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Acceptor-engineering tailored type-I photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

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Science China Chemistry 2024年

作者： Jiangao Li Niu Niu Deliang Wang Xue Liu yi qin Lei Wang Ben Zhong Tang Dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and the Fifth Affiliated Hospital Guangzhou Medical University School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

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Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

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Science China Chemistry 2024年第8期 2647-2660页

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Quality of life after pancreatic surgery

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World Journal of Gastroenterology 2024年第8期30卷 943-955页

作者： Shi-Zhen Li Ting-Ting Zhen yi Wu Min Wang Ting-Ting qin Hang Zhang Ren-yi qin Department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Pancreatic surgery is challenging owing to the anatomical characteristics of the pancreas.Increasing attention has been paid to changes in quality of life(QOL)after pancreatic surgery.AIM To summarize and analyze current research results on QOL after pancreatic surgery.METHODS A systematic search of the literature available on PubMed and EMBASE was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Relevant studies were identified by screening the references of retrieved articles.Studies on patients’QOL after pancreatic surgery published after January 1,2012,were included.These included prospective and retrospective studies on patients'QOL after several types of pancreatic surgeries.The results of these primary studies were summarized inductively.RESULTS A total of 45 articles were included in the study,of which 13 were related to pancreaticoduodenectomy(PD),seven to duodenum-preserving pancreatic head resection(DPPHR),nine to distal pancreatectomy(DP),two to central pancre-atectomy(CP),and 14 to total pancreatectomy(TP).Some studies showed that 3-6 months were needed for QOL recovery after PD,whereas others showed that 6-12 months was more accurate.Although TP and PD had similar influences on QOL,patients needed longer to recover to preoperative or baseline levels after TP.The QOL was better after DPPHR than PD.However,the superiority of the QOL between patients who underwent CP and PD remains controversial.The decrease in exocrine and endocrine functions postoperatively was the main factor affecting the QOL.Minimally invasive surgery could improve patients’QOL in the early Core Tip:This review summarizes and analyzes current research results on quality of life(QOL)after pancreatic surgery.The article covers the discussion and analysis of the QOL of various pancreatic surgeries.Which kind of surgical procedure has better QOL is controversial.The long-term benefits on QOL of minimally invasive surgery over open surgery are contro-INTRODUCTION

关键词： Quality of life Pancreaticoduodenectomy Duodenum-preserving pancreatic head resection Distal pancreatectomy Central pancreatectomy Total pancreatectomy

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Chain Extender-induced Hydrogen Bonding Organization Determines the Morphology and Properties of Thermoplastic Polycarbonate Polyurethane

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Chinese Journal of Polymer Science 2024年第1期42卷 87-96,I0009页

作者： yi-Lang qin Ping Zhu Chen-Xi Ouyang Xia Dong Fuwai Hospital Chinese Academyof Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBejing 100037China CASKey Laboratoryof Engineering Plastics CAS Research/Education Centerfor Excellence in Molecular SciencesInstitute ofChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Thermoplastic polycarbonate polyurethanes(PCUs) are multiblock copolymers that have been applied for medical devices for long time. Aliphatic diols are common chain extenders(CE) involved in the composition of the hard segments of PCU. However, limited knowledge was discovered about how the chemical structure of CE affects the hydrogen bonding organization within PCUs and their mechanical properties.To investigate this problem, a group of PCUs were synthesized respectively by extending the polymer chain with 1,4-butanediol(BDO),aminoethanol(MEA), ethanediol(EO) as three kinds of chain extenders. Tiny differences in the CE chemical structure results in remarkable variations in phase separation, condensed morphologies, thermal and mechanical properties, which are characterized by Fourier transform infrared spectrometer, atomic force microscopy, small-angle X-ray scattering, differential scanning calorimetry, and tensile tests. The microstructural evolution during unilateral deformation and the different mechanism induced by the different CEs was probed and unveil by in situ wide-and small-angle X-ray diffraction. Symmetry of CE can improve the organization of the hydrogen bonding. The coherence strength of the urethane/urea group also plays a key role by comparing the two PCUs with ethanediol and aminoethanol.

关键词： Thermoplastic polycarbonate polyurethane Chain extender Hydrogen bonding Mechanical properties

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Microstructure and mechanical properties of Ti/Al/Ti clad plates prepared via powder-in-tube method

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Journal of Iron and Steel Research(International) 2024年第3期31卷 670-687页

作者： Xian-lei Hu qin-cheng Xie yi Yuan ying Zhi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Suzhou Dongbao Haixing Metal Material Technology Co. Ltd.Suzhou 215600JiangsuChina School of Material Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

The Ti/Al/Ti clad plates exhibit a broad spectrum of potential applications.However,the conventional techniques of hot-pressing composite and explosive composite are intricate and environmentally hazardous.A novel method was introduced for preparing clad plates,namely,the powder-in-tube method.This method involves a combination of cold rolling,annealing at a temperature of 550℃,and double rolling.The morphology of the intermetallic compound layer was analyzed through the utilization of interface stripping test,tensile test,and microscopic characterization.The interface morphology,interface bonding properties,tensile fracture structures,and properties of plates under the first and second rolling were compared,along with the effects of intermetallic compounds on the interface properties.The results indicate that the powder-in-tube method,when annealed at 550℃,can produce a composite plate featuring a complete and uniform Ti/Al interface.The obtained plate exhibits a peeling strength of 21.5 N/mm,tensile strength of 424 MPa,and elongation of 11.5%.Furthermore,a systematic analysis was conducted to determine the causes of performance degra-dation observed during annealing at temperatures of 600 and 650℃.

关键词： Powder-in-tube method-Ti/Al/Ti clad plate Annealing Cold rolling-Mechanical property

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Learning accurate template matching with differentiable coarseto-fine correspondence refinement

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Computational Visual Media 2024年第2期10卷 309-330页

作者： Zhirui Gao Renjiao yi Zheng qin Yunfan Ye Chenyang Zhu Kai Xu College of Computer National University of Defense TechnologyChangsha 410073China

Template matching is a fundamental task in computer vision and has been studied for decades.It plays an essential role in manufacturing industry for estimating the poses of different parts,facilitating downstream tasks such as robotic grasping.Existing methods fail when the template and source images have different modalities,cluttered backgrounds,or weak textures.They also rarely consider geometric transformations via homographies,which commonly exist even for planar industrial parts.To tackle the challenges,we propose an accurate template matching method based on differentiable coarse-tofine correspondence refinement.We use an edge-aware module to overcome the domain gap between the mask template and the grayscale image,allowing robust matching.An initial warp is estimated using coarse correspondences based on novel structure-aware information provided by transformers.This initial alignment is passed to a refinement network using references and aligned images to obtain sub-pixel level correspondences which are used to give the final geometric transformation.Extensive evaluation shows that our method to be significantly better than state-of-the-art methods and baselines,providing good generalization ability and visually plausible results even on unseen real data.

关键词： template matching differentiable homography structure-awareness transformers

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Assessment on gas-polyethylene terephthalate solid interface partial discharge properties of C4F7N/CO_(2)gas mixture for eco-friendly gas insulating transformer

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High Voltage 2024年第1期9卷 35-45页

作者： Song Xiao yifan Wang Chenhua Ren Haoran Xia Yue Zhao Jingzi qin Xiaoxing Zhang yi Luo yi Li State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanHubeiChina Beijing International S&T Cooperation Base for Plasma Science and Energy Conversion Institute of Electrical EngineeringChinese Academy of SciencesBeijingChina State Grid Anhui Electric Power Company Anhui Electric Power Research Institute HefeiAnhuiChina Hubei Engineering Research Center for Safety Monitoring of New Energy and Power Grid Equipment School of Electrical and Electronic EngineeringHubei University of TechnologyWuhanHubeiChina

The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliability and gas–solid interface discharge decomposition characteristics of the gas–solid film insulation structure in GIT is indispensable.The authors simulated the gas–solid film insulation structure in GIT and explored the interface partial discharge(PD)characteristics of C4F7N/CO_(2)gas mixture with polyethylene terephthalate(PET).The effect of gas pressure,mixing ratio on gas–solid interface gas decomposition,PET degradation was investigated,and the interaction mechanism was analysed.It is found that the interface PD generated three degradation regions on a PET film.The gas–solid interface reaction in the electrode contact region and the discharge development trace was significantly higher than that of halation region.The content of gas decomposition products decreases with the increase of gas pressure and the PD intensity of SF6-PET is inferior to that of C_(4)F_(7)N/CO_(2)under the same condition.Relevant results provide reference for the development and application of C_(4)F_(7)N/CO_(2)based GIT.

关键词： interface solid insulation

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MicroR-9c-5p and novel-mir50 co-target Akt to regulate Lasioderma serricorne reproduction

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Insect Science 2024年第1期31卷 106-118页

作者： yi Yan Dong-Dong qin Hong Yang Kang-Kang Xu Can Li Wen-Jia Yang Provincial Key Laboratory for Agricultural Pest Management of Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

High fecundity is a common characteristic of insect pests which increases the difficulty of population control.Serine/threonine kinase Akt is an indispensable component of the insulin signaling pathway.Silencing of LsAkt severely hinders reproduction in Lasioderma serricorne,a stored product insect pest.However,the post-transcriptional pathway of LsAkt in L.serricorne remains unknown.This study identified 2 binding sites of miR-9c-5p and novel-mir50 in the coding sequences of LsAkt.The expression profiles of 2 microRNAs(miRNAs)and LsAkt displayed an opposite pattern during the adult stages.Luciferase reporter assay showed that novel-mir50 and miR-9c-5p could downregulate the expression of LsAkt.Overexpression of miR-9c-5p and novel-mir50 by injection of mimics inhibited the expression of LsAkt and reduced oviposition,decreased egg hatchability,and blocked ovarian development.It also decreased the expression of genes involved in ovarian development(LsVg and LsVgR)and the nutritional signaling pathway(LsTOR,LsS6K,and Ls4EBP),and reduced the phosphorylation of Akt.Conversely,injection of miR-9c-5p and novel-mir50 inhibitors induced the expressions of LsAkt,LsVg,LsVgR,LsTOR,LsS6K,and Ls4EBP,enhanced Akt phosphorylation level,and accelerated ovarian development.Injection of bovine insulin downregulated the expression of miR-9c-5p and novel-mir50 and upregulated the LsAkt expression.It also rescued the reproductive development defects associated with miR-9c-5p/novel-mir50 overexpression,forming a positive regulatory loop of insulin signaling.These results indicate that miR-9c-5p/novel-mir50 regulates the female reproduction of L.serricorne by targeting Akt in response to insulin signaling.The data also demonstrate the effects of the insulin/miRNA/Akt regulatory axis in insect reproduction.

关键词： Akt insulin Lasioderma serricorne microRNA reproduction

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Text Difficulty Study:Do Machines Behave the Same as Humans Regarding Text Difficulty?

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Machine Intelligence Research 2024年第2期21卷 283-293页

作者： Bowen Chen Xiao Ding yi Zhao Bo Fu Tingmao Lin Bing qin Ting Liu Research Center for Social Computing and Information Retrieval Harbin Institute of TechnologyHarbin 150001China Fundamental Technology Center China Construction Bank Financial Technology Co.Ltd.Beijing 100033China

With the emergence of pre-trained models,current neural networks are able to give task performance that is comparable to humans.However,we know little about the fundamental working mechanism of pre-trained models in which we do not know how they approach such performance and how the task is solved by the model.For example,given a task,human learns from easy to hard,whereas the model learns randomly.Undeniably,difficulty-insensitive learning leads to great success in natural language processing(NLP),but little attention has been paid to the effect of text difficulty in NLP.We propose a human learning matching index(HLM Index)to investigate the effect of text difficulty.Experiment results show:1)LSTM gives more human-like learning behavior than BERT.Additionally,UID-SuperLinear gives the best evaluation of text difficulty among four text difficulty criteria.Among nine tasks,some tasks’performance is related to text difficulty,whereas others are not.2)Model trained on easy data performs best in both easy and medium test data,whereas trained on hard data only performs well on hard test data.3)Train the model from easy to hard,leading to quicker convergence.

关键词： Cognition inspired natural language processing psycholinguistics explainability text difficulty curriculum learning

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To improve robustness of mechanical properties of semi-solid cast A356 alloy using taguchi design method

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China Foundry 2024年第2期21卷 175-184页

作者： yi-wu Xu Hong-yi Zhan Wei Tong Jin-ping Li Le-peng Zhang De-jiang Li Xiao-qin Zeng School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China China Science Lab General Motors Global Research&DevelopmentShanghai 201206China General Motors(China)Investment Co. Ltd.Shanghai 201206China China International Intellectech Corporation(CIIC) Beijing 100004China

Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase variations.The present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid casting.The focus was primarily on the robustness of mechanical properties based on Taguchi design method.By analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 h.In a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory robustness.The hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.

关键词： semi-solid casting taguchi design method signal-to-noise ratio mechanical property microstructure

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