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Striving For A New Growth Model

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China's Foreign Trade 2017年第6期 22-25页

作者： Zhiwei Zhang yi xiong Deutsche Bank

China will face some structural challenges in the next five years. Global interest rates will likely rise. The labor force in China is shrinldng. Property and infrastructure investments face constraints as growth is ... 详细信息

关键词： Striving A New Growth Mode

Privacy Preserving Discrete-Time Average Consensus by Injecting Edge-based Perturbations

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Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model

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作者： yi xiong Zhongkui Li College of Engineering Peking University

This paper aims to solve the privacy preserving average consensus problem for discrete-time multi-agent systems over balanced graphs. The main task is to design an algorithm that can guarantee average consensus and prevent agents’ initial state values from being disclosed in the meantime. To address the problem, a novel algorithm, which adds edge-based perturbations to the system, is proposed. At the first iteration, the proposed algorithm requires each agent to generate some designed perturbation signals and add them to the edges in the network. From the second iteration, all agents simply adopt a conventional average consensus protocol. A theoretical analysis of privacy preservation properties is then presented, which shows that our algorithm can prevent both internal honest-but-curious agents and external eavesdroppers from obtaining privacy. Finally, the effectiveness of the algorithm is demonstrated by a numeric simulation.

关键词： Privacy Preservation Average Consensus Edge-based Perturbations Multi-agent Systems

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Medicine in Novel Technology and Devices 2023年第2期18卷 267-271页

作者： Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello Zhidao Xia yi xiong Feihu Zhao Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering Faculty of Science&EngineeringSwansea UniversitySwanseaSA18ENUK Welsh Centre for Printing and Coating Faculty of Science and EngineeringSwansea UniversitySwanseaSA18ENUK Centre for Nanohealth Swansea University Medical School and Faculty of MedicineHealth and Life ScienceSwansea UniversitySwanseaSA35AUUK School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhen518055China

Mechanical stimulation,such as fluid-induced wall shear stress(WSS),is known that can influence the cellular ***,in some tissue engineering experiments in vitro,mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and *** 3D cell culturing,porous scaffolds are used for housing the *** is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor(such as perfusion bioreactor).To calculate the WSS generated on cells within scaffolds,usually computational fluid dynamics(CFD)simulation is ***,the limitations of the computational method for WSS calculation are:(i)the high time cost of the CFD simulation(in particular for the highly irregular geometries);(ii)accessibility to the CFD model for some cell culturing experimentalists due to the knowledge *** address these limitations,this study aims to develop an empirical model for calculating the WSS based on scaffold *** model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.

关键词： Wall shear stress Permeability Empirical model Tissue engineering scaffold Bioreactor

Effect of heat input on microstructure and mechanical properties of butt-welded dissimilar magnesium alloys joint

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Journal of Central South University 2018年第6期25卷 1358-1366页

作者： YANG Fang-zhou ZHOU Jie xiong yi-bo College of Materials Science and Engineering Chongqing UniversityChongqing 400044Chin The School of Robot Engineering and Mechanical-Electrical Engineering Chongqing University of Arts and SciencesChongqing 402168China ~ Central South University Press and Springer-Verlag GmbH Germanypart of Springer Nature 2018

The effects of heat input on the microstructures and mechanical properties of tungsten inert gas （TIG） butt-welded AZ31/MB3 dissimilar Mg alloys joint were investigated by microstructural observations, microhardness testing and tensile testing. The results reveal that with the increase of heat input, the width of welding seam increases obviously and the grains both in the fusion zone and the heat affected zone coarsen during TIG welding process. The tensile strength of butt-welded joint increases with the increase of heat input and the maximum joining strength of 242 MPa is obtained with wedding current of 90 A. However, lots of welding pores occur with the further increase of heat input, which results in the decrease of joining strength. It is experimentally demonstrated that robust joint can be obtained by TIG welding process.

