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Effect of Structure Pattern on the Performance of X80 Pipeline Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 874-877页

作者： ren yi,liu wen-yue,wang shuang,zhang shuai (Technical Center of Anshan Iron & Steel Co.Ltd.,Anshan 114009,Liaoning,China) Anshan Iron & Steel Co Ltd Ctr Tech Anshan 114009 Liaoning Peoples R China

The microstructure,dislocation and precipitation phases of X80 pipeline steel produced with different processes were analyzed by optical microscope and transmission electron microscope (TEM) contrastively,and the influence of structure pattern on the performance of X80 pipeline steel was *** result shows that the effects of acicular ferrite grain size,precipitate phase distribution,dislocation density and morphology on the material strength,toughness and brittle transmission temperatures were distinct,and solid solution strengthening,fine grain strengthening,dislocation strengthening and precipitation strengthening were the strengthening ways of X80 pipeline steel.

关键词： pipeline steel acicular ferrite dislocation precipitated phase toughness

Tribocorrosion behavior of antibacterial Ti-Cu sintered alloys in simulated biological environments

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Rare Metals 2022年第6期41卷 1921-1932页

作者： Jia-Qi zhang shuang Cao ying liu Mian-Mian Bao Jing ren Sheng-yi Li Er-Lin zhang Jian-Jie wang Departments of Immunology College of Basic MedicineJiamusi UniversityJiamusi 154007China Key Laboratory for Anisotropy and Texture of Materials School of Materials Science and EngineeringEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Ti-Cu alloys have strong antibacterial proper-ties,high strength and excellent corrosion resistance,which might be used in orthopedic and dental *** this paper,the tribocorrosion behaviors of Ti-Cu alloy with different Cu contents were investigated in four simulated biological environments compared with *** results showed that Ti-Cu sintered alloy exhibited higher corro-sion resistance,lower coefficient friction and wear loss than cp-Ti in all tested solutions due to the formation of fine and homogeneously distributed Ti_(2)Cu phase,espe-cially in solution with lower F ion and *** Cu content and extrusion process improved the corrosion resistance and the wear resistance because of high Ti_(2)Cu phase fraction and fine grain ***,aggressive solution,such as the solution with lower F ion and pH,accelerated wear in comparison with other solutions for cp-Ti and Ti-Cu sintered *** electron microscope(SEM)surface morphology demonstrated that the wear mecha-nism of cp-Ti during tribocorrosion process was mainly abrasive wear and adhesive wear while that of Ti-Cu alloy was abrasive *** summary,Ti-Cu sintered alloys showed much better tribocorrosion property than cp-Ti,which shows great potential application in condition for wear and corrosion resistance.

关键词： Ti-Cu alloys Tribocorrosion Corrosion Wear In vitro Antibacterial metal alloy

FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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Military Medical Research 2024年第4期11卷 521-542页

作者： Mi Zhou Yang-Wu-yue liu Yu-Hang He Jing-Yu zhang Hao Guo Hao wang Jia-Kui ren yi-Xun Su Teng Yang Jia-Bo Li wen-Hui He Peng-Jiao Ma Man-Tian Mi shuang-shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

Efficacy and safety of combined directly acting antivirals for treatment of Chinese chronic hepatitis C patients in a real-world setting

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World Journal of Gastroenterology 2017年第22期23卷 4072-4079页

作者： Jian-Hong Chen Zheng Zeng Xia-Xia zhang Yu zhang ren-wen zhang shuai wang Chi-Hong Wu Min Yu Dan liu Hong-Li Xi yi-Xing Zhou Yao-Yu An Xiao-Yuan Xu Department of Infectious Diseases Peking University First Hospital Department of Hepatology General Hospital of Beijing Military Region

AIM To assess the efficacy and safety of combined directly acting antivirals(DAAs) for the treatment of Chinese chronic hepatitis C(CHC) patients in a real-world *** Hospitalized CHC patients who were treated with DAAs at Peking University First Hospital between January 2015 and December 2016 were enrolled. Samples and clinical data were collected at 0 wk, 2 wk, 4 wk, 8 wk, 12 wk, or 24 wk during DAAs treatment and at 4 wk, 12 wk, and 24 wk after the end of treatment. RESULTS Fifty-four patients who underwent DAAs treatment were included in our study, of whom 83.3%(45/54) achieved rapid virological response at 2 wk after treatment initiation(RVR 2) and 94.4%(51/54)achieved sustained virological response at 24 wk after the end of treatment(SVR 24). Serum creatinine and uric acid levels at the end of treatment were significantly increased compared with baseline levels(83.6 ± 17.9 vs 88.8 ± 19.4, P 01 renal function indices and relative high frequency of AEs during combined DAAs treatment should be taken as a note of caution.

关键词： Chronic hepatitis C Directly acting antivirals Efficacy Safety China

热处理工艺对X80热煨弯管用钢组织性能的影响

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钢铁 2011年第5期46卷 81-84,88页

作者：张帅任毅王爽刘文月鞍钢股份有限公司技术中心辽宁鞍山114001

X80热煨弯管在弯制成型时要经历热处理过程,为保证弯管的最终性能需深入研究热处理工艺对X80弯管用钢组织性能的影响。采用不同工艺对X80热煨弯管用钢进行热处理,并对热处理后材料的组织性能及其与淬火温度和回火温度的关系进行了深入... 详细信息

