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Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19

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World Journal of Stem Cells 2024年第4期16卷 353-374页

作者： Xiang-yi hou La-Mu Danzeng yi-Lin Wu Qian-Hui Ma Zheng Yu Mei-ying Li Li-Sha Li The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchun 130021Jilin ProvinceChina Department of Pharmacy Jilin UniversityChangchun 130021Jilin ProvinceChina The First Hospital of Jilin University Jilin UniversityChangchun 130021Jilin ProvinceChina

Coronavirus disease 2019(COVID-19)is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection typically presents with fever and respiratory symptoms,which can progress to severe respiratory distress syndrome and multiple organ *** severe cases,these complications may even lead to *** of the causes of COVID-19 deaths is the cytokine storm caused by an overactive immune ***,suppressing the overactive immune response may be an effective strategy for treating *** stem cells(MSCs)and their derived exosomes(MSCs-Exo)have potent homing abilities,immunomodulatory functions,regenerative repair,and antifibrotic effects,promising an effective tool in treating *** this paper,we review the main mechanisms and potential roles of MSCs and MSCs-Exo in treating *** also summarize relevant recent clinical trials,including the source of cells,the dosage and the efficacy,and the clinical value and problems in this field,providing more theoretical references for the clinical use of MSCs and MSCs-Exo in the treatment of COVID-19.

关键词： COVID-19 Cytokine storm Immunomodulation Mesenchymal stem cell Mesenchymal stem cell-derived exosomes

Stark splitting of intense red emission for Er^(3+)in O_(h) symmetry sites realizing optical temperature sensing in biological applications

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Rare Metals 2024年第3期43卷 1263-1274页

作者： Yue Guo Lin-Jun Qin Jing Xu Xiao-Ping Jiang Xiao-Yu Yue yi hou Hao Shi Li-Xi Wang Qi-Tu Zhang Collage of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing211816China

Optical temperature sensing based on the fluorescence intensity ratio(FIR)of red emission for lanthanide ions holds significant relevance in non-contact temperature measurement for biological *** this study,the perovskite-structured KZnF_(3)is utilized as a host material for Er^(3+)to achieve a high-purity upconversion(UC)red *** observed Stark splitting of the red emission peak provides evidence of the energy level splitting of Er^(3+).Group theory is employed to decompose the spectral branching of Er^(3+)under the point group symmetry of KZnF_(3),allowing for the derivation of Stark splitting energy levels induced by the crystal field *** optical temperature-sensing behavior of the red UC luminescence was investigated,specifically examining the FIR of the splitting sub-peaks,which exhibited an exponential relationship with *** KZnF_(3):Yb^(3+),Er^(3+)demonstrated a relative sensitivity(S_(r))of 0.00182%·K^(-1)at 298 K,highlighting its excellent response to *** vivo bio-thermometry experiments conducted on chicken breast validated the material's ability to penetrate biological tissues and showed its significant sensitivity of the FIR to *** results establish KZnF_(3):Yb^(3+),Er^(3+)as a promising material for optical thermometry in various biological applications.

关键词： KZnF_(3) Er^(3+) Upconversion luminescence Stark splitting Temperature sensing

High-Efficiency Triple-Junction Solar Cells

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High-Efficiency Triple-Junction Solar Cells

Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

第十一届新型太阳能材料科学与技术学术研讨会

作者： Shunchang Liu yi hou Department of Chemical and Biomolecular Engineering National University of Singapore Solar Energy Research Institute of Singapore (SERIS) National University of Singapore

Multijunction solar cells offer an effective approach for surpassing the ShockleyQueisser limits in single-junction *** advancement of 1.7 eV perovskites has catalysed rapid progress in the field of perovskite-Si tandem solar cells. For further tapping the potential of multijunction devices,increasing the number of junctions to three has been demonstrated by Ⅲ-Ⅴ semiconductors to be an effective ***,the inferior ultrawide perovskite（1.9-2.0 eV） significantly impedes the development of perovskiteperovskite-Si triple-junction solar cells. Here,we incorporated a novel pseudohalide（cyanate,OCN） into ultrawide perovskites,and confirmed the successful integration of OCN into the perovskite lattice using TEM. This incorporation induced moderate lattice distortion,resulting in increased film uniformity and elevated formation energy for ***,a remarkable VOC of 1.422 V was attained in ultrawide perovskite solar cells,coupled with a V × FF product exceeding 80% of the S-Q ***,in triple-junction solar cells,a certified efficiency of 27.10% was achieved,with a peak efficiency of 27.62%,and the device maintained 80% of the original PCE after 300 h MPP tracking.

