检索结果-南通市图书馆

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

引用

Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： Hongfeng Guo Qihang Sun Xiaoli Huang Xiaohao Wang Feng Zhang wenzheng Qu Jinling Liu Xuejun Cheng Qiang Zhu wen yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy ***,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains *** have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain ***8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,***,Fut8 deficiency impairs learning and memory in ***,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of *** of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to *** levels of Itga6 inhibit the activity of the PI3K/Akt signaling ***,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 *** summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of Fe-As alloys by mechanical alloying and vacuum hot-pressed sintering:microstructure evolution,mechanical properties,and mechanisms

引用

Rare Metals 2024年第8期43卷 3876-3892页

作者： Fei Chai Fei-Ping Zhao Zhan Hu Shi-yi wen Ben-Hammouda Samia Ze-Lin Fu Xin-Ting Lai Yan-Jie Liang Xiao-Bo Min Li-Yuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Institute of Environmental EngineeringCentral South UniversityChangsha 410083HunanChin State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Building Civiland Environmental EngineeringConcordia UniversityMontreal H3G 1M8Canada

Arsenic materials have attracted great attention due to their unique ***,research concerning iron-arsenic(Fe-As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of ***,a new Fe-As alloy was obtained by mechanical alloying(MA) followed by vacuum hot-pressed sintering(VHPS).Moreover,a systematic study was carried out on the microstructural evolution,phase composition,leaching toxicity of As,and physical and mechanical properties of Fe-As alloys with varying weight fractions of As(20%,25%,30%,35%,45%,55%,65%,and 75%).The results showed that pre-alloyed metallic powders(PAMPs) have a fine grain size and specific supersaturated solid solution after MA,which could effectively improve the mechanical properties of Fe-As alloys by VHPS.A high density(> 7.350 g·cm^(-3)),low toxicity,and excellent mechanical properties could be obtained for FeAs alloys sintered via VHPS by adding an appropriate amount of As,which is more valuable than commercial Fe-As *** Fe-25% As alloy with low toxicity and a relatively high density(7.635 g·cm^(-3)) provides an ultra-high compressive strength(1989.19 MPa),while the Fe-65% As alloy owns the maximum Vickers hardness(HVo.5 899.41).After leaching by the toxicity characteristic leaching procedure(TCLP),these alloys could still maintain good mechanical performance,and the strengthening mechanisms of Fe-As alloys before and after leaching were *** in the grain size,micro structure,and phase distribution induced significant differences in the compressive strength and hardness.

关键词： Mechanical alloying Vacuum hot-pressed sintering High-pressure Arsenic-iron alloys Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevalence of hypertension and its associations with body composition across Chinese and American children and adolescents

引用

World Journal of Pediatrics 2024年第4期20卷 392-403页

作者： Li-Wang Gao yi-wen Huang Hong Cheng Xi Wang Hong-Bo Dong Pei Xiao yin-Kun Yan Xin-ying Shan Xiao-Yuan Zhao Jie Mi Center for Non-Communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56 Nanlishi RoadXicheng DistrictBeijing100045China Department of Epidemiology Capital Institute of PediatricsNo.2 Yabao RoadChaoyang DistrictBeijing100020China Key Laboratory of Major Diseases in Children Ministry of EducationBeijingChina

Background The age of onset of hypertension(HTN)is decreasing,and obesity is a significant risk *** prevalence and racial disparities in pediatric HTN and the association between body composition and blood pressure are insufficiently *** study aimed to evaluate the prevalence of HTN in Chinese and American children and adolescents and to assess the relationship between various body composition indices and *** Seven thousand,five hundred and seventy-three Chinese and 6239 American children and adolescents aged 8–18 years from the 2013–2015 China Child and Adolescent Cardiovascular Health study and the 2011–2018 National Health and Nutrition Examination Surveys were *** pressure and body composition(fat and muscle)were measured by trained *** crude prevalence and age-standardized prevalence rate(ASPR)of primary HTN and its subtypes[isolated systolic hypertension(ISH)and isolated diastolic hypertension(IDH)]were calculated based on 2017 American Academy of Pediatrics ***-adjusted linear regression coefficients and odds ratios(ORs)were calculated to assess the associations of body composition indicators with HTN,ISH and *** The ASPR of HTN was 18.5%in China(CN)and 4.6%in the United States(US),whereas the obesity prevalence was 7.4%and 18.6%,and the population attributable risk of HTN caused by overweight and obesity was higher in the US than in *** fat mass,muscle mass and body fat percentage mass were associated with a higher risk of HTN in both *** percent of muscle body mass had a protective effect on HTN and ISH in both countries[HTN(CN:OR=0.83,95%CI=0.78–0.88;US:OR=0.72,95%CI=0.64–0.81);ISH(CN:OR=0.87,95%CI=0.80–0.94;US:OR=0.71,95%CI=0.62–0.81)],and the protective effect was more common among children and adolescents with high levels of physical *** The burden of HTN in Chinese children and adolescents was substantial and much greater than that in the US,and th

