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FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

Nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei Jiang Ping Cao yi-Ming Wu Xian-Ke Liu Zhu-Jun fang Zhi-Yong Zhang Bin Shi Jun Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China National Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

关键词： Position reconstruction FPGA Readout electronics Neutron flux spatial distribution

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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong SHAO Ming-yi FU Yu ZHAO Rui-xia WANG Jing-wen fang Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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Natural sources,refined extraction,biosynthesis,metabolism,and bioactivities of dietary polymethoxyflavones(PMFs)

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Food Science and Human Wellness 2024年第1期13卷 27-49页

作者： Renyou Gan yi Liu Hang Li Yu Xia Huan Guo fang Geng Qiguo Zhuang Huabin Li Dingtao Wu Research Center for Plants and Human Health Institute of Urban AgricultureChinese Academy of Agricultural SciencesChengdu National Agricultural Science and Technology CenterChengdu 610213China Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural AffairsSichuan Engineering and Technology Research Centre of Coarse Cereal IndustralizationSchool of Food and Biological EngineeringChengdu UniversityChengdu 610106China China-New Zealand Belt and Road Joint Laboratory on Kiwifruit Sichuan Provincial Academy of Natural Resource SciencesChengdu 610213China Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China

Polymethoxyflavones(PMFs)are a type of uncommon dietary flavonoids,characterized by more than one methoxy group,which exist in limited plant species,like Citrus species and Kaempferia *** addition,different PMFs,such as nobiletin,sinensetin,tangeretin,and casticin,have been isolated from these natural *** have received increasing attention due to their multiple bioactivities,such as antioxidant,anti-inflammatory,anti-cancer,metabolic regulatory,immunoregulatory,neuroprotective,and skin protective *** bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut *** order to provide a comprehensive and updated review of PMFs,their natural sources,refined extraction,biosynthesis,metabolism,and bioactivities are summarised and discussed,with the emphasis on the molecular mechanisms of PMFs on regulating different chronic ***,PMFs may be promising flavonoids to the forefront of nutraceuticals for the prevention and/or treatment of certain human chronic diseases.

关键词： Nobiletin O-Methyltransferases Gut microbiota Bioactivities Molecular mechanism

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Highly dispersed Ru nanospecies on N-doped carbon/MXene composite for highly efficient alkaline hydrogen evolution

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Chinese Chemical Letters 2024年第4期35卷 153-159页

作者： Minying Wu Xueliang Fan Wenbiao Zhang Bin Chen Tong Ye Qian Zhang Yuanyuan fang Yajun Wang yi Tang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materialsand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China College of Chemistry&Materials Engineering Wenzhou UniversityWenzhou 325027China

Hydrogen has emerged as a promising environmentally friendly energy source. The development of lowcost, highly active, stable, and easily synthesized catalysts for hydrogen evolution reactions(HER) remains a significant challenge. This study explored the synthesis of nitrogen-doped MXene-based composite catalysts for enhanced HER performance. By thermally decomposing RuCl_(3) coordinated with melamine and formaldehyde resin, we successfully introduced nitrogen-doped carbon(N–C) with highly dispersed ruthenium(Ru) onto the MXene surface. The calcination temperature played a crucial role in controlling the size of Ru nanoparticles(Ru NPs) and the proportion of Ru single-atom(Ru SA), thereby facilitating the synergistic enhancement of HER performance by Ru NPs and Ru SA. The resulting catalyst prepared with a calcination temperature of 600℃, Ti_(3)C_(2)T_x-N/C-Ru-600(TNCR-600), exhibited exceptional HER activity(η10= 17 m V) and stability(160 h) under alkaline conditions. This work presented a simple and effective strategy for synthesizing composite catalysts, offering new insights into the design and regulation of high-performance Ru-based catalysts for hydrogen production.