关键词： triple-junction solar cells wide-bandgap perovskite pseudohalide

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang yi-Bo hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

Stepwise colloidal lithography toward scalable and various planar chiral metamaterials

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Rare Metals 2024年第2期43卷 723-735页

作者： Xiu Yang Yong Liu Fei-Liang Chen Qian-Qi Lin Rohit Chikkaraddy Shan-Shan Huang Shi-Lin Xian yi-Dong hou Jing-Lei Du Liang-Ping Xia Chun-Lei Du School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Zhuhai Multiscale Optoelectronics Technology Co. Ltd.Zhuhai915060China Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of Twente7500 AEEnschedeThe Netherlands School of Physics and Astronomy University of BirminghamBirminghamB152TTUK College of Physics Sichuan UniversityChengdu610065China Key Laboratory of Micro Nano Optoelectronic Devices and Intelligent Perception Systems Yangtze Normal UniversityChongqing408100China

Chiral metamaterials(CMs)composed by artificial chiral resonators have attracted great attentions in the recent decades due to their strong chiroptical resonance and identifiable interaction with chiral materials,facilitating practical applications in chiral biosensing,chiral emission,and display ***,the complex geometry of CMs improves the fabrication difficulty and hinders their scalable fabrication for practical applications,especially in the visible and ultraviolet *** potential strategy is the colloidal lithography that enables parallel fabrication for scalable and various planar ***,we demonstrate a stepwise colloidal lithography technique that uses sequential deposition from multiple CMs and expand their variety and *** geometry and optical chirality of building blocks from single deposition are systematically investigated,and their combination enables a significant extension of the range of chiral patterns by multiple-step *** approach resulted in a myriad of complex designs with different characteristic sizes,compositions,and shapes,which are particularly beneficial for the development of nanophotonic *** addition,we designed a flexible chiral device based on PDMS,which exhibits a good CD value and excellent stability even after multiple inward and outward *** excellent compatibility to various substrates makes the planar CMs more flexible in practical applications in microfluidic biosensing.

关键词： Chiral metamaterials Colloidal lithography Nanophotonics Metasurfaces Plasmonics Nanofabrications Flexible devices

论南海渔文化的特征与价值——以海南为考察中心

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南海学刊 2024年第3期10卷 117-125页

作者：侯毅中国社会科学院中国社会科学院大学北京102488 中国社会科学院中国边疆研究所北京102488

渔文化是中华优秀传统文化的重要组成部分。南海渔文化资源丰富,有鲜明的特色,具有很高的理论价值和开发利用潜力。应旗帜鲜明地提出南海渔文化的概念,大力推进南海渔文化理论研究,揭示南海渔文化的精神价值,丰富南海渔文化的时代内涵,... 详细信息

渔文化是中华优秀传统文化的重要组成部分。南海渔文化资源丰富,有鲜明的特色,具有很高的理论价值和开发利用潜力。应旗帜鲜明地提出南海渔文化的概念,大力推进南海渔文化理论研究,揭示南海渔文化的精神价值,丰富南海渔文化的时代内涵,发掘南海渔文化资源优势,促进南海渔文化的保护、传承与发展,更好地服务于海南社会经济发展。

关键词：南海海洋文化渔文化海南

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Taq DNA聚合酶的分子改造及其在探针法qPCR直扩体系中的应用

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华南理工大学学报（自然科学版） 2024年第4期52卷 8-16页

