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Journal of Iron and Steel Research(International) 2024年第1期31卷 3-23页

作者： Xue-cheng Peng Han-jie Guo Xin-fang Zhang yi-wa luo Ye Sun Jing Guo Rong-guang Yang Xiao-dan Zheng School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials University of Science and Technology Beijing(USTB)Beijing100083China Beijing Shougang Gitane New MATERIALS Co. Ltd.Beijing102206China

Heat-resistant alloys with excellent mechanical properties are widely used in various fields,and further improvement in their properties is essential to meet the requirements in new-generation advanced supercritical boilers,nuclear reactors,superheaters,and other new materials applications.To effectively enhance the comprehensive performance of heat-resistant alloys,second-phase particle strengthening has been widely studied,and in the face of different service envi-ronments of advanced heat-resistant steels,the selection of suitable second-phase particles is essential to maximize the performance of these alloys.To this end,three major types of reinforcing phases in heat-resistant alloys such as carbides,rare earth oxides,and intermetallic compounds are summarized.A comparative analysis of the precipitation behavior of the reinforcing phases with different types as well as the risks and means of controlling their use in service,is presented.Key parameters for the application of various types of second-phase particles in heat-resistant alloys are provided to support the design and preparation of new ultrahigh-performance heat-resistant alloys.

关键词： Heat-resistant alloy Second-phase particle Carbide Rare earth oxide Intermetallic compound Strengthening

Immunotherapy in liver transplantation for hepatocellular carcinoma:Pros and cons

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 163-180页

作者： yi luo Fei Teng Hong Fu Guo-Shan Ding Department of Liver Surgery and Organ Transplantation Changzheng HospitalNaval Medical UniversityShanghai 200003China

Liver transplantation(LT)has emerged as a curative strategy for hepatocellular carcinoma(HCC),but contributes to a higher predisposition to HCC recurrence in the immunosuppression context,especially for tumors beyond the Milan criteria.Although immunotherapy has dramatically improved survival for immunocompetent patients and has become the standard of care for a variety of tumors,including HCC,it is mainly used outside the scope of organ transplantation owing to potentially fatal allograft rejection.Nevertheless,accumulative evidence has expanded the therapeutic paradigms of immunotherapy for HCC,from downstaging or bridging management in the pretransplant setting to the salvage or adjuvant strategy in the posttransplant setting.Generally,immunotherapy mainly includes immune checkpoint inhibitors(ICIs),adoptive cell transfer(ACT)and vaccine therapy.ICIs,followed by ACT,have been most investigated in LT,with some promising results.Because of the complex tumor microenvironment and immunoreactivity when immunosuppressants are combined with immunotherapy,it is difficult to reach formulations for immunosuppressant adjustment and the optimal selection of immunotherapy as well as patients.In addition,the absence of effective biomarkers for identifying rejection and tumor response is still an unresolved barrier to successful clinical immunotherapy applications for LT.In this review,we comprehensively summarize the available evidence of immunotherapy used in LT that is specific to HCC.Moreover,we discuss clinically concerning issues regarding the concurrent goals of graft protection and antitumor response.

关键词： Hepatocellular carcinoma Liver transplantation Immunotherapy Immune checkpoint inhibitors Adoptive cell transfer Immunosuppressant

A review on SnFe2O4 and their composites: Synthesis, properties, and emerging applications

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Progress in Natural Science:Materials International 2022年第5期32卷 517-527页

作者： Hongru Han yi luo Yuefa Jia N.Hasan Chunli Liu School of Water and Environment Chang'an University Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region (Chang'an University) Department of Physics and Oxide Research Center Hankuk University of Foreign Studies

Tin ferrite(SnFe2O4) and their composites have been extensively studied due to their unique functional properties including appealing electronic band structure, good chemical stability, high magnetization, excellent biocompatible and earth-abundant nature. Over the past few years, SnFe2O4and their composites have been well designed and investigated for various kind of applications. In this review, the most important methods for SnFe2O4and their composites synthesis, such as co-precipitation, hydrothermal, solvothermal and sol-gel techniques are summarized. It is important to emphasize that this review mainly focuses on the application of SnFe2O4and their composites for environmental remediation, lithium-ion batteries and hydrogen peroxide sensors, which are discussed in detail for the first time. Apart from that, the key factors and essential means to improve their performance and functionality are systematically reported. Finally, the development prospect and challenge of SnFe2O4and their composites are introduced. It is anticipated that this review will be helpful in development of SnFe2O4and their composites with ameliorated performances for practical application in various fields.

