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Microbial Electrosynthesis for Producing Medium Chain Fatty Acids

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Engineering 2022年第9期16卷 141-153页

作者： Na chu Wen Hao Qinglian Wu Qinjun Liang Yong Jiang Peng Liang Zhiyong Jason Ren Raymond Jianxiong Zeng Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China College of Architecture and Environment Sichuan UniversityChengdu 610065China Department of Civil and Environmental Engineering&Andlinger Center for Energy and the Environment Princeton UniversityPrincetonNJ 08544USA

Microbial electrosynthesis(MES)employs microbial catalysts and electrochemistry to enhance CO_(2)bioconversion to organics with concurrent waste biorefining *** aim of this review is to comprehensively discuss the current state of the art and prospects of medium chain fatty acids(MCFAs)production in MES from CO_(2)and organic *** mechanisms and development of MCFAs production via conventional fermentation are introduced as *** on MCFAs production in MES are summarized,highlighting the strategy of multiple-electron donors(EDs).Challenges for MCFAs production in MES from CO_(2)are presented,and the primary discussions included methanogenesis inhibition,adenosine triphosphate(ATP)limitations of acetogens,and production of limited EDs via *** applications of electrochemical approaches to promote the bioconversion of actual waste materials with MCFAs production are ***,future directions are explored,including multi-stage reactions,substrate supply,product extraction,and microbial pathways.

关键词： Electro-fermentation Microbial electrochemistry Acetogen Chain elongation Electroactive microorganism

组蛋白H3K27me3沉默子重塑上调胃黏膜高级别上皮内瘤变磷酸甘油醛激酶1表达

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陆军军医大学学报 2024年第6期46卷 597-607页

作者：秦苾珺谭玉婷储召乐刘碧颖李先锋王涛陈东风崔红娟吴林育王斌西南大学医学研究院重庆400715 陆军军医大学陆军特色医学中心(大坪医院)消化内科消化系统肿瘤精准防治重庆市重点实验室重庆400042 重庆大学医学院重庆400044

目的绘制胃黏膜高级别上皮内瘤变(High-Grade Intraepithelial Neoplasia, HGIN)组织的组蛋白H3K27me3沉默子图谱,寻找沉默子调控的重要靶基因。方法从本院内镜中心收集HGIN与正常胃黏膜组织各24例,采用H3K27me3染色体靶向切割和标签... 详细信息

目的绘制胃黏膜高级别上皮内瘤变(High-Grade Intraepithelial Neoplasia, HGIN)组织的组蛋白H3K27me3沉默子图谱,寻找沉默子调控的重要靶基因。方法从本院内镜中心收集HGIN与正常胃黏膜组织各24例,采用H3K27me3染色体靶向切割和标签化(Cleavage Under Target&Tagmentation, CUT&Tag)测序技术捕获基因组修饰区域。通过生物信息学分析比较两类组织的沉默子信号特征以及差异;整合RNA测序数据及高通量染色体构象捕获技术(Hi-C)公共数据,分析沉默子重塑调控的靶基因及调控的潜在生物学过程。结果与正常胃黏膜相比,HGIN组织H3K27me3修饰数量减少,信号强度全局性降低,呈现H3K27me3信号峰重塑现象;转录组差异分析结果显示,与正常胃黏膜组织相比,HGIN共有8 887个差异表达基因,其中表达上调基因4 335个,表达下调基因4 552个,其中CTNNB1等肿瘤发生相关基因显著上调;整合分析表观组学和转录组学数据,发现沉默子丢失可能在转录水平上调氨基酸生物合成、精氨酸与脯氨酸代谢和糖酵解等关键代谢基因,如糖酵解关键酶磷酸甘油醛激酶1(phosphoglycerate kinase1,PGK1)表达,进而促进胃黏膜上皮内瘤变。结论组蛋白H3K27me3沉默子信号丢失是HGIN表观重塑特征之一,沉默子丢失可能与PGK1等糖酵解和氨基酸代谢基因表达紊乱相关。

关键词：胃高级别上皮内瘤变胃癌组蛋白修饰H3K27me3 沉默子磷酸甘油醛激酶1

FeNO联合TSLP对儿童咳嗽变异性哮喘与感染后咳嗽的鉴别价值及与小气道功能的关系

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海南医学 2024年第13期35卷 1854-1858页

