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Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang yi li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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乳铁蛋白减轻肠道功能障碍的研究进展

食品科学 2025年第2期46卷 317-326页

作者：李懿任鑫鑫王勤贺晓云中国农业大学食品科学与营养工程学院北京100083 中国农业大学动物科学技术学院北京100083

肠道屏障保持机体内环境稳定,当肠黏膜受损、肠道细胞间紧密连接被破坏和肠道菌群失调时会引发多种疾病。天然活性蛋白在肠道屏障修复中起着关键作用,乳铁蛋白是存在于哺乳动物乳汁中的糖蛋白,具有抗氧化、抗炎和抗菌等多种生物学功能... 详细信息

肠道屏障保持机体内环境稳定,当肠黏膜受损、肠道细胞间紧密连接被破坏和肠道菌群失调时会引发多种疾病。天然活性蛋白在肠道屏障修复中起着关键作用,乳铁蛋白是存在于哺乳动物乳汁中的糖蛋白,具有抗氧化、抗炎和抗菌等多种生物学功能。大量研究表明乳铁蛋白能够增强肠道紧密连接蛋白水平,促进肠细胞生长发育,下调炎症因子表达,调节免疫反应和肠道微生物多样性,参与维持肠道屏障稳态。本文对乳铁蛋白缓解肠道屏障功能障碍研究进展展开综述,有助于了解乳铁蛋白在肠道损伤中的作用机制,为乳铁蛋白制品干预肠道疾病提供参考。

关键词：乳铁蛋白肠道屏障生理活性肠道微生物

Phase-Sensitive Optical Time-Domain Reflectometry Amplified by Gated Raman Pump

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Photonic Sensors 2015年第4期5卷 345-350页

作者： yi li yi ZHOU li ZHANG Mengqiu FAN Jin li Key Laboratory of Optical Fiber Sensing & Communications (Ministry of Education) University of Electronic Scienceand Technology of China Chengdu 611731 China

A long-range phase-sensitive optical time-domain reflectometry is proposed and experimentally demonstrated, based on the gated Raman amplification （RA）. This technique can reduce the amplified spontaneous emissions （ASE） noise of the Raman pump while extend the sensing distance. A direct-detection based phase-sensitive optical time-domain reflectometry （O-OTDR） with an operation range of 50 km and a spatial resolution of 20 m has been demonstrated. The influence of different delay time of the gated Raman pump on the O-OTDR system is also discussed.

关键词： Fiber optic sensors Rayleigh scattering stimulated Raman scattering

Self-assembly of perovskite nanocrystals:From driving forces to applications

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Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： yi li Fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

Long time existence of Ricci-harmonic flow

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Frontiers of Mathematics in China 2016年第5期11卷 1313-1334页

作者： yi li Department of Mathematics Shanghai Jiao Tong University Shanghai 200240 China

We give a survey about recent results on Ricci-harmonic flow.

关键词： Ricci-harmonic flow (RHF) curvature pinching estimates bound edscalar curvature

Embeddings Among Quantum Affine sl_(n)

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Acta Mathematica Sinica,English Series 2024年第3期40卷 792-805页

作者： yi Qiang li Department of Mathematics University at BuffaloThe State University of New YorkBuffaloNY 14260USA

We establish an explicit embedding of a quantum affine sl_(n) into a quantum affine sl_(n)+*** embedding serves as a common generalization of two natural,but seemingly unrelated,embed-dings,one on the quantum affine Schur algebra level and the other on the non-quantum *** embedding on the quantum affine Schur algebras is used extensively in the analysis of canonical bases of quantum affine sln and gl_(n).The embedding on the non-quantum level is used crucially in a work of Riche and Williamson on the study of modular representation theory of general linear groups over a finite *** same embedding is also used in a work of Maksimau on the categorical representations of affine general linear *** further provide a more natural compatibility statement of the em-bedding on the idempotent version with that on the quantum affine Schur algebra level.A gl_(n)-variant of the embedding is also established.

