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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying Zhu Pu Chen Tong Zhou Zhe-yi han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Quantum Non-thermal Effect From Kerr-Newman Black Hole

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Communications in Theoretical Physics 2009年第3期51卷 450-452页

作者： han yi-Wen College of Computer Science Chongqing Technology and Business University Chongqing 400067 China

We present a short and direct derivation of Hawking radiation by using the Damour-Ruffini method, as taking into account the self-gravitational interaction from the Kerr-Newman black hole, It is found that the radiation is not exactly thermal, and because the derivation obey conservation laws, the non-thermal Hawking radiation can carry information from the black hole. So it can be used to explain the black hole information paradox, and the process satisfies unitary.

关键词： black hole Hawking radiation Damour Ruffini method quantum theory

Large deflection of curved elastic beams made of Ludwick type material

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Applied Mathematics and Mechanics(English Edition) 2017年第7期38卷 909-920页

作者： Hua LIU yi han Jialing YANG School of Aeronautic Science and Engineering Beihang University Beijing 100191 China

The large deflection of an axially extensible curved beam with a rectangular cross-section is investigated. The elastic beam is assumed to satisfy the Euler-Bernoulli postulation and be made of the Ludwick type material. Through reasonably simplified integration, the strain and curvature of the axis of the beam are presented in implicit formulations. The governing equations involving both geometric and material nonlin- earities of the curved beam are derived and solved by the shooting method. When the initial curvature of the beam is zero, the curved beam is degenerated into a straight beam, and the predicted results obtained by the present model are consistent with those in the open literature. Numerical examples are further given for curved cantilever and simply supported beams, and the couplings between elongation and bending are found for the curved beams.

关键词： large deflection curved beam Ludwick type material nonlinearity

Low-carbon Economic Dispatch of Electricity-Heat-Gas Integrated Energy Systems Based on Deep Reinforcement Learning

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1827-1841页

作者： Yuxian Zhang yi han Deyang Liu Xiao Dong Electrical Engineering Shenyang University of TechnologyShenyangChina College of Electrical Engineering Yingkou Institute of TechnologyYingkouChina School of Beijing Ke Dong Co. Ltd.NARI Group CorporationBeijingChina

The optimal dispatch methods of integrated energy systems(IESs) currently struggle to address the uncertainties resulting from renewable energy generation and energy demand. Moreover, the increasing intensity of the greenhouse effect renders the reduction of IES carbon emissions a priority. To address these issues, a deep reinforcement learning(DRL)-based method is proposed to optimize the low-carbon economic dispatch model of an electricity-heat-gas IES. In the DRL framework, the optimal dispatch model of the IES is formulated as a Markov decision process(MDP). A reward function based on the reward-penalty ladder-type carbon trading mechanism(RPLT-CTM) is introduced to enable the DRL agents to learn more effective dispatch strategies. Moreover, a distributed proximal policy optimization(DPPO) algorithm, which is a novel policy-based DRL algorithm, is employed to train the DRL agents. The multithreaded architecture enhances the exploration ability of the DRL agents in complex environments. Experimental results illustrate that the proposed DPPO-based IES dispatch method can mitigate carbon emissions and reduce the total economic cost. The RPLT-CTM-based reward function outperforms the CTM-based methods, providing a 4.42% and 6.41% decrease in operating cost and carbon emission, respectively. Furthermore, the superiority and computational efficiency of DPPO compared with other DRL-based methods are demonstrated by a decrease of more than 1.53% and 3.23% in the operating cost and carbon emissions of the IES, respectively.

关键词： Integrated energy system(IES) carbon trading optimal dispatch deep reinforcement learning(DRL) distributed proximal policy optimization

Zeolitic imidazolate framework-8 modified poly(vinylidene fluoride-cohexafluoropropylene)/polyacrylonitrile composite separators for Li-ion batteries

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Chinese Journal of Chemical Engineering 2023年第10期62卷 291-296页

作者： Yanhuai Ding Cong Zhang Hao Zheng yi han Institute of Rheological Mechanics Xiangtan UniversityXiangtan 411105China School of Mechanical Engineering and Mechanics Xiangtan UniversityHunan 411105China

As one of the most stable metal-organtic framework(MOF),zeolitic imidazolate framework-8(ZIF-8)has been widely studied for applications in the field of energy storage,catalysis,and environment *** this paper,ZIF-8 was employed to enhance the electrochemical properties and thermal stability of the electrospun poly(vinylidene fluoride-co-hexafluoropropylene)/polyacrylonitrile(PVDF-HFP/PAN)composite *** results indicate that the test cells assembled with the composite separators show improved rate capability,high discharge capacity,and stable cycling *** addition of ZIF-8 can improve the affinity of PVDF-HFP/PAN toward liquid electrolytes,and further enhance the ionic conductivity of the composite *** addition,the thermal stability of the PVDF-HFP/PAN separator has been improved by ZIF-8 *** work can provide insight into the application of MOF materials in Li-ion batteries.

关键词： Nanotechnology ZIF-8 PVDF-HFP/PAN Composites Electrolytes

AlN precipitation during steel solidification using CA model

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Journal of Iron and Steel Research International 2022年第11期29卷 1789-1799页

作者： Lei Cui yi-han Shi Xiang-ning Meng Key Laboratory for Ecological Metallurgy of Multi-Metallic Ores Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

Based on the principles of metal solidification and cellular automaton(CA),as well as AlN precipitation thermodynamics and kinetics,a CA model of interdendritic AlN precipitation was established by coupling a large-size mesh describing the dendrite growth of Fe-C-Al-N alloys and a small-size mesh representing AlN precipitation based on transient chemical *** results of single dendrite growth stimulated by this model were compared with the Lipton-Glicksman-Kurz solution to verify the correctness of the matrix dendrite growth *** AlN morphology and dimensions obtained from the CA model simulations are following the experimental *** presence of equiaxed dendrite in the computational domain results in a significant coarsening of the columnar dendrite and a uniform solute distribution around them,and the AlN solid phase fraction *** of AlN precipitation at different wetting angles were also performed,and it was found that the solid phase fraction of AlN decreased with the increase in wetting ***,it is confirmed that the established model is an effective method to simulate interdendritic AlN precipitation.

关键词： Metal solidification Cellular automaton Wetting angle AlN precipitation Dendrite growth

Reversible photoswitching self-assembly of azobenzene-functionalized hyperbranched polyglycerol induced by host-guest chemistry

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Science China Chemistry 2012年第4期55卷 604-611页

作者： han yi GAO Chao HE XiaoHua MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Chemistry East China Normal UniversityShanghai 200062China

Reversible assembly and disassembly of rodlike large complex micelles have been achieved by applying photoswitching of supramolecular inclusion and exclusion of azobenzene-functionalized hyperbranched polyglycerol and acyclodextrin as driv ing force, promising a versatile system for selfassembly switched by light. Hydrogennuclear magnetic resonance （H NMR） and Fourier transform infrared （FTIR） spectroscopy were applied to characterize the azobenzenefunctionalized hyperbranched polyglycerol. Atomic force microscopy （AFM）, transmission electron microscopy （TEM） and dynamic laser light scattering （DLS） were employed to investigate and track the morphology of the rodlike large complex micelles before and after irradiation of UV light.

关键词： azobenzene hyperbranched polyglycerol reversible self-assembly host-guest chemistry

Grid graph-based large-scale point clouds registration

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International Journal of Digital Earth 2023年第1期16卷 2448-2466页

作者： yi han Guangyun Zhang Rongting Zhang School of Geomatics Science and Technology Nanjing Tech UniversityNanjingPeople's Republic of China

Automatic registration of unordered point clouds is the prerequisite forurban reconstruction. However, most of the existing technologies stillsuffer from some limitations. On one hand, most of them are sensitive tonoise and repetitive structures, which makes them infeasible for theregistration of large-scale point clouds. On the other hand, most of themdealing with point clouds with limited overlaps and unpredictablelocation. All these problems make it difficult for registration technology toobtain qualified results in outdoor point cloud. To overcome theselimitations, this paper presents a grid graph-based point cloud registration(GGR) algorithm to align pairwise scans. First, point cloud is divided into aset of 3D grids. We propose a voting strategy to measure the similaritybetween two grids based on feature descriptor, transforming thesuperficial correspondence into 3D grid expression. Next, a graphmatching is proposed to capture the spatial consistency from putativecorrespondences, and graph matching hierarchically refines thecorresponding grids until obtaining point-to-point *** experiments demonstrated that the proposed algorithmobtains good performance in terms of successful registration rate, rotationerror, translation error, and outperformed the state-of-the-art approaches.

关键词： Point cloud alignment scan matching graph algorithms reconstruction

HYPERSURFACES WITH CONSTANT MEAN CURVATURE IN A HYPERBOLIC SPACE

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Acta Mathematica Scientia 2011年第3期31卷 1091-1102页

作者：苏变萍舒世昌 yi Annie han Department of Science Xi'an University of Architecture and Technology Department of Mathematics Xianyang Normal University Department of Mathematics Borough of Manhattan Community College City University of New York

Let Mn be an n-dimensional complete connected and oriented hypersurface in a hyperbolic space H（n＋1）（c） with non-zero constant mean curvature H and two distinct principal curvatures. In this paper, we show that （1） if the multiplicities of the two distinct principal curvatures are greater than 1,then Mn is isometric to the Riemannian product Sk（r）×H（n-k）（-1/（r2 ＋ ρ2））, where r 〉 0 and 1 〈 k 〈 n - 1;（2）if H2 〉 -c and one of the two distinct principal curvatures is simple, then Mn is isometric to the Riemannian product S（n-1）（r） × H1（-1/（r2 ＋ρ2）） or S1（r） × H（n-1）（-1/（r2 ＋ρ2））,r 〉 0, if one of the following conditions is satisfied （i） S≤（n-1）t22＋c2t（-2）2 on Mn or （ii）S≥ （n-1）t21＋c2t（-2）1 on Mn or（iii）（n-1）t22＋c2t（-2）2≤ S≤（n-1）t21＋c2t（-2）1 on Mn, where t_1 and t_2 are the positive real roots of （1.5）.

关键词： hypersurface hyperbolic space scalar curvature mean curvature principal curvature