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Targeted delivery of factors and cells for improving cardiac tissue regeneration and heart function following myocardial infarction

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Engineered Regeneration 2024年第2期5卷 210-227页

作者： Kamila Raziyeva Zharylkasyn Zharkinbekov yevgeniy Kim Arman Saparov School of Medicine Nazarbayev UniversityAstana 010000Kazakhstan

Following myocardial infarction(MI),cardiac tissue undergoes irreversible cellular alterations,with cardiomy-ocytes being replaced by fibrotic *** order to improve tissue regeneration,a previously characterized chitosan-based cryogel,which was designed by our group,was *** treatment regimen involved the sequen-tial delivery of the cryogel loaded with specific cytokines and growth factors,followed by a separate injection of pre-differentiated ***,the cryogel loaded with interleukin-10 and transforming growth factor-βwas injected into infarcted tissue immediately after MI induction,targeting the acute inflammatory *** day four post-MI,a second injection was administered,this time utilizing cryogel loaded with vascular endothelial growth factor and fibroblast growth factor-2,aimed at promoting tissue regeneration and ***-quently,on day six post-MI,the experimental group received cardiomyocyte-like cells,smooth muscle cells,and endothelial *** purpose of these cells,in synergy with cytokines and growth factors,was to repopulate the lost cellular populations,thereby enhancing myocardial *** treatment improved myocardial tissue regeneration,increased cardiac output,ejection fraction,and reduced fibrotic ***,the chitosan-based cryogel,enriched with anti-inflammatory and proangiogenic factors and supplemented with pre-differentiated cells,offers a promising platform for controlled release of therapeutics,promoting substantial tissue repair and regeneration following MI.

关键词： Myocardial infarction Tissue regeneration Cryogel Growth factors Stem cells

Prophylaxis with intraocular pressure lowering medication and glaucomatous progression in patients receiving intravitreal anti-VEGF therapy

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1611-1618页

作者： Jeanette Du James T Patrie Xiao-Yu Cai Bruce E Prum yevgeniy Shildkrot New York Eye and Ear Infirmary of Mount Sinai 310 East 14 StreetNew YorkNY 10003USA Department of Public Health Sciences University of VirginiaP.0.Box 800717CharlottesvilleVirginia 22908USA Department of Ophthalmology University of Virginia School of Medicine1300 Jefferson Park AveCharlottesvilleVirginia 22908USA

AIM: To investigate whether pretreatment with pressurelowering medication prior to anti-vascular endothelial factor(VEGF) injections had an effect on glaucomatous progression in patients with preexisting glaucoma or ocular hypertension(OHT).METHODS: A total of 66 eyes from 54 patients with a preexisting diagnosis of glaucoma or OHT, treated with six or more anti-VEGF injections were selected for chart review. Primary outcome measures were rate of visual field loss in d B/year, rate of change in retinal nerve fiber layer(RNFL) thickness in microns/year, and need for additional glaucoma ***: The number of eyes requiring additional glaucoma medication was 5 of 20(25.0%) and 14 of 46(30.4%) for the pretreated and non-pretreated groups, respectively. The number of eyes requiring glaucoma laser or surgery was 4 of 20(20.0%) and 13 of 46(28.3%) for the pretreated and non-pretreated groups, respectively. Estimated mean rate of pattern standard deviation decline was not significant in either group(P>0.073), with no difference between groups(P=0.332). Although both groups showed significant RNFL change from baseline(P<0.011), no difference was detected between groups(P=0.467).CONCLUSION: Pretreatment has no detectable effect on structural or functional glaucomatous progression. Patients receiving repeated injections may be at risk for glaucomatous complications requiring invasive intervention.

关键词： anti-vascular endothelial growth factor therapy pretreatment glaucomatous progression

Early CD8 T-cell memory precursors and terminal effectors exhibit equipotent in vivo degranulation

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Cellular & Molecular Immunology 2015年第4期12卷 400-408页

作者： yevgeniy Yuzefpolskiy Florian M. Baumann Vandana Kalia Surojit Sarkar Center for Molecular Immunology and Infectious Diseases Department of Veterinary and Biomedical Sciences and The Huck Institutes of Life Sciences ThePennsylvania State University University Park PA USA

