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Animal models of pulmonary hypertension due to left heart disease

Animal Models and Experimental Medicine 2022年第3期5卷 197-206页

作者： Shao-Fei Liu Yi Yan Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlinGermany DZHK(German Centre for Cardiovascular Research) Partner Site BerlinBerlinGermany Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany DZHK(German Centre for Cardiovascular Research) Partner Site Munich Heart AllianceMunichGermany

Pulmonary hypertension due to left heart disease(PH-LHD) is regarded as the most prevalent form of pulmonary hypertension(PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease(LHD). Clinically, there are no drugs or treatments that directly address PH-LHD, and treatment of LHD alone will not also ameliorate PH. To target the underlying physiopathological alterations of PH-LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH-LHD are required. There are several available models for PH-LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular endothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH-LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH-LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH-LHD. Therefore, this review will summarize the characteristics of each PH-LHD animal model and discuss the advantages and limitations of the different models.

关键词： animal model l eft ventricular failure metabolic syndrome pulmonary hypertension due to left heart disease pulmonary vascular remodeling

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Nanoparticles Study on the Indosinian Xiaomei Shear Zone in the Hainan Island,China:Implication to Developmental Stage and Formation Mechanism of Nanoparticles in a Fault Zone

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Journal of Earth Science 2020年第5期31卷 957-967页

作者： yang Zhou Baoyun Shen Yi Yan Hailing Liu yan yan Key Laboratory of Ocean and Marginal Sea Geology Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong University of Technology Guangzhou 510006China South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China

Nanoparticles are widely observed in the natural shear zone and experimental slip faults, which can lubricate the fault and significantly reduce the friction coefficient during seismic slip. But it is still not clear how the nanoparticles develop during the process of sliding. Clarifying the development stage of nanoparticles in a fault zone is critical to understanding the formation mechanisms of nanoparticles and the mechanism of fault weakening from a nanoperspective. In this study, four types of nanoparticles were found in the Indosinian Xiaomei shear zone, including spherical nanoparticles, rod-like nanograins and their aggregations. Ultramicroscopic analyses indicate that polished patches are highly smooth and composed of tightly packed spherical nanoparticles and well orientated rod-like nanograins during slip at high velocities. Meanwhile, the dome nanoparticles were formed by the calcite thermal decomposition due to frictional heat during highspeed sliding. The polygonal grooves are possibly related to high temperature(>900℃) grain boundary sliding deformation mechanisms. However, the porous and rough surfaces are accompanied by a series of holes and parallel "scratches" during a subsequent low-velocity stage. To ascertain the chemical composition of these nanoparticles, the energy dispersive spectrometer(EDS) test were conducted. The results suggest that materials rich in Fe, MgO and wollastonite are likely to form the rod-like nanograins, while materials rich in SiO2 are likely to form the spherical nanoparticles.

关键词： nanoparticles slip faults development stage Xiaomei shear zone composition

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Effects of coal seam dip angle on the outburst in coal roadway excavation

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International Journal of Mining Science and Technology 2019年第5期29卷 757-764页

作者： Cheng Hou yinghua Zhang Yi Yan University of Science and Technology Beijing Beijing 100083China Department of Mechanical Engineering McGill UniversityMontrealQC H3A 0C3Canada

The prevention and forecast of coal and gas outburst has always been one of the key issues in coal mining safety.By simulating the process of tunneling in coal seam with different dip angle through FLAC3D software,the dangerous zone in which outburst may occur and the probability of outburst near the working face were predicted through the distribution of stress,displacement and plastic zone.Then we discussed the size of unstable area in the surrounding rock through the distribution of stress and the variation curve of the displacement on the roadway wall.The results show that,with an increase of the coal seam dip angle,the risk of outburst in the working face rises gradually.And the dangerous areas in which may outburst occur moves to the upper part of coal seam.The size of unstable area in the surrounding rock increases with the increase of coal seam dip angle.

关键词： Dip angle Stress concentration Plastic zone Displacement Coal and gas outburst

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Evaluation of Smoking Cessation Intervention Effectiveness in Smoking Cessation Clinics-China,2019–2021

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China CDC weekly 2023年第21期5卷 469-474页

作者： Li Xie Yongfu yan yan yang yi Nan Lin Xiao Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Since 2014,the Chinese government has advocated for the development of smoking cessation clinics(SCCs)within each provincial-level administrative division(PLAD).What is added by this report?In the 2019–2021 period,the self-reported 7-day point prevalence of abstinence rates(PPAR)at 1-month and 3-month follow-up were 26.2%and 23.5%,respectively.What are the implications for public health practice?The interventions implemented by SCCs in this investigation proved to be successful.It is imperative to employ extensive tobacco control strategies in order to enhance the motivation of smokers to seek assistance for cessation from SCCs.

关键词： smoke motivation has

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A simple image-based method for online moisture content estimation of iron ore green pellets

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Journal of Iron and Steel Research(International) 2023年第5期30卷 851-863页

作者： Shu-yi Zhou Xiao-yan Liu College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362006FujianChina

Moisture content(MC)is an important quality metric of iron ore green pellets in pelletizing process in ironmaking industry.Current image-based methods for MC estimation may result in big errors for gray-scale pellet images captured under various lighting conditions.We proposed a simple image-based method to improve the MC estimation accuracy by illumination correction and linear regression modeling.Firstly,the illumination of the pellet image was transformed into the reference illumination by use of a color checker chart and piecewise linear interpolation,so that the influence of different illuminations could be greatly reduced.By experimental analysis,it was found that MC is approximately adversely proportional to the average intensity of the transformed images.A simple model for MC prediction was then established by linear fitting.Experiments demonstrated that the proposed method has good robustness to different lighting conditions and achieves the best performance in metrics of mean square error,mean absolute error and maximum absolute error in comparison with five state-of-art MC estimating methods.Application on a working disk pelletizer shows that the proposed method can predict well the change of moisture content with time,and its computing efficiency can satisfy the requirement for online MC monitoring during the pelletizing process.

关键词： Green pellet Moisture content Image processing Pelletizing process

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Achieving desired nodal lines in freely vibrating structures via material-field series-expansion topology optimization

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Frontiers of Mechanical Engineering 2023年第3期18卷 187-201页

作者： Yi Yan Xiaopeng ZHANG Jiaqi HE Dazhi WANG yangjun LUO State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China School of Mechanical Engineering Dalian University of TechnologyDalian 116024China School of Science Harbin Institute of TechnologyShenzhen 518055China

Accurately controlling the nodal lines of vibrating structures with topology optimization is a highly challenging task.The major difficulties in this type of problem include a large number of design variables,the highly nonlinear and multi-peak characteristics of iteration,and the changeable orders of eigenmodes.In this study,an effective material-field series-expansion(MFSE)-based topology optimization design strategy for precisely controlling nodal lines is proposed.Here,two typical optimization targets are established:(1)minimizing the difference between structural nodal lines and their desired positions,and(2)keeping the position of nodal lines within the specified range while optimizing certain dynamic performance.To solve this complex optimization problem,the structural topology of structures is first represented by a few design variables on the basis of the MFSE model.Then,the problems are effectively solved using a sequence Kriging-based optimization algorithm without requiring design sensitivity analysis.The proposed design strategy inherently circumvents various numerical difficulties and can effectively obtain the desired vibration modes and nodal lines.Numerical examples are provided to validate the proposed topology optimization models and the corresponding solution strategy.

关键词： nodal line topology optimization structural dynamics design material-field series-expansion

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Imaginary Modules over the Affine Nappi-Witten Algebra

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Acta Mathematica Sinica,English Series 2022年第6期38卷 1041-1053页

作者： yi Xin BAO yan An CAI School of Sciences Harbin Institute of Technology(Shenzhen)Shenzhen 518055P.R.China Department of Mathematics Soochow UniversitySuzhou 215006P.R.China

In this paper,we consider the imaginary highest weight modules and the imaginary Whittaker modules for the affine Nappi-Witten algebra.We show that simple singular imaginary Whittaker modules at level(κ、c)(κ∈C~*)are simple imaginary highest weight modules.The necessary and sufficient conditions for these imaginary modules to be simple are given.All simple imaginary modules are classified.