关键词： Body composition Children and adolescents China Child and Adolescent Cardiovascular Health Hypertension National Health and Nutrition Examination Surveys

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimization of extreme ultraviolet vortex beam based on high harmonic generation

引用

Chinese Physics B 2024年第5期33卷 459-464页

作者：肖礴赵逸文程方晶王革文姜威王一琛胡杰梁红静马日 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China College of Science Jilin Institute of Chemical TechnologyJilin 132022China

In high harmonic generation(HHG),Laguerre–Gaussian(LG) beams are used to generate extreme ultraviolet(XUV)vortices with well-defined orbital angular momentum(OAM),which have potential applications in fields such as microscopy and *** experimental study on the HHG driven by vortex and Gaussian beams is conducted in this *** is found that the intensity of vortex harmonics is positively correlated with the laser energy and gas *** structure and intensity distribution of the vortex harmonics exhibit significant dependence on the relative position between the gas jet and the laser *** ring-like structures observed in the vortex harmonics,and the interference of quantum paths provide an explanation for the distinct structural ***,by adjusting the relative position between the jet and laser focus,it is possible to discern the contributions from different quantum *** optimization of the HH vortex field is applicable to the XUV,which opens up a new way for exploiting the potential in optical spin or manipulating electrons by using the photon with tunable orbital angular momentum.

关键词： high harmonic generation phase matching extreme ultraviolet vortex beam quantum path interference

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

带有整体单极的Reissner-Nordstrom-AdS黑洞在扩展相空间中的霍金辐射

引用

物理学报 2024年第2期73卷 104-111页

作者：韩亦文胡成洪云重庆工商大学物理系重庆400067 成都东软学院基础教学学院成都611844

本文研究了带有整体单极的Reissner-Nordstrom-AdS黑洞在扩展相空间中出射粒子的量子隧穿辐射过程.其中,将宇宙学参数视为动态变量而不同于之前研究工作中将其视为常数而忽略其贡献.具体地,在计算出射粒子隧穿率时将宇宙学参数引入计算... 详细信息

本文研究了带有整体单极的Reissner-Nordstrom-AdS黑洞在扩展相空间中出射粒子的量子隧穿辐射过程.其中,将宇宙学参数视为动态变量而不同于之前研究工作中将其视为常数而忽略其贡献.具体地,在计算出射粒子隧穿率时将宇宙学参数引入计算并将其解释为热力学压强.计算结果表明,出射粒子的隧穿率与粒子出射前后黑洞的贝肯斯坦-霍金熵差成正比,辐射谱偏离了纯热谱,该结果与将宇宙学参数视为常数的情况完全相同.这意味着在扩展相空间中可以得到粒子的隧穿概率,并且隧穿过程不依赖于热力学状参量,这一工作自然地进一步将霍金辐射推广到了带有整体单极Reissner-Nordstrom-AdS黑洞扩展相空间中.结果表明,整体单极子尽管影响粒子的动力学行为和热力学量,但并不影响熵变和隧穿率.

关键词：霍金辐射宇宙学参数热力学压强整体单级

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国新型城镇化的合理均衡和实施路径

引用

财经理论与实践 2024年第5期45卷 90-97页

作者：文艺湘潭大学商学院湖南湘潭411105

农村剩余劳动力和农村人口向城镇的转移是城镇化的表征之一。城乡劳动生产率或劳均收入的均衡在根本上决定了合理的城镇化率。依据城乡人口迁移模型和国家统计局数据,根据调整后的城乡收入均衡条件计算得到中国合理城镇化率为84%左右,... 详细信息

农村剩余劳动力和农村人口向城镇的转移是城镇化的表征之一。城乡劳动生产率或劳均收入的均衡在根本上决定了合理的城镇化率。依据城乡人口迁移模型和国家统计局数据,根据调整后的城乡收入均衡条件计算得到中国合理城镇化率为84%左右,大致相当于已完成城镇化国家的中等水平;结合城镇化内在统一于经济发展过程的规律分析,到21世纪中叶我国可以基本完成城镇化进程。新型城镇化本质上要求实现城镇化与经济发展阶段的适应匹配,要着力促进城乡产业发展、就业和收入均衡,完善城乡公共基础设施和公共服务,优化城镇空间布局体系,加强宜居环境建设和历史文化保护,走高质量的新型城镇化道路。