关键词： magnesium alloy TIG welding microstructure mechanical property

Macroscopic analysis of time dependent plasticity in Ti alloys

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Journal of Materials Science & Technology 2022年第29期124卷 135-140页

作者： yi xiong Phani S.Karamched Chi-Toan Nguyen David M.Collins Christopher M.Magazzeni Edmund Tarleton Angus J.Wilkinson Department of Materials University of OxfordParks RoadOxford OX13PHUnited Kingdom Department of Materials and Processes Safran SASafran TechMany-les-Hameaux 78772France School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom Department of Engineering Science University of OxfordParks RoadOxford OX13PJUnited Kingdom

Cold dwell fatigue is the critical technological issue in Ti alloys used in the cooler front sections of aerospace jet *** subjected to a sustained load(stress dwell),the lifetime of these Ti components can be drastically reduced by as much as an order of magnitude[1–4].Without a clear understanding of the effect,safety concerns are raised.

关键词： alloys fatigue lifetime

Notch3 regulates the activation of hepatic stellate cells

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World Journal of Gastroenterology 2012年第12期18卷 1397-1403页

作者： yi-xiong Chen Zhi-Hong Weng Shu-Ling Zhang Depart-ment of Hepatology and Infectious Disease Union HospitalTongji Medical College Huazhong University of Science andTechnology Wuhan 430022 Hubei Province China

AIM： To investigate whether Notch signaling is involved in liver fibrosis by regulating the activation of hepatic stellate cells （HSCs）.METHODS： Immunohistochemistry was used to detect the expression of Notch3 in fibrotic liver tissues of patients with chronic active hepatitis. The expression of Notch3 in HSC-T6 cells treated or not with transforming growth factor （TGF）-β1 was analyzed by iramunofluorescence staining, The expression of Notch3 and myofibroblastic marker （z-smooth muscle actin （（z-SMA） and collagen 1 in HSC-T6 cells transfected with pcDNA3. I-N3ICD or control vector were detected by Western blotting and immunofluorescence staining. Moreover, effects of Notch3 knockdown in HSC-T6 by Notch3 siRNA were investigated by Western blotting and immunofluorescence staining.RESULTS： The expression of Notch3 was significantly up-regulated in fibrotic liver tissues of patients withchronic active hepatitis, but not detected in normal liver tissues. Active Notch signaling was found in HSC-T6 cells. TGF-β1 treatment led to up-regulation of Notch3 expression in HSC-T6 cells, and over-expression of Notch3 increased the expression of α-SMA and collagen I in HSC-T6 without TGF-β1 treatment. Interestingly, transient knockdown of Notch3 decreased the expression of myofibroblastic marker and antagonized TGF-β1 induced expression of α-SMA and collagen I in HSC-T6.CONCLUSION： Notch3 may regulate the activation of HSCs, and the selective interruption of Notch3 may provide an anti -fibrotic strategy in hepatic fibrosis.

关键词： Notch signaling Myofibroblast Liver fibrosis Hepatic stellate cells siRNA

Chiral transfer amidst one-dimensional linear polymers and twodimensional network covalent organic frameworks:Striking a fine balance between helicity and crystallinity

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Nano Research 2024年第6期17卷 5726-5734页

作者： Xinlin Zha Mengjuan Zuo Guilin Xu Zhong Yan Haining You yi xiong ying Liu yingying Li Liyan Yang Ke Liu Mufang Li Tao Zhao Dong Wang College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Key Laboratory of Textile Fiber and Products Ministry of EducationWuhan Textile UniversityWuhan 430200China

