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World Journal of Gastrointestinal Oncology 2024年第3期16卷 577-582页

作者： Qiu-Yu Jiang Ru-yi xue Department of Gastroenterology and Hepatology Zhongshan HospitalShanghai Institute of Liver DiseaseFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Shanghai Baoshan District Wusong Central Hospital(Zhongshan Hospital Wusong BranchFudan University)Shanghai 200940China

We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting ***,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers *** and PLR are promising markers for clinical *** models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite ***,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.

关键词： Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Immunecheckpoint inhibitor Immune-related adverse event

Crowding-in or Crowding-out:How Infrastructure Investment Affects Household Consumption

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China Finance and Economic Review 2024年第1期13卷 43-66页

作者： Zhiyu Yan Yufei Yuan yi xue School of International Business and Economics University of International Business and Economics

This paper constructs a dynamic model of household consumption decisions and accordingly designs empirical analyses to identify how infrastructure investment affects private *** estimation results of provincial panel data reveal that infrastructure investment can not only indirectly promote household consumption through the income channel but also directly promote household consumption expansion through the expectations channel,with a significant"crowding-in"***,the effect is significantly weaker in provinces with a lower housing supply elasticity,showing the"crowding-out"pattern through the wealth *** survey data provide an explanation for individual *** investment has a greater pushing effect on house prices in provinces with a lower housing supply *** house price growth has significant"crowding-out"effects on the consumption of wealthy *** not only significantly weakens the driving effect of infrastructure investment on aggregate household consumption,but also increases wealth inequality in the long *** paper explains how infrastructure investment affects household consumption and the corresponding role played by house prices,providing empirical evidences for theoretical studies related to macro-regulatory policies in China.

关键词： infrastructure investment household consumption housing supply elasticity macro regulatory policies

Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions

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Zoological Research 2024年第1期45卷 95-107页

作者： Hai-Yang Wang Lan-Xiang Liu xue-yi Chen Yang-Dong Zhang Wen-Xia Li Wen-Wen Li Lian Wang Xiao-Long Mo Hong Wei Ping Ji Peng Xie NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China College of Stomatology and Affiliated Stomatological Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China Department of Neurology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China Department of Pathology Faculty of Basic MedicineChongqing Medical UniversityChongqing 400016China Department of Neurology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Yu-Yue Pathology Scientific Research Center Chongqing 401329China

The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many ***,the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain *** study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any *** conducted succinylome analysis of hippocampal proteins in germ-free(GF)and specific pathogen-free(SPF)mice and metagenomic analysis of feces from SPF *** results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of *** bioinformatics analyses revealed 584 succinylation sites on 455 proteins,including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF *** constructed a panoramic map of gut microbiota-regulated succinylation,acetylation,and phosphorylation,and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular *** correlation analysis indicated that 13 taxa,predominantly belonging to the Bacteroidetes phylum,were correlated with the biological functions of post-translational *** correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular *** study highlights the hippocampal physiological changes induced by the absence of gut microbiota,and proteomic quantification of succinylation,phosphorylation,and acetylation,contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes.

关键词： Gut microbiota Hippocampal protein Post-translational modifications Succinylation Acetylation Phosphorylation

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国内外教育数字化转型研究的比较分析

黑龙江高教研究 2024年第5期42卷 130-137页

作者：王萍薛一雪中国医科大学辽宁沈阳110122

教育数字化转型是通过综合应用数字技术,掌握数字化能力,构建智慧教育生态和数字治理体系的过程。为比较国内外教育数字化转型领域的研究成果和特征,以Web of Science核心合集和CNKI数据库为数据源,借助CiteSpace可视化软件,围绕文献作... 详细信息

教育数字化转型是通过综合应用数字技术,掌握数字化能力,构建智慧教育生态和数字治理体系的过程。为比较国内外教育数字化转型领域的研究成果和特征,以Web of Science核心合集和CNKI数据库为数据源,借助CiteSpace可视化软件,围绕文献作者、机构、关键词等信息进行聚类分析。研究发现:在教育数字化转型领域,国内发文量自2022年迅速上升,发文最多的机构是华东师范大学开放教育学院。国外发文量最高的国家是西班牙,最多的机构是墨西哥蒙特雷技术与高等教育学院。国外的研究热点主要侧重高等教育体系,呈现相对稳定的演进趋势;国内更关注职业教育,并逐步衍生出部分新的研究主题。国内存在主要问题包括基础设施建设急需标准规范体系引领,数字化技术与教育教学缺乏深度融合,教育评估与监测缺少成熟度评估规范。

