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Nesting and Berth Allocation by an Expert System Using Heuristic Search

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Journal of Software Engineering and Applications 2017年第4期10卷 311-323页

作者： Dongmok sheen Yoonho Seo School of Naval Architecture and Ocean Engineering University of Ulsan Ulsan Korea School of Industrial Management Engineering Korea University Seoul Korea

Nesting is a common problem in industries such as shipbuilding, auto-maker, clothing, shoe-making, and furniture, in which various parts are cut off from a stock or stocks while minimizing the wastes or maximizing the utilization of the stock. Berth allocation at seaside is also considered one form of two dimensional nesting problems, in which a ship is assigned a location for service during a certain time slot. This paper presents an expert system using a heuristic search method for nesting problems. The parts and stocks are represented by pixels with which utility function is used to evaluate current state in search tree. The system is developed in CLIPS, an expert system shell and applied to various example problems with different constraints and to a berth allocation example to illustrate its applicability under different conditions.

关键词： Nesting Berth Allocation Heuristic Search CLIPS

Modeling the Surface Cross-Contamination of Salmonellaspp. on Ready-to-Eat Meat via Slicing Operation

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Food and Nutrition Sciences 2011年第9期2卷 916-924页

作者： Shiowshuh sheen Cheng-An Hwang 不详

Salmonella spp. surface transfer patterns/models between ready-to-eat (RTE) deli meat and a typical meat slicer are presented. A five-strain cocktail of Salmonella spp. was inoculated directly onto the rim of a round slicer blade at an initial level of ca. 4, 5, 6, 7 or 8 log CFU/blade (ca. 3, 4, 5, 6 or 7 log CFU/cm2 of the blade edge area). Thereafter, a RTE deli meat (ham) was sliced to a thickness of 1.5 - 2.0 mm. In another cross-contamination scenario, a clean blade was initially used to slice ham, which was pre-surface-inoculated with the Salmonella cocktail (ca. 2, 3, 4, 5, 6 or 7 log CFU/cm2 with a total area of 100 cm2), followed by slicing of an un-inoculated ham. The log CFU of Salmonella per ham slice was determined and empirical models were developed. The models, follow the decreasing Power law, predict the surface cross-contamination of Salmonella spp. (at any initial level) for sliced deli meat (ham) and will provide a useful tool in developing RTE meat risk assessments. Surface transfer patterns of three foodborne pathogens, i.e. Listeria monocytogenes, E. coli O157:H7 and Salmonella predicted by models are also presented.

关键词： Salmonella Surface Transfer Cross-Contamination Modeling Slicing

IFN-a production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and-independent pathways

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Cellular & Molecular Immunology 2011年第2期8卷 181-188页

作者： Hong-Ren Yu Hsin-Chun Huang Ho-Chang Kuo Jiunn-Ming sheen Chia-Yo Ou Te-Yao Hsu Kuender D Yang Department of Pediatrics Chang Gung Memorial Hospital-Kaohsiung Medical CenterGraduate Institute of Clinical Medical ScienceChang Gung University College of MedicineTaiwan Department of Obstetrics Chang Gung Memorial Hospital-Kaohsiung Medical CenterGraduate Institute of Clinical Medical ScienceChang Gung University College of MedicineTaiwan

Understanding the defense mechanisms of the host of an organism is important for infection *** previous studies,we demonstrated that interferon-a(IFN-a),but not IL-12,was produced by human peripheral blood mononuclear cells infected with varicella-zoster virus(VZV).Here,we investigated what kind of cell(s)and which signal molecule(s)are involved in IFN-a *** cell isolation and ELISA,we found that plasmacytoid dendritic cells(pDCs)were responsible for IFN-a production during VZV *** also found that Toll-like receptor 9(TLR9)was involved in VZV-induced IFN-a production because inhibitory CpG oligodeoxynucleotide inhibited IFN-a ***-inactivated VZV-induced IFN-a production was lower than that of active VZV,indicating another TLR9-independent *** studies demonstrated that double-stranded RNA-dependent protein kinase,but not DNA-dependent protein kinase was involved in VZV-induced IFN-a ***,these results suggest that pDCs play an important role in IFN-a production during VZV infection through TLR9-dependent and-independent pathways.