作者：高艺伟马莹莹张曼储卫红彭韶郑州大学第一附属医院小儿内科河南郑州450000

目的探究呼出气一氧化氮(FeNO)联合胸腺基质淋巴细胞生成素(TSLP)对儿童咳嗽变异性哮喘(CVA)与感染后咳嗽(PIC)的鉴别价值,并分析FeNO、TSLP与CVA病情、小气道功能的关系,为临床诊疗提供有利依据。方法选取2021年6月至2023年4月郑州大... 详细信息

目的探究呼出气一氧化氮(FeNO)联合胸腺基质淋巴细胞生成素(TSLP)对儿童咳嗽变异性哮喘(CVA)与感染后咳嗽(PIC)的鉴别价值,并分析FeNO、TSLP与CVA病情、小气道功能的关系,为临床诊疗提供有利依据。方法选取2021年6月至2023年4月郑州大学第一附属医院儿科诊治收治的90例CVA患儿作为CVA组,另选取同期90例PIC患儿作为PIC组。比较两组患儿的临床资料和FeNO、TSLP水平,绘制受试者工作特征(ROC)曲线及曲线下面积(AUC)分析FeNO联合TSLP对CVA与PIC的鉴别价值;比较CVA不同病情严重程度和病情阶段患儿的小气道功能[FEF25(%)、FEF50(%)、FEF75(%)、FEF25~75(%)]和FeNO、TSLP水平,采用Spearman和Pearson相关系数法分析FeNO、TSLP与CVA小气道功能、病情阶段、病情严重程度的相关性。结果CVA组患儿的FeNO、TSLP水平明显高于PIC组,差异均有统计学意义(P中度组>重度组,差异均有统计学意义(P<0.05);轻度组患儿的FeNO、TSLP水平<中度组<重度组,差异均有统计学意义(P<0.05);临床缓解期组患儿的FEF25、FEF50、FEF75、FEF25~75明显高于急性发作期组,FeNO、TSLP水平明显低于急性发作期组,差异均有统计学意义(P<0.05);Pearson相关系数法分析结果显示,FeNO、TSLP与FEF25、FEF50、FEF75、FEF25~75均呈负相关(P<0.05);Spearman相关系数法分析结果显示,FeNO、TSLP与病情阶段、病情严重程度均呈正相关(P<0.05)。结论与PIC患儿比较,CVA患儿FeNO、TSLP水平异常升高,其联合鉴别诊断CVA与PIC具有较高价值,且FeNO、TSLP水平与患儿病情、小气道功能密切相关。

关键词：呼出气一氧化氮胸腺基质淋巴细胞生成素咳嗽变异性哮喘感染后咳嗽小气道功能

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使用高光谱成像技术对田间杂草进行表征和识别

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塔里木大学学报 2024年第3期36卷 89-97页

作者：柳莹莹尹雁玲刘江华尹勇储涛涛江阳塔里木大学机械电气化工程学院新疆阿拉尔843300 塔里木大学生命科学与技术学院新疆阿拉尔843300 新宾满族自治县上夹河镇综合事务服务中心辽宁抚顺113000

进行杂草表征和分类对于智慧农业杂草清除与田间管理而言至关重要,然而杂草识别精度较低的问题尚未得到深入探究。本研究以田间杂草为研究对象,建立了农业地区7种杂草物种的高光谱数据库。首先,使用地面高光谱相机采集了高光谱图像,提... 详细信息

进行杂草表征和分类对于智慧农业杂草清除与田间管理而言至关重要,然而杂草识别精度较低的问题尚未得到深入探究。本研究以田间杂草为研究对象,建立了农业地区7种杂草物种的高光谱数据库。首先,使用地面高光谱相机采集了高光谱图像,提取并分析了每个物种的代表性光谱曲线、光谱剖面特征,并对各物种进行主成分分析,揭示了不同杂草物种的差异性。采用多元散射校正、归一化、一阶和二阶差分求导对原始光谱数据进行预处理。最后通过建立支持向量机与一维卷积神经网络分类模型,用于高光谱图像中识别杂草。结果表明,MSC-1DCNN模型的分类效果最佳,不同物种的用户准确性为95.71%~100%。该研究不仅为了解杂草物种的高光谱特征以及杂草管理提供了有力的保障,而且也有助于自动化除草机器人的研制与无人农场的实施。

关键词：杂草高光谱卷积神经网络田间管理

Turbulence Modulations in the Boundary Layer of a Horizontal Particle-Laden Channel Flow

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Chinese Physics Letters 2010年第6期27卷 129-132页