关键词： SnFe 2 O 4 Synthesis Environmental remediation Lithium-ion batteries Hydrogen peroxide sensors

Crosstalk among Oxidative Stress,Autophagy,and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells:A Mixed Computational and Experimental Study

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Current Medical Science 2024年第3期44卷 578-588页

作者： yi-miao luo Shu-sen LIU Ming ZHAO Wei WEI Jiu-xiu YAO Jia-hui SUN Yu CAO Hao LI Department of Geriatrics Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan)Beijing100901China Department of Integration of Chinese and Western Medicine Peking University Health Science CenterBeijing100191China School of Pharmacy Harbin University of CommerceHarbin150028China Xiyuan Hospital China Academy of Chinese Medical ScienceBeijing100901China Wangjing Hospital China Academy of Chinese Medical ScienceBeijing100102China

Objective Brain microvascular endothelial cells (BMECs) were found to shift from their usually inactive state to an active state in ischemic stroke (IS) and cause neuronal damage. Ginsenoside Rb1 (GRb1),a component derived from medicinal plants,is known for its pharmacological benefits in IS,but its protective effects on BMECs have yet to be explored. This study aimed to investigate the potential protective effects of GRb1 on BMECs. Methods An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to mimic ischemia-reperfusion (I/R) injury. Bulk RNA-sequencing data were analyzed by using the Human Autophagy Database and various bioinformatic tools,including gene set enrichment analysis (GSEA),Gene Ontology (GO) classification and enrichment analysis,Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis,protein-protein interaction network analysis,and molecular docking. Experimental validation was also performed to ensure the reliability of our findings. Results Rb1 had a protective effect on BMECs subjected to OGD/R injury. Specifically,GRb1 was found to modulate the interplay between oxidative stress,apoptosis,and autophagy in BMECs. Key targets such as sequestosome 1 (SQSTM1/p62),autophagy related 5 (ATG5),and hypoxia-inducible factor 1-alpha (HIF-1α) were identified,highlighting their potential roles in mediating the protective effects of GRb1 against IS-induced damage. Conclusion GRbl protects BMECs against OGD/R injury by influencing oxidative stress,apoptosis,and autophagy. The identification of SQSTM1/p62,ATG5,and HIF-1α as promising targets further supports the potential of GRb1 as a therapeutic agent for IS,providing a foundation for future research into its mechanisms and applications in IS treatment.

关键词： ischemic stroke ginsenoside Rb1 brain microvascular endothelial cells oxidative stress autophagy apoptosis bioinformatic analysis

Frontiers of COVID-19-related myocarditis as assessed by cardiovascular magnetic resonance

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World Journal of Clinical Cases 2022年第20期10卷 6784-6793页

作者： yi luo Ben-Tian Liu Wei-Feng Yuan Can-Xian Zhao The First People’s Hospital of Longquanyi District Chengdu 610100Sichuan ProvinceChina Department of Radiology Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Medical Imaging Chengdu Second People’s HospitalChengdu 610011Sichuan ProvinceChina

Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.In some patients,COVID-19 is complicated with myocarditis.Early detection of myocardial injury and timely intervention can significantly improve the clinical outcomes of COVID-19 patients.Although endomyocardial biopsy(EMB)is currently recognized as the‘gold standard’for the diagnosis of myocarditis,there are large sampling errors,many complications and a lack of unified diagnostic criteria.In addition,the clinical methods of treating acute and chronic COVID-19-related myocarditis are different.Cardiac magnetic resonance(CMR)can evaluate the morphology of the heart,left and right ventricular functions,myocardial perfusion,capillary leakage and myocardial interstitial fibrosis to provide a noninvasive and radiation-free diagnostic basis for the clinical detection,efficacy and risk assessment,and followup observation of COVID-19-related myocarditis.However,for the diagnosis of COVID-19-related myocarditis,the Lake Louise Consensus Criteria may not be fully applicable.COVID-19-related myocarditis is different from myocarditis related to other viral infections in terms of signal intensity and lesion location as assessed by CMR,which is used to visualize myocardial damage,locate lesions and quantify pathological changes based on various sequences.Therefore,the standardized application of CMR to timely and accurately evaluate heart injury in COVID-19-related myocarditis and develop rational treatment strategies could be quite effective in improving the prognosis of patients and preventing potential late-onset effects in convalescent patients with COVID-19.

关键词： COVID-19 Myocarditis Cardiovascular magnetic resonance Inflammation Diagnosis Infection

National Image Construction from the Perspective of Multimodal Metaphor-A Case Study of the Opening Ceremony of the Beijing Winter Olympics

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Journal of Literature and Art Studies 2024年第4期14卷 290-294页

作者： luo yi ZHOU Jing Wuhan University of Technology WuhanChina

The national image is a comprehensive concept with a distinct political feature,including the international image presented to the outside world,and also encompassing the national identity of the people.With the development of globalization,international cultural communication has become a crucial part of shaping the national image,and the opening ceremony of the Beijing Winter Olympics has become an important opportunity for China to showcase its national image to the world in the post-pandemic era.Based on Forceville’s multimodal metaphor theory,this paper examines the metaphorical phenomena contained in the performance and their functions,effects,and purposes in the construction of the national image.It is found that there are many scenes,images,and narratives in the opening ceremony,including war metaphor,competition metaphor,personification metaphor,and other conceptual metaphors.The focus of this paper is on multimodal metaphor in a broad sense,mainly encompassing auditory and visual modes.Through the use of these multimodal metaphors,the opening ceremony of the Winter Olympics builds an image of a vibrant,peace-loving,and responsible country,which not only demonstrates China’s cultural self-confidence,but also expresses the Chinese people’s beautiful vision for the early reunification of the motherland.

