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The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin

Journal of Integrative Medicine 2021年第5期19卷 451-459页

作者： Pinar Tatli Seven Ismail Seven Selcan Karakus Seda Iflazoglu Mutlu Seyma Ozer Kaya Gozde Arkali Merve Ilgar Ezgi Tan yesim muge sahin Deniz Ismik Ayben Kilislioglu Department of Animal Nutrition and Nutritional Diseases Faculty of Veterinary MedicineFirat UniversityElazig23119Turkey Department of Plant and Animal Production Vocation School of SivriceFtrat UniversityElazig 23119Turkey Department of Chemistry Faculty of EngineeringIstanbul University-CerrahpasaIstanbul 34320Turkey Department of Reproduction and Artificial Insemination Faculty of Veterinary MedicineFirat UniversityElazig 231J9Turkey Department of Physiology Faculty of Veterinary MedicineFirat UniversityElazig 23119Turkey Istanbul Arel University ArelPOTKAM(Polymer Technologies and Composite Application and Research Center)Istanbul 34537Turkey Department of Biomedical Engineering Faculty of Engineering and ArchitectureIstanbul Arel UniversityIstanbul 34537Turkey Department of Electrical Electronics Engineering Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul 34083Turkey

Objective: Chemotherapeutic drugs, such as cisplatin(CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and nano-propolis(NP) can alleviate oxidative stress and apoptosis in rats with testicular damage induced by ***: In this study, polymeric nanoparticles including propolis were synthesized with a green sonication method and characterized using Fourier transform-infrared spectroscopy, Brunauer-EmmettTeller, and wet scanning transmission electron microscopy techniques. In total, 56 rats were divided into the following seven groups: control, CP, propolis, NP-10, CP + propolis, CP + NP-10, and CP + ***(100 mg/kg), NP-10(10 mg/kg), and NP-30(30 mg/kg) treatments were administered by gavage daily for 21 d, and CP(3 mg/kg) was administered intraperitoneally in a single dose. After the experiment,oxidative stress parameters, namely, malondialdehyde(MDA), glutathione(GSH), glutathione peroxidase(GPx), and catalase(CAT), and apoptotic pathways including B cell leukemia/lymphoma-2 protein(Bcl-2)and Bcl-2-associated X protein(Bax) were measured in testicular tissues. Furthermore, sperm quality and weights of the testis, epididymis, right cauda epididymis, seminal vesicles and prostate were ***: Propolis and NP(especially NP-30) were able to preserve oxidative balance(decreased MDA levels and increased GSH, CAT, and GPx activities) and activate apoptotic pathways(decreased Bax and increased Bcl-2) in the testes of CP-treated rats. Sperm motility in the control, CP, and CP + NP-30 groups were 60%, 48.75%, and 78%, respectively(P<0.001). Especially, NP-30 application completely corrected the deterioration in sperm features induced by ***: The results show that propolis and NP treatments mitigated the side effects of CP on spermatogenic activity, antioxidant situation, and apoptosis in rats.

关键词： Cisplatin Nano-propolis Reproductive system Testicular damage

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