关键词： Quantum affine sl_(n) embeddings

Effect of Nb and Mo on the Microstructure, Mechanical Properties and Ductility-Dip Cracking of Ni–Cr–Fe Weld Metals

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 928-939页

作者： Xu Zhang Dian-Zhong li yi-yi li Shan-Ping Lu Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences

A series of Ni-Cr-Fe welding wires with different Nb and Mo contents were designed to investigate the effect of Nb and Mo on the rnicrostructure, mechanical properties and the ductility-dip cracking susceptibility of the weld metals by optical microscopy （OM）, scanning electron microscopy, X-ray diffraction as well as the tensile and impact tests. Results showed that large Laves phases formed and distributed along the interdendritic regions with high Nb or Mo addition. The Cr-carbide （M23C6） was suppressed to precipitate at the grain boundaries with high Nb addition. Tensile testing indicates that the ultimate strength of weld metals increases with Nb or Mo addition. However, the voids formed easily around the large Laves phases in the interdendritic area during tensile testing for the weld metal with high Mo content. It is found that the tensile fractographs of high Mo weld metals show a typical feature of interdendritic fracture. The high Nb or Mo addition, which leads to the formation of large Laves phases, exposes a great weakening effect on the impact toughness of weld metals. In addition, the ductility-dip cracking was not found by OM in the selected cross sections of weld metals with different Nb additions. High Nb addition can eliminate the ductility-dip cracking from the Ni-Cr-Fe weld metals effectively.

关键词： Nb Mo Laves phase Microstructure Mechanical properties

Effect of Aging on the Microstructure and Mechanical Properties of 1460 Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第4期28卷 454-459页

作者： Juan Ma De-Sheng Yan li-Jian Rong yi-yi li Institute of Metal Research Chinese Academy of Sciences

Effects of the aging temperature on the hardening response, the tensile properties and the precipitate micro- structure evolution of 1460 alloy were studied in this work. It was found that Al3 （Sc, Zr） and δ′ （Al3li） phases were precipitated from the matrix at the very early aging stage, while the precipitation of T1 （Al2Culi） and θ′ （Al2Cu） was much slower than that of the δ′ phase. When aging at higher temperature （160 and 190 ℃）, the δ′, T1 and θ′ phases tended to form simultaneously and grow up very quickly. Conversely, the δ′ and θ″ （Al2Cu） phases were precipitated separately and more dispersive at lower aging temperature （130 ℃）. Taken together, the alloy aged at 160 ℃ exhibited improved mechanical properties owing to the uniform dispersion of the fine T1 precipitates.

关键词： Al-li alloy Precipitate Precipitation hardening process Mechanical property

Influence of a multi-step process on the thickness reduction error of sheet metal in a flexible rolling process

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 76-85页

作者： yi li Ming-zhe li Kai liu Dieless Forming Technology Center Roll Forging Institute Jilin University College of Materials Science and Engineering Jilin University

Flexible rolling is a forming process based on thickness reduction, and the precision of thickness reduction is the key factor affecting bending deformation. The major purpose of the present work is to solve the problem of bending deformation error caused by insufficient thickness reduction. Under the condition of different rolling reductions with the same sheet thickness and the same thickness reduction with different sheet thicknesses, the thickness reduction error of sheet metal is analyzed. In addition, the bending deformation of sheet metal under the same conditions is discussed and the influence of the multi-step forming process on the thickness reduction error is studied. The results show that, under the condition of the same sheet thickness, the thickness reduction error increases with increasing rolling reduction because of an increase in work hardening. As rolling reduction increases, the longitudinal bending deformation decreases because of the decrease of the maximum thickness difference. Under the condition with the same thickness reduction, the thickness reduction error increases because of the decrease of the rolling force with increasing sheet thickness. As the sheet thickness increases, the longitudinal bending deformation increases because of the increase in the maximum thickness difference. A larger bending deformation is divided into a number of small bending deformations in a multi-step forming process, avoiding a sharp increase in the degree of work hardening; the thickness reduction error is effectively reduced in the multi-step forming process. Numerical simulation results agree with the results of the forming experiments.

关键词： flexible rolling convex surface numerical simulation thickness reduction error multi-step forming process