Early after priming, effector CD8 T cells are distinguished into memory precursor and short-lived effector cell subsets （MPECs and SLECs）. Here, we delineated a distinct in vivo heterogeneity in killer cell lectin-like receptor G1 （KLRG-1） expression, which was strongly associated with diverse MPEC and SLEC fates. These in vivo MPECs and SLECs expressed equivalent levels of cytotoxic molecules and effector cytokines. Using a unique in vivodegranulation assay, we found that the MPECs and SLECs similarly encountered infected target cells and elaborated equivalent levels of cytotoxicity in vivo. These data provide direct in vivoevidence that memory-fated ceils pass through a robust effector phase. Additionally, the preferential localization of the MPECs in the lymph nodes, where a lesser degree of cytotoxicity was elaborated, suggests that the MPECs may be protected from excessive stimulation and terminal differentiation by virtue of their differential tissue localization. These data provide novel mechanistic insights into the linear decreasing potential model of memory differentiation.

关键词： CD8 MPEC SLEC in vivo degranulation effector cytotoxicity

Ammonia-oxidizing archaea and bacteria are structured by geography in biological soil crusts across North American arid lands

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Ecological Processes 2013年第1期2卷 98-107页

作者： yevgeniy Marusenko Scott T Bates Ian Anderson Shannon L Johnson Tanya Soule Ferran Garcia-Pichel School of Life Sciences Arizona State UniversityP.O.Box 874501TempeAZ 85287-4501USA Cooperative Institute for Researchin Environmental Sciences University of ColoradoBoulderCO80309USA Bioscience Division B-11Los Alamos National LaboratoryLos AlamosNM87545USA Department of Biology Indiana University-Purdue UniversityFort WayneINUSA

Introduction:Biological soil crusts(BSCs)can dominate surface cover in dry lands worldwide,playing an integral role in arid land biogeochemistry,particularly in N fertilization through fixation and *** is a characteristic and universal N transformation in BSCs that becomes important for the export of N beyond the microscopic bounds of the crust *** contribution of ammonia-oxidizing bacteria(AOB)in BSCs has been shown,but the role and extent of the recently discovered ammonia-oxidizing archaea(AOA)have ***:We sampled various types of crusts in four desert regions across the western United States and characterized the composition and size of ammonia-oxidizing communities using clone libraries and quantitative PCR targeting the amoA gene,which codes for the ammonia monooxygenase enzyme,universally present in ammonia-oxidizing ***:All archaeal amoA sequences retrieved from BSCs belonged to the Thaumarchaeota(Nitrososphaera associated Group I.1b).Sequences from the Sonoran Desert,Colorado Plateau,and Great Basin were indistinguishable from each other but distinct from those of the Chihuahuan *** on amoA gene abundances,archaeal and bacterial ammonia oxidizers were ubiquitous in our survey,but the ratios of archaeal to bacterial ammonia oxidizers shifted from bacterially dominated in northern,cooler deserts to archaeally dominated in southern,warmer ***:Archaea are shown to be potentially important biogeochemical agents of biological soil crust N *** associated with different types of BSCs and biogeographical factors reveal a niche differentiation between AOA and AOB,possibly driven by temperature.

关键词： Biological soil crust Desert Arid amoA Ammonia oxidation Nitrification Nitrogen cycle Thaumarchaeota

The Thermal Inertia Characteristics of the System Ocean-Atmosphere

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Journal of Geographic Information System 2012年第5期4卷 479-482页

作者： Habibullo I. Abdussamatov Sergey I. Khankov yevgeniy V. Lapovok Space Research of the Sun Sector Pulkovo Observatory St. Petersburg Russia

To estimate the time delay between the planetary temperature change and the change of the incoming solar radiation fraction absorbed by the ocean and the atmosphere, the analytical energy balance model is presented. The model generalization allows of using averaged data for model parameterization. Using the model, the time delay is investigated on four model cases of absorbed radiation change. The interconnections among the time delay, the planetary thermal inertia and the ocean active layer depth are established.