作者： LI Jing LIU Zhao-Hui WANG Han-Feng CHEN Sheng LIU Ya-Ming HAN Hai-Feng ZHENG chu-Guang State Key Laboratory of Coal Combustion Huazhong University of Science and Technology Wuhan 430074

Turbulence modulations are experimentally investigated using particle image velocimetry （PIV） in the lower boundary layer of a fully developed horizontal channel flow. A simultaneous two-phase PIV measurement technique is adopted to acquire the turbulent statistics quantities and to examine the coherent structures in the near-wall region. Polythene beads with diameters of 60 μm are used as dispersed phases, and the PIV measurements have been performed at three mass loadings varying from 2.5 ×10^-4 to 5 × 10^-3. All the experiments are performed at a wall shear Reynolds number of Reτ = 430. The results show that the presence of the particles suppresses the coherent structures, with shorter streamwise extent of the quasistrearnwise structures, and then, the wall-normal velocity fluctuations and shear Reynolds stresses are both decreased in the near-core region. In addition, as a result of the particle wake, the turbulence intensity and shear Reynolds stress both increase in the vicinity of the wall. Due to the drag effects of the particles on the gas, the streamwise velocity gradients decrease in the outer region and increase in the viscous sublayer, meanwhile the thickness of the viscous sublayer also decreases. These results cause the peak values of the streamwise velocity fluctuations adjacent to the wall to increase, and the peak positions shift to the wall. This is the reason for decreasing the near-wall region and increasing the near-core region of the streamwise velocity fluctuations in appearance.

关键词： Reynolds stress Wakes Flow in channels Turbulence intensities Statistical analysis Drag

The Power of Inbreeding： NGS-Based GWAS of Rice Reveals Convergent Evolution during Rice Domestication

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Molecular Plant 2016年第7期9卷 975-985页

作者： Hongru Wang Xun Xu Filipe Garrett Vieira Yunhua Xiao Zhikang Li Jun Wang Rasmus Nielsen Chengcai chu State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academyof Sciences Beijing 100101 China Cotlege of Life Sciences University of Chinese Academy of Sciences Beijing 100101 China BGI-Shenzhen Shenzhen 518083 China Centre for GeoGenetics University of Copenhagen 1350 Copenhagen Denmark Institute of Crop Sciences/National Key Facilities for Crop Gene Resources and Genetic Improvement Chinese Academy of Agricultural Sciences 12 SouthZhong-Guan-Cun Street Beijing 100081 China Department of Integrative Biology University of California Berkeley CA 94720 USA These authors contributed equally to this article.

Low-coverage whole-genome sequencing is an effective strategy for genome-wide association studies in hu- mans, due to the availability of large reference panels for genotype imputation. However, it is unclear whether this strategy can be utilized in other species without reference panels. Using simulations, we show that this approach is even more relevant in inbred species such as rice （Oryza sativa L.）, which are effectively haploid, allowing easy haplotype construction and imputation-based genotype calling, even without the availability of large reference panels. We sequenced 203 rice varieties with well-characterized phenotypes from the United States Department of Agriculture Rice Mini-Core Collection at an average depth of 1.5~ and used the data for mapping three traits. For the first two traits, amylose content and seed length, our approach leads to direct identification of the previously identified causal SN Ps in the major-effect loci. For the third trait, pericarp color, an important trait underwent selection during domestication, we identified a new major-effect locus. Although known loci can explain color variation in the varieties of two main subspecies of Asian domesticated rice,japonica and indica, the new locus identified is unique to another domesticated rice subgroup, aus, and together with existing loci, can fully explain the major variation in pericarp color in aus. Our discovery of a unique genetic basis of white pericarp in aus provides an example of convergent evolution during rice domestication and suggests that aus may have a domestication history independent of japonica and indica.

关键词： inbreeding GWAS rice pericarp color

T-2 toxin-induced apoptosis involving Fas,p53,Bcl-xL,Bcl-2,Bax and caspase-3 signaling pathways in human chondrocytes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 455-463页

作者： Jing-hong CHEN Jun-ling CAO Yong-lie chu Zhi-lun WANG Zhan-tian YANG Hong-lin WANG Ministry of Education Key Laboratory of Environment and Genes related to Diseases Institute of Endemic Diseases School of Medicine Xi ＇an Jiaotong University Xi ＇an 710061 China