关键词： IFN-a mononuclear cells plasmacytoid dendritic cell TLR9 varicella-zoster virus

Amendment of Cavity Perturbation Technique for Loss Tangent Measurement at Microwave Frequencies

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Amendment of Cavity Perturbation Technique for Loss Tangent ...

"Defective" mutations of hepatitis D viruses in chronic hepatitis D patients

2006 7th International Symposium on Antennas, Propagation and EM Theory

作者： Jyh sheen Department of Electronic Engineering National Formosa University

Theoretically,the quality factor of a metal resonant cavity will be increased after introducing a lossless dielectric ***,for the conventional cavity perturbation method,widely used on the measurements of microwave dielectric properties,this increment of quality factor is not put into the consideration of calculation on loss tangent ***,the conventional resonant perturbation formulae for dielectric loss measurement should be *** amendment is introduced in this study and the measuring error on loss tangent on the conventional formula is *** have shown the improvement of measurement accuracy by this modification.

关键词： Amendment of Cavity Perturbation Technique for Loss Tangent Measurement at Microwave Frequencies

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World Journal of Gastroenterology 2005年第11期11卷 1658-1662页

作者： Jaw-Ching Wu Sheng-Chieh Hsu Shen-Yung Wang Yi-Hsiang Huang I-Jane sheen Hsuan-Hui Shih Wan-Jr Syu Institute of Clinical Medicine Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan China Division of Gastroenterology School of Medicine National Yang-Ming University Taipei Taiwan China Institute of Microbiology and Immunology

AIM: To verify whether 'defective' mutations existed in hepatitis D virus (HDV).METHODS: Hepatitis delta antigen (HDAg)-codingsequences were amplified using Pfu DNA polymerases with proof-reading activities from sera of five patients with chronic hepatitis D. Multiple colonies were sequenced for each patient. Pfu analyzed a total of 270 HDV *** representative defective HDV clones were constructed in expression plasmids and transfected into a human hepatoma cell line. Cellular proteins were extracted and analyzed by Western ***: Four of five cases (80%) showed defective HDV genomes in their sera. The percentage of defective genomes was 3.7% (10/270). The majority (90%) of the defective mutations were insertions or deletions that resulted in frameshift and abnormal stop translation of the HDAg. The predicted mutated HDAg ranged from 45amino acids to ＞214 amino acids in length. Various domains of HDAg associated with viral replication or packaging were affected in different HDV isolates. Western blot analysis showed defected HDAg in predicted ***: 'Defective' viruses do exist in chronic HDV infected patients, but represented as minor strains. The clinical significance of the 'defected' HDV needs further study to evaluate.

关键词： Defective virus Hepatitis D virus Hepatitis B virus Polymerase chain reaction Hepatitis delta antigen

Effects of Sodium Lactate on the Survival of Listeria Monocytogenes, Escherichia coliO157:H7, and Salmonellaspp. in Cooked Ham at Refrigerated and Abuse Temperatures

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Food and Nutrition Sciences 2011年第5期2卷 464-470页

作者： Cheng-An Hwang Shiowshuh sheen Vijay Juneja Residue Chemistry and Predictive Microbiology Research Unit Eastern Regional Research Center Agricultural Research Service United States Department of Agriculture Wyndmoor USA