The current landscape of chiral covalent organic frameworks(COFs)predominantly centered on constructing asymmetric molecular-scale chirality,often introducing an inherent contradiction to the COF symmetry and limiting ***,we overcome these challenges by achieving chiral transfer between one-dimensional(1D)imine linear polymers(LPs)and two-dimensional(2D)networkβ-ketoenamine COFs composed of achiral *** successfully synthesize several 1D imine LPs with mesoscopic helical chirality,comprising achiral C2-symmetric terephthalaldehyde and diamine linkers in a chiral supramolecular transcription *** the irreversible tautomerism mechanism within the linker replacement approach,terephthalaldehyde(TPA)units in these helical 1D LPs are substituted with C3-symmetric 1,3,5-triformylphloroglucinol(TP),yielding the corresponding 2D networkβ-ketoenamine *** and helicity of the resultantβ-ketoenamine COFs intimately hinge on reaction conditions,including the aldehyde stoichiometry of Tp and TPA,as well as the quantity and concentration of the catalyst *** optimized conditions,the nucleation and growth were precisely governed,achieving a harmonious equilibrium of crystallinity and helicity within the generated 2D networkβ-ketoenamine COFs,even with covalent bond rupture,recombination,and topological transition(from[C2+C2]to[C3+C2]).Impressively,the ground state chirality inherent to helical 1D LPs seamlessly transfers to helical 2D networkβ-ketoenamine *** study not only offers new perspectives on the development of chiral functional COFs,but also provides fresh insights into the precise control of COFs'microscopic morphology.

关键词： chiral covalent organic frameworks chiral transfer dimensional transformation helicity

Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma

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Genes & Diseases 2023年第5期10卷 2137-2150页

作者： Yunyi Liu Juan Li Hailong Ou Dan Qi Bei Hu Yuxi Xu Jian Hu yi xiong Luling Xia Jason HHuang Xiaoxiao Hu Erxi Wu State Key Laboratory of Chemo/Biosensing and Chemometrics College of BiologyMolecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082China Shenzhen Research Institute Hunan UniversityShenzhenGuangdong 518000China Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTX 76508USA Department of Respiratory Medicine The Third Xiangya HospitalCentral South UniversityChangshaHunan 410013China Texas A&M University School of Medicine College StationTX 77843USA Texas A&M University School of Pharmacy College StationTX 77843USA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Greater Bay Area Institute for Innovation Hunan UniversityGuangzhouGuangdong 511300China

Aptamers,short single DNA or RNA oligonucleotides,have shown immense application potential as molecular probes for the early diagnosis and therapy of ***,conventional cell-SELEX technologies for aptamer discovery are time-consuming and *** we discovered a new aptamer BC-3 by using an improved rapid X-Aptamer selection process for human bladder carcinoma,for which there is no specific molecular probe *** show that BC-3 exhibited excellent affinity in bladder cancer cells but not normal *** demonstrate that BC-3 displayed high selectivity for tumor cells over their normal counterparts in vitro,in mice,and in patient tumor tissue *** endocytosis pathway analysis revealed that BC-3 internalized into bladder cancer cells via clathrin-mediated ***,we identified ribosomal protein S7(RPS7)as the binding target of BC-3 via an integrated methodology(mass spectrometry,colocalization assay,and immunoblotting).Together,we report that a novel aptamer BC-3 is discovered for bladder cancer and its properties in the disease are *** findings will facilitate the discovery of novel diagnostic and therapeutic strategies for bladder cancer.

关键词： Bladder cancer Cell-SELEX Clathrin-mediated endocytosis Intracellular colocalization Ribosomal protein S7 X-aptamer selections

GenomeSyn:a bioinformatics tool for visualizing genome synteny and structural variations

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Journal of Genetics and Genomics 2022年第12期49卷 1174-1176页

作者： Zu-Wen Zhou Zhi-Guang Yu Xiao-Ming Huang Jin-Shen Liu yi-xiong Guo Ling-Ling Chen Jia-Ming Song State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanningGuangxi 530004China College of Stomatology Guangxi Medical UniversityNanningGuangxi 530021China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubei 430070China

Advances in the next-generation and long-read sequencing technologies have promoted the development of genome-wide comparative genomics analysis,and constructing pangenomes and identifying structural variations(SVs)are becoming the frontier of *** genomics is of critical importance for determining the gene function and the evolutionary basis of traits.

关键词： traits Genome structural