关键词：教育数字化转型 CiteSpace 知识图谱比较分析研究热点

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人类命运共同体视阈下的制度型开放

国际商务（对外经济贸易大学学报） 2024年第2期 28-40页

作者：薛熠徐梦瑶对外经济贸易大学国际经济贸易学院北京100029

制度型开放为构建人类命运共同体创造了必要条件。一方面,制度型开放是构建人类命运共同体的需要,在如今百年未有之大变局的国际背景下,制度型开放通过协调和融合制度、规则、管理和标准等方面,为构建人类命运共同体创建有利的条件;另... 详细信息

制度型开放为构建人类命运共同体创造了必要条件。一方面,制度型开放是构建人类命运共同体的需要,在如今百年未有之大变局的国际背景下,制度型开放通过协调和融合制度、规则、管理和标准等方面,为构建人类命运共同体创建有利的条件;另一方面,制度型开放是党和国家推动构建人类命运共同体的重要体现,推进制度型开放的过程也是构建人类命运共同体的过程,以充分践行人类命运共同体的内涵。为此,在构建人类命运共同体的各发展阶段中,制度型开放要建立开放的贸易和投资政策,不断完善投资环境,积极参与国际规则制定,加强可持续发展合作。

关键词：制度型开放人类命运共同体高水平对外开放

Prolonged course of Paxlovid administration in a centenarian with COVID-19:A case report

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World Journal of Radiology 2024年第9期16卷 489-496页

作者： yi-xue Zhang Juan Tang Dan Zhu Chun-Yan Wu Mei-Lan Liang Yuan-Tao Huang Department of Healthcare Haikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikou 570208Hainan ProvinceChina Department of Healthcare Hainan Chengmei HospitalHaikou 570000Hainan ProvinceChina

BACKGROUND According to the population statistics in 2023,there were 110000 people aged over 100 years in China,and the experience of using Paxlovid(nirmatrelvir/ritonavir)for centenarians is particularly *** article reports our experience of using Paxlovid in a centenarian with the novel coronavirus disease 2019(COVID-19)*** SUMMARY A 103-year-old female with mild COVID-19 and renal insufficiency was given sufficient Paxlovid for 2 days and a half dose for 3 *** treatment,the patient was complicated with lung infection and heart failure,and nucleic acid remained *** expert consultation,a full dose of Paxlovid was given again on the 9th day of admission for 2 days and a half dose for 3 ***,anti-heart failure and antibiotics were administered;the heart failure and pulmonary infection were ***,on the 33^(th) day of admission,nucleic acid turned negative,body temperature returned to normal,cough and sputum,fatigue,poor appetite and other symptoms basically *** patient was given Paxlovid via nasal feeding for 2 courses without deterioration of liver and kidney function,diarrhea,nausea and vomiting,myalgia,chest tightness and other side effects,and was discharged from hospital with good *** This case suggests that Paxlovid can be used cautiously in centenarians with renal insufficiency and two courses of treatment can be considered in patients with persistent positive nucleic acid.

关键词： COVID-19 Paxlovid Centenarians Renal insufficiency Heart failure Lung infection Case report

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肺结节性病变-肺腺癌病理新进展

中国综合临床 2024年第1期40卷 36-40页

作者：易伟强吴艺根伊雪厦门医学院附属第二医院胸心外科、厦门医学院呼吸疾病研究所厦门361021 厦门医学院基础部病理解剖教研室厦门361023

肺结节性病变包括良性和恶性肺结节。肺腺癌是恶性肺结节中最常见的一种类型。肺腺癌包括前驱腺体病变、微浸润性腺癌、浸润性黏液腺癌和非黏液腺癌,病理学亚型不同,其手术方式及预后也不尽相同。目前认为肿瘤肺泡腔内播散及亚型中微乳... 详细信息

肺结节性病变包括良性和恶性肺结节。肺腺癌是恶性肺结节中最常见的一种类型。肺腺癌包括前驱腺体病变、微浸润性腺癌、浸润性黏液腺癌和非黏液腺癌,病理学亚型不同,其手术方式及预后也不尽相同。目前认为肿瘤肺泡腔内播散及亚型中微乳头成分和实性成分的占比直接影响外科手术方式及预后。故本研究提出对于前驱腺体病变可以楔形肺切除;微浸润性腺癌可以亚肺叶切除;浸润性腺癌需肺叶切除加淋巴结清扫。即使是Ia期的肺腺癌患者,如果含有肺泡腔内播散、微乳头、胸膜侵犯成分亦推荐术后辅助治疗。

