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Environmental pollution and DNA methylation： carcinogenesis, clinical significance, and practical applications

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Frontiers of Medicine 2015年第3期9卷 261-274页

作者： yi cao Laboratory of Molecular and Experimental Pathology Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.

关键词： environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention

Numerical simulation of ice accretion in supercooled large droplet conditions

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Science China(Technological Sciences) 2019年第7期62卷 1191-1201页

作者： cao yi Hua XIN Miao School of Aeronautic Science and Engineering Beihang University

The simulated methods for ice accretion on two-dimensional airfoil surface are established completely under the Eulerian framework in supercooled large droplet(SLD) conditions. The two-dimensional code to solve the partial differential equations(PDEs) of droplet phase is derived to simulate the impingement characteristic of SLD. Also, several semi-empirical models which explain the droplet-wall interaction are compared and discussed to show respective features when simulating the splashing phenomenon. In particular, a new boundary condition for wall called penetrable wall for splashing droplet(PWSD) is proposed to deal with the impingement of SLD on solid surface, which efficiently improves the accuracy of simulation. Then the improved impingement characteristic of SLD is input into the extended mass and heat transfer model to simulate the ice growth on airfoil surface. The multistep advanced method is carried out to better match the physical phenomenon of ice growth. At last, the simulated results of critical parameters: local droplet collection efficiency and the height of ice growth are compared with the experimental data which verify the applicability of proposed models.

关键词： numerical simulation supercooled large droplet ice accretion penetrable wall for splashing droplet

Improved Lightweight Deep Learning Algorithm in 3D Reconstruction

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Computers, Materials & Continua 2022年第9期72卷 5315-5325页

作者： Tao Zhang yi cao School of Mechanical Engineering North China University of Water Conservancy and Hydroelectric PowerZhengzhou450045China Department of Electrical and Computer Engineering University of WindsorWindsorONN9B 3P4Canada

The three-dimensional(3D)reconstruction technology based on structured light has been widely used in the field of industrial measurement due to its many *** at the problems of high mismatch rate and poor real-time performance caused by factors such as system jitter and noise,a lightweight stripe image feature extraction algorithm based on You Only Look Once v4(YOLOv4)network is ***,Mobilenetv3 is used as the backbone network to effectively extract features,and then the Mish activation function and Complete Intersection over Union(CIoU)loss function are used to calculate the improved target frame regression loss,which effectively improves the accuracy and real-time performance of feature *** experiment results show that the model size after the improved algorithm is only 52 MB,the mean average accuracy(mAP)of fringe image data reconstruction reaches 82.11%,and the 3D point cloud restoration rate reaches 90.1%.Compared with the existing model,it has obvious advantages and can satisfy the accuracy and real-time requirements of reconstruction tasks in resource-constrained equipment.

关键词： 3D reconstruction feature extraction deep learning lightweight YOLOv4

A meeting to celebrate the centennial birthday of Yuan-Cheng Fung:the father of modern biomechanics and foreign member of the Chinese Academy of Sciences

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National Science Review 2019年第6期6卷 1100-1101页

作者： yi cao Department of Physics Nanjing University

On 20–23 September 2019, many students, friends and colleagues of Professor Yuan-Cheng Fung, together with more than120 scientists and engineers worldwide, gathered at Catamaran Resort in San Diego to attend the first International Conference on Biomechanics and Medical Engineering(ICBME2019)and celebrate the 100th birthday of Fung, the father of modern biomechanics and the creator of tissue engineering.

关键词： A meeting to celebrate the centennial birthday of Yuan-Cheng Fung:the father of modern biomechanics and foreign member of the Chinese Academy of Sciences

Adsorption and Decomposition of NH3 on Ni/Pt（111） and Ni/WC（001） Surfaces： A First-Principles Study

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Chinese Journal of Chemical Physics 2016年第6期29卷 710-716,I0002页

作者： Ai-ai Shen yi-lin cao Schoolof:ChemistryandChemicalEnEineerin~.HenanNormalUniversity.Xinxi~n~453007.China

Density functional theory was used to study the NH3 behavior on Ni monolayer covered Pt（111） and WC（001）. The electronic structure of the surfaces, and the adsorption and decomposition of NH3 were calculated and compared. Ni atoms in the monolayer behave different from that in Ni（111）. More dz2 electrons of Ni in monolayer covered systems were shifted to other regions compared to Ni（111）, charge density depletion on this orbital is crucial to NH3 adsorption. NH3 binds more stable on Ni/Pt（lll） and Ni/WC（001） than on Ni（111）, the energy barriers of the first N-H bond scission were evidently lower on Ni/Pt（111） and Ni/WC（001） than on Ni（111）, these are significant to NH3 decomposition. N recombination is the rate-limiting step, high reaction barrier implies that N2 is produced only at high temperatures. Although WC has similar properties to Pt, differences of the electronic structure and catalytic activities are observed for Ni/Pt（111） and Ni/WC （001）, the energy barrier for the rate-determined step increases on Ni/WC（001） instead of decreasing on Ni/Pt（lll） when compared to Ni（111）. the N recombination barrier by modifying To design cheaper and better catalysts, reducing Ni/WC（001） is a critical question to be solved.

