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小柱软腭植入术治疗习惯性鼾声及轻中度睡眠呼吸暂停

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中国耳鼻咽喉头颈外科 2005年第10期12卷 619-621页

作者：殷善开易红良鲁文莺吴红敏曹振宇上海交通大学耳鼻咽喉科研究所上海交通大学附属第六人民医院耳鼻咽喉科鼾症诊治中心上海200233

目的探讨小柱软腭植入术对习惯性鼾声及轻中度阻塞性睡眠呼吸暂停低通气综合征(obstructivesleepapneahypopneasyndrome,OSAHS)的疗效。方法6例经多导睡眠监测(polysomnography,PSG)确诊为轻及中度OSAHS,呼吸暂停低通气指数(apneahypopneaindex,AHI)<40,2例习惯性鼾声患者行小柱软腭植入术,术前、术后均行PSG,鼾声VAS评分及ESS评分。结果术后随访3个月,6例轻及中度OSAHS患者的AHI由术前的23±8.29次/小时下降至11.75±5.62次/小时,鼾声VAS评分从8.5±1.29降至3.5±0.82,ESS评分由术前的15.75±4.11下降至10.25±4.32;2例习惯性鼾声患者的鼾声VAS评分由术前的平均6.5下降至3.5,患者及家属都感满意。1例患者有异物感。未发生植入物排出、感染、出血及腭咽闭合功能不全等并发症。结论小柱软腭植入术对改善鼾声及睡眠呼吸暂停有较确切的近期疗效,而长期疗效有待进一步观察。

关键词：睡眠呼吸暂停,阻塞性腭,软植入物,实验性外科手术阻塞性睡眠呼吸暂停低通气综合征轻中度习惯性植入术鼾声软腭

Global, regional, and national burden of early-onset gastric cancer

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Cancer Biology & Medicine 2024年第8期21卷 667-678页

作者： Nuopei Tan hongliang Wu Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang yi Teng Qianru Li Jiachen Wang Changfa Xia Wanqing Chen Department of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: The burden of gastric cancer(GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to ***: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database. The 5-year interval age-standardised incidence rates(ASIRs) were evaluated using cancer registry data from volumes X±XII of the Cancer Incidence in Five Continents(CI5). Correlation analysis was used to evaluate the relationship between ASIR or the age-standardised mortality rate(ASMR) and the Human Development Index(HDI).Results: There was an estimated global 968,000 new GC cases and 660,000 deaths in 2022, with male predominance. GC ASIRs and ASMRs were 9.2 and 6.1 per 100,000 persons, respectively. East Asia had the highest burden, with 53.8% of cases and 48.2% of deaths among all geographic regions. There was a significant correlation between ASIR and HDI. Over three 5-year intervals from 2003 to 2017, the incidence of GC notably decreased in most countries but peaked at 2008±2012 in New Zealand, Turkey, and South Africa. Several countries in Europe, Oceania, and America suggest an increasingly concerning trend among younger individuals, especially ***: GC is a significant health issue, especially among males and in geographic regions with an HDI, such as eastern Asia. While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments, a rising trend persists among younger individuals. Comprehensive prevention strategies tailored to different age patterns are clearly needed.

关键词： Gastric cancer cancer burden GLOBOCAN incidence mortality

Excessive Daytime Sleepiness and Metabolic syndrome in Men with Obstructive Sleep Apnea:a large cross-sectional study

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Excessive Daytime Sleepiness and Metabolic syndrome in Men w...

中国睡眠研究会第九届学术年会

作者： yiqun Fu Yunyan Xia hongliang yi Huajun Xu Jian Guan Shankai yin Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital Otolaryngological Institute of Shanghai Jiao Tong University Clinical Research Center Shanghai Jiao Tong University School of Medicine

Purpose Excessive daytime sleepiness(EDS),a cardinal feature of obstructive sleep apnea(OSA),contributes to decreased productivity and increased risk of occupational *** may also relate to the metabolic syndrome(MetS).The aim of this cross-sectional study was to examine the role of EDS in metabolic dysfunction and the relation between EDS and MetS in men with *** The records of 2241 consecutive male participants who underwent standard polysomnography(PSG) were *** daytime sleepiness was assessed by using the Epworth sleepiness scale(ESS).Anthropometric,metabolic and polysomnographic parameters were *** Compared to non-EDS ones,males with both EDS and OSA seemed to be more obese,had higher blood pressure,more severe insulin resistance,dyslipidemia and lower LSpO(p<0.05).The metabolic score was significantly higher in the EDS group among severe OSA subjects(3.01±1.16 vs2.67±1.19,p<0.01).After adjustment for confounders,ESS score,BMI,Log ODI,age,smoking and alcoholism significantly predicted the metabolic score(P=0.049,p=0.020;p=0.367,p=0.000;P=0.221,p=0.000;P=0.084,p=0.000;P=0.063,p=0.002;P=-0.051,p=0.011,respectively).ConclusionsEDS was independently correlated with metabolic syndrome in men with *** study suggested that EDS patients should be comprehensively assessed for metabolic dysregulation.