关键词： multimodal metaphor national image Olympic Winter Games Opening Ceremony

A Future Perspective on In-Sensor Computing

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Engineering 2022年第7期8卷 19-21页

作者： Wen Pan Jiyuan Zheng Lai Wang yi luo Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China

The use of artificial intelligence(AI)is escalating rapidly in most applications nowadays,thanks to breakthroughs in biology and mathematics.Novel hardware systems are greatly needed to meet the requirements of AI,which include computing capacity and energy efficiency.One of the major aims of AI is to mimic the functions of the human brain,which are enabled by the massive interconnection of neurons.For example,the visual cortex is the region of the brain that processes visual information.The human vision system,which includes the visual cortex,is highly compact and energy efficient.The retina contains hundreds of millions of light-sensitive neurons interconnected by preprocessing and control neurons to enhance image quality,extract features,and recognize objects.Once light-sensitive neurons have detected trivial signals,they are disabled thereafter,and only the critical information is transferred to the cortex for deep processing.

关键词： hardware artificial breakthrough

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Investigation on effect of semiconducting screen on space charge behaviour of polypropylene-based polymers for HVDC cables

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High Voltage 2022年第5期7卷 968-981页

作者： Mingyu Zhou Haitian Wang Xintong Ren George Chen yi luo Fan Yu Global Energy Interconnection Research Institute Europe GmbH BerlinGermany The Tony Davies High Voltage Laboratory University of SouthamptonSouthamptonHampshireUK Global Energy Interconnection Research Institute Co. Ltd.BeijingChina

High voltage direct current(HVDC)power transmission cable is critical for realising sustainability through renewable energy revolution.Eco-friendly thermoplastic polypropylene(PP)-based polymers/nanocomposites are regarded as promising candidates for replacing current thermoset crosslinked polyethylene(XLPE)cables.As an essential component of the extruded HVDC cable for improving conductor/insulation interface and suppressing charge injection to insulation at high DC electrical stresses,developing semiconducting(SC)screens that are compatible with PP-based insulation is of similar importance but has not been well studied yet.This work aims at designing PP-based semiconducting screens and investigating space charge behaviours of SC/PP/SC sandwich specimen to unfold the effect of semiconducting materials,bonding methods,applied DC electric field,and temperature on charge injection,accumulation,transportation,and dissipation in PP-based insulation.Although conventional thermal,mechanical,and low field electrical characterisations demonstrated that all of the developed semiconducting materials meet the performance criteria of commercial semiconducting materials,their space charge and local electric field distribution varied significantly at high DC fields.Compared with the traditional non-bonded configuration used at lab-scale,charge injection was enhanced in hot-pressed SC/PP/SC samples with tightly bonded interfaces,which better reflects the real situation in extruded cables.High temperature further intensified charge injections.Besides,our results also revealed that high temperature and electric field strongly influence charge mobilities and consequently their distribution and local electric field in PP-based insulations.

关键词： charge insulation effect

《经典释文》“视”字音注及所涉脂、之混并考辨

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语言研究 2024年第2期44卷 73-78页

作者：罗毅安徽大学文学院合肥230031

《经典释文》中“视”字所注“常旨反”“市止反”“常止反”“市志反”等四个反切皆是后人所改,“市至反”“如字”音才是陆氏原书中的音注,而所注“音示”乃以注音形式表通假,并进一步指出《经典释文》中为“视”字所注音切脂、之不混... 详细信息

《经典释文》中“视”字所注“常旨反”“市止反”“常止反”“市志反”等四个反切皆是后人所改,“市至反”“如字”音才是陆氏原书中的音注,而所注“音示”乃以注音形式表通假,并进一步指出《经典释文》中为“视”字所注音切脂、之不混,且脂、之混并的时间当不晚于唐玄宗开元年间。

关键词：《经典释文》 “视”字音注脂之混并考辨

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Fabrication of Ce-ReS_(2)by Molten Salt for Electrochemical Hydrogen Evolution

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Transactions of Tianjin University 2022年第6期28卷 440-445页

作者： Ran Chen Minghai Ma yi luo Liping Qian Shunli Wan Shengyou Xu Xinsong She College of Life&Environmental Sciences Huangshan UniversityHuangshan 245041China

Renewable and economical generation of hydrogen via electrochemical methods shows great potential in addressing the energy crisis.In this study,an emerging molten salt method was adopted for the synthesis of a cerium-modifi ed rhenium disulfi de nanosheet for electrical hydrogen evolution reactions.The prepared 1%Ce-doped rhenium disulfi de(ReS_(2))sample showed promoted hydrogen evolution performance in both acid and alkaline electrolytes compared to bare ReS_(2).Generating of abundant defects in ReS_(2)exposed more reaction active sites.Moreover,adding cerium accelerated the hydrogen evolution dynamics.Hopefully,this work will off er new insight into developing ReS_(2)-based electrocatalysts for hydrogen evolution reactions.

关键词： Hydrogen Molten salt Ce-doped rhenium disulfi de Defects

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