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Nano Research 2019年第6期12卷 1229-1249页

作者： Xiaolan Xue Renpeng Chen Changzeng Yan Peiyang Zhao yi hu Wenjun Zhang Songyuan Yang Zhong Jin Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

The ammonia synthesis from nitrogen and water under ambient conditions is one of the most inviting but challenging reaction *** nitrogen is abundant in the atmosphere and the ammonia synthesis reaction is exothermic on the thermodynamics,the conversion of N2 to ammonia is actually hard to proceed owing to the chemical inertness and stability of N2 *** industry,ammonia synthesis is carried out by the Haber-Bosch process under harsh conditions (300-500 ℃,20-30 MPa) associated with the requirement of substantial energy input and the enormous emission of greenhouse gases (e.g.,CO2).Recently,a growing number of studies on photo(electro)catalytic and electrocatalytic nitrogen reduction reaction (NRR) in aqueous solution have attracted extensive attention,which holds great promise for nitrogen fixation under room temperature and atmospheric ***,the very low efficiency and ambiguous mechanism still remain as the major hurdles for the development of photochemical and electrochemical NRR *** we provide an overview of the latest progresses,remaining challenges and future prospects in photocatalytic and electrocatalytic nitrogen ***,this review offers a helpful guidance for the reasonable design of photocatalysts and electrocatalysts towards NRR by combining theory predictions and experiment *** hope this review can stimulate more research interests in the relatively understudied but highly promising research field of NRR.

关键词： heterogeneous catalysis nitrogen fixation ammonia synthesis photocatalytic electrocatalytic nitrogen reduction

Characteristics of Sb6Te4/VO2 Multilayer Thin Films for Good Stability and Ultrafast Speed Applied in Phase Change Memory

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Chinese Physics Letters 2018年第9期35卷 53-56页

作者： yi-Feng hu Xuan Guo Qing-Qian Qin Tian-Shu Lai School of Mathematics and Physics Jiangsu University of TechnologyChangzhou 213000 State Key Laboratory of Optoelectronic Materials and Technology School of PhysicsSun Yat-Sen UniversityGuangzhou 510275 State Key Laboratory of Silicon Materials Zhejiang UniversityHangzhou 310027 Key Laboratory of Microelectronic Devices ＆ Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029

The Sb6 Te4/VO2 multilayer thin films are prepared by magnetron sputtering and the potential application in phase change memory is investigated in detail. Compared with Sb6 Te4, Sb6 Te4/VO2 multilayer composite thin films have higher phase change temperature and crystallization resistance, indicating better thermal stability and less power consumption. Also, Sb6 Te4/VO2 has a broader energy band of 1.58 eV and better data retention （125℃ for 103/）. The crystallization is suppressed by the multilayer interfaces in Sbf Te4/VO2 thin film with a smaller rms surface roughness for Sbf Te4/VO2 than monolayer Sb4Te6. The picosecond laser technology is applied to study the phase change speed. A short crystallization time of 5.21 ns is realized for the Sb6Te4 （2nm）/VO2 （8nm） thin film. The Sb6 Te4/VO2 multilayer thin film is a potential and competitive phase change material for its good thermal stability and fast phase change speed.

关键词： VO Te Characteristics of Sb6Te4/VO2 Multilayer Thin Films for Good Stability and Ultrafast Speed Applied in Phase Change Memory Sb

A Pricing Model of Airbag Options with Discrete Monitoring

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Acta Mathematicae Applicatae Sinica 2024年

作者： Min hu Shui-yi hu Cong QIN Fan ZHOU Center for Financial Engineering Soochow UniversitySuzhou College of Liberal Arts and Sciences University of Connecticut

In this paper, we propose a pricing model of airbag options with discrete monitoring, time-varying barriers, early exercise opportunities, and other popular features simultaneously. We show that the option value is a viscosity solution of a PDE system. In particular, a closed-form solution is obtained in the classic BlackScholes economy with no early exercise opportunities. For the general case, we develop a numerical algorithm and conduct an extensive numerical analysis after calibrating the model to the CSI 500 index in China. Greek letters, dynamic hedging, and assessment of investing in airbag options are also studied.