The objective of this study was to determine the effect of sodium lactate on the survival of Listeria monocytogenes, Escherichia coli O157: H7, and Salmonella spp. in cooked ham during storage at refrigerated and abuse temperatures. Cooked ham was added with 0% - 3% lactate, inoculated with a multiple-strain mixture of L. monocytogenes, E. coli O157: H7, or Salmonella spp. and stored at 4oC - 15oC for up to 35 day. The growth of the three pathogens was inhibited in ham containing 3% lactate, and no growth of E. coli O157: H7 and Salmonella spp. occurred at the lowest storage tem- peratures of 6 and 8oC, respectively. In ham containing no lactate, the average growth rates were 0.256 - 0.380 log CFU/day for L. monocytogenes at 4oC - 8oC, 0.242 - 0.315 log CFU/day for E. coli O157: H7 at 8oC - 15oC, and 0.249 - 0.328 log CFU/day for Salmonella spp. at 10oC - 15oC. The addition of 1% or 2% lactate significantly (P < 0.05) reduced the growth rates of the three pathogens, and the effect was more profound at lower temperatures. Salmonella spp. were more sensitive to the effect of lactate than L. monocytogenes and E. coli O157: H7. Polynomial models were developed to describe the growth rates of the three pathogens as affected by the lactate concentration and storage tem- perature. Results from this study demonstrate the effect of lactate on the growth of L. monocytogenes, E. coli O157: H7, and Salmonella spp. in cooked ham and indicate the effective lactate concentrations and storage temperatures that can be used to enhance the microbiological safety of ready-to-eat ham products.

关键词： Ham Lactate Listeria Monocytogenes Escherichia Coli O157: H7 Salmonella spp.

Risks of rapid decline renal function in patients with type 2 diabetes

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World Journal of Diabetes 2014年第6期5卷 835-846页

作者： Yi-Jing sheen Wayne HH Sheu Division of Endocrinology and Metabolism Department of Internal MedicineTaichung HospitalMinistry of Health and Welfare Division of Endocrinology and Metabolism Department of Internal MedicineTaichung Veterans General Hospital School of Medicine National Defense Medical Center School of Medicine National Yang-Ming University Institute of Medical Technology National Chung-Hsing University

Progressive rising population of diabetes and related nephropathy, namely, diabetic kidney disease and associated end stage renal disease has become a major global public health issue. Results of observational studies indicate that most diabetic kidney disease progresses over decades; however, certain diabetes patients display a rapid decline in renal function, which may lead to renal failure within months. Although the definition of rapid renal function decline remained speculative, in general,it is defined by the decrease of estimated glomerular filtration rate(e GFR) in absolute rate of loss or percent change. Based on the Kidney Disease: Improving Global Outcomes 2012 clinical practice guidelines, a rapid decline in renal function is defined as a sustained declinein e GFR of > 5 m L/min per 1.73 m2 per year. It has been reported that potential factors contributing to a rapid decline in renal function include ethnic/genetic and demographic causes, smoking habits, increased glycated hemoglobin levels, obesity, albuminuria, anemia, low serum magnesium levels, high serum phosphate levels, vitamin D deficiency, elevated systolic blood pressure, pulse pressure, brachial-ankle pulse wave velocity values, retinopathy, and cardiac autonomic neuropathy. This article reviews current literatures in this area and provides insight on the early detection of diabetic subjects who are at risk of a rapid decline in renal function in order to develop a more aggressive approach to renal and cardiovascular protection.

关键词： Type 2 diabetes Diabetic kidney disease Rapid decline Estimated glomerular filtration rate Albuminuria

Intraluminal versus infiltrating gallbladder carcinoma:Clinical presentation,ultrasound and computed tomography

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World Journal of Gastroenterology 2009年第45期15卷 5662-5668页

作者： Tze-Yu Lee Sheung-Fat Ko Chung-Cheng Huang Shu-Hang Ng Jiun-Lung Liang Hsuan-Ying Huang Min-Chi Chen Shyr-Ming sheen-Chen Department of Radiology Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China Department of Pathology Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China Public Health and Biostatistics Consulting Center Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China Department of Surgery Chang Gung University College of Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Kaohsiung Hsien 833 Taiwan China

