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Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi Suo-Qun Zhao Ru-yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui Yang Dong-Sheng Zhou Min fang Bo ying Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

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Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-yi Ding Min-Jiang Chen Ling-Feng Wu Gao-Feng Shu Shi-Ji fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang Jian-Song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

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Application Strategies of Spatial Refinement Design in Ancient Cities Supported by Digital Te-Zhaoyu Ancient City in Qixian County as an Example

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Journal of Literature and Art Studies 2024年第6期14卷 474-490页

作者： BAI Zhao-yi fang Yu-xin WEN Jia-hao School of Fine Arts Shanxi UniversityTaiyuanShanxi030006China School of Architecture and Urban Planning Beijing University of Civil Engineering and ArchitectureBeijingChina

Digital technology provides a method of quantitative investigation and data analysis for contemporary landscape spatial analysis,and related research is moving from image recognition to digital algorithmic analysis,providing a more scientific and macroscopic way of *** key to refinement design is to refine the spatial design process and the spatial improvement strategy *** the ancient city of Zhaoyu in Qixian County,Shanxi Province as an example,(1)based on obtaining the integrated data of the ancient city through the drone tilt photography,the style and landscape of the ancient city are modeled;(2)the point cloud data with spatial information is imported into the point cloud analysis platform and the data analysis is carried out from the overall macroscopic style of the ancient city to the refinement level,which results in the formation of a more intuitive landscape design scheme,thus improving the precision and practicability of the landscape design;(3)Based on spatial big data,it starts from the spatial aggregation level,spatial distribution characteristics and other evaluation index system to achieve the refinement analysis of the *** technology and methods are used throughout the process to explore the refined design path.

关键词： digital technology Zhaoyu Ancient City tilt photography point cloud data

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基于辐射传输模型探究机载高光谱激光雷达的植被垂直生化组分探测能力

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光谱学与光谱分析 2024年第7期44卷 2083-2092页

作者：郝一硕牛沂芳王力毕恺艺中国科学院空天信息创新研究院遥感与数字地球重点实验室(中国科学院)北京100101 中国科学院大学北京100049

自然环境下的植被群落,由于各种群之间以及种群与环境间的竞争与选择,常呈现出一定的垂直结构,对于同一植株的不同生长阶段,在垂直方向也有着不同的生理生化参数。对这种三维立体分布特征进行探测,能够进行生态环境立体化定量评价,对森... 详细信息

自然环境下的植被群落,由于各种群之间以及种群与环境间的竞争与选择,常呈现出一定的垂直结构,对于同一植株的不同生长阶段,在垂直方向也有着不同的生理生化参数。对这种三维立体分布特征进行探测,能够进行生态环境立体化定量评价,对森林碳储量估算和生物多样性保护等具有重要意义。传统的被动光学遥感以及激光雷达在植被生化参数垂直探测方面有较大的局限性,而高光谱激光雷达(Hyperspectral LiDAR,HSL)这一新型探测仪器的出现为探测植被生理生化参数垂直分布提供了新的手段。但由于受到硬件方面的限制,HSL在机载平台下对森林复杂立体场景的适用性尚未得到充分研究。故首先基于HSL原型样机在实验室开展小尺度的室内测量,以火炬花植株为目标,验证其对空间信息和光谱信息的一体化提取能力;随后进一步使用三维辐射传输模型构建具有垂直异质性特征的森林场景,模拟机载HSL设备实现森林的高光谱三维点云提取,结合植被指数和随机森林模型对场景中三种不同植被冠层的叶绿素浓度和类胡萝卜素浓度进行反演。结果表明:室内实验证实了HSL回波信息可以有效区分植株不同高度处光谱曲线的差异,火炬花上部红色叶片和下部绿色叶片的归一化植被指数分别小于和大于0.5;基于三维辐射传输模型成功构建了虚拟森林场景的机载HSL高光谱三维点云,在得到的24组植被指数中,有17组指数表现出良好的探测精度(平均绝对百分比误差MAPE<13%);植被叶绿素反演模型R^(2)达到0.93,上层、中层和下层的平均绝对误差MAE分别为6.26、3.40和2.81;类胡萝卜素反演模型R^(2)为0.91,上层、中层和下层的MAE分别为1.59、2.58和0.39。该研究显示出HSL设备是一种立体化提取植被光谱信息的有效手段,在探测森林等复杂植被场景的生化组分垂直分布方面具有巨大的应用潜力。

关键词：森林立体场景机载高光谱激光雷达三维辐射传输模型植被生化组分

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IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian fang Amy Cai Lilian Bu Jane Shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

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Multi-objective global optimization approach predicted quasi-layered ternary TiOS crystals with promising photocatalytic properties