关键词： Obstructive sleep apnea excessive daytime sleepiness dyslipidemia metabolic syndrome

女性甲状腺癌术后促甲状腺激素抑制治疗研究进展

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中华耳鼻咽喉头颈外科杂志 2018年第5期53卷 397-400页

作者：宋凡易红良上海市第六人民医院耳鼻咽喉头颈外科 200030

分化型甲状腺癌（DTC）是女性好发的一种恶性肿瘤，在分化型甲状腺癌术后长期进行促甲状腺激素抑制治疗可有效降低肿瘤复发的风险以及控制疾病的进展，但同时会导致机体处于亚临床甲状腺功能亢进的状态，对女性产生不良的影响，除易导... 详细信息

分化型甲状腺癌（DTC）是女性好发的一种恶性肿瘤，在分化型甲状腺癌术后长期进行促甲状腺激素抑制治疗可有效降低肿瘤复发的风险以及控制疾病的进展，但同时会导致机体处于亚临床甲状腺功能亢进的状态，对女性产生不良的影响，除易导致心血管疾病外，还可导致性激素代谢的改变、月经紊乱、妊娠影响及骨质疏松等疾病。本文就女性甲状腺癌术后促甲状腺激素抑制治疗的最新研究进行综述。

关键词：甲状腺肿瘤促甲状腺激素抑制治疗女性

Factors associated with positional obstructive sleep apnea-hypopnea syndrome

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Factors associated with positional obstructive sleep apnea-h...

中国睡眠研究会第九届学术年会

作者： Xiao Jiao Lili Meng Suru Liu Jian Guan hongliang yi Shankai yin Department of Otolaryngology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalOtolaryngology Institute of Shanghai Jiao Tong University

OBJECTIVE To explore the main factors associated with positional obstructive sleep apneahypopnea syndrome（OSAHS）.METHODS 661 OSAHS patients were divided to non-positional obstructive sleep apnea（NPOSA） and positional obstructive sleep apnea（POSA）.All patients were assessed by the Friedman staging system,Epworth Sleepiness Scale（ESS） questionnaire and anthropometry before overnight *** blood test included fasting glucose and lipid profile *** forward conditional logistic regression analysis was used to assess the simultaneous contribution of all parameters on positional dependency and established prediction model for screening positional OSAHS *** There were 364 NPOSA patients and 297 POSA patients（55.1%vs 44.9%）.Significant differences were found in the values of body mass index（BMI）,neck circumference（NC）,waist circumference（WC）,hip circumference（HC）,ESS score and AHI between NPOSA and POSA group,and POSA group had lower NC,WC,HC,BMI,ESS score,AHI,fasting glucose and apolipoprotein-B values than NPOSA group（p ＜ 0.01）.One model was PRE-1=0.066 × Min S02-0.026 × WC-2.436,which AUC was 0.741（95%CI:0.705 to 0.774）,with sensitivity 71.7% and specificity 70.3%,and another model that only included AHI was PRE-2=-0.053×AHI +1.188,which AUC was 0.784（95%CI:0.751 to 0.815） with sensitivity 93.3%and specificity 54.9%.CONCLUSION The main correlative factors of POSA were AHI,Min SO2 and *** greater WC and more severity of OSAHS,the lower proportion of POSA was.

关键词： obstructive sleep apnea hypopnea syndrome positional dependent apnea hyponea index waist circumference minimal oxyhemoglobin saturation

An Effective Model for Screening Moderate-to-severe Obstructive Sleep Apnea Based on the STOP-BANG questionnaire

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An Effective Model for Screening Moderate-to-severe Obstruct...

中国睡眠研究会第十四届全国学术年会

作者： Jian Guan Huajun Xu Juanjuan Zou Yuyu Wang hongliang yi Shankai yin Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

Background: This study aimed to develop a more effective screening model for moderate-to-severe obstructive sleep apnea(OSA) based on the best questionnaire among ESS, NoSAS and STOP-BANG ***: This cross-sectional study screened 2031 consecutive subjects referred with suspected OSA from 2012 to 2016, including the test cohort from 2012 to 2014 and the validation cohort from 2014 to 2016. Anthropometric measurements, polysomnographic data, ESS, NoSAS scores and STOP-BANG scores were recorded. Receiver operating characteristic curve analyses were performed and the final predictive models were verified in a validation ***: A total of 1840 adults were finally included. The performance of ESS, NoSAS and STOP-BANG questionnaires in screening OSA was compared. The diagnostic accuracy of STOP-BANG questionnaire was superior to ESS and NoSAS. A predictive model based on STOP-BANG yielded an area under the curve(AUC) of 0.931(95% CI : 0.915-0.946), and the sensitivity and specificity were 84.47(95% CI: 81.4-87.2) and 87.36(95% CI: 83.9-90.3) respectively. In the validation cohort, the AUC was 0.955(95% CI: 0.938-0.969), with a sensitivity and specificity of 86.79(95% CI: 83.2-89.9) and 90.88(95% CI: 87.2-93.8) respectively. In addition, the model performed moderately in screening mild OSA with the AUC being 0.771(95% CI: 0.721-0.815). Conclusions: The STOP-BANG questionnaire was effective in screening moderate-to-severe OSA. And a STOP-BANG-based predictive model afforded excellent diagnostic efficacy, which could be applied in clinical practice.