AIM： To compare clinical presentation and ultrasound （US） and computed tomography （CT） sensitivity between intraluminal and infiltrating gallbladder carcinoma （GBCA）. METHODS： This retrospective study evaluated 65 cases of GBCA that were categorized morphologically into the intraluminaI-GBCA （n = 37） and infiltrating-GBCA （n = 28） groups. The clinical and laboratory findings, presence of gallstones, gallbladder size, T-staging, nodal status, sensitivity of preoperative US and CT studies, and outcome were compared between the two groups. RESULTS： There were no significant differences between the two groups with respect to female predominance, presence of abdominal pain, serum aminotransferases level, T2-T4 staging, and regional metastatic nodes. Compared with the patients with intraluminaI-GBCA, those with infiltrating-GBCA were significantly older （65.49 ± 1.51 years vs 73.07 ± 1.90 years）, had a higher frequency of jaundice （3/37 patients vs 13/28 patients） and fever （3/37 patients vs 10/28 patients）, higher alkaline phosphatase （119.36 ± 87.80 IU/L vs 220.68 ± 164.84 IU/L） and total bilirubin （1.74 ± 2.87 mg/L vs 3.50 ± 3.51 mg/L） levels, higher frequency of gallstones （12/37 patients vs 22/28 patients）, smaller gallbladder size （length, 7.47± 1.70 cm vs 6.47 ± 1.83 cm; width, 4.21 ± 1.43 cm vs 2.67 ± 0.93 cm）, and greater proportion of patients with 〈 12 mo survival （16/37 patients vs 18/28 patients）. The sensitivity for diagnosing intraluminal- GBCA with and without gallstones was 63.6% and 91.3% by US, and 80% and 100% by CT, respectively. The sensitivity for diagnosing infiltrating-GBCA with and without gallstones was 12.5% and 25% by US, and 71.4% and 75% by c-r, respectively. CONCLUSION： In elderly women exhibiting small gallbladder and gallstones on US, especially those with jaundice, fever, high alkaline phosphatase and bilirubin levels, CT may reveal concurrent infiltrating-GBCA.

关键词： Gallbladder neoplasms Carcinoma Ultrasound Computed tomography

MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding

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World Journal of Gastroenterology 2011年第16期17卷 2120-2125页

作者： Chun-Yen Lin I-Shyan sheen Tsung-Nan Lin Chun-Jung Lin Wen-Juei Jeng Chien-Hao Huang Yu-Pin Ho Cheng-Tang Chiu Department of Hepato-Gastroenterology Linkou Medical CenterChang Gung Memorial Hospital and Chang Gung University College of Medicine

AIM:To investigate the outcomes,as well as risk factors for 6-wk mortality,in patients with early rebleeding after endoscopic variceal band ligation (EVL) for esophageal variceal hemorrhage (EVH).METHODS:Among 817 EVL procedures performed for EVH between January 2007 and December 2008,128 patients with early rebleeding,defined as rebleeding within 6 wk after EVL,were enrolled for ***:The rate of early rebleeding after EVL for acute EVH was 15.6% (128/817).The 5-d,6-wk,3-mo,and 6-mo mortality rates were 7.8%,38.3%,55.5%,and 58.6%,respectively,in these early rebleeding *** use of beta-blockers,occurrence of hypovolemic shock,and higher model for end-stage liver disease (MELD) score at the time of rebleeding were independent predictors for 6-wk mortality.A cut-off value of 21.5 for the MELD score was found with an area under ROC curve of 0.862 (P < 0.001).The sensitivity,specificity,positive predictive value,and negative predictive value were 77.6%,81%,71.7%,and 85.3%,*** for the 6-mo survival rate,patients with a MELD score ≥ 21.5 had a significantly lower survival rate than patients with a MELD score < 21.5 (P < 0.001).CONCLUSION:This study demonstrated that the MELD score is an easy and powerful predictor for 6-wk mortality and outcomes of patients with early rebleeding after EVL for EVH.

关键词： Model for end-stage liver disease score Esophageal variceal hemorrhage Rebleeding Cirrhosis Mortality