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Chinese Physics B 2024年第8期33卷 447-454页

作者：向依婕高思妍王春雷方海平段香梅郑益峰张越宇 Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences School of Materials Science and Engineering East China University of Science and Technology College of Science Shanghai University School of Physics East China University of Science and Technology School of Physical Science and Technology Ningbo University Wenzhou Institute University of Chinese Academy of Sciences (UCAS)

Titanium dioxide（TiO2） has attracted considerable research attentions for its promising applications in solar cells and photocatalytic ***,the intrinsic challenge lies in the relatively low energy conversion efficiency of TiO2,primarily attributed to the substantial band gaps（exceeding 3.0 eV） associated with its rutile and anatase *** multi-objective global optimization,we have identified two quasi-layered ternary Ti-O-S crystals,composed of titanium,oxygen,and *** calculations of formation energy,phonon dispersions,and thermal stability confirm the chemical,dynamical and thermal stability of these newly discovered *** the state-of-art hybrid density functional approach and many-body perturbation theory（quasiparticle GW approach and Bethe-Salpeter equation）,we calculate the optical properties of both the TiOS ***,both phases show favorable photocatalytic characteristics,featuring band gaps suitable for visible optical absorption and appropriate band alignments with water for effective charge carrier ***,ternary compound TiOS holds the potential for achieving high-efficiency photochemical conversion,showing our multi-objective global optimization provides a new approach for novel environmental and energy materials design with multicomponent compounds.

关键词： first principles calculations multi-objective global optimization photocatalysis

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新时期商业银行转型发展路径

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中国金融 2024年第14期 44-45页

作者：房毅恒丰银行党委

随着经济结构调整、产业转型升级的推进,金融结构也将从银行信贷主导的间接融资体系向资本市场主导的直接融资体系逐步演变。面对金融结构变迁,银行以扩张信贷规模创造价值的路径受阻,金融供给出现结构性矛盾。为此,商业银行要以党建引... 详细信息

随着经济结构调整、产业转型升级的推进,金融结构也将从银行信贷主导的间接融资体系向资本市场主导的直接融资体系逐步演变。面对金融结构变迁,银行以扩张信贷规模创造价值的路径受阻,金融供给出现结构性矛盾。为此,商业银行要以党建引领金融强国建设,围绕经济转型升级这一战略,以深化供给侧结构性改革为抓手,积极探索转型发展路径。

关键词：产业转型升级金融结构变迁经济转型升级金融供给结构性矛盾信贷规模经济结构调整转型发展路径

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Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

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Corneal nerve changes by anti-glaucoma medications examined by in vivo confocal microscopy

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1645-1653页

作者： Xin-Yuan Zhu Qing-Shu Ge Zong-yi Li Long-fang Zhou Qian-Wen Bu ying Su Xin-Jie Wang Qing-Jun Zhou Xiao-Jing Pan Die Hu School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071Shandong ProvinceChina School of Ophthalmology Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina

AIM:To evaluate the effects of antiglaucoma eye drops on corneal nerves by in vivo confocal microscopy(IVCM).METHODS:This study comprised 79 patients diagnosed with glaucoma and 16 healthy control *** the glaucoma patients,54 were treated with medication,while 25 remained *** corneal images were evaluated by IVCM,and then ACCMetrics was used to calculate the following parameters:corneal nerve fiber density(CNFD),branch density(CNBD),fiber length(CNFL),total branch density(CTBD),fiber area(CNFA),fiber width(CNFW),and fractal dimension(CNFrD).The correlation between IVCM parameters and drugs was evaluated using non-parametric measurements of Spearman’s rank correlation ***:The CNFD was reduced in glaucoma groups compared to healthy subjects(P<0.01).Patients using anti-glaucoma medications exhibited poorer confocal parameters compared to untreated *** the number of medications and usage count increased,CNFD,CNBD,CNFL,CTBD,CNFA,and CNFrD experienced a decline,while CNFW increased(all P<0.01).For the brinzolamide-therapy group,there was a significant decrease in CNFD and CNFL compared to the other monotherapy groups(P<0.001).In the absence of medication,CNFD in males was lower than that in females(P<0.05).Among patients under medication therapy,CNFD remained consistent between males and ***:Antiglaucoma eye drops affect the microstructure of corneal *** and ACCMetrics are useful tools that could be used to evaluate the corneal nerve changes.

关键词： glaucoma therapy corneal nerve fibers in vivo confocal microscopy ACCMetrics

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Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-Yuan Li yi-Ming Jing Xue Shen Ming-Yue Tang Hong-Hong Shen Xin-Wei Li Zi-Shu Wang fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis

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