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Lung function after growing rod surgery for progressive early-onset scoliosis： a preliminary study

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Chinese Medical Journal 2011年第23期124卷 3858-3863页

作者： JIANG Yu ZHAO Yu WANG yi-peng qiu Gui-xing WENG Xi-sheng LI Ye Department of Orthopedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Pulmonary problems often occur in patients with early-onset scoliosis （EOS）. However, lung function in patients with EOS after growing rod surgery has not been documented. The aim of this study was to investigate lung function after the treatment for EOS with growing rod and its possible correlative factors. Methods Eight patients with EOS were treated with growing rod surgery at Peking Union Medical College Hospital from September 2002 to September 2009. Four patients had finished the final fusion surgery （group 1）, and the other 4 （group 2） were in the process of periodic lengthening. Preoperative forced vital capacity （FVC）, ratio of FVC to predicted FVC, forced expiratory volume in 1 second （FEV1）, ratio of FEV1 to predicted FEV1, and radiographic measurements of Cobb＇s angle and C7-S1 distance were recorded. Lung function changes and correlations between lung function changes and radiographic changes （Cobb＇s angle and C7-S1 distance） were analyzed. Results In group 1, FVC and FEV1 both increased. FVC showed a significant difference （P=0.01）, but FEV1 did not （P =0.05）. In group 2, FVC and FEV1 also increased, and both showed a significant difference （P=0.04 and P=0.02, respectively）. Ratio of FVC to predicted FVC and ratio of FEV1 to predicted FEV1 changed similarly and did not show statistical differences in the 2 groups. There were no significant correlations between lung function changes and radiographic changes （Cobb＇s angle and C7-S1 distance）（P=0.10 and P=0.41, respectively）. Conclusions Lung function increases after growing rod surgery in patients with EOS. Lung function changes do not correlate with Cobb＇s angle changes or C7-S1 distance changes.

关键词： growing rod early-onset scoliosis lung function

Efficacy of the Dynamic Interspinous Assisted Motion system in clinical treatment of degenerative lumbar disease

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Chinese Medical Journal 2010年第21期123卷 2974-2977页

作者： ZHAO Yu WANG yi-peng qiu Gui-xing ZHAO Hong ZHANG Jian-guo ZHOU Xi Department of Ortllopedic Surgery Peking Union Medical College Hospital Chinese Acadamy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background The Dynamic Interspinous Assisted Motion （DIAM） system was designed to stabilize degenerative spinal segments without fusion surgery, maintain segment motion and prevent adjacent segment degeneration. The aim of thisstudy was to investigate clinical efficacy of the DIAM system in treatment of degenerative lumbar disease in *** Eight cases of lumbar vertebral instability were treated with the DIAM system at Peking Union MedicalCollege Hospital from June 2006 to January 2008. There were 6 female and 2 male subjects with a mean age of 46.9years and a range of 40-52 years. Radiographs and scores on outcome measures included the visual analogue scale （VAS） for pain and the Oswestry disability index （ODI）. These scores were recorded before surgery and after surgery at intervals of 3-month, 6-month, 1-year and the final follow-up *** The follow-up time ranged from 12-31 months, with an average of 20.6 months. There were significant differences between preoperative and postoperative scores at each follow-up evaluation （P 〈0.05）. However, there was no significant difference between each postoperative follow-up score （P 〉0.05）. There were significant differences between preoperative and postoperative L4-5 segment activity at each time interval （P 〈0.05）, but no obvious difference was found within each postoperative follow-up evaluation （P 〉0.05）. The ODI and VAS score improvements were directly correlated with segment activity （r 〉0.7, P 〈0.05）.Conclusions The DIAM system appears to be a useful and effective treatment in the surgical management of degenerative lumbar disease in certain patients. However, long-term follow-up is needed to evaluate the clinical outcomes of the device.

关键词： lumbar vertebra low back pain prosthesis implant treatment outcome

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro

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Acta Pharmacologica Sinica 2004年第10期 114-120页

作者： Yu-ping peng, yi-hua qiu, Jian-lan JIANG, Jian-jun WANGDepartment of Biological Science and Technology and the State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 Department of Physiology and Jiangsu Key Laboratory of Neurore generation,Nantong Medical College, Nantong 226001, China

AIM: To explore effects of exogenous and endogenous catecholamines on function of lymphocytes and primary mechanisms mediating the effects. METHODS: Splenocytes of rats were exposed to norepinephrine (NE), a- or p-adrenoceptor antagonists plus NE, or α-methyl-p-tyrosine (α-MT), and then concanavalin A (Con A)-induced interleukin-2 (IL-2) production and natural killer (NK) cell cytotoxicity were determined by MTT assay and LDH assay, respectively. RESULTS: Optical density (OD) values of NE-treated groups, which reflected IL-2 production, were 0.63, 0.61, and 0.60, respectively for 1×10-10, 1×10-9, and 1×10-8 mol/L NE. They were all significantly reduced in comparison with control value of 0.68 (P<0.01). The effect of NE was blocked by either phentolamine (an α-adrenoceptor antagonist) or propanolol (a β-adrenoceptor antagonist). OD values of α-MT, an inhibitor of tyrosine hydroxylase, at doses of 1×10-10,1×10-9, and 1×10-8 mol/L respectively were 0.71, 0.71, and 0.69, which were all notably hig

