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Chronic Real-Ambient PM_(2.5)Exposure Exacerbates Cardiovascular Risk via Amplifying Liver Injury in Mice Fed with a High-Fat and High-Cholesterol Diet

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Environment & Health 2024年第4期2卷 221-232页

作者： yi Chen Hiu lok Ngan Yuanyuan Song Zenghua Qi Lifang Zhao Chuan Dong Ruijin Li Yanbo Li Zhu Yang Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong SAR 000000China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou 510006China Institute of Environmental Science Shanxi UniversityTaiyuan 030006China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100029China

Epidemiology has associated fine particulate matter(PM_(2.5))exposure with an increased cardiovascular ***,the underlying mechanism,particularly from the liver perspective,remains ***,the influence of chronic PM_(2.5)exposure on cardiovascular risk in mice fed a high-fat and high-cholesterol diet(HFCD)was studied by using a real-world PM_(2.5)exposure *** showed that PM_(2.5)exposure elevated the serum levels of nonhigh-density lipoprotein cholesterol(non-HDL-C)and oxidized low-density lipoprotein(oxLDL)in HFCD-fed mice,demonstrating increased cardiovascular *** investigate the molecular mechanism,lipidomics and metabolomics analyses were conducted and revealed that PM_(2.5)exposure enhanced lipid accumulation and disturbed purine metabolism and glutathione metabolism in the liver of HFCD-fed mice,contributing to the elevated non-HDL-C levels and intensified oxidative ***,PM_(2.5)exposure increased total cholesterol levels by upregulating Hmgcr expression and downregulating Cyp7a1 expression in the livers of HFCD-fed *** HDL-C level was reduced by inhibiting the hepatic Abca1 and Abcg1 expression and decreasing the levels of ApoA-I and ***,the PM_(2.5)-induced pro-oxidative environment impeded the oxLDL clearance and further triggered inflammation,in turn exacerbating oxidative stress and oxLDL *** study demonstrated a synergy of PM_(2.5)and HFCD on cardiovascular risk and illuminated the molecular mechanism in PM_(2.5)-susceptible populations.

关键词： PM_(2.5) HFCD Metabolomics Lipidomics Cardiovascular risk

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui yi Ho Feijun Hu Yujeong Kim Hill Lam Lau ying lo Law Chi Seng Leung Chun yin Tong Kai Kap Wong Wing Lam yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Temperature-and thickness-dependence of robust out-of-plane ferroelectricity in CVD grown ultrathin van der Waals a-In2Se3 layers

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Nano Research 2020年第7期13卷 1897-1902页

作者： Weng Fu Io Shuoguo Yuan Sin yi Pang lok Wing Wong Jiong Zhao Jianhua Hao Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina

Two-dimensional(2D)ferroelectric materials with unique structure and extraordinary optoelectrical properties have attracted intensive research in the field of nanoelectronic and optoelectronic devices,such as optical sensors,transistors,photovoltaics and non-volatile memory ***,the transition temperature of the reported ferroelectrics in 2D limit is generally low or slightly above room temperature,hampering their applications in high-temperature electronic ***,we report the robust high-temperature ferroelectricity in 2D a-In2Se3,grown by chemical vapor depostion(CVD),exhibiting an out-of-plane spontaneous polarization reaching above 200℃.The polarization switching and ferroelectric domains are observed in In2Se;nanoflakes in a wide temperature *** coercive field of the CVD grown ferroelectric layers ilustrates a room-temperature thickness dependency and increases drastically when the film thickness decreases;whereas there is no large variance in the coercive field at dfterent termperature from the samples with identical *** results show the stable ferroelectricit of In2Se3 nanoflakes maintained at high temperature and open up the opportunities of 2D materials for novel applications in high-temperature nanoelectronic devices.

关键词： ln2Se3 two-dimensional(2D)materials ferroelectricity high-temperature coercive field

Actinomycosis mimicking recurrent carcinoma after Whipple's operation

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World Journal of Gastroenterology 2005年第11期11卷 1722-1724页

作者： Jun-Te Hsu Hung-Chieh lo yi-yin Jan Department of General Surgery

Actinomycosis is a rare, chronic, spreading, suppurative,granulomatous and fibrosing infection. Actinomyces are normal inhabitants of the oral cavity and gastrointestinal tract. They rarely cause disease and are seldom reported as pathogens. Herein, we reported on a 69-year-old male patient who had undergone Whipple's operation due to ampulla Vater carcinoma, and became infected with actinomycosis at the pancreaticojejunostomy, which mimicked a recurrent malignancy. He was treated with radical resection of the mass at the pancreaticojejunostomy and had an uneventful postoperative course.

关键词： Actinomycosis Carcinoma Pancreaticojejunostomy Recurrent Whipple

Using recombinant adhesive proteins as durable and green flame-retardant coatings

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Synthetic and Systems Biotechnology 2021年第4期6卷 369-376页

作者： Weng I.Leong Owen lok In lo Fong Tin Cheng Wai Man Cheong Leo Chi U.Seak Pui Ching Middle School(Macao) Edificio Pui Ching7A Av.de Horta e CostaMacao SARChina Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridgeCB23DYUnited Kingdom The Centre for Inflammation Research University of Edinburgh47 Little France CrescentEdinburghEH164TJUnited Kingdom

Current fire retardants are known to be toxic to humans and our *** environmental-friendly flame retardants(FRs),protein-based flame retardants have been studied extensively recently,even though they are not *** this study,we designed,synthesized and tested a durable protein-based FR through the fusion of the adhesion domain from either mussel foot protein-5(mfp-5)or cellulose-binding domain(CBD)with flame retardant protein(SR protein and alpha casein).We first verified the expression of the recombinant proteins in Escherichia coli using Western ***,we coated the fusion protein(carrying cell lysates)to cotton fabrics and wood and verified with Infrared(IR)*** a vertical burning test and wood flammability test,we confirmed the flame retardancy of the materials after the protein *** the vertical burning test,the SR protein and alpha casein flame retardant proteins with the CBD adhesion domain showed a 50.0%and 43.3%increase in flame *** data is also consistent in the wood flame retardancy *** imaging experiments also suggested these new fire retardants can be preserved on the materials well even after ***,our results showed that flame-retardant proteins with adhesion domains are high potential candidates of green alternative flame retardants.

关键词： Flame retardant protein Cellulose-binding domain(CBD) Mussel foot protein-5(mfp-5)

Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

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Neural Regeneration Research 2022年第7期17卷 1566-1575页

作者： Angela Ka Wai Lai Tsz Chung Ng Victor Ka lok Hung Ka Cheung Tam Chi Wai Cheung Sookja Kim Chung Amy Cheuk yin lo Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina Department of Anesthesiology Laboratory and Clinical Research Institute for PainThe University of Hong KongHong Kong Special Administration RegionChina Macao University of Science and Technology TaipaMacao Special Administration RegionChinaSchool of Biomedical SciencesThe State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong Kong Special Administration RegionChina

Reperfusion therapy is the preferred treatment for ischemic stroke,but is hindered by its short treatment window,especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated *** mechanisms underlying exacerbated hemorrhage are not fully *** study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2Akita/+mice to mimic patients with diabetes undergoing delayed mechanical *** results showed that at as early as 2 hours after reperfusion,Ins2Akita/+mice exhibited rapid development of neurological deficits,increased infarct and hemorrhagic transformation,together with exacerbated down-regulation of tight-junction protein ZO-1 and upregulation of blood-brain barrier-disrupting matrix metallopeptidase 2 and matrix metallopeptidase 9 when compared with normoglycemic Ins2+/+*** indicated that diabetes led to the rapid compromise of vessel integrity immediately after reperfusion,and consequently earlier death and further aggravation of hemorrhagic transformation 22 hours after *** observation was associated with earlier and stronger up-regulation of pro-angiogenic vascular endothelial growth factor(VEGF)and its downstream phospho-Erk1/2 at 2 hours after reperfusion,which was suggestive of premature angiogenesis induced by early VEGF up-regulation,resulting in rapid vessel disintegration in diabetic *** reticulum stress-related pro-apoptotic C/EBP homologous protein was overexpressed in challenged Ins2Akita/+mice,which suggests that the exacerbated VEGF up-regulation may be caused by overwhelming endoplasmic reticulum stress under diabetic *** conclusion,the results mimicked complications in patients with diabetes undergoing delayed mechanical thrombectomy,and diabetes-induced accelerated VEGF up-regulation is likely to underlie exacerbated hemorrhagic transformat

关键词： blood-brain barrier brain injury diabetes mellitus hemorrhagic transformation infarct ischemia/reperfusion injury middle cerebral artery occlusion mouse model stroke vascular endothelial growth factor

ZnSe及其Mn掺杂复合材料光吸收催化性能和高压结构性能研究

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光谱学与光谱分析 2024年第2期44卷 380-385页

作者：王世霞王晓雨胡天意上海理工大学材料与化学学院上海200093

ZnSe半导体材料是制备光电器件和光催化反应催化剂的重要原材料。其单体材料具有强光下易变质、电子-空穴复合等现象。通过元素掺杂制备ZnSe复合材料,并与单体材料对比研究了元素掺杂所提升的ZnSe的光学及结构性能。首先采用水热法实验... 详细信息

ZnSe半导体材料是制备光电器件和光催化反应催化剂的重要原材料。其单体材料具有强光下易变质、电子-空穴复合等现象。通过元素掺杂制备ZnSe复合材料,并与单体材料对比研究了元素掺杂所提升的ZnSe的光学及结构性能。首先采用水热法实验室制备纯ZnSe和Mn∶Zn加入比分别为5%、10%、15%和20%的ZnSe复合材料,对比材料形貌、结构,光吸收和催化性能,结果显示掺杂比为10%的样品结晶度最高,杂质成型量最少,催化性能最佳。采用Mao-Bell型金刚石压腔结合原位拉曼光谱探究纯ZnSe和掺杂比为10%的样品的高压结构相变行为,以探究元素掺杂对样品结构性能的影响。研究结果:(1)扫描电子显微镜(SEM)图显示,加入Mn元素后制得的ZnSe样品形貌为球状,与纯样大致相同,球状颗粒表面有小颗粒负载,且随着Mn加入量的增加,表面负载的物质增多;(2)X射线衍射(XRD)图谱表明,ZnSe样品结构为立方闪锌矿结构,随着Mn加入量的增加,样品MnSe特征峰增强,杂质MnO_(2)成型越完全。掺杂比为10%的样品ZnSe结晶度高,杂质成型量少;(3)固体紫外漫反射(UV-Vis)结果表明,掺杂比为10%的样品对光的吸收边最大,禁带宽度最小,为1.65 eV;(4)光催化实验结果显示,掺杂比为10%的样品催化降解甲基橙的效率最大,6 h降解85.4%。研究表明掺杂Mn元素比为10%的ZnSe复合材料,光吸收和催化性能相对最好。金刚石压腔结合原位拉曼光谱探究ZnSe样品和掺杂比为10%的样品的高压相变结果表明,(1)纯ZnSe的lo声子模在压力上升到12.3 GPa时基本消失,TO声子模在压力上升到20.8 GPa时消失,整个加压过程中没有新峰生成,纯ZnSe发生闪锌矿相向岩盐矿相转变的高压行为;(2)复合材料的TO声子模在6.9 GPa时发生劈裂,在8.0 GPa时208 cm^(-1)处有新峰出现,表明在此压力下部分样品由闪锌矿相转变为辰砂矿相。在10.8 GPa时辰砂矿相的峰消失,体系发生由辰砂矿相向岩盐矿相转变;加压至18.8 GPa,lo声子模非常微弱,几近消失,此时体系中的闪锌矿相完全转化为岩盐矿相。研究了不同条件下ZnSe的光催化性能和相变行为,探究了不同掺杂比对ZnSe光催化性能的影响,确定掺杂比为10%的ZnSe样品为最佳掺杂比复合材料,丰富了极端条件下ZnSe的物理化学性质的多样性研究。

关键词： ZnSe Mn掺杂光吸收性能光催化性能高压相变

A MESO-β SCALE SIMULATION OF THE EFFECTS OF BOREAL FOREST ECOSYSTEM ON THE loWER ATMOSPHERE

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Acta meteorologica Sinica 2001年第1期15卷 116-128页

作者：王汉杰 yi-FanLI AloysiusK.lo Ecoenvironment Research Center in Atmospheric Boundary Layer(EERC/ABL) Beijing 100085 Modeling and Integration Research Division Atmospheric Environment Service Environment Canada.Toronto.OntarioCanada M3H 5T4

Based on the Intensive Field Campaign(IFC-1)data of Boreal Ecosystem-Atmosphere Study (BOREAS).a three-dimensional meso-β scale model is used to simulate the effect of boreal forests on the lower atmosphere.A fine horizontal resolution of 2 km×2 km is used in order to distinguish the vegetative heterogeneity in the boreal region.A total of 20×25 grid points cover the entire sub- modeling area in BOREAS' South Study Area(SSA).The ecosystem types and their coverage in each grid square are extracted from the North American Land Cover Characteristics Data Base (NALCCD)generated by the *** Survey(USGS)and the University of Nebraska- Lincoln(UNL).The topography of the study area is taken from the Digital Elevation Map(DEM) of *** model outputs include the components of the energy balance budget within the canopy and at the *** turbulence parameters in the atmospheric boundary layer and the wind. temperature and humidity profiles extending up to a height of 1500 *** addition to the fine time and spatial step,the unique feature of the present model is the incorporation of both dynamic and biological effects of the Boreal forest into the model parameterization *** model results compare favorably with BOREAS' IFC-1 data in 1994 when the forest was in the luxuriant growing period.

关键词： boreal forest atmospheric boundary layer mesoscale modeling turbulent kinetic energy

种植业保险对农地规模化经营的激励效应——基于2011-2021年省级面板数据的经验证据

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保险研究 2024年第4期 34-47页

作者：张伟钟伟霞陈小知刘心怡易沛广东金融学院保险学院广东金融学院农村普惠保险与社会保障创新发展研究中心

本文采用2011~2021年的省级面板数据,运用双向固定效应模型实证分析种植业保险对农地规模化经营的影响。研究发现,种植业保险能够显著促进农地规模化经营。机制分析显示:种植业保险通过激励农户增加农业资本投入、优化农村劳动力要素配... 详细信息

本文采用2011~2021年的省级面板数据,运用双向固定效应模型实证分析种植业保险对农地规模化经营的影响。研究发现,种植业保险能够显著促进农地规模化经营。机制分析显示:种植业保险通过激励农户增加农业资本投入、优化农村劳动力要素配置和推动农业技术进步,引导和激励农户从传统农业生产模式向专业化、集约化的现代生产模式转型,最终促进农地规模化经营。异质性分析表明:在东西部地区、非粮食主产区和不易发生自然灾害地区,种植业保险对农地规模化经营的作用更为显著。基于此,建议中央和地方各级财政进一步提升对种植业保险的补贴力度,特别是提高中部地区和自然灾害高发地区的种植业保险保费补贴力度,推动其从“保成本”向“保收入”转变,激励更多农户从事专业化农业生产,从而助力农地的适度规模经营。

关键词：种植业保险农地规模化经营耕地资源禀赋激励效应