transplantation Prednisone

Investigation of the Column Function in Gradient Column

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Chemical Research in Chinese Universities 1994年第3期10卷 259-262页

作者： YUN Xi-qin KOU Deng-min DENG yi and LU xuan-yu(Department of Chemistry, Nankai University, Tianjin, 300071)

ＩｎｖｅｓｔｉｇａｔｉｏｎｏｆｔｈｅＣｏｌｕｍｎＦｕｎｃｔｉｏｎｉｎＧｒａｄｉｅｎｔＣｏｌｕｍｎＹＵＮＸｉ－ｑｉｎ；ＫＯＵＤｅｎｇ－ｍｉｎ；ＤＥＮＧＹｉａｎｄＬＵＸｕａｎ－ｙｕ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔ... 详细信息

ＩｎｖｅｓｔｉｇａｔｉｏｎｏｆｔｈｅＣｏｌｕｍｎＦｕｎｃｔｉｏｎｉｎＧｒａｄｉｅｎｔＣｏｌｕｍｎＹＵＮＸｉ－ｑｉｎ；ＫＯＵＤｅｎｇ－ｍｉｎ；ＤＥＮＧＹｉａｎｄＬＵＸｕａｎ－ｙｕ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＮａｎｋａｉＵｎｉｖｅｒｓｉ...

关键词： GC column Gradientally loaded column Column function

Lactobacillus plantarum and quercetin synergistically ameliorate hyperuricemia through targeting multiple pathways

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Food Science and Human Wellness 2024年

作者： Lin-Yan Zhu Meng-Yue Zhang Juan-Cheng yi-xuan Zhang School of Life Science and Biopharmaceutics， Shenyang Pharmaceutical University

Hyperuricemia is a prevalent metabolic disorder resulting from dysregulation of purine metabolism， often accompanied by inflammation. It is characterized by an abnormal elevation in uric acid levels. In our investigation， the combined treatment with Lactobacillus plantarum DY1 and quercetin suppressed the activity of xanthine oxidase and adenosine deaminase， decreased the levels of uric acid， TNF-α and IL-β， downregulated gene expression of URAT1 and GLUT9， and upregulated OAT1 and ABCG2. The combination increased the abundance of Lactobacillus and decreased the abundance of norank＿f＿norank＿o＿Clostridia＿UCG-014 and Roseburia. Metabolomics analysis revealed that the combination of probiotics and quercetin exhibited distinct metabolic pathways compared to their individual administrations. When compared to probiotics alone， the combination led to alterations in glutathione metabolism (oxidized glutathione and glutathione) as well as sphingolipid metabolism (sphingosine and sphinganine). When compared to quercetin alone， the combination resulted in variations in tryptophan metabolism (indole-3-acetamide， 5-hydroxy-L-tryptophan， indoleacetaldehyde， 3-(3-Indolyl)-2-oxopropanoic acid， 3-indoleacetic acid and 3-methylindole) along with purine metabolism (UA， xanthosine， cAMP， ADP and adenosine monophosphate). The subsequent fecal microbiota transplantation proved that the effect of the combination on reducing uric acid levels was mediated by the gut microbiota. Therefore， this new combination can be considered a promising adjuvant therapy capable of synergistically alleviating hyperuricemia.

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Exogenous Hematin Alleviates Mercury-induced Oxidative Damage in the Roots of Medicago sativa

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Journal of Integrative Plant Biology 2007年第12期49卷 1703-1713页

作者： yi Han Wei xuan Tian Yu Wen-Bing Fang Tian-Ling Lou yin Gao Xiao-Yue Chen XiaoXiao Wen-Biao Shen College of Life Sciences Laboratory of Nanjing Agricultural University and Carl Zeiss Far East Nanjing Agricultural University Nanjing 210095 China

In the present study, we evaluated the protective effect of exogenous heme oxygenase-1 （HO-1 EC 1.***.99.3） inducer hematin against mercury-induced oxidative damage in the roots of Alfalfa （Medicago sativa L.）. Plants exposed to mercury （HgCl2） exhibited a significant increase of lipid peroxidation, as well as inhibition of root elongation. However, hematin （50 μM） supplementation to HgCl2 （100 μmol/L） treated plants effectively reduced the lipid peroxidation and partially increased the root elongation. These responses were mimicked by the application of aqueous solution of carbon monoxide （CO） with 50% saturation. Also, treatment with hematin could result in the potent induction of HO-1 transcript in the root tissues, as detected 12h following treatment. Moreover, the activation of anti-oxidant enzyme, including glutathione reductase, monodehydroascorbate reductase and superoxide dismutase activities, and the decrease of lipoxygenase activity, were induced by hematin at 12h or 24h, which was further confirmed by histochemical staining for the detection of lipid peroxidation and loss of membrane integrity. Whereas, ascorbate peroxidase and guaiacol peroxidase isozyme activities or their transcripts were reduced, respectively, indicating that hydrogen peroxide might act as a signal to mediate Hg- tolerance at the beginning of treatment. The ameliorating effects of hematin were specific, since the CO scavenger hemoglobin differentially reversed the above actions. Taken together, our results suggested that hematin exhibits a vital role in protecting the plant against Hg-induced oxidative damage.

关键词： carbon monoxide hematin Medicago sativa mercury toxicity oxidative stress.

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热斑迁移路径上非定常气膜冷却特性研究

工程热物理学报 2018年第9期39卷 1991-1996页

作者：王天壹宣益民南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016

热斑在涡轮级中迁移会引起叶片局部温度过高,影响叶片使用寿命。本文在涡轮进口存在热斑的工况下,对整级涡轮叶栅进行数值模拟,研究热斑迁移路径上的气膜非定常冷却特性。结果表明:气膜孔附近区域流场和温度场的变化与主流周期性相同,... 详细信息

热斑在涡轮级中迁移会引起叶片局部温度过高,影响叶片使用寿命。本文在涡轮进口存在热斑的工况下,对整级涡轮叶栅进行数值模拟,研究热斑迁移路径上的气膜非定常冷却特性。结果表明:气膜孔附近区域流场和温度场的变化与主流周期性相同,动叶前缘经历热斑流场的时间约占整个周期的1/4。叶片前缘冷却射流可以冲散到达叶片前缘的热斑高温流体,热斑核心温度降低。采用压力脉动的气膜冷却的冷却效率低于常规气膜冷却,冷却效率随脉动频率的升高而增大。

关键词：热斑非定常模拟动静叶干涉脉动气膜冷却冷却效率

Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-ying Li Ning-Ning Zhao yi-xuan Geng Qian Han Jian-Ge Qiu Bing-Hua Jiang Zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer