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Clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer

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Asian Journal of Andrology 2019年第2期21卷 131-136页

作者： Guo-Wen Lin Gao-Xiang Li Bo Dai Ding-Wei Ye Yun-yi kong Yue Wang yi-Jun Shen Department of Urology Fudan University Shanghai Cancer CenterShanghai 20032China Department of Oncology Fudan University Shanghai Medical CollegeShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castratio n-resista nt prostate can cer(mCRPC).A total of 146 patie nts with docetaxel-naive group(103 cases)and docetaxel-resista nt group(43 cases)were en rolled from the Sha nghai Cancer Center(Sha nghai,Chin a)in this retrospective cohort *** efficacy endpoints were prostate-specific antigen response rate,prostate-specific antigen progress!on-free survival,clinical/radiographic progression-free survival,and overall survival in response to abiraterone plus *** higher prostate-specific antigen response rate was found in docetaxel-naive group(54.4%,56/103)compared to docetaxel-resistant group(34.9%,15/43)(P=0.047).In addition,significantly higher median prostate-specific antigen progress!on-free survival(14.0 vs 7.7 months,P=0.005),clinical or radiographic progression-free survival(17.0 vs 12.5 months,P=0.003),and overall survival(27.0 vs 18.0 mon ths,P=0.016)were found in docetaxel-naTve group compared to docetaxel-resistant group,*** univariate and multivariate analyses indicated that lower albumin and visceral metastases were independent significant predictors for shorter overall *** sum up,our data suggested that abiraterone plus prednisone was efficient in both docetaxel-naTve and docetaxel-resistant Chinese ***,higher PSA response rate and longer overall survival were observed in the docetaxel-naTve group,which suggested that abiraterone was more effective for docetaxel-naive patients than for docetaxel failures.

关键词： abiraterone acetate castration-resistant prostate cancer clinical activity docetaxel-naive docetaxel-pretreated

Real-Time Slab Quality Diagnosis and Analysis System Based on Solidification Mechanism

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Journal of Iron and Steel Research International 2013年第12期20卷 40-46页

作者： FENG Ke WANG Shui-gen HAN Zhi-wei kong yi-wen CAO Jian-feng CISDI Research and Development Co. Ltd. Continuous Casting Department CISDI Engineering Co.Ltd.

According to the two types of slab defects （surface crack and internal crack）, a real-time slab quality diag nosis and analysis system named CISDI_SQDS ONLINE R2011 was developed based on heat transfer and solidifica tion simulation, stress and strain calculation as well as metallurgical process analysis about continuous casting, com- bined with expert knowledge database for specific casting events. The respective crack formation indexes were intro duced as the theoretical reference data for slab quality level evaluation. Meanwhile, both the quality loss factors relat ed to casting metallurgical rules and the adjusting factors related to casting events were taken into full consideration, which was integrated organically with theoretical analysis and expert system. The system can be widely used as an important theoretical tool for prediction and control of slab quality in slab continuous casting process.

关键词： slab continuous casting internal crack surface crack quality diagnosis

Leonurine: From Gynecologic Medicine to Pleiotropic Agent

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Chinese Journal of Integrative Medicine 2020年第2期26卷 152-160页

作者： LI Yun-yun LIN yi-kong LIU Xin-hua WANG Li YU Min LI Da-jin ZHU yi-zhun DU Mei-rong NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research) Hospital of Obstetrics and Gyn ecologyFuda n Un iversity Sha nghai Medical CollegeShanghai(200011)China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai(200011)China Shanghai Key Laboratory of Bioactive Small Molecules Department of PharmacologySchool of PharmacyFudan UniversityShanghai(201203)China State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy Macao Un iversity of Science and Tech no logyMacao SARChina

Leonurus japonicus Houtt,a Chinese traditional herbal medicine,has been widely used to cure gynecological diseases,such as incomplete abortion and ***,a major active alkaloid compound only be found in Leonurus japonicus Houtt,has been successfully extracted and *** evidence has shown that leonurine can regulate a variety of pathologic processes including oxidative stress,inflammation,fibrosis,apoptosis,and multiple metabolic ***,we have reviewed the pharmacological actions and biological functions of leonurine,with a focus on the role of leonurine in the amelioration of various pathological *** into the related signaling pathways and molecular mechanisms have strengthened our understanding on the function of leonurine in the alleviation of multiple pathological *** summary of the existing researches should help direct future research into the basic science and clinical applications in related diseases.

关键词： leonurine Leonurus japonicus Houtt Chinese medicine oxidative stress inflammation fibrosis clinical application

Factors influencing biochemical recurrence in patients who have received salvage radiotherapy after radical prostatectomy： a systematic review and meta-analysis

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Asian Journal of Andrology 2017年第4期19卷 493-499页

作者： Zhong-Wei Jia Kun Chang Bo Dai Yun-yi kong Yue Wang Yuan-Yuan Qu yi-Ping Zhu Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Fudan University Shanghai Medical College Shanghai China Department of Pathology Fudan University Shanghai Cancer Center Shanghai China

Several studies have evaluated the risk factors influencing biochemical recurrence （BCR） of prostate cancer in patients receiving salvage radiotherapy （SRT） for BCR after radical prostatectomy （RP）, but the results remain conflicting. In this study, we performed a meta-analysis to resolve this conflict. We searched the following databases： PubMed, Embase, and Web of Science using the following terms in ＂All fields＂：＂salvage radiation therapy,＂＂salvage IMRT, S-IMRT, salvage radiotherapy, SRT, radical prostatectomy,＂＂RP, biochemical recurrence,＂＂BCR,＂＂biochemical relapse.＂ Eleven studies, with a total of 1383 patients, were included in our meta-analysis. Of all the variables, only Gleason score （GS）〉7 （odds ratio [OR]： 3.82; 95% confidence interval [CI]： 2.60-5.64） and pathological tumor （pT） stage 〉3a （OR： 1.82; 95% Ch 1.36-2.42） were positively correlated with BCR. However, SRT combined with androgen deprivation therapy （ADT）（OR： 0.63; 95% CI： 0.44-0.90） and radiation therapy （RT） dose 〉64 Gy （OR： 0.35; 95% CI： 0.19-0.64） were negatively correlated with BCR. Perineural invasion （OR： 2.64; 95% CI： 1.11-6.26）, preoperative prostate-specific antigen （PSA）〉10 ng m1-1 （OR： 1.36; 95% CI： 0.94-1.96）, positive surgical margin （OR： 0.92; 95% Ch 0.7-1.19）, and seminal vesicle involvement （SVI）（OR： 1.09; 95% Ch. 0.83-1.43） had no effect on BCR. Our meta-analysis indicated that pT stage, GS, RT dose, and SRT combined with ADT may influence BCR, while preoperative PSA, surgical margin, perineural invasion, and SVI have only a weak effect on BCR.

关键词： biochemical recurrence prostate cancer radical prostatectomy risk factors salvage radiotherapy

High-temperature Thermo-oxidative Aging of Vulcanized Natural Rubber Nanocomposites:Evolution of Microstructure and Mechanical Properties

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Chinese Journal of Polymer Science 2023年第8期41卷 1287-1297,I0010页

作者： Zhou-Xian Li yi-Ran kong Xiang-Fei Chen Ya-Jiang Huang Ya-Dong Lv Guang-Xian Li College of polymer science and engineering State key laboratory of polymer materials engineering of ChinaSichuan UniversityChengdu 610065China

The aging of natural rubber(NR)at high temperatures will seriously affect its service lifetime in many key *** the present work,the changes in microstructure and mechanical properties of semi-efficient vulcanized NR/carbon black(CB)vulcanizates during thermooxidative aging at high temperatures(150-200℃)and a moderate temperature(95℃)were *** high temperatures,a two-stage aging behavior,which was characteristic of a first rapid decline and then a continuous rise in the crosslinking density(ve),was identified and was found to be closely related to the depletion behavior of *** surface cracking behavior observed in the second stage of high-temperature aging was discussed in terms of the grafting reaction of macromolecular radicals on CB particles and thermal *** contrast,the aging of NR at moderate temperatures was much mild,which featured a continuous increase in ve and an oxidation mechanism dominated by peroxy radicals attacking double *** general,the mechanical properties of NR vulcanizates during high-temperature aging depended on the competition effects of structural evolution in the crosslinked network and oxidation-induced chain scission.