关键词： Thermal Inertia Planetary Temperature Total Solar Irradiance System Ocean-Atmosphere

Complete remission of primary hepatic lymphoma in a patient with human immunodeficiency virus

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World Journal of Clinical Cases 2015年第2期3卷 186-190页

作者： David Widjaja Mohammad Al Shelleh Myrta Daniel yevgeniy Skaradinskiy Division of Gastroenterology and Division of Oncology and Hematology Department of MedicineBronx Lebanon Hospital Center

Diffuse large B cell primary hepatic lymphoma is a rare disease with limited available information regarding treatment strategy. Although the liver contains lymphoid tissue and is an important site for lymphocytes activation, primary hepatic lymphoma is rare. Host factors make the liver a poor environment for malignant lymphoma development. Its coexistence with human immunodeficiency virus(HIV) infection increases morbidity and mortality risks. Additionally, jaundice increases chances of developing adverse effects from chemotherapy. Here, we report a case of diffuse large B cell primary hepatic lymphoma in a 32-year-old HIV positive man. Due to elevated liver enzyme levels and jaundice, the patient was initially treated with an R-DHAP regimen, which was replaced with an R-CHOP regimen. Restaging images with a positron emission tomography scan after the latest chemotherapy cycle confirmed remission. This is the first report of complete remission of primary hepatic diffuse large B cell lymphoma in an HIV positive patient in the English literature.

关键词： Primary hepatic lymphoma Diffuse B cell lymphoma Human immunodeficiency virus R-DHAP R-CHOP

Modeling of the Earth’s Planetary Heat Balance with Electrical Circuit Analogy

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Journal of Electromagnetic Analysis and Applications 2010年第3期2卷 133-138页

作者： Habibullo I. Abdussamatov Alexander I. Bogoyavlenskii Sergey I. Khankov yevgeniy V. Lapovok 不详

The integral heat model for the system of the Earth’s surface—the atmosphere—the open space based on the electrical circuit analogy is presented. Mathematical models of the heat balance for this system are proposed. Heat circuit which is analog of the electrical circuit for investigating the temperature dependencies on the key parameters in the clear form is presented.

关键词： Electrical Circuit Analogy Planetary Heat Balance Climate Trends

The Influence of the Atmospheric Transmission for the Solar Radiation and Earth’s Surface Radiation on the Earth’s Climate

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Journal of Geographic Information System 2010年第4期2卷 194-200页

作者： Habibullo I. Abdussamatov Alexander I. Bogoyavlenskii Sergey I. Khankov yevgeniy V. Lapovok Pulkovo Observatory

The physical and mathematical model of the planetary heat balance is developed to establish the influence of the atmospheric transmission for the solar radiation in the shortwave spectrum range and for the surface IR radiation in the longwave spectrum range on the Earth’s climate. It is shown the possibility of the decreas- ing of the atmospheric and surface temperatures with the decreasing of the atmospheric transmission for IR spectrum range, and this decreasing can’t be equilibrated with the change of the atmospheric transmission for the incoming solar radiation.

关键词： Climate Atmospheric Transmission Planetary Heat Balance

Obesity trends in Russia. The impact on health and healthcare costs

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Health 2012年第12期4卷 1471-1484页

作者： Ketevan Rtveladze Tim Marsh Laura Webber Fanny Kilpi yevgeniy Goryakin Anna Kontsevaya Antonina Starodubova Klim McPherson Martin Brown Department of Internal Disease No. 2 Therapeutic Faculty Russian State Medical University (RSMU) Moscow Russia Department of Primary Prevention in Primary Care National Research Center for Preventive Medicine Moscow Russia Department of Social Research Population Research Unit University of Helsinki Helsinki Finland Modelling Department Micro Health Simulations London UK New College University of Oxford Oxford UK The London School of Hygiene and Tropical Medicine London UK

Similar to most developed countries, obesity rates inRussiahave been steadily increasing. This has led to a high burden of obesity related diseases and associated healthcare costs. The micro-simulation model has been utilized to project body mass index (BMI) and BMI related disease burden and healthcare costs. Incidence, mortality, survival and healthcare costs were collected for thirteen diseases. The results have been simulated for 3 hypothetical scenarios to project a potential impact of policy interventions: 1) assuming no reduction in BMI;2) 1% reduction in mean BMI across the population;3) 5% reduction in mean BMI across the population. Nearly 58% of the female population was obese (BMI ≥30 kg/m2) or overweight (BMI 25 -29.9 kg/m2) in 2010, and the prevalence is projected to decrease to 54% in 2050. The rates are predicted to increase for men from 51% in 2010 to 76% in 2050. The prevalence rates will triple for some obesity-related diseases. A one percent decrease in BMI across the population will save more than two billion US Dollars in 2030 and 2050. Despite female obesity prevalence starting at a higher point than the men, obesity is predicted to increase in males but not females. Disease and economic burden attributed to these obesity rates are still severe and the country should implement strong policies to tackle the obesity epidemic.

关键词： Obesity Trends Russia Health Healthcare Costs