关键词： HER activity Highly dispersed Ru-based catalysts MXene Alkaline condition

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Efficient photocatalytic biomass-alcohol conversion with simultaneous hydrogen evolution over ultrathin 2D NiS/Ni-CdS photocatalyst

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Chinese Chemical Letters 2024年第7期35卷 422-427页

作者： Zongyi Huang Cheng Guo Quanxing Zheng Hongliang Lu Pengfei Ma Zhengzhong fang Pengfei Sun Xiaodong yi Zhou Chen State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Materials Key Laboratory of High Performance Ceramic Fibers(Xiamen University)Ministry of EducationXiamen UniversityXiamen 361005China Technology Center China Tobacco Fujian Industrial Co.Ltd.Xiamen 361021 China

The photocatalytic conversion of biomass into high-value chemicals,coupled with simultaneous hydrogen(H_(2))evolution,leveraging the electrons and holes generated by solar energy,holds great promise for addressing energy *** this study,we constructed a dual functional photocatalytic system formed by NiS loaded on Ni doped two-dimensional(2D)CdS nanosheet(NiS/Ni-CdSNS)heterostructure for visible-light-driven H_(2)evolution and ethanol oxidation to ***,the 2D NiS/NiCdSNS exhibited significant activity and selectivity in both photocatalytic H_(2)evolution and ethanol oxidation,achieving yields of 7.98 mmol g^(-1)h^(-1)for H_(2)and 7.33 mmol g^(-1)h^(-1)for *** heterogeneous interface of the composite facilitated efficient charge separation,while NiS provided abundant sites for proton reduction,thereby promoting the overall dual-functional photocatalytic *** functional theory calculations further reveal that both Ni doping and NiS loading can reduce the reaction energy barrier of ethanol oxidation of free radicals,and NiS/Ni-CdSNS composite materials exhibit stronger ethanol C-H activation ability to generate key intermediate·CH(OH)CH_(3)on the *** work serves as a valuable guide for the rational design of efficient dual functional photocatalytic systems that combine H_(2)evolution with the selective conversion of organic compounds into high-value chemicals.

关键词： Photocatalysis Biomass-alcohol oxidation H_(2)evolution Dual-functional catalysis

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Lithium Sulfur Batteries:Insights from Solvation Chemistry to Feasibility Designing Strategies for Practical Applications

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Energy & Environmental Materials 2024年第4期7卷 5-27页

作者： Jian Tan Longli Ma Yuan Wang Pengshu yi Chuming Ye Zhan fang Zhiheng Li Mingxin Ye Jianfeng Shen Institute of Special Materials and Technology Fudan University Department of Materials Science Fudan University Department of Chemistry Fudan University

Rechargeable lithium-sulfur (Li-S) batteries,featuring high energy density,low cost,and environmental friendliness,have been dubbed as one of the most promising candidates to replace current commercial rechargeable Li-ion ***,their practical deployment has long been plagued by the infamous"shuttle effect"of soluble Li polysulfides (LiPSs) and the rampant growth of Li dendrites.

关键词： characterization tools design strategies Li–S batteries practical applications solvation chemistry

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Recent progress of two-dimensional metal-base catalysts in urea oxidation reaction

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Rare Metals 2024年第8期43卷 3607-3633页

作者： Qi-Xiang Huang fang Wang Yong Liu Bi-ying Zhang fang-Ya Guo Zhong-Qiu Jia Hao Wang Tian-Xiang Yang Hai-Tao Wu Feng-Zhang Ren Ting-Feng yi School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China Henan Province International Joint Laboratory of Materials for Solar Energy Conversion and Lithium Sodium Based Battery Luoyang 471023China School of Chemistry and Life Sciences Suzhou University of Science and TechnologySuzhou 215009China School of Materials Science and Engineering Northeastern UniversityShenyang110819China