关键词： Natural rubber nanocomposites High-temperature Thermo-oxidative aging

The Genus Alpinia:A Review of Its Phytochemistry and Pharmacology

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World Journal of Traditional Chinese Medicine 2016年第1期2卷 26-41页

作者： Wei-Jie Zhang Jian-Guang Luo Ling-yi kong State Key Laboratory of Natural Medicines Department of Natural Medicinal Chemistry China Pharmaceutical University Department of Natural Medicinal Chemistry China Pharmaceutical University

Genus Alpinia consists of over 250 species, which are widely distributed in south and southeast Asia. Many plants of genus Alpinia have been used for thousands of years to treat digestive system diseases and as anti-inflammatory drugs. Phytochemical research on this genus has led to the isolation of different kinds of diarylheptanoids, terpenes triterpenoids, phenylbutanoids, lignans, and flavonoids. Experimental evidences revealed that both the crude extracts and pure constituents isolated from the genus Alpinia exhibit a wide range of bioactivities such as anticancer, anti-oxidant, anti-bacterial, anti-viral, cardiovascular, and digestive system protective effects. Here, we summarize the phytochemistry and pharmacology investigation of the genus Alpinia, which can provide reference for further research and drug development.

关键词： Genus Alipinia phytochemistry pharmacology a review

Microstructure and thermal expansion of copper-based amorphous alloys during structural relaxation

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China Foundry 2020年第1期17卷 8-14页

作者： Jin-bei Zhao Xin-hui Fan Bing Li Ke Yang yi-long kong Zhao Wang College of Materials and Chemical Engineering Xi’an Technological University

(Cu43Zr48Al9)98Y2 amorphous alloy bar was prepared by the arc melting copper mold absorption casting method,and then,the amorphous alloy was annealed at different temperatures for different *** influence of heating rate on thermal expansion and thermal stability was studied by thermomechanical analysis(TMA),and the microstructure evolution of the amorphous alloy during structural relaxation and crystallization was studied by XRD and *** show that the structural evolution behavior of the(Cu43Zr48Al9)98Y2 amorphous alloy can be divided into five different stages(structural relaxation preparation stage,structural relaxation stage,first crystallization stage,second crystallization stage,and grain growth stage).When the heating rate is 20 K/min,the amorphous alloy has the smallest thermal expansion coefficient and the best thermal *** width of the supercooled liquid region is 66.42 *** with different relaxation states were prepared by annealing at the heating rate of 20 K/*** structural evolution of amorphous alloys with different relaxation states is as follows:amorphous→CuZr2+AlCu2Zr7→CuZr2+AlCu2Zr7+CuZr(B2)+CuZr(M)+Cu10Zr7→CuZr2+AlCu2Zr7+CuZr(B2)+CuZr(M).After annealing at 706 K and 726 K(in the supercooled liquid region)for 1.5 h,the amorphous-nanocrystalline composites were *** the annealing temperature is 706 K,the crystallization process of the sample is as follows:amorphous→Cu10Zr7→Cu10Zr7+CuZr,and for the sample at 726 K,it is as follows:amorphous→CuZr2+AlCu2Zr7+Cu10Zr7→Cu10Zr7+CuZr2→CuZr2+CuZr(B2)+Cu10Zr7.

关键词： amorphous-nanocrystalline composite materials structural relaxation microstructure thermal expansion thermal stability

Coumarin-glycoside and Ferulate from Peucedanum decursivum

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Chinese Chemical Letters 2000年第4期11卷 315-318页

作者： Ling yi kong Nian Huan YAO (Department of Natural Medicinal Chemistry, China Pharmaceutical University. Nanjing 210038) China Pharmaceut Univ Dept Nat Med Chem Nanjing 210038 Peoples R China

Two new compounds named decuroside VI(1) and decursidate (2) were isolated from the roots of Peucedanum decursivum - a traditional Chinese medicine. Their structures were elucidated on the basis of chemical evidence a... 详细信息

关键词： Peucedanum decursivum decuroside VI decursidate

New Coumarins From Peacedanum Decursivum

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Chinese Chemical Letters 1999年第6期10卷 477-480页

作者： Nian Huan YAO Ling yi kong(Department of phytochemistry. China Pharmaceutical University. Nan-ling 210038) China Pharmaceut Univ Dept Phytochem Nanjing 210038 Peoples R China

Four new Coumarins named Decursitin B, C, D. F have been isolated from traditional Chinese medicine - the root of Peacedanum decursivum. Their structures were elucidated by chemical evidences and spectral analysis.

关键词： Peacedanum decursivum decursitin B decursitin C decursitin D decursitin F