关键词： Ni monolayer Electronic structure NH3 decomposition Density functionaltheory

Optimal Feedback Control of Oil Reservoir Waterflooding Processes

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International Journal of Automation and computing 2016年第1期13卷 73-80页

作者： A.S.Grema yi cao School of Energy Environment & Agrifood Cranfield University

Waterfiooding is a process where water is injected into an oil reservoir to supplement its natural pressure for increment in productivity. The reservoir properties are highly heterogeneous, its states change as production progresses which require varying injection and production settings for economic recovery. As water is injected into the reservoir, more oil is expected to be produced. There is also likelihood that water is produced in association with the oil. The worst case is when the injected water meanders through the reservoir, it bypasses pools of oil and gets produced, Therefore, any effort geared toward finding the optimal settings to maximize the value of this venture can never be over emphasized. Waterflooding can be formulated as an optimal control problem. However, traditional optimal control is an open-loop solution, hence cannot cope with various uncertainties inevitably existing in any practical systems. Reservoir models are highly uncertain. Its properties are known with some degrees of certainty near the well-bore region only. In this work, a novel data-driven approach for control variable （CV） selection was proposed and applied to reservoir waterflooding process for a feedback strategy resulting in optimal or near optimal operation. The results indicated that the feedback control method was close to optimal in the absence of uncertainty. The loss recorded in the value of performance index, net present value （NPV） was only 0.26%. Furthermore, the new strategy performs better than the open-loop optimal control solution when system/model mismatch was considered. The performance depends on the scale of the uncertainty introduced. A gain in NPV as high as 30.04% was obtained.

关键词： Oil reservoir management intelligent wells optimal control theory feedback control geological uncertainty.

Multi-layer Contribution Propagation Analysis for Fault Diagnosis

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International Journal of Automation and computing 2019年第1期16卷 40-51页

作者： Ruo-Mu Tan yi cao School of Water Energy and Environment Cranfield University College of Chemical and Biological Engineering Zhejiang University

The recent development of feature extraction algorithms with multiple layers in machine learning and pattern recognition has inspired many applications in multivariate statistical process monitoring. In this work, two existing multi-layer linear approaches in fault detection are reviewed and a new one with extra layer is proposed in analogy. To provide a general framework for fault diagnosis in succession, this work also proposes the contribution propagation analysis which extends the original definition of contribution of variables in multivariate statistical process monitoring. In fault diagnosis stage, the proposed contribution propagation analysis for multilayer linear feature extraction algorithms is compared with the fault diagnosis results of original contribution plots associated with single layer feature extraction approach. Plots of variable contributions obtained by the aforementioned approaches on the data sets collected from a simulated benchmark case study(Tennessee Eastman process) as well as an industrial scale multiphase flow facility are presented as a demonstration of the usage and performance of the contribution propagation analysis on multi-layer linear algorithms.

关键词： Process monitoring fault detection and diagnosis contribution plots feature extraction multivariate statistics

The differentiability of solutions for elliptic equations which degenerate on part of the boundary of a convex domain

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Applied Mathematics(A Journal of Chinese Universities) 2018年第4期33卷 421-435页

作者： SONG Jia-xin cao yi Department of Mathematics and Information Science Shaanxi Normal University

In this paper,we study the differentiability of solutions on the boundary for equartions of type L;u=;u/x;+|x|;;u/y;=f（x,y）,where λ is an arbitrary positive number. By introducing a proper metric that is related to the elliptic operator L;, we prove the differentiability on the boundary when some well-posed boundary conditions are satisfied. The main difficulty is the construction of new barrier functions in this article.

关键词： elliptic equations convex domain differentiability

Cascading failures in local-world evolving networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1336-1340页

作者： Zhe-jing BAO yi-jia cao School of Electrical Engineering Zhejiang University Hangzhou 310027 China College of Electrical and Information Engineering Hunan University Changsha 410082 China

The local-world (LW) evolving network model shows a transition for the degree distribution between the exponential and power-law distributions, depending on the LW size. Cascading failures under intentional attacks in LW network models with different LW sizes were investigated using the cascading failures load model. We found that the LW size has a significant impact on the network's robustness against deliberate attacks. It is much easier to trigger cascading failures in LW evolving networks with a larger LW size. Therefore, to avoid cascading failures in real networks with local preferential attachment such as the Internet, the World Trade Web and the multi-agent system, the LW size should be as small as possible.

关键词： Complex network Local world (LW) Cascading failures Power-law Attack