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Torin2 overcomes sorafenib resistance via suppressing mTORC2-AKT-BAD pathway in hepatocellular carcinoma cells

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 547-554页

作者： yi-Ting hu Zhe-Yue Shu Jing-hua Jiang Qin-Fen Xie Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren UniversityShulan International Medical CollegeHangzhou 310022China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Jinhua Municipal Central HospitalJinhua 321000China

Background:Sorafenib is an oral multi-kinase inhibitor that was approved by the US Food and Drug Administration for the treatment of patients with advanced hepatocellular carcinoma(HCC).However,resistance to sorafenib is an urgent problem to be resolved to improve the therapeutic efficacy of *** the activation of AKT/mTOR played a pivotal role in sorafenib resistance,we evaluated the effect of a dual mTOR complex 1/2 inhibitor Torin2 on overcoming the sorafenib resistance in HCC ***:The sorafenib-resistant huh7 and Hep3B cell lines were established from their parental cell *** synergistic effect of sorafenib and Torin2 on these cells was measured by cell viability assay and quantified using the Chou-Talalay *** induced by the combination of sorafenib and Torin2 and the alteration in the specific signaling pathways of interest were detected by Western ***:Sorafenib treatment inversely inhibited AKT in parental but activated AKT in sorafenib-resistant huh7 and Hep3B HCC cells,which underscores the significance of AKT ***2 and sorafenib synergistically suppressed the viability of sorafenib-resistant cells via apoptosis ***2 successfully suppressed the sorafenib-activated mTORC2-AKT axis,leading to the dephosphorylation of Ser136 in BAD protein,and increased the expression of total BAD,which contributed to the apoptosis in sorafenibresistant HCC ***:In this study,Torin2 and sorafenib showed synergistic cytostatic capacity in sorafenibresistant HCC cells,via the suppression of mTORC2-AKT-BAD *** results suggest a novel strategy of drug combination for overcoming sorafenib resistance in HCC.

关键词： Torin2 Sorafenib resistance Hepatocellular carcinoma mTORC2-AKT-BAD pathway

Tiaoxin Recipe, a Chinese herbal formula, inhibits microRNA-34a expression in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease

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Journal of Integrative Medicine 2019年第6期17卷 404-409页

作者： yi-ran hu San-li Xing Chuan Chen Ding-zhu Shen Jiu-lin Chen Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine

Objective: To investigate the effect and underlying mechanisms of Tiaoxin Recipe(a Chinese herbal formula) treatment on Alzheimer's disease(AD).Methods: Twelve-week-old APPswe/PS1 DE9(APP/PS1) double transgenic mice were used as a model of AD-afflicted mice. One group of mice was treated with Tiaoxin Recipe by gastrogavage for 12 weeks,while two other groups were given intraperitoneal injections of nicotinamide adenine dinucleotide or FK866 for 4 weeks. Morris water maze and thioflavin S staining tests were performed to evaluate cognitive impairment and amyloid plaque deposition, respectively. Serum amyloid-β1-42(Aβ1-42) content was detected using an enzyme-linked immunosorbent assay, and quantitative reverse transcriptionpolymerase chain reaction was performed to examine the expression levels of microRNA-34 a(miR-34 a) in cortex and hippocampus samples of the study ***: Compared with the normal control group, the memory and learning abilities of the APP/PS1 model group were found to be impaired(P ying the development of early-stage AD by inhibiting the expression of miR-34 a.

关键词： Alzheimer's disease Tiaoxin Recipe MicroRNA-34a Transgenic mice Amyloid-β Herb

Optimizing Locations and Scales of Emergency Warehouses Based on Damage Scenarios

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Journal of the Operations Research Society of China 2020年第3期8卷 437-456页

作者： Bo-Chen Wang Miao Li yi hu Lin huang Shu-Min Lin School of Management Shanghai UniversityShanghai 200444China

Choosing the locations and the capacities of emergency warehouses for the storage of relief materials is critical to the quality of services provided in the wake of a largescale emergency such as an *** paper proposes a stochastic programming model to determine disaster sites’locations as well as their scales by considering damaged scenarios of the facility and by introducing seismic resilience to describe the ability of disaster sites to resist *** objective of the model is to minimize fixed costs of building emergency warehouses,expected total transportation costs under uncertain demands of disaster sites and penalty costs for lack of relief materials.A local branching(LB)based solution method and a particle swarm optimization(PSO)based solution method are proposed for the *** numerical experiments are conducted to assess the efficiency of the heuristic according to the real data of Yunnan province in China.

关键词： Emergency warehouse location Damage scenario Disaster resilience Stochastic programming

A Highly Sensitive In-Situ Turbidity Sensor With Low Power Consumption

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Photonic Sensors 2014年第1期4卷 77-85页

作者： yi hu Lei Sun Shuming Ye Hang Chen Kai Jiang Jianming Pan College of Biomedical Engineering&Instrumentation Science in Zhejiang University Hangzhou310027China Key lab of Biomedical Engineering of Ministry of Education in Zhejiang University Hangzhou310027China Laboratory of Marine Ecosystem and Biogeochemistry State Oceanic Administration(SOA)Hangzhou310012China

A highly sensitive in-situ turbidity sensor with the low power consumption was proposed and evaluated in this study. To meet the practical requirements of the in-situ detection, we have designed the light scattering path, watertight mechanical structure, and ultra-weak scattering light detecting method. Experiments showed that the sensor had a sensitivity of 0.0076 FTU with the concentration range of 0 - 25 FTU and the R-square of 0.9999. The sensor could withstand the water pressure in depth of 1000m and had the low power consumption in the active mode 10.4mA, sleep mode 65 pA with a supply voltage of 8.4V. Southern China Sea buoy experiments indicated that the sensor could work well in the actual in-situ environment. In comparison with sensors of other companies, our sensor had relatively more comprehensive performance.

关键词： In-situ turbidity sensor high sensitivity low power consumption water tight mechanical structure

Empowering highway network:Optimal deployment and strategy for dynamic wireless charging lanes

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Communications in Transportation Research 2023年第1期3卷 176-186页

作者： Mingyang Pei Hongyu Zhu Jiazheng Ling yi hu Handong Yao Lingshu Zhong School of Civil Engineering and Transportation South China University of TechnologyGuangzhou510640China Boyd Research and Education Center University of GeorgiaAthens30602USA School of Systems Science and Engineering Sun Yat-Sen UniversityGuangzhou510399China

Amid escalating energy crises and environmental pressures,electric vehicles(EVs)have emerged as an effective measure to reduce reliance on fossil fuels,combat climate change,uphold sustainable energy and environmental development,and strive towards carbon peaking and neutrality *** study introduces a nonlinear integer programming model for the deployment of dynamic wireless charging lanes(DWCLs)and EV charging strategy joint optimization in highway *** into account established charging resources in highway service areas(HSAs),the nonlinear charging characteristics of EV batteries,and the traffic capacity constraints of *** model identifies the deployment of charging facilities and the EV charging strategy as the decision-making variables and aims to minimize both the DWCL construction and user charging *** ensuring that EVs maintain an acceptable state of charge(SoC),the model combines highway EV charging demand and highway EV charging strategy to optimize the DWCL deployment,thus reducing the construction cost of wireless charging facilities and user charging *** efficacy and universality of the model are demonstrated using the classical Nguyen-Dupius network as a numerical example and a real-world highway network in Guangdong Province,***,a sensitivity analysis is conducted to corroborate the stability of the *** results show that the operating speed of EVs on DWCLs has the largest impact on total cost,while battery capacity has the *** comprehensive study offers vital insights into the strategic deployment of DWCLs,promoting the sustainable and efficient use of EVs in highway networks.

关键词： Electric vehicle Dynamic wireless charging lane Charging strategy Nonlinear charging characteristics Optimal deployment

Shallow Water Body Data Processing Based on the Seismic Oceanography

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Journal of Ocean University of China 2013年第3期12卷 319-326页

作者： LIU huaishan hu yi yiN Yanxin WANG Linfei TONG Siyou MA Hai Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationOcean University of China

Physical properties of sea water,such as salinity,temperature,density and acoustic velocity,could be demarcated through degradation of energy caused by water absorption,attenuation and other *** overcome the challenging difficulties in the quick monitoring of these physical properties,we have explored the high resolution marine seismic survey to instantly characterize *** on the unique wavefield propagating in the sea water,we have developed a new approach to suppress the noise caused by the shallow sea water disturbance and obtain useful information for estimating the sea water *** approach improves seismic data with high signal-to-noise ratio and *** seismic reflection imaging can map the sea water structure *** with the knowledge of local water body structure profile over years,the instant model for predicting the sea water properties could be built using the seismic data acquired from the specially designed high precision marine seismic *** model can also be updated with instant observation and the complete data processing *** present study has the potential value to many applications,such as 3D sea water monitoring,engineering evaluation,geological disaster assessment and environmental assessment.

关键词： seismic oceanography seismic exploration seismic reflection profiling marine water body characteristics rapidmonitoring

Study on effects of the secondary fuel manifold unfold pressure on engine starting performance

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Propulsion and Power Research 2017年第4期6卷 253-258页

作者： Jianbing Cai Gaiqi Li Jianhua Li yi hu Aero Engine Corporation of China Hunan Aviation Powerplant Research InstituteZhuzhou 412002China

The fuel manifold is an import accessory through which the fuel enters in combustor,after measuring in fuel control *** component test results of fuel manifolds show that,when the starting fuel supply is given and the primary fuel manifold relative unfold pressure is at constant,the adjustment of the secondary fuel manifold turn-on pressure has effects on fuel flow through the secondary fuel manifold and the time of fuel into the combustion *** verification test of the secondary fuel manifold unfold pressure influence on engine starting performance has been conducted,showing that the unfold pressure variation of the secondary fuel manifold has great influence on the engine start *** test research results have important guidance and reference meaning for confirming the secondary fuel manifold unfolds pressure.

关键词： Fuel manifold The primary fuel manifold The secondary fuel manifold Switch pressure Turbo-shaft engine