关键词： Affine Nappi-Witten algebra imaginary Verma modules imaginary highest weight modules imaginary Whittaker modules simple modules

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Mild hypothermia as a treatment for central nervous system injuries Positive or negative effects?

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Neural Regeneration Research 2013年第28期8卷 2677-2686页

作者： Rami Darwazeh Yi Yan Department of Neurosurgery the First Affiliated Hospital of Chongqing Medical University

Besides local neuronal damage caused by the primary insult, central nervous system injuries may secondarily cause a progressive cascade of related events including brain edema, ischemia, oxida- tive stress, excitotoxicity, and dysregulation of calcium homeostasis. Hypothermia is a beneficial strategy in a variety of acute central nervous system injuries. Mild hypothermia can treat high in- tracranial pressure following traumatic brain injuries in adults. It is a new treatment that increases survival and quality of life for patients suffering from ischemic insults such as cardiac arrest, stroke, and neurogenic fever following brain trauma. Therapeutic hypothermia decreases free radical pro- duction, inflammation, excitotoxicity and intracranial pressure, and improves cerebral metabolism after traumatic brain injury and cerebral ischemia, thus protecting against central nervous system damage. Although a series of pathological and physiological changes as well as potential side ef- fects are observed during hypothermia treatment, it remains a potential therapeutic strategy for central nervous system injuries and deserves further study.

关键词： neural regeneration reviews brain injury spinal cord injury central nervous system injury mildhypothermia therapeutic hypothermia traumatic brain injury neuroregeneration

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Giant cyst in heterotopic pregnancy:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3864-3869页

作者： yi-yan Kong Kasonde Chanda Xiao-yan ying Department of Obstetrics and Gynecology Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND The coexistence of a heterotopic pregnancy with a giant ovarian cyst is an incredibly rare abnormal pregnancy in cases of natural conception.The incidence of this condition has increased significantly as a result of the continuous development of assisted reproductive technologies.When this type of pregnancy occurs,both the continuation of intrauterine pregnancy and the life of the pregnant woman are severely threatened.Early diagnosis and treatment using safe and effective methods are paramount in this situation.CASE SUMMARY A 30-year-old primigravida at a gestation age determined as 8 wk 4 d by scan was admitted to the hospital with heterotopic pregnancy and a right ovarian cyst.Laparoscopic resection of the ectopic pregnancy was performed,but the intrauterine pregnancy and ovarian cyst were preserved.CONCLUSION The approach to a patient with heterotopic pregnancy and a giant ovarian cyst is individualized base on the fertility requirements.We recommend the following:(1)If the patient satisfies parity and has no fertility requirement,a laparoscopic salpingectomy should be performed and the giant ovarian cyst and intrauterine pregnancy removed;(2)If the patient has fertility requirements wishes to have more children in the future,laparoscopic salpingectomy or salpingostomy should be performed and the intrauterine pregnancy preserved.Serial ovarian cyst aspiration can be performed under ultrasound and resection can be done after delivery;and(3)Heterotopic pregnancy should be diagnosed early by active surveillance during antenatal visits using ultra sound as this is important for the avoidance of catastrophic complications.

关键词： Heterotopic pregnancy Ectopic pregnancy Giant ovarian cyst Case report

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Digital Platform 'Memory of the World: Chinese Traditional Music Sound Archives'Launched Online

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China & The World Cultural Exchange 2022年第6期88卷 27-30页

作者： Yi Yan 不详

On April 23,2022,the digital platform "Memory of the World:Chinese Traditional Music Sound Archives"collected and developed by the Chinese National Academy of Arts was officially Gunched online(https://***)for test run.It was sponsored by the Chinese National Academy of Arts and organized by the Library,the Music Research Institute and the Information Center of the Chinese National Academy of Arts.The launch was held online,with the video speech by Han Ziyong,President of the Chinese National Academy of Arts and the China National Arts and Crafts Museum as well as releva nt experts and scholars,singing high praise of the development and launch of the platform.

关键词： Online World Sound

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