关键词： catecholamines norepinephrine phentolamine propranolol α-methyl-p-tyrosine interleukin-2 natural killer cell

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电流转移型高压直流断路器

电力系统自动化 2016年第21期40卷 98-104页

作者：许烽江道灼黄晓明陆翌裘鹏国网浙江省电力公司电力科学研究院浙江省杭州市310014 浙江大学电气工程学院浙江省杭州市310027

混合式高压直流断路器是目前处理直流电网故障较为认可的一种方式,但其存在造价昂贵、使用个数多等问题。为有效解决此类弊端,提出一种电流转移型高压直流断路器,并对其故障隔离控制时序进行了研究。电流转移型高压直流断路器借鉴了混... 详细信息

混合式高压直流断路器是目前处理直流电网故障较为认可的一种方式,但其存在造价昂贵、使用个数多等问题。为有效解决此类弊端,提出一种电流转移型高压直流断路器,并对其故障隔离控制时序进行了研究。电流转移型高压直流断路器借鉴了混合式高压直流断路器的关键部件和设计理念,将直流母线以及与其相连的混合式直流断路器进行了整合,以整体概念对断路器进行了再设计,优化了设备利用价值。在保证同等直流故障处理能力的前提下,相比混合式高压直流断路器,其投资成本大幅度降低。为验证电流转移型高压直流断路器的有效性,在PSCAD/EMTDC内建立了一个三端单极直流网络模型。仿真结果验证了电流转移型高压直流断路器在隔离直流线路故障方面的可行性和有效性。

关键词：直流电网电流转移型高压直流断路器直流故障控制策略经济性

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高校嵌入式审计模式的构建

盐城师范学院学报（人文社会科学版） 2019年第4期39卷 82-85页

作者：彭怡秋南通大学审计处

嵌入式审计是将审计工作直接嵌入高校内部管理之中,通过实时监督,对风险进行事前预防、事中控制和事后监督的一种审计模式。推行嵌入式审计是新形势下转变高校现行内部审计模式、弥补高校内部审计力量不足、适应高校审计信息化发展和深... 详细信息

嵌入式审计是将审计工作直接嵌入高校内部管理之中,通过实时监督,对风险进行事前预防、事中控制和事后监督的一种审计模式。推行嵌入式审计是新形势下转变高校现行内部审计模式、弥补高校内部审计力量不足、适应高校审计信息化发展和深化审计成效的需要,是实现高校内部审计全覆盖、提升审计工作效率和质量、防范审计风险的一种有效举措。高校嵌入式审计模式的构建需要在组织架构与人员配置、工作内容及一般流程上有所创新;需要高校创新审计理念,大力推进审计信息化建设,强化高校内审队伍建设,积极整合各类审计资源。

关键词：高校嵌入式审计内部审计

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两种鼠耳蝠的核型、G带和C带研究

四川动物 2011年第6期30卷 882-885页

作者：彭毅秋李国红谷晓明贵州师范大学生物科学学院贵阳550001

使用肺、心脏等组织进行培养,用空气干燥法制作染色体标本,以胰酶法制作G带,BSG法制作C带,分析了贵州2种鼠耳蝠的核型、G带和C带。水鼠耳蝠Myotisdaubentoni和小鼠耳蝠Myotisdividii的染色体数均为2n=44,拥有3对大型和1对中型中着丝粒... 详细信息

使用肺、心脏等组织进行培养,用空气干燥法制作染色体标本,以胰酶法制作G带,BSG法制作C带,分析了贵州2种鼠耳蝠的核型、G带和C带。水鼠耳蝠Myotisdaubentoni和小鼠耳蝠Myotisdividii的染色体数均为2n=44,拥有3对大型和1对中型中着丝粒染色体,染色体臂数(FN)=52;这2种鼠耳蝠的G带是相似的,且与该属大部分物种也相似,表明该属的核型进化很保守。水鼠耳蝠的C带与小鼠耳蝠不同,前者的端着丝粒染色体有丰富的端带,而后者缺乏。依据端带状况,讨论了部分鼠耳蝠的进化关系。

关键词：水鼠耳蝠小鼠耳蝠核型 G带 C带

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying Zhu Pu Chen Tong Zhou Zhe-yi Han Jun Xiao Jian-Feng Ma Wen Ma peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway