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γδT cells:origin and fate,subsets,diseases and immunotherapy

Signal Transduction and Targeted Therapy 2023年第12期8卷 5769-5806页

作者： yi hu Qinglin hu Yongsheng Li Ligong Lu Zheng Xiang Zhinan yin Dieter Kabelitz Yangzhe Wu Microbiology and Immunology Department School of MedicineFaculty of Medical ScienceJinan UniversityGuangzhouGuangdong 510632China Guangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment Zhuhai Institute of Translational MedicineZhuhai People’s Hospital Affiliated with Jinan UniversityJinan UniversityZhuhaiGuangdong 519000China Department of Medical Oncology Chongqing University Cancer HospitalChongqing 400030China Biomedical Translational Research Institute Jinan UniversityGuangzhouGuangdong 510632China Institute of Immunology Christian-Albrechts-University KielKielGermany

The intricacy of diseases,shaped by intrinsic processes like immune system exhaustion and hyperactivation,highlights the potential of immune renormalization as a promising strategy in disease *** recent years,our primary focus has centered onγδT cell-based immunotherapy,particularly pioneering the use of allogeneic Vδ2+γδT cells for treating late-stage solid tumors and tuberculosis ***,we recognize untapped potential and optimization opportunities to fully harnessγδT cell effector functions in *** review aims to thoroughly examineγδT cell immunology and its role in ***,we elucidate functional differences betweenγδT cells and theirαβT cell *** also provide an overview of major milestones inγδT cell research since their discovery in ***,we delve into the intricate biological processes governing their origin,development,fate decisions,and T cell receptor(TCR)rearrangement within the *** examining the mechanisms underlying the anti-tumor functions of distinctγδT cell subtypes based onγδTCR structure or cytokine release,we emphasize the importance of accurate subtyping in understandingγδT cell *** also explore the microenvironment-dependent functions ofγδT cell subsets,particularly in infectious diseases,autoimmune conditions,hematological malignancies,and solid ***,we propose future strategies for utilizing allogeneicγδT cells in tumor *** this comprehensive review,we aim to provide readers with a holistic understanding of the molecular fundamentals and translational research frontiers ofγδT cells,ultimately contributing to further advancements in harnessing the therapeutic potential ofγδT cells.

关键词： γδT immunotherapy diseases

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Unraveling the macroevolution of horseshoe bats(Chiroptera: Rhinolophidae: Rhinolophus)

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Zoological Research 2023年第1期44卷 169-182页

作者： Wei-Jian Guo yi Wu Kai He yi-Bo hu Xiao-Yun Wang Wen-hua Yu Key Laboratory of Conservation and Application in Biodiversity of South China School of Life SciencesGuangzhou UniversityGuangzhouGuangdong 510000China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Unraveling the diversification mechanisms of organisms is a fundamental and important macroevolutionary question regarding the diversity,ecological niche, and morphological divergence of life. However, many studies have only explored diversification mechanisms via isolated factors. Here,based on comparative phylogenetic analysis, we performed a macroevolutionary examination of horseshoe bats(Chiroptera: Rhinolophidae:Rhinolophus), to reveal the inter-relationships among diversification, intrinsic/extrinsic factors, and climatic ecological niche characteristics. Results showed a general slowing trajectory during diversification, with two dispersal events from Asia into Southeast Asia and Africa playing key roles in shaping regional heterogeneous diversity. Morphospace expansions of the investigated traits(e.g., body size,echolocation, and climate niche) revealed a decoupled pattern between diversification trajectory and trait divergence, suggesting that other factors(e.g., biotic interactions) potentially played a key role in recent diversification. Based on ancestral traits and pathway analyses, most Rhinolophus lineages belonging to the same region overlapped with each other geographically and were positively associated with the diversification rate, implying a competitive prelude to speciation. Overall, our study showed that multiple approaches need to be integrated to address diversification history. Rather than a single factor, the joint effects of multiple factors(biogeography, environmental drivers, and competition) are responsible for the current diversity patterns in horseshoe bats, and a corresponding multifaceted strategy is recommended to study these patterns in the future.

关键词： Diversification Rhinolophus Historical biogeography Abiotic/Biotic factors Climatic niche characteristics Competition

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Charge storage mechanism of MOF-derived Mn2O3 as high performance cathode of aqueous zinc-ion batteries

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Journal of Energy Chemistry 2021年第1期30卷 277-283,I0009页

作者： Min Mao Xingxing Wu yi hu Qunhui Yuan Yan-Bing He Feiyu Kang Tsinghua Shenzhen International Graduate School Division of Energy&EnvironmentTsinghua UniversityShenzhen 518055GuangdongChina Laboratory of Advanced Materials Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Advanced Welding and Joining and School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055GuangdongChina

Aqueous Zinc-ion batteries(ZIB) are attracting immense attention because of their merits of excellent safety and quite cheap properties compared with lithium-ion batteries(LIB).Manganese oxide is one of the most important cathode materials of *** this paper,α-Mn2O3 used as cathode of ZIB is synthesized via Metal-Organic Framework(MOF)-derived method,which delivers a high specific capacity of225 mAh g^(-1) at 0.05 A g^(-1) and 92.7 mAh g^(-1) after 1700 cycles at 2 A g^(-1).The charge storage mechanism of α-Mn2O3 cathode is found to greatly depend on the discharge current *** lower current density discharging,the H+ and Zn2+ are successively intercalated into the α-Mn2O3 before and after the "turning point" of discharge voltage and their discharging products present obviously different morphologies changing from flower-like to large plate-like *** a higher current density,the low-voltage plateau after the turning point disappears due to the decrease of amount of Zn2+ intercalation and the H+intercalation is dominated in α-Mn2 *** study provides significant understanding for future design and research of high-performance Mn-based cathodes of ZIB.

关键词： Zinc ion batteries α-Mn2O3 Metal-organic framework(MOF) Charge storage mechanism

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Complexation of hypocrellins and bivalent metals and one-electron reduction of the complexes with electron donor

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Chinese Journal of Chemistry 1993年第6期11卷 532-539页

作者： Jing-yi An Fei Tian yi-Zhen hu Li-Jin Jiang Institute of Photographic Chemistry Chinese Academy of Sciences Beijing 100101

The complexation of HA (or HB) with bivalent metals was examined by UV-Vis and NMR spectroscopy, and all of the complexes obtained have a metal-ligand ratio of 1:*** photoinduced reduction of the complexes of HA-Zn^(2+) and HA Mg2+ (or HB-Zn^(2+), HB-Mg2+) in the presence of 1-benzyl-1,4-dihydro-nicotinamide as the electron donor was investigated by UV-Vis and ESR spectroscopy. The studies demonstrated that illumination of the complexes of HA(HB)-Zn^(2+) and HA(HB)-Mg^(2+) led to the accumulation of the chelated semiquinone radical anions.

关键词： HB

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Effect of Carbon Particles with Different Topological Shape on the Rheological Behavior of PVA Aqueous Dispersion

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Chinese Journal of Polymer Science 2022年第11期40卷 1402-1410页

作者： Qing-Sheng Ni Miao Du Guo-Rong Shan yi-hu Song Qiang Zheng State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Institute of Zhejiang University-Quzhou Quzhou324000China Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Poly(vinyl alcohol)(PVA)is usually processed and used in a form of aqueous dispersion.A large number of inter-and intramolecular hydrogen bonds make it very difficult to obtain suitable rheological behavior for *** this study,carbon particles with different topological shapes were added into PVA aqueous dispersion to tune the steady and dynamic rheological *** results show that the zero-dimensional particles(carbon black,CB)increase monotonically the zero-shear viscosity of PVA dispersion,while the one-dimensional particles(carbon nanotubes,CNTs)make it first increase,and then decrease and rise again,like an N-shape,and the two-dimensional particles(graphene oxide,GO)can make it first decrease and then increase,exhibiting a *** is believed that the topological shape of the carbon particles brought about these *** zero-dimensional particles mainly act as physical crosslinking points due to their small *** at a certain content,both CNTs and GO can destroy the intermolecular hydrogen bonds between PVA chains because the PVA chains can twine around the slim CNTs and the large planar size of GO prevents the adsorbed PVA from forming hydrogen bond with other *** high hydroxyl value of carbon particle surface could strengthen this *** is expected that the viscosity of polymer dispersion can be regulated by particles with different topological shape and the surface characteristic,so as to widen the operable concentration range during preparing composite functional materials.

关键词： Topological shape Hydrogen bond Rheological behavior PVA aqueous dispersion

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Gradient Estimates and Harnack Inequality for a Nonlinear Parabolic Equation on Complete Manifolds

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Communications in Mathematics and Statistics 2013年第4期1卷 437-464页

作者： Jiaxian Wu yi-hu Yang Department of Mathematics Tongji UniversityShanghai 200092China Department of Mathematics Shanghai Jiao Tong UniversityShanghai 200240China

Let M be a noncompact complete Riemannian *** this paper,we consider the following nonlinear parabolic equation on M ut(x,t)=△u(x,t)+au(x,t)ln u(x,t)+bu^α(x,t).We prove a Li–Yau type gradient estimate for positive solutions to the above equation;as an application,we also derive the corresponding Harnack *** results generalize the corresponding ones proved by Li(J Funct Anal 100:233–256,1991).

关键词： Gradient estimate Ricci curvature Harnack inequality Nonlinear parabolic equation

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Constant Barrier Strategies in a Two-state Markov-modulated Dual Risk Model

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 679-690页

作者： Xue-min MA Kui LUO Guang-ming WANG yi-jun hu School of Mathematics and Statistics Wuhan University Wuhan 430072 China

In this paper, we consider the dividend problem in a two-state Markov-modulated dual risk model, in which the gain arrivals, gain sizes and expenses are influenced by a Markov process. A system of integro-differential equations for the expected value of the discounted dividends until ruin is derived. In the case of exponential gain sizes, the equations are solved and the best barrier is obtained via numerical example. Finally, using numerical example, we compare the best barrier and the expected discounted dividends in the two-state Markov-modulated dual risk model with those in an associated averaged compound Poisson risk model. Numerical results suggest that one could use the results of the associated averaged compound Poisson risk model to approximate those for the two-state Markov-modulated dual risk model.

关键词： Dual risk model Markov-modulated risk model barrier strategy

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Research on scheduling of robotic transient survey for Antarctic Survey Telescopes(AST3)

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Research in Astronomy and Astrophysics 2018年第1期18卷 59-68页

作者： Qiang Liu Peng Wei Zhao-hui Shang Bin Ma yi hu National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Tianjin Normal University Tianjin 300387 China

Antarctic Survey Telescopes（AST3） are designed to be fully robotic telescopes at Dome A,Antarctica,which aim for highly efficient time-domain sky surveys as well as rapid response to special transient events（e.g.,gamma-ray bursts,near-Earth asteroids,supernovae,etc.）.Unlike traditional observations,a well-designed real-time survey scheduler is needed in order to implement an automatic survey in a very efficient,reliable and flexible way for the unattended *** present a study of the survey strategy for AST3 and implementation of its survey scheduler,which is also useful for other survey projects.

关键词： telescope survey methods:observational techniques:miscellaneous

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Optomechanical sensing with on-chip microcavities

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Frontiers of physics 2013年第5期8卷 475-490页

作者： yi-Wen hu Yun-Feng Xiao Yong-Chun Liu Qihuang Gong State Key Laboratory for Artificial Microstructure and Mesoscopic Physics School of Physics Peking University Beijing 100871 China

The coupling between optical and mechanical degrees of freedom has been of broad interest for a long time. However, it is only until recently, with the rapid development of optical mierocavity research, that we are able to manipulate and utilize this coupling process. When a high Q microeavity couples to a mechanical resonator, they can consolidate into an optomeehanieal system. Benefitting from the unique characteristics offered by optomeehanical coupling, this hybrid system has become a promising platform for ultrasensitive sensors to detect displacement, mass, force and acceleration. In this review, we introduce the basic physical concepts of cavity optomechanies, and describe some of the most typical experimental cavity optomechanical systems for sensing applications. Finally, we discuss the noise arising from various sources and show the potentiality of optomechanical sensing towards quantum-noise-limited detection.

关键词： optical microcavities mechanical resonators cavity optomechanics optical sensing,integrated photonics

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Convolution Kernels Implementation of Cardinalized Probability Hypothesis Density Filter

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Acta Mathematicae Applicatae Sinica 2013年第4期29卷 739-748页

作者： Yue MA Jian-zhang Zhu Qian-qing QIN yi-jun hu School of Mathematics and Information Sciences North China University of Water Resources and Electric Power School of Mathematics and Statistics Wuhan University State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan University

The probability hypothesis density （PHD） propagates the posterior intensity in place of the poste- rior probability density of the multi-target state. The cardinalized PHD （CPHD） recursion is a generalization of PHD recursion, which jointly propagates the posterior intensity function and posterior cardinality distribution. A number of sequential Monte Carlo （SMC） implementations of PHD and CPHD filters （also known as SMC- PHD and SMC-CPHD filters, respectively） for general non-linear non-Gaussian models have been proposed. However, these approaches encounter the limitations when the observation variable is analytically unknown or the observation noise is null or too small. In this paper, we propose a convolution kernel approach in the SMC-CPHD filter. The simuIation results show the performance of the proposed filter on several simulated case studies when compared to the SMC-CPHD filter.

关键词： random finite set (RFS) probability hypothesis density (PHD) filter cardinalized probability hypothesis density (CPHD) filter convolution kernel

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