关键词： obstructive sleep apnea screening model sensitivity specificity STOP-BANG questionnaire

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侵犯喉气管的甲状腺癌治疗研究进展

中华耳鼻咽喉头颈外科杂志 2016年第9期51卷 716-720页

作者：李丽娅易红良上海交通大学附属第六人民医院耳鼻咽喉头颈外科 200233

甲状腺癌是耳鼻咽喉头颈外科的常见恶性肿瘤，其发病率具有逐年增加的趋势。由于甲状腺的特殊解剖学位置，一旦癌变侵犯喉、气管则预后较差，手术治疗仍然是侵犯喉气管甲状腺癌患者的首选治疗方式，具有提高生存率、降低复发率、解除气... 详细信息

甲状腺癌是耳鼻咽喉头颈外科的常见恶性肿瘤，其发病率具有逐年增加的趋势。由于甲状腺的特殊解剖学位置，一旦癌变侵犯喉、气管则预后较差，手术治疗仍然是侵犯喉气管甲状腺癌患者的首选治疗方式，具有提高生存率、降低复发率、解除气道梗阻等症状、改善术后生活质量等优势。在手术治疗之外，还存在放化疗、^131I及分子靶向等治疗手段。本文就侵犯喉、气管的甲状腺治疗研究进展作一综述。

关键词：甲状腺肿瘤喉气管侵犯耳鼻喉外科手术放化疗 ^131I治疗分子靶向治疗

Changes in cerebral metabolites in obstructive sleep apnea:a systemic review and meta-analysis

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Changes in cerebral metabolites in obstructive sleep apnea:a...

中国睡眠研究会第九届学术年会

作者： Yunyan Xia yiqun Fu Huajun Xu Jian Guan hongliang yi Shankai yin Department of Otolaryngology Head and Neck Surgery&Center of Sleep Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital Otolaryngological Institute of Shanghai Jiao Tong University Clinical Research Center Shanghai Jiao Tong University School of Medicine

Background Cognitive impairment is associated with changes in cerebral metabolites in patients with obstructive sleep apnea（OSA）.Severalstudies have used magnetic resonance spectroscopy（MRS） to detect variations incerebral metabolites;however,the results have been *** meta-analysissummarizesthe differences in cerebral metabolites between patients with OSA and *** Two electronic databases,PubMed andEmbase,were searched for articles（published before March 31,2016） describing studies that used MRS to evaluate the cerebral metabolite *** overall effects were measured using the weighted mean difference with a 95%confidence *** analysis and sensitivity analysis were used to explore the sources of between-study heterogeneity and the stability of the *** bias was also *** Thirteen studies were ultimately *** the hippocampus,the N-acetylaspartate（NAA）/creatine ratio was lower in patients with *** the frontal lobe,only the NAA/choline ratio was lower in patients with *** Cerebral metabolites are significantly altered in the hippocampus in patients with *** clinical studies are needed to explore the underlying mechanisms between OSA and the changes in cerebral metabolites in the brain.

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Obstructive Sleep Apnea and Peripheral Arterial Disease:Evidence and potential mechanisms

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Obstructive Sleep Apnea and Peripheral Arterial Disease:Evid...

中国睡眠研究会第九届学术年会

Purpose Obstructive sleep apnea（OSA） is associated with cardiovascular *** has been proposed as an intermediate between OSA and incident cardiovascular *** arterial disease（PAD） is a manifestation of atherosclerosis in the vascular bed of the lower extremity *** aimed to summarize the relationship between OSA and PAD and discuss the potential pathophysiological *** Two electronic databases,PubMed andEMBASE,were searched for articles（published before April 2016） describing studies that evaluated association between among OSA,atherosclerosis and *** showed the results involved in the association in clinical and rodent *** Six clinical studies（five cross-sectional and one case-control） have investigated the association between PAD and OSA and established a bidirectional *** rodent studies revealed that intermittent hypoxia induced by OSA played a central role in promoting *** From clinical and rodent perspectives,we conclude that there is a positive association among OSA,atherosclerosis,and *** prospective,randomized controlled studies are needed to establish the cause-effect relationships involved.

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