关键词：新型城镇化合理城镇化水平城乡一体化中国式现代化

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elliptically polarized high-order harmonic generation of Ar atom in an intense laser field

引用

Chinese Physics B 2024年第5期33卷 453-457页

作者：胡杰王一琛景秋霜姜威王革文赵逸文肖礴梁红静马日 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China College of Science Jilin Institute of Chemical TechnologyJilin 132022China

High-order harmonic generation(HHG) of Ar atom in an elliptically polarized intense laser field is experimentally investigated in this ***,the anomalous ellipticity dependence on the laser ellipticity(ε) in the lower-order harmonics is observed,specifically in the 13rd-order,which displays a maximal harmonic intensity at ε ≈ 0.1,rather than at ε = 0 as *** contradicts the general trend of harmonic yield,which typically decreases with the increase of laser *** this study,we attribute this phenomenon to the disruption of the symmetry of the wave function by the Coulomb effect,leading to the generation of a harmonic with high *** finding provides valuable insights into the behavior of elliptically polarized harmonics and opens up a potential way for exploring new applications in ultrafast spectroscopy and light–matter interactions.

关键词： high-order harmonic generation Coulomb effect elliptically polarized intense laser field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

子宫肌瘤和子宫腺肌病聚焦超声消融手术术后中医辨证治疗

引用

中国实用妇科与产科杂志 2024年第9期40卷 908-912页

作者：文怡成都中医药大学附属医院四川成都610072

聚焦超声消融手术(focused ultrasound ablation surgery,FUAS)治疗子宫肌瘤和子宫腺肌病的疗效确切,已广泛应用于临床。由于这两种疾病的特点,使得所有保留子宫的治疗均存在复发可能,术后的药物联合治疗和长期管理尤为重要。目前,在FUA... 详细信息

聚焦超声消融手术(focused ultrasound ablation surgery,FUAS)治疗子宫肌瘤和子宫腺肌病的疗效确切,已广泛应用于临床。由于这两种疾病的特点,使得所有保留子宫的治疗均存在复发可能,术后的药物联合治疗和长期管理尤为重要。目前,在FUAS术后除了常配合使用促性腺激素释放激素激动剂(GnRH-a)、左炔诺孕酮宫内缓释系统(LNG-IUS)或地诺孕素外,中医药干预也显示了其疗效优势。文章就中医药在子宫肌瘤和子宫腺肌病FUAS术后的应用进行阐述及讨论。

关键词：聚焦超声消融手术中医药子宫肌瘤子宫腺肌病

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

引用

International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li Sheng-Mei Zhou Ling-Yu Zhang An-Ni Lin Yang Zhang Jing Jiang Xin Che yi-wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMI<25.00 kg/m^(2)),the overweight group(25.00≤BMI<30.00 kg/m^(2)),and the obesity group(BMI≥30.00 kg/m^(2)).The one-way ANOVA and the Chi-square test were used for ***’s correlation analysis was used to evaluate the relationships between the measured ***:This research covered the left eyes of 3 groups of 434 age-and sex-matched subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

音乐疗法干预焦虑的作用机制

引用

中国临床心理学杂志 2024年第3期32卷 711-716页

作者：周子涵潘文谊邱依雯李红雷怡四川师范大学脑与心理科学研究院成都610000 深圳大学心理学院深圳518000 华南师范大学心理学院广州510000

焦虑是当代人普遍面临的情绪问题,音乐疗法可以有效缓解焦虑。通过系统回顾相关研究,本文首先阐述了音乐材料与治疗方式对音乐疗法的焦虑干预效果的影响,随后,基于影响因素,从生理、认知神经和社会沟通三个方面提出假说,试图揭示音乐疗... 详细信息

焦虑是当代人普遍面临的情绪问题,音乐疗法可以有效缓解焦虑。通过系统回顾相关研究,本文首先阐述了音乐材料与治疗方式对音乐疗法的焦虑干预效果的影响,随后,基于影响因素,从生理、认知神经和社会沟通三个方面提出假说,试图揭示音乐疗法干预焦虑的作用机制。未来研究应进一步探索不同音乐治疗类型对不同焦虑亚型的疗效差异,注重音乐治疗与其他治疗手段的结合以及关注青少年焦虑群体音乐治疗的特殊性。

关键词：焦虑音乐疗法机制

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：