X80热煨弯管在弯制成型时要经历热处理过程,为保证弯管的最终性能需深入研究热处理工艺对X80弯管用钢组织性能的影响。采用不同工艺对X80热煨弯管用钢进行热处理,并对热处理后材料的组织性能及其与淬火温度和回火温度的关系进行了深入研究。结果表明:随着淬火温度升高,材料强度提高,韧性降低;而随着回火温度的升高,材料的组织、位错、第二相析出等均发生变化,使材料强度呈起伏变化趋势,韧性则逐渐升高。根据强韧性匹配原则,最终确定了适宜的热处理工艺参数。

关键词：热处理 X80 热煨弯管

850MPa级管线用钢板的焊接热模拟试验研究

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金属热处理 2011年第4期36卷 54-57页

作者：刘文月任毅王爽张帅鞍钢股份有限公司技术中心钢铁产品研究所辽宁鞍山114009

采用焊接热模拟技术对屈服强度为850 MPa管线用平板进行了热影响区的模拟试验,研究该钢在不同峰值温度和冷却时间下的组织与性能,测定了其热影响区的显微硬度。结果表明,钢板基体组织为下贝氏体,经历不同的热循环后,热影响区组织有不同... 详细信息

采用焊接热模拟技术对屈服强度为850 MPa管线用平板进行了热影响区的模拟试验,研究该钢在不同峰值温度和冷却时间下的组织与性能,测定了其热影响区的显微硬度。结果表明,钢板基体组织为下贝氏体,经历不同的热循环后,热影响区组织有不同程度的变化;在所选择的工艺参数范围内,热影响区的显微硬度没有降低;在(α+γ)两相区受热后的冲击吸收能量降低了31 J,是整个热影响区的脆性区域。

关键词：管线钢焊接热模拟热影响区显微组织

Moving Epidemic Method for Surveillance and Early Warning of Hand, Foot, and Mouth Disease in Beijing, China

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Biomedical and Environmental Sciences 2023年第12期36卷 1162-1166页

作者： DONG shuai Bing wang Yu HUO Da ZHAO Hao liu Bai Wei LI ren Qing GAO Zhi Yong wang Xiao Li zhang Dai Tao wang Quan yi JIA Lei YANG Peng Institute of Infectious and Endemic Diseases Control Beijing Center for Disease Prevention and ControlBeijing 100013China School of Public Health Capital Medical UniversityBejjing 100069China Beijing Office of Center for Global Health Beiing Center for Disease Prevention and ControlBeijing 100013China

Hand,foot,and mouth disease (HFMD) is an acute infection caused by enteroviruses that is commonly seen in children^([1]).High infectivity,large number of asymptomatic infections,complex transmission routes,and rapid spread make it difficult to control *** 2008,China has reported> 23 million HFMD cases,including>0.15million severe cases^([2]).HFMD tops the list of notifiable infectious diseases in terms of case number and incidence rate,leading to a huge disease burden^([3]).Timely and accurate assessment of HFMD epidemics is essential for a holistic understanding of the outbreaks and for effective prevention and control ***,there are no quantitative indicators to determine the duration and intensity of HFMD epidemics in Beijing.

关键词： prevention acute diseases

Collective cell behaviors manipulated by synthetic DNA nanostructures

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Fundamental Research 2023年第5期3卷 809-812页

作者： Xiaochen wang Xiwen Xing shuang Lu Guangle Du yi zhang Yubin renYulong Sun Jing Sun Qihui Fan Kai liu Fan wang Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001China Department of Biotechnology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Organic Chemistry I University of UlmAlbert-Einstein-Allee 1189081 UlmGermany Songshan Lake Materials Laboratory Dongguan 523808China

Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound *** development of new chemical strategies to achieve largescale control of cells’collective motion is essential for biomedical *** a series of DNA nanostructures with different dimensions were synthesized and their influences on cells’collective migration and packing behaviors in epithelial monolayers were *** found that the framed DNA nanoassemblies effectively reduced the cells’speed by increasing the rigidity of cells,while the lipid-DNA micelles had a more pronounced effect on cells’projection area and shape *** DNA nanostructures all significantly enhanced the dependence of cells’speed on their shape *** results indicate that cells’mobility in monolayers can be manipulated by chemical intercellular interactions without any genetic *** may provide a new chemical strategy for tissue engineering and tumor therapy.

关键词： DNA materials Nanomaterial Cell monolayer Collective motion Tissue engineering

装炉温度对管线用高强度宽厚板性能和组织的影响

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材料热处理学报 2021年第10期42卷 87-94页

作者：张帅任毅王爽高红海洋装备用金属材料及其应用国家重点实验室辽宁鞍山114009 鞍钢集团钢铁研究院辽宁鞍山114009

利用工业试验研究了装炉温度对管线用高强度宽厚板的性能、微观组织、合金元素固溶和析出相的影响。结果表明:由于热装铸坯厚度截面存在较大的温度差异,720℃装炉时,铸坯内部未发生γ-α相变的比例大,使奥氏体粗大,脆性断裂倾向高;550... 详细信息

利用工业试验研究了装炉温度对管线用高强度宽厚板的性能、微观组织、合金元素固溶和析出相的影响。结果表明:由于热装铸坯厚度截面存在较大的温度差异,720℃装炉时,铸坯内部未发生γ-α相变的比例大,使奥氏体粗大,脆性断裂倾向高;550℃装炉时,铸坯厚度中心附近γ-α相变不充分,导致钢板的晶粒细化和DWTT性能低于室温装炉。热装时铸坯中合金元素的固溶量高,促进10 nm以下的细小析出相的形成,但会导致晶粒粗化和微观组织中铁素体比例减少。因此,热装钢板的抗拉强度和DWTT剪切面积低于室温冷装钢板。

关键词：管线钢热装微观组织固溶析出