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Mechanisms of secondary degeneration after partial optic nerve transection

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Neural Regeneration Research 2014年第6期9卷 565-574页

作者： Hong-ying Li yi-Wen ruan Chao-Ran Ren Qi Cui Kwok-Fai So Department of Ophthalmology the University of Hong Kong State Key Laboratory of Brain and Cognitive Science the University of Hong Kong GHM Institute of CNS Regeneration Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University

Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associated with secondary degeneration including apoptosis, necrosis, autophagy, oxidative stress, excitotoxicity, derangements in ionic homeostasis and calcium influx. Glial cells, such as microglia, astrocytes and oligodendrocytes, have also been demon- strated to take part in the process of secondary injury. Partial optic nerve transection is a useful model which was established about 13 years ago. The merit of this model compared with other optic nerve injury models used for glaucoma study, including complete optic nerve transection model and optic nerve crush model, is the possibility to separate primary degeneration from secondary degeneration in location. Therefore, it provides a good tool for the study of secondary degeneration. This review will focus on the research progress of the mechanisms of secondary degeneration using partial optic nerve transection model.

关键词： secondary degeneration partial injury optic nerve oxidative stress excitotoxicity calci-um overload mitochondrion macrophage astrocyte oligodendrocyte

Effects of Branched-chain Amino Acids on Nutritional Metabolism and Pharmacoeconomics in Patients with Severe Abdominal Trauma

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Current Medical Science 2021年第5期41卷 894-900页

作者： Bin XU Di WU Jiang-xia XIANG ying ZHANG yi ruan Xiao CHEN Department of Nuclear Medicine Chongqing University Central HospitalChongqing 400014China Department of Pharmacy Chongqing University Central HospitalChongqing 400014China Department of Traumatology Chongqing University Central HospitalChongqing 400014China

Objective:To observe the influences of branched-chain amino acids(BCAAs)on nutrition metabolism and prognosis of patients with severe abdominal trauma;at the same time,to analyze and evaluate the pharmacoeconomics of ***:A total of 75 severe abdominal trauma patients were recruited from June 2016 to December 2017 and randomly divided into control group and observation *** surgery and basic treatment,parenteral nutrition support therapy with iso-nitrogen and iso-calorie of both groups was ***,an equivalent of 8.5%(18AA-Ⅱ)and 10%(20AA)compound AA injection was administrated to the control and observation groups,*** nitrogen balance,serum protein level and plasma amino spectrum of the patients were observed before and after ***,the hospital stay,survival rate,complications,adverse reactions and hospitalization costs were also ***:After a 7-day course treatment,the nitrogen balance level of the two groups was significantly improved,but no significant difference was found between *** addition,the serum protein level and plasma amino spectrum of the two groups was generally improved when compared to before *** with the control group,the level of albumin and transferrin in the observation group was improved significantly after treatment,while no difference in plasma amino spectrum was found between the two ***,the cost analysis showed remarkably reduced hospitalization costs in the observation ***:To a certain degree,BCAAs could improve the nutritional metabolism and prognosis of patients with severe abdominal trauma,and have good cost-effectiveness.

关键词： branched-chain amino acids severe abdominal trauma nutrition metabolism prognosis pharmacoeconomics

Investigation of multiple metal nanoparticles near-field coupling on the surface by discrete dipole approximation method

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Optoelectronics Letters 2021年第5期17卷 257-261页

作者： yin Ping Lin Qiang ruan yi Chen Jing-jing Zhejiang Provincial Key Laboratory&Collaborative Innovation Center for Quantum Precision Measurement College of ScienceZhejiang University of TechnologyHangzhou310023China College of Computer Science and Technology Zhejiang UniversityHangzhou310001China College of Zhijiang Zhejiang University of TechnologyShaoxing312000China

We use the method of discrete dipole approximation with surface interaction to construct a model in which a plurality of nanoparticles is arranged on the surface of BK7 glass. Nanoparticles are in air medium illuminated by evanescent wave generated from total internal reflection. The effects of the wavelength, the polarization of the incident wave, the number of nanoparticles and the spacing of multiple nanoparticles on the field enhancement and extinction efficiency are calculated by our model. Our work could pave the way to improve the field enhancement of multiple nanoparticles systems.

关键词： Investigation of multiple metal nanoparticles near-field coupling on the surface by discrete dipole approximation method

Pressure dependent modulation instability in photonic crystal fiber filled with argon gas

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Chinese Physics B 2018年第9期27卷 338-341页

作者： He-Lin Wang Ai-Jun Yang XiaoLong Wang Bin Wu yi ruan Center for Optics ＆ Optoelectronics Research Zhefiang University of TechnologyHangzhou 310023China College of Science Zhefiang University of TechnologyHangzhou 310023China

By using the designed photonic crystal fiber filled with argon gas, the effect of gas pressure on modulation instability（MI） gain is analyzed in detail. The MI gain bandwidth increases gradually as the argon gas pressure rises from 1 P0 to 400 P0（P0 is one standard atmosphere）, while its gain amplitude slightly decreases. Moreover, the increase of the incident light power also results in the increase of MI gain bandwidth in the Stokes or anti-Stokes region when the incident power increases from 1 W to 200 W. Making use of the optimal parameters including the higher argon gas pressure（400 P0） and the incident light power（200 W）, we finally obtain a 100 nm broadband MI gain. These results indicate that controlling the MI gain characteristic by changing the argon gas pressure in PCF is an effective way when the incident light source is not easy to satisfy the requirement of practical application. This method of controlling MI gain can be used in optical communication and laser shaping.

关键词： modulation instability gas pressure light power.broadband gain

Core muscle functional strength training for reducing the risk of low back pain in military recruits:An open-label randomized controlled trial

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Journal of Integrative Medicine 2022年第2期20卷 145-152页

作者： Xin Wang Wen-juan Song yi ruan Bing-chu Li Can Lü Nian Huang Fan-fu Fang Wei Gu School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Rehabilitation Changhai HospitalNaval Medical UniversityShanghai 200433China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Background:Core muscle functional strength training(CMFST)has been reported to reduce injuries to the lower ***,no study has confirmed whether CMFST can reduce the risk of low back pain(LBP).Objective:This study identified the effects of CMFST on the incidence of LBP in military ***,setting,participants and intervention:We performed a prospective,open-label,randomized,controlled study in a population of young healthy male naval recruits from a Chinese basic combat training *** were randomly assigned to either the core group or the control *** additional to normal basic combat training,recruits in the core group underwent a CMFST program for 12 weeks,while recruits in the control group received no extra *** outcome measures:At the beginning of the study and at the 12 th week,the number of participants with LBP was counted,and lumbar muscle endurance was *** addition,when participants complained of LBP,they were assessed using the visual analog scale(VAS)and Roland Morris Disability Questionnaire(RMDQ).Results:A total of 588 participants were included in the final analysis(295 in the core group and 293 in the control group).The incidence of LBP in the control group was about twice that of the core group over the 12-week study(20.8%vs 10.8%,odds ratio:2.161–2.159,P<0.001).The core group had better lumbar muscle endurance at 12 weeks than the control group([200.80±92.98]s vs[147.00±84.51]s,P<0.01).There was no significant difference in VAS score between groups,but the core group had a significantly lower RMDQ score at week 12 than the control group(3.33±0.58 vs 5.47±4.41,P<0.05).Conclusion:This study demonstrated that the CMFST effectively reduced the incidence of LBP,improved lumbar muscle endurance,and relieved the dysfunction of LBP during basic military training.

关键词： Low back pain Core exercise Recruits Randomized controlled trial

Quantitative analysis of early diabetic retinopathy based on optical coherence tomography angiography biological image

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World Journal of Clinical Cases 2021年第25期9卷 7365-7371页

作者： Yan Shi Peng-Yao Lin yi-Meng ruan Cheng-Fei Lin Shan-Shan Hua Bo Li Department of Ophthalmology Ningbo First HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND With the development of the economy and improvements in living standards,the incidences of diabetes mellitus(DM)and diabetic retinopathy(DR),which is a complication of DM,are on the *** To analyze early DR in patients with macular zone changes in biological images using optical coherence tomography angiography METHODS A prospective case study was performed on 59 participants:35 healthy eyes(control group),35 eyes with diabetes but no DR group(no DR group),and 35 eyes with mild DR(NPDR group).All quantitative comparisons of parameters,including the fovea vascularity area,circularity index,and vascular complexity parameters,were performed using a biological image analysis *** The foveal avascular zone(FAZ)area,FAZ circularity index,number of branches in the area,and the total of the single branches’length in the area was 0.366±0.031,0.834±0.037,3241.8±268.3,and 3.860×107±0.194×107,and 0.421±0.030,0.739±0.023,2956.6±476.4,and 3.177×107±0.161×107 in the no DR group and the NPDR group,respectively,which were significantly different from the corresponding parameters of the control group(P<0.05).Moreover,there were significant differences between these two groups(P<0.05).CONCLUSION This study shows that early microcirculation changes in the macular area of the retina is associated with disease *** changes in DR can be analyzed using optical coherence tomography angiography.

关键词： Optical coherence tomography angiography Quantitative analysis Diabetic retinopathy

Knowledge about, attitude and acceptance towards, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern China: A cross-sectional survey

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Journal of Integrative Medicine 2022年第1期20卷 34-44页

作者： Jing Hong Xiao-wan Xu Jing Yang Jing Zheng Shu-mei Dai Ju Zhou Qing-mei Zhang yi ruan Chang-quan Ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Integrative Oncology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Oncology The Fint Affiliated HospitalBengbu Medical CollegeBengbu 233010Anhui ProvinceChina Department of Nursing Fuyang Cancer HospitalFuyang 236000Anhui ProvinceChina Department of Cardiac Rehabilitation Shanghai First Rehabilitation HospitalShanghai 200090China Department of Radiation Oncology Anhui Chest HospitalHefei 230022Anhui ProvinceChina Department of Anesthesiology Chaohu HospitalAnhui Medical UniversityHefei 238000Anhui ProvinceChina

Objective: The coronavirus disease 2019(COVID-19) pandemic has had a serious impact on health all over the world. Cancer patient, whose immunity is often compromised, faces a huge ***, some COVID-19 vaccines are being developed and applied on general population;however,whether cancer patients should take COVID-19 vaccine remains unknown. Our study aimed to explore the knowledge, attitude, acceptance, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern ***: A cross-sectional study was conducted in Eastern China from June 17 th to September 3 rd, *** were selected using a convenience sampling method. A self-report questionnaire was developed to assess knowledge about the COVID-19 vaccine, attitude towards the vaccine and acceptance of the vaccine;following a review of similar studies previously published in the scientific literature, multivariate logistic regression analysis was used to determine the predictors associated with COVID-19 vaccine ***: A total of 2158 cancer patients were enrolled in this study. The rate of vaccine hesitancy was 24.05%(519/2158);further, among the participants of vaccine acceptance, 767 had taken COVID-19 vaccine(35.54%), and 872 were willing to get vaccinated(40.01%). A total of 24 variables including demographic characteristics, clinical status of cancer, impact of COVID-19 pandemic on study participants,patients’ knowledge about the COVID-19 vaccine, and attitude towards the vaccine, had significant differences between the ‘‘vaccine hesitancy" population and ‘‘vaccine acceptance" *** logistic regression analysis indicated that parameters including alcohol consumption(odds ratio [OR] = 1.849;95% confidence interval [CI]: 1.375–2.488;P-reference [P-Ref] < 0.001 vs nondrinkers), income impacted by COVID-19 pandemic(OR = 1.930, 2.037 and 2.688 for mild, moderate,and severe impact, respectively;all P-Ref < 0.01 vs no impact), know

关键词： COVID-19 Cancer Vaccine Knowledge Attitude Predictors Intention Vaccine hesitancy

无电网电压传感器的直驱式风力发电系统建模及控制

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高电压技术 2010年第5期36卷 1287-1292页

作者：杨勇阮毅苏州大学城市轨道交通学院苏州215021 上海大学机电工程与自动化学院上海200072

直驱式风力发电系统使风力机与发电机之间直接相连,提高系统效率和可靠性。为此,采用了back-back的双PWM拓扑结构。机侧变换器采用间接转矩矢量控制,通过调节永磁同步发电机的转速,实现风能的最大跟踪;为了提高网侧并网逆变器的可靠性... 详细信息

直驱式风力发电系统使风力机与发电机之间直接相连,提高系统效率和可靠性。为此,采用了back-back的双PWM拓扑结构。机侧变换器采用间接转矩矢量控制,通过调节永磁同步发电机的转速,实现风能的最大跟踪;为了提高网侧并网逆变器的可靠性和抗电网电压波动,同时进一步降低并网逆变器的成本,提出了一种基于锁相环和虚拟电网磁链的无电网电压传感器的控制策略,并应用于直驱式风力发电系统中。仿真结果表明该控制策略实现了最大风能跟踪和并网逆变器功率因数为1的控制,从而验证了该方案的可行性和正确性。

关键词：直驱式间接转矩矢量控制锁相环虚拟电网磁链并网逆变器最大风能跟踪

Cytotoxic Diarylheptanoids from Pericarps of Juglans Cathayensis Dode

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Chemical Research in Chinese Universities 2008年第4期24卷 427-429页

作者： LI yi-xiu ruan Han-li ZHOU Xue-feng ZHANG Yong-hui PI Hui-fang WU Ji-zhou Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 P R. China

A novel diarylheptanoid, named Jugcathanin（1）, along with two known diarylheptanoids（2,3）, were isolated from the fresh pericarps ofduglans Cathayensis Dode. A known triterpene（4） and a known aphthaoquinone（5） were also isolated from the plant. Their structures were elucidated on the basis of spectroscopic studies. All the compounds exhibited moderate cytotoxicities against human Hela, HepG2, and HL-60 cell lines.

关键词： duglans Cathayensis Dode Jugcathanin Antitumor activity