关键词：肺结节性病变恶性肺结节肺腺癌病理分型预后外科手术

中国财产保险公司财务预警研究——基于随机森林财务诊断法

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保险研究 2024年第4期 20-33页

作者：段伊雪彭雪梅方匡南西南财经大学金融学院厦门大学经济学院

建立健全保险业财务预警机制可以为保险业审慎性监管提供工具,有助于维护金融安全。由于“偿二代”对保险公司财务风险的监测滞后,本文提出了随机森林财务诊断法,尝试提前识别财产保险公司潜在的财务风险并预警,并基于2016~2021年81家... 详细信息

建立健全保险业财务预警机制可以为保险业审慎性监管提供工具,有助于维护金融安全。由于“偿二代”对保险公司财务风险的监测滞后,本文提出了随机森林财务诊断法,尝试提前识别财产保险公司潜在的财务风险并预警,并基于2016~2021年81家财产保险公司的数据进行检验。研究发现,随机森林财务诊断法的预警准确性显著高于其他模型,创新指标具有预警价值,多个指标对财务危机的贡献度呈现明显的“阈值效应”,且净资产收益率、每百元保费经营活动净现金流量和净资产变动率三者具有识别财务危机的“联合效应”。本文研究结果有助于监管机构在众多保险机构中快速筛选出问题公司,并能够助力财产保险业界实现对财务危机公司的“诊断+治疗”功能。

关键词：财产保险公司财务预警随机森林模型财务诊断法

A typical Riedel Shear Pattern of active faults in the Laolongwan Basin， Northeastern Tibetan Plateau

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Journal of Earth Science 2024年

作者： Kai-Xun WANG Xiao-Gang LI Wei SHI Xiang-You FENG Qian YANG Jie LI Zheng-Jian XU Zhou-Jun PENG Shao-Hua XU yi-xue XIONG Mao LIN School of Petroleum Engineering， Chongqing University of Science and Technology Chongqing Key Laboratory of Complex Oil and Gas Field Exploration and Development， Chongqing University of Science and Technology Geophysics Research Institute of Jiangsu Oilfield Company，SINOPEC SinoProbe Laboratory， Chinese Academy of Geological Sciences Academy of Dazu Rock Carvings

Riedel shear system， consists of some different oriented faults and derivative structures， is an important pattern of tectonic activity and stress regulation， which has been widely applied to the interpretation of intracontinental deformation. The Laolongwan Basin， located in the western Haiyuan fault zone at the northeastern Tibetan Plateau， is a key area to study the Cenozoic intracontinental deformation in the northeastern plateau， which formed a complex active fault system during the Cenozoic. However， the activity of these faults and their kinematic mechanism remain unclear. In this contribution， based on detailed structural interpretation of remote sensing image， field observations and OSL dating analysis， we propose a Riedel Shear model of active fault system in the Laolongwan basin. Our observations show that this active fault system is consist of four major faults， including the left strike-slip Hasi Shan Fault and Zihong Shan Fault with thrusting characteristics， the Southern Zihong Shan thrust fault and the Mijia Shan normal fault. The fault offset and OSL dating analyses suggest that the left-lateral slip rate of the Hasi Shan Fault is ～ 2.60-3.01 mm/a since ca. 15 ka， whereas the Zihong Shan Fault is ～ 1.10-1.13 mm/a since ca. 14 ka. Fault-slip vectors analyses indicate that the active fault system related to the Riedel Shear in the Laolongwan Basin was controlled by the regional ENE-WSW compressive stress. This compression also caused the significant left-lateral strike-slip movement along the Haiyuan Fault zone at the same time， which might result from the northeastward continuous expanding of the Tibetan Plateau during the late Cenozoic.

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“多波束测线问题”的问题解析

数学建模及其应用 2024年第1期13卷 76-86页

作者：薛毅北京工业大学理学院北京100124

给出2023年“高教社杯”全国大学生数学建模竞赛B题“多波束测线问题”的求解方法,并针对学生在参赛论文中出现的问题作了简要的说明与点评.为保证求解的连贯性,论文的前一部分是问题的求解,后一部分是参赛论文的点评.

关键词：多波束测线海道测量测线规划