Objective:To investigate the effects of T-2 toxin on expressions of Fas,p53,Bcl-xL,Bcl-2,Bax and caspase-3 on human ***:Human chondrocytes were treated with T-2 toxin(1～20 ng/ml)for 5 ***,p53 and other apoptosis-related proteins such as Bax,Bcl-2,Bcl-xL,caspase-3 were determined by Western blot analysis and their mRNA expressions were determined by reverse transcriptase-polymerase chain reaction(RT-PCR).Results:Increases in Fas,p53 and the pro-apoptotic factor Bax protein and mRNA expressions and a decrease of the anti-apoptotic factor Bcl-xL were observed in a dose-dependent manner after exposures to 1～20 ng/ml T-2 toxin,while the expression of the anti-apoptotic factor Bcl-2 was ***,T-2 toxin could also up-regulate the expressions of both pro-caspase-3 and caspase-3 in a dose-dependent ***:These data suggest a possible underlying molecular mechanism for T-2 toxin to induce the apoptosis sig- naling pathway in human chondrocytes by regulation of apoptosis-related proteins.

关键词： Apoptosis Apoptosis-related proteins Chondrocyte T-2 toxin

Eco-Environmental Impact Assessment of Pre-Leisure Beach Nourishment on the Benthic Invertebrate Community at Anping Coast

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China Ocean Engineering 2011年第2期25卷 215-236页

作者： chun-Han SHIH Yi-Yu KUO Ta-Jen chu Wen-Chieh CHOU Wei-Tse CHANG Ying-Chou LEE Institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Department of Leisure and Recreation Management Chung Hua University Hsinchu 30012 China Department of Civil Engineering Chung Hua University Hsinchu 30012 China

In recent years, owing to global warming and the rising sea levels, beach nourishment and groin building have been increasingly employed to protect coastal land from shoreline erosion. These actions may degrade beach habitats and reduce biomass and invertebrate density at sites where they were employed. We conducted an eco-environmental evaluation at the Anping artificial beach-nourishment project area. At this site, sand piles within a semi-enclosed spur groin have been enforced by use of eco-engineering concepts since 2003. Four sampling sites were monitored during the study period from July 2002 to September 2008. The environmental impact assessment and biological investigations that we conducted are presented here. The results from this study indicate that both biotic （number of species, number of individual organisms, and Shannon-Wiener diversity） and abiotic parameters （suspended solids, biological oxygen demand, chemical oxygen demand, dissolved inorganic nitrogen, dissolved inorganic phosphorus, total phosphorus, total organic carbon, median diameter, and water content） showed significant differences before and after beach engineering construction. Biological conditions became worse in the beginning stages of the engineering but improved after the restoration work completion. This study reveals that the composition of benthic invertebrates changed over the study period, and two groups of organisms, Bivalvia and Gastropoda, seemed to be particularly suitable to this habitat after the semi-enclosed artificial structures completion.

关键词： beach nourishment benthic invertebrate eco-engineering ecological restoration spur groin

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CCUS-EOR管道工程管材选择研究

油气田地面工程 2024年第6期43卷 1-8页

作者：来海雷褚会娟张会忠蒋风松朱海大庆油田设计院有限公司

由于国内关于超临界/密相CO_(2)管道输送的工程应用几乎为零,也无针对性的管材选择标准规范,因此,对CCUS-EOR全产业链地面工程技术体系与建设模式取得成果进行归纳总结,论述了CO_(2)管道管材选择标准的适用性和HFW钢管、SMLS钢管及SAWL... 详细信息

由于国内关于超临界/密相CO_(2)管道输送的工程应用几乎为零,也无针对性的管材选择标准规范,因此,对CCUS-EOR全产业链地面工程技术体系与建设模式取得成果进行归纳总结,论述了CO_(2)管道管材选择标准的适用性和HFW钢管、SMLS钢管及SAWL钢管的差异性及对CO_(2)管道输送的适应性,对CO_(2)管道输送的管材选择提出以下建议:CCUS-EOR管道具有难止裂、泄漏后温降大、易腐蚀等特点,管材应具有优良低温性能、较高止裂韧性和耐腐蚀性;虽然国内外CO_(2)管道输送还未形成具有科学性、全面性和系统性的标准体系,但可借鉴传统的石油、天然气管道材料和施工做法;管材选择的关键是钢管技术指标对使用要求的满足性,要综合考虑管材的价格、性能、冲击韧性等因素以及对工程条件的适应性。

关键词： CCUS-EOR 管材选择 HFW焊管 SAWL焊管 SMLS钢管

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