作者：胡松青袁家惠刘光毅侯轶华南理工大学食品科学与工程学院广东广州510640 广州英赞生物科技有限公司广东广州510555 华南理工大学轻工科学与工程学院广东广州510640

Taq DNA聚合酶作为实时荧光定量聚合酶链式反应(qPCR)技术的核心组分,其性能优劣直接影响qPCR技术的进一步发展。然而,野生型Taq DNA聚合酶的耐抑制剂性能差、延伸性能不足。为获得具有高性能的Taq DNA聚合酶,采用基因工程技术将双链DN... 详细信息

Taq DNA聚合酶作为实时荧光定量聚合酶链式反应(qPCR)技术的核心组分,其性能优劣直接影响qPCR技术的进一步发展。然而,野生型Taq DNA聚合酶的耐抑制剂性能差、延伸性能不足。为获得具有高性能的Taq DNA聚合酶,采用基因工程技术将双链DNA结合蛋白Sso7d或Sto7d融合在野生型Taq DNA聚合酶的N端或C端,构建了4个均可溶表达的改造体,再经过耐受性测试筛选较优的改造体,结果显示:改造体Taq-Sto的耐受性最高,其热稳定性不受影响,且在1 s/kbp的延伸条件下能成功扩增靶标,表明Taq-Sto具有增强的延伸性能,在TaqMan探针法qPCR体系中对腐殖酸、单宁酸、全血等抑制剂同样表现出良好的耐受性。EMSA实验发现:Taq-Sto对DNA模板的结合亲和力有所提高,有利于增强Taq-Sto对模板的竞争力;将Taq-Sto应用于非洲猪瘟病毒(ASFV)的TaqMan探针法qPCR检测,与商品化试剂相比,Taq-Sto具有更低的ASFV检出限,且在体积分数为2%~6%的猪粪便样本或猪肉样本中的检测灵敏度分别为100.0%和85.4%,说明Taq-Sto在直扩qPCR检测领域更具有优势。

关键词： Taq DNA聚合酶双链DNA结合蛋白耐受性聚合酶链式反应

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储能技术在光伏并网发电系统中的应用

通信电源技术 2024年第6期41卷 100-102页

作者：侯怡北京诚惠电力工程有限公司北京102100

文章概述了储能技术,阐述了光伏并网发电系统,给出了储能技术在光伏并网发电系统中的应用,并详细阐述了储能系统如何解决光伏发电的功率波动问题。结果表明,储能系统能够有效匹配电力生产和消纳,减轻电网压力,并在电网故障或检修时提供... 详细信息

文章概述了储能技术,阐述了光伏并网发电系统,给出了储能技术在光伏并网发电系统中的应用,并详细阐述了储能系统如何解决光伏发电的功率波动问题。结果表明,储能系统能够有效匹配电力生产和消纳,减轻电网压力,并在电网故障或检修时提供备用电源支持。在某30 MW光伏电站的实例中,配置储能系统后,成功减少了脱网考核费用,并增加了上网电量收益,提升了光伏电站的运营效益,稳固了光伏发电在能源结构中的主体地位,促进了清洁能源的利用和环境保护。

关键词：储能技术光伏并网发电系统

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方坯连铸机开浇短切头切割吊运优化改进

水钢科技 2024年第1期 45-49页

作者：侯毅首钢水钢钢轧事业部贵州六盘水55328

本文从开浇采用短切头的背景出发,深入浅出地对开浇短切头切割吊运进行优化改进,分析论证各种切割吊运的优点和缺点,最终优化改进为设计制作开浇短切头自动落入存放槽,停浇后再指挥行车将存放槽内短切头吊走,收到了良好的效果,提升了开... 详细信息

本文从开浇采用短切头的背景出发,深入浅出地对开浇短切头切割吊运进行优化改进,分析论证各种切割吊运的优点和缺点,最终优化改进为设计制作开浇短切头自动落入存放槽,停浇后再指挥行车将存放槽内短切头吊走,收到了良好的效果,提升了开浇短切头达标率,降低了钢铁料消耗,节约了生产成本.

关键词：开浇短切头火焰切割机存放槽