Urea oxidation reaction(UOR)is an auxiliary water electrolysis hydrogen production technology developed in recent years to replace oxygen evolution reaction and reduce energy consumption,which can produce hydrogen more efficiently by low theoretical potential,reduce the average cost of electrochemical hydrogen production,and is a frontier research hotspot for renewable hydrogen ***-dimensional(2D)nanomaterials as electrocatalysts have many favorable potential,such as it can effectively reduce the resistivity of materials and increase the specific surface area with *** paper reviews the application of 2D materials in UOR in alkaline *** a cross-sectional comparison of various material performance data including overpotential,Tafel slope,electrochemical active surface area(ECSA)and it stability test was conducted,which could illustrate the differences between materials composed of different *** addition,the main challenges hindering the progress of research on 2D materials in urea electrocatalysis processes and promising materials in this field in future are summarized and *** is believed that this review will contribute to designing and analyzing highperformance 2D urea electrocatalysts for water splitting.

关键词： Water splitting Urea oxidation reaction Two-dimensional Transition metal compounds Noble/non-noble metals

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From Perspective of Hippocampal Plasticity:Function of Antidepressant Chinese Medicine Xiaoyaosan

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Chinese Journal of Integrative Medicine 2024年第8期30卷 747-758页

作者： ZHANG Wu-jing GUO Ze-xuan WANG yi-di fang Shao-yi WAN Chun-miao YU Xiao-long GUO Xiao-fang CHEN Yue-yue ZHOU Xuan HUANG Jun-qing LI Xiao-juan CHEN Jia-xu FAN Li-li Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhou510632China

The hippocampus is one of the most commonly studied brain regions in the context of *** volume of the hippocampus is significantly reduced in patients with depression,which severely disrupts hippocampal ***,antidepressant therapies that target hippocampal neuroplasticity have not been identified as *** medicine(CM)can slow the progression of depression,potentially by modulating hippocampal ***(XYS)is a CM formula that has been clinically used for the treatment of *** is known to protect Gan(Liver)and Pi(Spleen)function,and may exert its antidepressant effects by regulating hippocampal *** this review,we have summarized the association between depression and aberrant hippocampal ***,we have discussed the researches published in the last 30 years on the effects of XYS on hippocampal neuroplasticity in order to elucidate the possible mechanisms underlying its therapeutic action against *** results of this review can aid future research on XYS for the treatment of depression.

关键词： depression hippocampal neuroplasticity Xiaoyaosan Chinese medicine

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Cuproptosis mediates copper-induced testicular spermatogenic cell death

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Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-yi Zhang Xu-Jun Yu Jun-Jun Li Yao Xiao Guang-Sen Li fang Yang Liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Strengthening and control of second-phase particle precipitation in ferritic/austenitic/martensitic heat-resistant alloys:a review

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Journal of Iron and Steel Research International 2024年第1期31卷 3-23页

作者： Xue-cheng Peng Han-jie Guo Xin-fang Zhang yi-wa Luo Ye Sun Jing Guo Rong-guang Yang Xiao-dan Zheng School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials University of Science and Technology Beijing(USTB)Beijing100083China Beijing Shougang Gitane New MATERIALS Co. Ltd.Beijing102206China

Heat-resistant alloys with excellent mechanical properties are widely used in various fields,and further improvement in their properties is essential to meet the requirements in new-generation advanced supercritical boilers,nuclear reactors,superheaters,and other new materials *** effectively enhance the comprehensive performance of heat-resistant alloys,second-phase particle strengthening has been widely studied,and in the face of different service envi-ronments of advanced heat-resistant steels,the selection of suitable second-phase particles is essential to maximize the performance of these *** this end,three major types of reinforcing phases in heat-resistant alloys such as carbides,rare earth oxides,and intermetallic compounds are summarized.A comparative analysis of the precipitation behavior of the reinforcing phases with different types as well as the risks and means of controlling their use in service,is *** parameters for the application of various types of second-phase particles in heat-resistant alloys are provided to support the design and preparation of new ultrahigh-performance heat-resistant alloys.

关键词： Heat-resistant alloy Second-phase particle Carbide Rare earth oxide Intermetallic compound Strengthening

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